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The map label for this gene is HYS2 [H]

Identifier: 20095019

GI number: 20095019

Start: 1594854

End: 1596443

Strand: Reverse

Name: HYS2 [H]

Synonym: MK1583

Alternate gene names: 20095019

Gene position: 1596443-1594854 (Counterclockwise)

Preceding gene: 20095022

Following gene: 20095018

Centisome position: 94.19

GC content: 60.31

Gene sequence:

>1590_bases
GTGAAAGGTGAGGAGACTAAACAACTGGCGCGCAAAGTCGCGGAAGAGTACGGCGTACTCTTAACACCCGAAGCGCTCCG
AGAGCTGGAGGATGAAGATGACGCCCCCGAGGTACTTGAGAAATCGGATGAGGTGGATCTTCCCGTGTTCACCGCTCAGC
TGATCCGAGGAGAGGTGGATCCGGACTTCCTCGAGGGGATGGAAGGGGACGTTTACGAGATACTCGAAGCGGAAGAAAGT
GAAGAGGAACATGAGGCGCGCCCGCGGGCGGAGCGTCCCTCCAAGTTGCCCCCTGCCGCCGAGGTCGACGCGGAGGTGGA
AATCCTCGAAGAGGCACGTTCCGTGTCCGCGAATGGTAGTGTGGAGGGATTCGTGGCGCACTTCCGAGATCGTCTCGAGA
AACTCCGACCACTCGTTAAAGCCAAGCTCGACGGAGAATGGGTGAAGGACATCGGAGAGCTCGTGGAGCGGGCGCGCCGT
GAACCCGGGAATTACTGCGTCGCCGGAGTGGTGACGGGCCTCCGAGAGACGGAGCGCGCGTTCCTCCTCGACTTGGAGGA
TGAGGCGGGAAAGGTCCGGGTGGTGATCTCGAAACCTAAAGCCCCGAAAATCTCGGAGAAGGTCAGGCGCGACGTCGCCC
CCGGGATGGTGATCGGCGTCAAGGGGTTCGTCAAAGTCGAGCGCGGCCCCGTGATGTTCGTCGGCGACCGGTACGGTGAG
GTGACGTTACCGGGTGAGGGAGACCACAAGAGCCGAGTTCCGGCCGTGGAGGACGACGTGAAGGCCGTCTTCATCGGAGA
CGTGCACATCGGATCGAAGAAGTTCAGGGAGGATCTCTTCCGCAGGTTCTTGGAGTGGTTGAACGACCCGAACGACCCAG
TGGCGAGCCGCGTGAAGTACGTCATAGTGACCGGAGATGTTGTCGACGGAATCGGGATATACCCGGGTCAGCGCGAGGAG
CTCGAGATCGCCGATATAGACGAGCAATATCAGCGGTTCGCGGAGTACCTAGAACTCCTGCCGGACTGGGTCGAGGTGAT
CGTGATACCGGGGAACCACGATGCCCTCCGACAAGCGCTCCCACAGCCGAGCCTCAGCTCCTCGGATCCGGCTCAACCAC
TCACCGAGCTCGACGGCGTCCACCTGCCTTCCAATCCCGCACTCGTGCGGATCCACGGAGAACTAGACGTGCTCCTGTTC
CACGGGCAGTCCCTGGACGATATAATCATCGACCACCCCGACGCGGAACACAACCCGGACGGGGTAAGGAAGGCCGTCAA
GCTGTGCCTCCGCGCGCGTCACCTGGTACCTATATACGGAGGGTCCGTTCCGATAGCTCCCCTTCCGGAGGATTACCTCG
CGATACGGAAACTTCCGCACGTCCTTGCCGTGGGACACACCCACGTGAGCGCCGTCGAGGTTTGGAACGGCTGCAACGTG
ATATCGACGGCCACGTTCCAAGAACAGACTGAGTTCCAGAAAAAAGTCGGAATAAGCCCCACGGTCGGCCGCGTCATCGT
ACTGAACATGCGTCGGGATGAGTACGAGAATCCGAAGCGTAGGTTTACGATCGTAGATCTCACCGGTTAA

Upstream 100 bases:

>100_bases
CGGCCGCTATCCGCACCGTCCATACTACTGGCCGCAACCCGGGACGGCCCCCGAACGGCCACGCCGGCCCCCGTCTTAAT
CCCGTTTCGGGGGGAGTTCC

Downstream 100 bases:

