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The map label for this gene is FwdA [H]

Identifier: 20094965

GI number: 20094965

Start: 1539750

End: 1541495

Strand: Direct

Name: FwdA [H]

Synonym: MK1529

Alternate gene names: 20094965

Gene position: 1539750-1541495 (Clockwise)

Preceding gene: 20094964

Following gene: 20094966

Centisome position: 90.84

GC content: 60.25

Gene sequence:

>1746_bases
TTGGCCAAAGAACTTCTGATCAAGAACGCCTGCGTGTACGACCCCCTCAACGGGATCGAAGGCGAGGTTATGGACATCGG
GGTGAAGGACGGTAAGATCGTCGACCCTTCCGAAGTCGACGAGTCCAAGGCGAAGGTTATCGACGCGGAAGGTCGCCTGA
CAATGGCCGGAGGTGTCGACATCCACGCGCACGTGGCCGGTCCGAAGGTCAACGTGGGTCGTATATTCAGACCCGAGGAC
AGCCGCCGCCTCCAGGTGGCGATCAAGAAGCTCGGAACGCGTTCGGGTACTGGATTTTCGGTCCCGTCGACCACGATCAC
GGGGTACCTGTACGCCCAGATGGGATACACCACCGTGATGGAAGCCGCCACCCCGCCGCTGCTGACCAGACACACCCACG
AGGAGATCAGGGACACTCCGATCCTGGACGAAGGCGCGTACACGCTGATGGCCAACAACTGGATCCTGTACGAGTACATC
AAGGAAGGCGAACTCGAAAAGGCGGCCGCGTACGCCGCCTGGTTGCTCCGAGCGACCAAGGGTTTTGTGATAAAGATGGT
GAACCCCGGCGGTACCGAGGCCTGGGGATGGGGTGAGAACGTCCACAGTCTGGACGATCCCGTACCCTACTTCGAGATCA
CCCCGGCCGAGATCTACCAGAACTACGTCAAGATCAACGAGATGCTGGGTCTACCACACTCGATTCACATCCACCCGAAC
CTCCTCGGTGAGCCCGGTAACTACGAGATCACGACGGACAGCTGGGACGTGATCAAGAAGACGGGTGTGGAGCCGAACCC
CGAGATAGGTGAACGTGAGCAGGTCGTGCACAACACGCACGTACAGTTCCACTCGTACGGCGGTGACTCTTGGCCGACGT
TCGAGTCGAAGGCCGAGGAGGTCGCGAAATACCTGAACAAGAACGACCACGTGACGGTCGACCTGGGTGCGGTCACCCTG
GACGAGACCACGACCATGACCGCCGACGGTCCGCTCGAGTGGGAGCTGCAGGAGCTGACGGGCTTCAAGTGGGCGAACTA
CGACGTCGAGCTTGAGACGGGATCGGGCGTGGTACCGTTCATCTACAGTCCGAAGAACCCCGTGCACTCGGTTCAGTGGG
CTATCGGTCTGGAGATCGCGCTTCTAACCGAGAATCCATGGCAGGTCGTGATCTCGACGGACCACCCGAACGCGGGCCCG
TTCATCCGGTACCCGAGGATCATCGCGTGGCTGATGAGCGAACCGTACCGTGAGGAGTGGATCGAAAACGTACACCCGTG
GGTGGGCCAGCGCGCGGCGATCGCGACCATCGACCGCGAATACACATGGACCGACATCACGATCACGACTCGGGCCGCCC
CGGCGAAGATGTTGGGTCTCTCGGACCGTATCGGACACCTGGGTGAGGGCGCTTACGCGCACATCGCCATCTACGACATC
AAACCCGACGAGGTGGATCCCTCGCGGGACTACGAGGAAGTGGAGAAGGCCATGGAGCAGGCGTGGCTCGTAGTGAAGGA
CGGAGAGATCGTAGTTCAGGAAGGTGTAGTGGTGAACGAACCCGTCGGGCGTACTTACTGGGTCGACGTTAAGGTTCCGG
AGGATCTGCTCGAGGAAGTCAAGAAGGACCTTGAGACGAAGTTCCGGCGCTACTACTCCGTGAACCTGGGCAACTACCAG
GTCCAGGACGTGTACATCCCGAAGGAGGAGCGAATCGTAATCGACGCCCGCGATCGCCTCTCGTAA

Upstream 100 bases:

>100_bases
GATGTCCCGAATGCGGGCGGGAAGCTAACGTGGCACCCTCCCGCCGTAAGATCGTGTGTTGAAAGGAGCACAGCTCCGGG
TGTCGGATGGGGGGGTTCGT

Downstream 100 bases:

>100_bases
ACGTTCTTTCCTCGGGGGGTACCTCGGTTGAAAGAGGTCGTGTTGACGCCGAAAGGAGAACCGGACGTACCGCTCGAGGC
CGAAGTTATATGCCCGGACG

Product: formylmethanofuran dehydrogenase subunit A

Products: CO2; methanofuran; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 581; Mature: 580

