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The map label for this gene is MoeA [C]

Identifier: 20094960

GI number: 20094960

Start: 1535907

End: 1537154

Strand: Direct

Name: MoeA [C]

Synonym: MK1524

Alternate gene names: 20094960

Gene position: 1535907-1537154 (Clockwise)

Preceding gene: 20094959

Following gene: 20094961

Centisome position: 90.62

GC content: 63.06

Gene sequence:

>1248_bases
GTGTCAAAGCGTAAGTACAGGGGCTTCGTGTATACGGACGACTTGGCCAAGCCCGAAGAGTTCATCCGGTTCCTACGCCG
CTTCCTCTCGCCTCCGGAGCCCGAGACCGTGGAAGTAGGGCCCGAACTCTCGGGACGTGTACTCGCGGAAGACGTCCGTG
CGGAGCGCCCCTCTCCACCCTTCACCCGCTCCGCTATGGACGGATACGCCGTGAGATCCGAGGACGCCGAGCCCGGGGCC
AGGTTGAAGGTCGTAGGCGAGTCGAGGATAGGAGAAGGTACCGACGTCAAAGTCGGTCCGGGAGAGGCCGTGTACGTCGA
CACCGGGGCTCCCGTTCCGGAGGGTGCGGACGCCGTCATCCCCGTGGAGTTCGTGGAACGCGACGGTGACGAGATAATCG
TGGAAGAAGGCGTCGACCCGGGGGATAACCTGGACCCGGCCGGCTGCTACGTCGAAGAGGGAGAAGTTCTCTACCGATCC
GGACACCTCGTCGAGCCCGTGGACGTGGGCGTGATGCTCGAACACGGCGTGGAGGAGGTGGATGTCCACAGGCCCCTGCG
GGTCTCGATCGTGGTAACTGGGAACGAGCTCGTCCACCGTCCATCGGAGCTGGAAAGTGAAACACAGGTGGTAGACTGCA
TCGGTCCCGTGCTCACCGCGGAGCTGGAGAACATGGGCTGCGTCGAGGTAGTGGGAACGAGCTTAGTCAAGGATGATCCG
GGAGAGATCCGTGAGACCGTGGAGGATTACGCCGATCGCTCCGATGTGGTTCTGATCACGGGCGGATCCTCGGTGGGGGA
GAGGGACCACGTCAAGGACATCCTGGACGACACGTTCGACGCCTTCATCCACGGGATCAGGGCCCGACCCGGACGTCCGT
TCGGTATCGCCGCGCGGGAGGGAACAGTCGCCTTCACCCTGCCCGGGTGGCCCACGTCGTGTTATTCTACCTTCCGGGTT
TGGGTGGTACCTTCGCTACTCGTGCTGGCCGGAGCGGACCCGTTGGTGGTCGGATTCGAGACCGAAGCCACCGGGATAAA
GTCCAAGCGCGAGGTCGGCGTGATAGCACGCGTTCGTTTGACCTCCGACGGCGCCGAAGGATTGTCTCGGGACCGTTCCA
GTCACTTCGCGCTGTTTCGGGAGACCGACGGCTTCGCCCTAGTTCCTCCTGGAGGCTCGGAGCGTGCTCTGATTCTCCCG
CTGCGCGGGTTCCTCAACTTGTTCGATGAGGTAGAACGCAAGTTCTGA

Upstream 100 bases:

>100_bases
GAGCGTATCGGTGACTCCTTCACCGTTTTAATCGGTGGGAAGGCGGTGGACGTGAACTCCGTAGATGAGGCACTGGAGGA
GCTGAAACGGGGTGTGGAAA

Downstream 100 bases:

>100_bases
AGGTGTCCACCGGCCGTCCACCCGTCCCCGCCGACCCCACTTATTTAACTCCGAGGTGTCGGAGCGGGTGCGAAGACCGG
TGGGGGTCGCGGGTTGGTAA

Product: molybdopterin biosynthesis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 415; Mature: 414

Protein sequence:

>415_residues
MSKRKYRGFVYTDDLAKPEEFIRFLRRFLSPPEPETVEVGPELSGRVLAEDVRAERPSPPFTRSAMDGYAVRSEDAEPGA
RLKVVGESRIGEGTDVKVGPGEAVYVDTGAPVPEGADAVIPVEFVERDGDEIIVEEGVDPGDNLDPAGCYVEEGEVLYRS
GHLVEPVDVGVMLEHGVEEVDVHRPLRVSIVVTGNELVHRPSELESETQVVDCIGPVLTAELENMGCVEVVGTSLVKDDP
GEIRETVEDYADRSDVVLITGGSSVGERDHVKDILDDTFDAFIHGIRARPGRPFGIAAREGTVAFTLPGWPTSCYSTFRV
WVVPSLLVLAGADPLVVGFETEATGIKSKREVGVIARVRLTSDGAEGLSRDRSSHFALFRETDGFALVPPGGSERALILP
LRGFLNLFDEVERKF

Sequences:

