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The map label for this gene is yggV [C]

Identifier: 20095030

GI number: 20095030

Start: 1603551

End: 1604117

Strand: Reverse

Name: yggV [C]

Synonym: MK1594

Alternate gene names: 20095030

Gene position: 1604117-1603551 (Counterclockwise)

Preceding gene: 20095032

Following gene: 20095029

Centisome position: 94.64

GC content: 57.67

Gene sequence:

>567_bases
ATGAAAGTGTTATTTGCAACGGGCAATATCGGAAAGTACCATGAGGCCAAGCAGATATTAGCGCGGTACGGCATCGAAGT
CGAGCGCGTTGACCTCGACTACCCGGAGCTTCAATCTGACAGCTTAGAGGAGATCGCCGCCTACGGGGCCCGGTACTGTG
CTGAGTCGTTGGGTCAGCCGGTGATAGTCGAAGACTCGGGCCTGTTTATCGAAGCTTTGAACGGGTTCCCAGGGCCGTAC
TCCGCCTACGTGTTCGACACGATCGGTAACGAGGGTATCTTGAAGTTGTTGGAGGGGGAGGAGAACCGCAAGGCCGAATT
CATCTCGGTCGTAGGCTACTGCGAGCCCGGCGGTCGACCGGTAACCTTCACCGGCGAGATCCGCGGGCGGATAGCGGAGG
AACCCCGAGGTGAAGAGGGCTTCGGCTACGATCCTATCTTCATCCCGGAGGGTGAAGACAGTACGTTCGCGGAGCTGGGA
GTCGAGGAAAAGTGTAAAATATCGCACCGGACCAAGGCGCTCGAGAGGTTCGCGGAGTGGTACAAGAATAACGTGGCGGG
GAGGTGA

Upstream 100 bases:

>100_bases
GTCGTATGGCTTTATTACTCTCGGACAACTTATATCACTCCCTTGAGATTTTTCGTCGAAACGCCATTTTACTCGAATTT
AAACCTTGGGTGGATGGAAT

Downstream 100 bases:

>100_bases
TCAGTCTTGGCGCGTATGCATTCACGTGACAGAGGCAAGTCAGGATCAACCAGACCCCCCAGAGTAGCTCCCCCGTCGTG
GGTGGAGTACTCGCCCGAGG

Product: xanthosine triphosphate pyrophosphatase

Products: NA

Alternate protein names: Nucleoside triphosphate phosphohydrolase; NTPase

Number of amino acids: Translated: 188; Mature: 188

Protein sequence:

>188_residues
MKVLFATGNIGKYHEAKQILARYGIEVERVDLDYPELQSDSLEEIAAYGARYCAESLGQPVIVEDSGLFIEALNGFPGPY
SAYVFDTIGNEGILKLLEGEENRKAEFISVVGYCEPGGRPVTFTGEIRGRIAEEPRGEEGFGYDPIFIPEGEDSTFAELG
VEEKCKISHRTKALERFAEWYKNNVAGR

Sequences:

>Translated_188_residues
MKVLFATGNIGKYHEAKQILARYGIEVERVDLDYPELQSDSLEEIAAYGARYCAESLGQPVIVEDSGLFIEALNGFPGPY
SAYVFDTIGNEGILKLLEGEENRKAEFISVVGYCEPGGRPVTFTGEIRGRIAEEPRGEEGFGYDPIFIPEGEDSTFAELG
VEEKCKISHRTKALERFAEWYKNNVAGR
>Mature_188_residues
MKVLFATGNIGKYHEAKQILARYGIEVERVDLDYPELQSDSLEEIAAYGARYCAESLGQPVIVEDSGLFIEALNGFPGPY
SAYVFDTIGNEGILKLLEGEENRKAEFISVVGYCEPGGRPVTFTGEIRGRIAEEPRGEEGFGYDPIFIPEGEDSTFAELG
VEEKCKISHRTKALERFAEWYKNNVAGR

Specific function: Hydrolyzes non-standard nucleotides such as XTP and dITP/ITP. Might exclude non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions

COG id: COG0127

COG function: function code F; Xanthosine triphosphate pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAM1 NTPase family

Homologues:

Organism=Homo sapiens, GI15626999, Length=188, Percent_Identity=34.0425531914894, Blast_Score=104, Evalue=6e-23,
Organism=Homo sapiens, GI31657144, Length=157, Percent_Identity=34.3949044585987, Blast_Score=91, Evalue=7e-19,
Organism=Escherichia coli, GI1789324, Length=194, Percent_Identity=38.1443298969072, Blast_Score=108, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17556833, Length=184, Percent_Identity=39.1304347826087, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6322529, Length=192, Percent_Identity=35.4166666666667, Blast_Score=106, Evalue=3e-24,
Organism=Drosophila melanogaster, GI19920712, Length=174, Percent_Identity=41.3793103448276, Blast_Score=124, Evalue=4e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NTPA_METKA (Q8TV07)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_614877.1
- ProteinModelPortal:   Q8TV07
- SMR:   Q8TV07
- GeneID:   1478189
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK1594
- NMPDR:   fig|190192.1.peg.1590
- HOGENOM:   HBG697237
- OMA:   GPYAEYV
- BioCyc:   MKAN190192:MK1594-MONOMER
- BRENDA:   3.6.1.15
- HAMAP:   MF_01405
- InterPro:   IPR002637
- InterPro:   IPR020922
- PANTHER:   PTHR11067
- TIGRFAMs:   TIGR00042

Pfam domain/function: PF01725 Ham1p_like

EC number: =3.6.1.15

Molecular weight: Translated: 20900; Mature: 20900

Theoretical pI: Translated: 4.33; Mature: 4.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLFATGNIGKYHEAKQILARYGIEVERVDLDYPELQSDSLEEIAAYGARYCAESLGQP
CEEEEECCCCCCHHHHHHHHHHHCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCC
VIVEDSGLFIEALNGFPGPYSAYVFDTIGNEGILKLLEGEENRKAEFISVVGYCEPGGRP
EEEECCCEEEEECCCCCCCCCEEEEECCCCCCCEEEECCCCCCCEEEEEEEEEECCCCEE
VTFTGEIRGRIAEEPRGEEGFGYDPIFIPEGEDSTFAELGVEEKCKISHRTKALERFAEW
EEEEHHHCCEECCCCCCCCCCCCCCEEEECCCCCHHHHCCCCCHHHHHHHHHHHHHHHHH
YKNNVAGR
HHHCCCCC
>Mature Secondary Structure
MKVLFATGNIGKYHEAKQILARYGIEVERVDLDYPELQSDSLEEIAAYGARYCAESLGQP
CEEEEECCCCCCHHHHHHHHHHHCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCC
VIVEDSGLFIEALNGFPGPYSAYVFDTIGNEGILKLLEGEENRKAEFISVVGYCEPGGRP
EEEECCCEEEEECCCCCCCCCEEEEECCCCCCCEEEECCCCCCCEEEEEEEEEECCCCEE
VTFTGEIRGRIAEEPRGEEGFGYDPIFIPEGEDSTFAELGVEEKCKISHRTKALERFAEW
EEEEHHHCCEECCCCCCCCCCCCCCEEEECCCCCHHHHCCCCCHHHHHHHHHHHHHHHHH
YKNNVAGR
HHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11930014