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The map label for this gene is Dcd_2

Identifier: 20095002

GI number: 20095002

Start: 1580875

End: 1581339

Strand: Direct

Name: Dcd_2

Synonym: MK1566

Alternate gene names: 20095002

Gene position: 1580875-1581339 (Clockwise)

Preceding gene: 20095001

Following gene: 20095003

Centisome position: 93.27

GC content: 62.15

Gene sequence:

>465_bases
GTGATCTTGGGAGAGTACGTACTTCGGGATCTATTCCCCGACTTGGACGAGGACCAGTACCAGCCGGCCGGCATCGATCT
CAAGCTGGATAGAGTTTTCCGCCTCGAGGGCCGGGGGGCTCTGTTGGAGGGCGACGATAAGCGGCTGCCGGAGTACCGCG
AGGTCGAAACCGAAGGTGGAGTATTCGAGCTCGAACCGAACGTCCCTTACGTACTCGAACTGGCGCCCGAGCTCGAGATT
CCCGAGGATACTGCCGTCTTATTCCTCCCGCGGTCTACCCTGTTGAGATCCGGTGTTTCCGTGCACACGGCCCTCGGCGA
TCCGGGTTTCAGGGGCAAGATCAGGGTCCTCGCCGTCAACCACCACGCGGCACCGTACCGGATAGCCCATGGAGAACGAG
TCGTTCAGGCCGTGTTCCTCCGGGCGGAAGACGCGGGTCGGTACGAGGGGGACTACGGCCGATGA

Upstream 100 bases:

>100_bases
CGCTGGGACCGCGGGTCCGAGACCTAGAGAGCACCCCTACCGGACGCCTGCTACTAGCATCCTCTCAGACCGTGTGGGTC
GTGAAGGGGGCGCTGAACGA

Downstream 100 bases:

>100_bases
CAGTGGTAGTGGTCGTGCGGAAAGGTAGACTCGTCCGATCAGCGTCCGGCGGCGTGCTAGAGGCCGACTCGTCGTCTACT
CTTATCCTCACGGAGGAGAT

Product: deoxycytidine deaminase

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase

Number of amino acids: Translated: 154; Mature: 154

Protein sequence:

>154_residues
MILGEYVLRDLFPDLDEDQYQPAGIDLKLDRVFRLEGRGALLEGDDKRLPEYREVETEGGVFELEPNVPYVLELAPELEI
PEDTAVLFLPRSTLLRSGVSVHTALGDPGFRGKIRVLAVNHHAAPYRIAHGERVVQAVFLRAEDAGRYEGDYGR

Sequences:

>Translated_154_residues
MILGEYVLRDLFPDLDEDQYQPAGIDLKLDRVFRLEGRGALLEGDDKRLPEYREVETEGGVFELEPNVPYVLELAPELEI
PEDTAVLFLPRSTLLRSGVSVHTALGDPGFRGKIRVLAVNHHAAPYRIAHGERVVQAVFLRAEDAGRYEGDYGR
>Mature_154_residues
MILGEYVLRDLFPDLDEDQYQPAGIDLKLDRVFRLEGRGALLEGDDKRLPEYREVETEGGVFELEPNVPYVLELAPELEI
PEDTAVLFLPRSTLLRSGVSVHTALGDPGFRGKIRVLAVNHHAAPYRIAHGERVVQAVFLRAEDAGRYEGDYGR

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA

COG id: COG0717

COG function: function code F; Deoxycytidine deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dCTP deaminase family. Archaeal dUTPase subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DUT_METKA (Q8TV34)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_614849.1
- ProteinModelPortal:   Q8TV34
- GeneID:   1478161
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK1566
- NMPDR:   fig|190192.1.peg.1562
- HOGENOM:   HBG541035
- OMA:   IQQCGID
- ProtClustDB:   CLSK798221
- BioCyc:   MKAN190192:MK1566-MONOMER
- BRENDA:   3.6.1.23
- HAMAP:   MF_00635
- InterPro:   IPR008180

Pfam domain/function: PF00692 dUTPase

EC number: =3.6.1.23

Molecular weight: Translated: 17315; Mature: 17315

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
0.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILGEYVLRDLFPDLDEDQYQPAGIDLKLDRVFRLEGRGALLEGDDKRLPEYREVETEGG
CCHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEEECCCCCEEECCCCCCCCHHEECCCCC
VFELEPNVPYVLELAPELEIPEDTAVLFLPRSTLLRSGVSVHTALGDPGFRGKIRVLAVN
EEEECCCCCEEEEECCCCCCCCCCEEEEECHHHHHHCCCEEEEECCCCCCCCEEEEEEEE
HHAAPYRIAHGERVVQAVFLRAEDAGRYEGDYGR
CCCCCEEECCHHHHHHHHHEECCCCCCCCCCCCC
>Mature Secondary Structure
MILGEYVLRDLFPDLDEDQYQPAGIDLKLDRVFRLEGRGALLEGDDKRLPEYREVETEGG
CCHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEEECCCCCEEECCCCCCCCHHEECCCCC
VFELEPNVPYVLELAPELEIPEDTAVLFLPRSTLLRSGVSVHTALGDPGFRGKIRVLAVN
EEEECCCCCEEEEECCCCCCCCCCEEEEECHHHHHHCCCEEEEECCCCCCCCEEEEEEEE
HHAAPYRIAHGERVVQAVFLRAEDAGRYEGDYGR
CCCCCEEECCHHHHHHHHHEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11930014