>100_bases
ACACTCCGCTACGGCATCCGAACGGGGTGAAGCCGTTGGAACATCCCGAAGTCACTCGGGCCGTGATGGTGCCGTTCACC
AAGGTGGCCGCCGGAATCCT

Product: DNA polymerase II small subunit

Products: NA

Alternate protein names: Pol II; DP1 [H]

Number of amino acids: Translated: 529; Mature: 529

Protein sequence:

>529_residues
MKGEETKQLARKVAEEYGVLLTPEALRELEDEDDAPEVLEKSDEVDLPVFTAQLIRGEVDPDFLEGMEGDVYEILEAEES
EEEHEARPRAERPSKLPPAAEVDAEVEILEEARSVSANGSVEGFVAHFRDRLEKLRPLVKAKLDGEWVKDIGELVERARR
EPGNYCVAGVVTGLRETERAFLLDLEDEAGKVRVVISKPKAPKISEKVRRDVAPGMVIGVKGFVKVERGPVMFVGDRYGE
VTLPGEGDHKSRVPAVEDDVKAVFIGDVHIGSKKFREDLFRRFLEWLNDPNDPVASRVKYVIVTGDVVDGIGIYPGQREE
LEIADIDEQYQRFAEYLELLPDWVEVIVIPGNHDALRQALPQPSLSSSDPAQPLTELDGVHLPSNPALVRIHGELDVLLF
HGQSLDDIIIDHPDAEHNPDGVRKAVKLCLRARHLVPIYGGSVPIAPLPEDYLAIRKLPHVLAVGHTHVSAVEVWNGCNV
ISTATFQEQTEFQKKVGISPTVGRVIVLNMRRDEYENPKRRFTIVDLTG

Sequences:

>Translated_529_residues
MKGEETKQLARKVAEEYGVLLTPEALRELEDEDDAPEVLEKSDEVDLPVFTAQLIRGEVDPDFLEGMEGDVYEILEAEES
EEEHEARPRAERPSKLPPAAEVDAEVEILEEARSVSANGSVEGFVAHFRDRLEKLRPLVKAKLDGEWVKDIGELVERARR
EPGNYCVAGVVTGLRETERAFLLDLEDEAGKVRVVISKPKAPKISEKVRRDVAPGMVIGVKGFVKVERGPVMFVGDRYGE
VTLPGEGDHKSRVPAVEDDVKAVFIGDVHIGSKKFREDLFRRFLEWLNDPNDPVASRVKYVIVTGDVVDGIGIYPGQREE
LEIADIDEQYQRFAEYLELLPDWVEVIVIPGNHDALRQALPQPSLSSSDPAQPLTELDGVHLPSNPALVRIHGELDVLLF
HGQSLDDIIIDHPDAEHNPDGVRKAVKLCLRARHLVPIYGGSVPIAPLPEDYLAIRKLPHVLAVGHTHVSAVEVWNGCNV
ISTATFQEQTEFQKKVGISPTVGRVIVLNMRRDEYENPKRRFTIVDLTG
>Mature_529_residues
MKGEETKQLARKVAEEYGVLLTPEALRELEDEDDAPEVLEKSDEVDLPVFTAQLIRGEVDPDFLEGMEGDVYEILEAEES
EEEHEARPRAERPSKLPPAAEVDAEVEILEEARSVSANGSVEGFVAHFRDRLEKLRPLVKAKLDGEWVKDIGELVERARR
EPGNYCVAGVVTGLRETERAFLLDLEDEAGKVRVVISKPKAPKISEKVRRDVAPGMVIGVKGFVKVERGPVMFVGDRYGE
VTLPGEGDHKSRVPAVEDDVKAVFIGDVHIGSKKFREDLFRRFLEWLNDPNDPVASRVKYVIVTGDVVDGIGIYPGQREE
LEIADIDEQYQRFAEYLELLPDWVEVIVIPGNHDALRQALPQPSLSSSDPAQPLTELDGVHLPSNPALVRIHGELDVLLF
HGQSLDDIIIDHPDAEHNPDGVRKAVKLCLRARHLVPIYGGSVPIAPLPEDYLAIRKLPHVLAVGHTHVSAVEVWNGCNV
ISTATFQEQTEFQKKVGISPTVGRVIVLNMRRDEYENPKRRFTIVDLTG

Specific function: Possesses two activities:a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase [H]

COG id: COG1311

COG function: function code L; Archaeal DNA polymerase II, small subunit/DNA polymerase delta, subunit B