>Translated_415_residues
MSKRKYRGFVYTDDLAKPEEFIRFLRRFLSPPEPETVEVGPELSGRVLAEDVRAERPSPPFTRSAMDGYAVRSEDAEPGA
RLKVVGESRIGEGTDVKVGPGEAVYVDTGAPVPEGADAVIPVEFVERDGDEIIVEEGVDPGDNLDPAGCYVEEGEVLYRS
GHLVEPVDVGVMLEHGVEEVDVHRPLRVSIVVTGNELVHRPSELESETQVVDCIGPVLTAELENMGCVEVVGTSLVKDDP
GEIRETVEDYADRSDVVLITGGSSVGERDHVKDILDDTFDAFIHGIRARPGRPFGIAAREGTVAFTLPGWPTSCYSTFRV
WVVPSLLVLAGADPLVVGFETEATGIKSKREVGVIARVRLTSDGAEGLSRDRSSHFALFRETDGFALVPPGGSERALILP
LRGFLNLFDEVERKF
>Mature_414_residues
SKRKYRGFVYTDDLAKPEEFIRFLRRFLSPPEPETVEVGPELSGRVLAEDVRAERPSPPFTRSAMDGYAVRSEDAEPGAR
LKVVGESRIGEGTDVKVGPGEAVYVDTGAPVPEGADAVIPVEFVERDGDEIIVEEGVDPGDNLDPAGCYVEEGEVLYRSG
HLVEPVDVGVMLEHGVEEVDVHRPLRVSIVVTGNELVHRPSELESETQVVDCIGPVLTAELENMGCVEVVGTSLVKDDPG
EIRETVEDYADRSDVVLITGGSSVGERDHVKDILDDTFDAFIHGIRARPGRPFGIAAREGTVAFTLPGWPTSCYSTFRVW
VVPSLLVLAGADPLVVGFETEATGIKSKREVGVIARVRLTSDGAEGLSRDRSSHFALFRETDGFALVPPGGSERALILPL
RGFLNLFDEVERKF

Specific function: Involved In The Biosynthesis Of A Demolybdo-Cofactor (Molybdopterin), Necessary For Molybdo-Enzymes. Seems To Be Involved In A Step Of Activation Of Molybdenum In The Form Of Thiomolybdenum. [C]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=373, Percent_Identity=32.7077747989276, Blast_Score=156, Evalue=4e-38,
Organism=Homo sapiens, GI66932975, Length=373, Percent_Identity=32.7077747989276, Blast_Score=156, Evalue=4e-38,
Organism=Escherichia coli, GI1787049, Length=369, Percent_Identity=31.1653116531165, Blast_Score=151, Evalue=9e-38,
Organism=Caenorhabditis elegans, GI25147659, Length=312, Percent_Identity=30.7692307692308, Blast_Score=118, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI17562606, Length=171, Percent_Identity=30.4093567251462, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17136978, Length=284, Percent_Identity=29.2253521126761, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24638841, Length=284, Percent_Identity=29.2253521126761, Blast_Score=103, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 45111; Mature: 44980

Theoretical pI: Translated: 4.32; Mature: 4.32

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKRKYRGFVYTDDLAKPEEFIRFLRRFLSPPEPETVEVGPELSGRVLAEDVRAERPSPP
CCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHCCCCCCC
FTRSAMDGYAVRSEDAEPGARLKVVGESRIGEGTDVKVGPGEAVYVDTGAPVPEGADAVI
CCHHHCCCCEEECCCCCCCCEEEEEECCCCCCCCEEEECCCCEEEEECCCCCCCCCCCEE
PVEFVERDGDEIIVEEGVDPGDNLDPAGCYVEEGEVLYRSGHLVEPVDVGVMLEHGVEEV
EHHHHHCCCCEEEEECCCCCCCCCCCCCCEEECCCEEEECCCEECCCCCCCEECCCCHHH
DVHRPLRVSIVVTGNELVHRPSELESETQVVDCIGPVLTAELENMGCVEVVGTSLVKDDP
CCCCCEEEEEEEECHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCH
GEIRETVEDYADRSDVVLITGGSSVGERDHVKDILDDTFDAFIHGIRARPGRPFGIAARE
HHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECC
GTVAFTLPGWPTSCYSTFRVWVVPSLLVLAGADPLVVGFETEATGIKSKREVGVIARVRL
CEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCEEEEEEE
TSDGAEGLSRDRSSHFALFRETDGFALVPPGGSERALILPLRGFLNLFDEVERKF
CCCCHHHHHCCCCCCEEEEEECCCEEEECCCCCCCEEEEEHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SKRKYRGFVYTDDLAKPEEFIRFLRRFLSPPEPETVEVGPELSGRVLAEDVRAERPSPP
CCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHCCCCCCC
FTRSAMDGYAVRSEDAEPGARLKVVGESRIGEGTDVKVGPGEAVYVDTGAPVPEGADAVI
CCHHHCCCCEEECCCCCCCCEEEEEECCCCCCCCEEEECCCCEEEEECCCCCCCCCCCEE
PVEFVERDGDEIIVEEGVDPGDNLDPAGCYVEEGEVLYRSGHLVEPVDVGVMLEHGVEEV
EHHHHHCCCCEEEEECCCCCCCCCCCCCCEEECCCEEEECCCEECCCCCCCEECCCCHHH
DVHRPLRVSIVVTGNELVHRPSELESETQVVDCIGPVLTAELENMGCVEVVGTSLVKDDP
CCCCCEEEEEEEECHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCH
GEIRETVEDYADRSDVVLITGGSSVGERDHVKDILDDTFDAFIHGIRARPGRPFGIAARE
HHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECC
GTVAFTLPGWPTSCYSTFRVWVVPSLLVLAGADPLVVGFETEATGIKSKREVGVIARVRL
CEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCEEEEEEE
TSDGAEGLSRDRSSHFALFRETDGFALVPPGGSERALILPLRGFLNLFDEVERKF
CCCCHHHHHCCCCCCEEEEEECCCEEEECCCCCCCEEEEEHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]