Protein sequence:

>581_residues
MAKELLIKNACVYDPLNGIEGEVMDIGVKDGKIVDPSEVDESKAKVIDAEGRLTMAGGVDIHAHVAGPKVNVGRIFRPED
SRRLQVAIKKLGTRSGTGFSVPSTTITGYLYAQMGYTTVMEAATPPLLTRHTHEEIRDTPILDEGAYTLMANNWILYEYI
KEGELEKAAAYAAWLLRATKGFVIKMVNPGGTEAWGWGENVHSLDDPVPYFEITPAEIYQNYVKINEMLGLPHSIHIHPN
LLGEPGNYEITTDSWDVIKKTGVEPNPEIGEREQVVHNTHVQFHSYGGDSWPTFESKAEEVAKYLNKNDHVTVDLGAVTL
DETTTMTADGPLEWELQELTGFKWANYDVELETGSGVVPFIYSPKNPVHSVQWAIGLEIALLTENPWQVVISTDHPNAGP
FIRYPRIIAWLMSEPYREEWIENVHPWVGQRAAIATIDREYTWTDITITTRAAPAKMLGLSDRIGHLGEGAYAHIAIYDI
KPDEVDPSRDYEEVEKAMEQAWLVVKDGEIVVQEGVVVNEPVGRTYWVDVKVPEDLLEEVKKDLETKFRRYYSVNLGNYQ
VQDVYIPKEERIVIDARDRLS

Sequences:

>Translated_581_residues
MAKELLIKNACVYDPLNGIEGEVMDIGVKDGKIVDPSEVDESKAKVIDAEGRLTMAGGVDIHAHVAGPKVNVGRIFRPED
SRRLQVAIKKLGTRSGTGFSVPSTTITGYLYAQMGYTTVMEAATPPLLTRHTHEEIRDTPILDEGAYTLMANNWILYEYI
KEGELEKAAAYAAWLLRATKGFVIKMVNPGGTEAWGWGENVHSLDDPVPYFEITPAEIYQNYVKINEMLGLPHSIHIHPN
LLGEPGNYEITTDSWDVIKKTGVEPNPEIGEREQVVHNTHVQFHSYGGDSWPTFESKAEEVAKYLNKNDHVTVDLGAVTL
DETTTMTADGPLEWELQELTGFKWANYDVELETGSGVVPFIYSPKNPVHSVQWAIGLEIALLTENPWQVVISTDHPNAGP
FIRYPRIIAWLMSEPYREEWIENVHPWVGQRAAIATIDREYTWTDITITTRAAPAKMLGLSDRIGHLGEGAYAHIAIYDI
KPDEVDPSRDYEEVEKAMEQAWLVVKDGEIVVQEGVVVNEPVGRTYWVDVKVPEDLLEEVKKDLETKFRRYYSVNLGNYQ
VQDVYIPKEERIVIDARDRLS
>Mature_580_residues
AKELLIKNACVYDPLNGIEGEVMDIGVKDGKIVDPSEVDESKAKVIDAEGRLTMAGGVDIHAHVAGPKVNVGRIFRPEDS
RRLQVAIKKLGTRSGTGFSVPSTTITGYLYAQMGYTTVMEAATPPLLTRHTHEEIRDTPILDEGAYTLMANNWILYEYIK
EGELEKAAAYAAWLLRATKGFVIKMVNPGGTEAWGWGENVHSLDDPVPYFEITPAEIYQNYVKINEMLGLPHSIHIHPNL
LGEPGNYEITTDSWDVIKKTGVEPNPEIGEREQVVHNTHVQFHSYGGDSWPTFESKAEEVAKYLNKNDHVTVDLGAVTLD
ETTTMTADGPLEWELQELTGFKWANYDVELETGSGVVPFIYSPKNPVHSVQWAIGLEIALLTENPWQVVISTDHPNAGPF
IRYPRIIAWLMSEPYREEWIENVHPWVGQRAAIATIDREYTWTDITITTRAAPAKMLGLSDRIGHLGEGAYAHIAIYDIK
PDEVDPSRDYEEVEKAMEQAWLVVKDGEIVVQEGVVVNEPVGRTYWVDVKVPEDLLEEVKKDLETKFRRYYSVNLGNYQV
QDVYIPKEERIVIDARDRLS

Specific function: Unknown

COG id: COG1229

COG function: function code C; Formylmethanofuran dehydrogenase subunit A

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013108
- InterPro:   IPR012027
- InterPro:   IPR011059 [H]

Pfam domain/function: PF07969 Amidohydro_3 [H]