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA polymerase delta/II small subunit family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007185
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365
- InterPro:   IPR011149 [H]

Pfam domain/function: PF04042 DNA_pol_E_B; PF01336 tRNA_anti [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 58981; Mature: 58981

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGEETKQLARKVAEEYGVLLTPEALRELEDEDDAPEVLEKSDEVDLPVFTAQLIRGEVD
CCCHHHHHHHHHHHHHCCEEECHHHHHHCCCCCCCHHHHCCCCCCCCHHHHHHHHCCCCC
PDFLEGMEGDVYEILEAEESEEEHEARPRAERPSKLPPAAEVDAEVEILEEARSVSANGS
HHHHCCCCCCHHHHHCCCCCHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCC
VEGFVAHFRDRLEKLRPLVKAKLDGEWVKDIGELVERARREPGNYCVAGVVTGLRETERA
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHCCCE
FLLDLEDEAGKVRVVISKPKAPKISEKVRRDVAPGMVIGVKGFVKVERGPVMFVGDRYGE
EEEEECCCCCEEEEEEECCCCCCHHHHHHHHCCCCEEEECCEEEEEECCCEEEEECCCCE
VTLPGEGDHKSRVPAVEDDVKAVFIGDVHIGSKKFREDLFRRFLEWLNDPNDPVASRVKY
EECCCCCCCCCCCCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHCCCCCCHHCCEEE
VIVTGDVVDGIGIYPGQREELEIADIDEQYQRFAEYLELLPDWVEVIVIPGNHDALRQAL
EEEECCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHC
PQPSLSSSDPAQPLTELDGVHLPSNPALVRIHGELDVLLFHGQSLDDIIIDHPDAEHNPD
CCCCCCCCCCCCCHHHCCCCCCCCCCCEEEEECCEEEEEECCCCCCCCEEECCCCCCCHH
GVRKAVKLCLRARHLVPIYGGSVPIAPLPEDYLAIRKLPHVLAVGHTHVSAVEVWNGCNV
HHHHHHHHHHHHCCEEEEECCCCCCCCCCHHHHHHHHCCHHEEECCCHHHHEECCCCCCE
ISTATFQEQTEFQKKVGISPTVGRVIVLNMRRDEYENPKRRFTIVDLTG
EEECHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCEEEEEEECC
>Mature Secondary Structure
MKGEETKQLARKVAEEYGVLLTPEALRELEDEDDAPEVLEKSDEVDLPVFTAQLIRGEVD
CCCHHHHHHHHHHHHHCCEEECHHHHHHCCCCCCCHHHHCCCCCCCCHHHHHHHHCCCCC
PDFLEGMEGDVYEILEAEESEEEHEARPRAERPSKLPPAAEVDAEVEILEEARSVSANGS
HHHHCCCCCCHHHHHCCCCCHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCC
VEGFVAHFRDRLEKLRPLVKAKLDGEWVKDIGELVERARREPGNYCVAGVVTGLRETERA
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHCCCE
FLLDLEDEAGKVRVVISKPKAPKISEKVRRDVAPGMVIGVKGFVKVERGPVMFVGDRYGE
EEEEECCCCCEEEEEEECCCCCCHHHHHHHHCCCCEEEECCEEEEEECCCEEEEECCCCE
VTLPGEGDHKSRVPAVEDDVKAVFIGDVHIGSKKFREDLFRRFLEWLNDPNDPVASRVKY
EECCCCCCCCCCCCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHCCCCCCHHCCEEE
VIVTGDVVDGIGIYPGQREELEIADIDEQYQRFAEYLELLPDWVEVIVIPGNHDALRQAL
EEEECCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHC
PQPSLSSSDPAQPLTELDGVHLPSNPALVRIHGELDVLLFHGQSLDDIIIDHPDAEHNPD
CCCCCCCCCCCCCHHHCCCCCCCCCCCEEEEECCEEEEEECCCCCCCCEEECCCCCCCHH
GVRKAVKLCLRARHLVPIYGGSVPIAPLPEDYLAIRKLPHVLAVGHTHVSAVEVWNGCNV
HHHHHHHHHHHHCCEEEEECCCCCCCCCCHHHHHHHHCCHHEEECCCHHHHEECCCCCCE
ISTATFQEQTEFQKKVGISPTVGRVIVLNMRRDEYENPKRRFTIVDLTG
EEECHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9348040 [H]