EC number: 1.2.99.5

Molecular weight: Translated: 65357; Mature: 65226

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKELLIKNACVYDPLNGIEGEVMDIGVKDGKIVDPSEVDESKAKVIDAEGRLTMAGGVD
CCCHHEECCCEECCCCCCCCCCEEEEECCCCCEECCHHCCCCHHEEEECCCCEEEECCCE
IHAHVAGPKVNVGRIFRPEDSRRLQVAIKKLGTRSGTGFSVPSTTITGYLYAQMGYTTVM
EEEEECCCCCCCCEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEECCHHHHH
EAATPPLLTRHTHEEIRDTPILDEGAYTLMANNWILYEYIKEGELEKAAAYAAWLLRATK
HHCCCCHHCCCCHHHHHCCCCCCCCCEEEEECCEEEEEEHHCCCHHHHHHHHHHHHHCCC
GFVIKMVNPGGTEAWGWGENVHSLDDPVPYFEITPAEIYQNYVKINEMLGLPHSIHIHPN
CEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHCCCEEEEECCC
LLGEPGNYEITTDSWDVIKKTGVEPNPEIGEREQVVHNTHVQFHSYGGDSWPTFESKAEE
CCCCCCCEEEECCCHHHHHHCCCCCCCCCCCHHHHHHHCEEEEEECCCCCCCCHHHHHHH
VAKYLNKNDHVTVDLGAVTLDETTTMTADGPLEWELQELTGFKWANYDVELETGSGVVPF
HHHHHCCCCCEEEEEEEEEECCCEEEECCCCCCEEHHHHCCCEEECEEEEEECCCCEEEE
IYSPKNPVHSVQWAIGLEIALLTENPWQVVISTDHPNAGPFIRYPRIIAWLMSEPYREEW
EECCCCCCCEEEEEEEEEEEEEECCCEEEEEECCCCCCCCCEEHHHHHHHHHCCHHHHHH
IENVHPWVGQRAAIATIDREYTWTDITITTRAAPAKMLGLSDRIGHLGEGAYAHIAIYDI
HHHCCCCCCCCEEEEEECCCEEEEEEEEEECCCCHHHHCCHHHHCCCCCCCEEEEEEEEC
KPDEVDPSRDYEEVEKAMEQAWLVVKDGEIVVQEGVVVNEPVGRTYWVDVKVPEDLLEEV
CCCCCCCCCCHHHHHHHHHHEEEEEECCCEEEECCEEEECCCCCEEEEEEECCHHHHHHH
KKDLETKFRRYYSVNLGNYQVQDVYIPKEERIVIDARDRLS
HHHHHHHHHEEEEEECCCEEEEEEECCCCCEEEEECHHCCC
>Mature Secondary Structure 
AKELLIKNACVYDPLNGIEGEVMDIGVKDGKIVDPSEVDESKAKVIDAEGRLTMAGGVD
CCHHEECCCEECCCCCCCCCCEEEEECCCCCEECCHHCCCCHHEEEECCCCEEEECCCE
IHAHVAGPKVNVGRIFRPEDSRRLQVAIKKLGTRSGTGFSVPSTTITGYLYAQMGYTTVM
EEEEECCCCCCCCEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEECCHHHHH
EAATPPLLTRHTHEEIRDTPILDEGAYTLMANNWILYEYIKEGELEKAAAYAAWLLRATK
HHCCCCHHCCCCHHHHHCCCCCCCCCEEEEECCEEEEEEHHCCCHHHHHHHHHHHHHCCC
GFVIKMVNPGGTEAWGWGENVHSLDDPVPYFEITPAEIYQNYVKINEMLGLPHSIHIHPN
CEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHCCCEEEEECCC
LLGEPGNYEITTDSWDVIKKTGVEPNPEIGEREQVVHNTHVQFHSYGGDSWPTFESKAEE
CCCCCCCEEEECCCHHHHHHCCCCCCCCCCCHHHHHHHCEEEEEECCCCCCCCHHHHHHH
VAKYLNKNDHVTVDLGAVTLDETTTMTADGPLEWELQELTGFKWANYDVELETGSGVVPF
HHHHHCCCCCEEEEEEEEEECCCEEEECCCCCCEEHHHHCCCEEECEEEEEECCCCEEEE
IYSPKNPVHSVQWAIGLEIALLTENPWQVVISTDHPNAGPFIRYPRIIAWLMSEPYREEW
EECCCCCCCEEEEEEEEEEEEEECCCEEEEEECCCCCCCCCEEHHHHHHHHHCCHHHHHH
IENVHPWVGQRAAIATIDREYTWTDITITTRAAPAKMLGLSDRIGHLGEGAYAHIAIYDI
HHHCCCCCCCCEEEEEECCCEEEEEEEEEECCCCHHHHCCHHHHCCCCCCCEEEEEEEEC
KPDEVDPSRDYEEVEKAMEQAWLVVKDGEIVVQEGVVVNEPVGRTYWVDVKVPEDLLEEV
CCCCCCCCCCHHHHHHHHHHEEEEEECCCEEEECCEEEECCCCCEEEEEEECCHHHHHHH
KKDLETKFRRYYSVNLGNYQVQDVYIPKEERIVIDARDRLS
HHHHHHHHHEEEEEECCCEEEEEEECCCCCEEEEECHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: formylmethanofuran; H2O; acceptor

Specific reaction: formylmethanofuran + H2O + acceptor = CO2 + methanofuran + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]