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The map label for this gene is coaD

Identifier: 20094940

GI number: 20094940

Start: 1520450

End: 1520923

Strand: Reverse

Name: coaD

Synonym: MK1504

Alternate gene names: 20094940

Gene position: 1520923-1520450 (Counterclockwise)

Preceding gene: 20094941

Following gene: 20094939

Centisome position: 89.73

GC content: 60.34

Gene sequence:

>474_bases
TTGACTCCCTTGGCCAGGTTCCGCAAAGTGGTCGTCGGAGGTACATTCGACAGGTTACACCTGGGTCACCAGCGCCTGTT
GTCCGTAGCGCTCGAGCTGGGAGACCGAGTGGTGATAGGTGTCACGACGGACTCCTTCGTCCGTGAGGAGGGGAAGAAAG
GGGTCGAACCCTTCGAGGAGAGGGTGCGGGCCGTCCGAAGGTTCGTCGAGGAGAAAGGAGCGTCGGATCGAGTTGAGATC
GTTCCGTTGGAGGATCGCTACGGCACGACGCTGGAAGACGACGAGATGGACGCGATCGTCGTGAGTCCGGAGACGGAACC
GGTGGCGTTGGAGATCAACGAGCTCAGGAGGAAGCGCGGTTTTCCACCGTTATCCATCGTCGTCATTCCGTTCGTGCTGG
ACGGTGACGGTAGGAAGATATCCTCCAGCCGGCTGCGGGGAGAGGTGGATGAAGGTCCGTGTCGGGACGACTAA

Upstream 100 bases:

>100_bases
ACCTACGAAGAGCCTCGATCCAGAGAGTACTCCGGGAACTCCGCCATGGCTTCTTGGAGGTAGGTGAAGCGCTGAAGGCC
GTATACGACATCTTAGGAGG

Downstream 100 bases:

>100_bases
CCCCGTGAAAGTCCGGGCGACGGAGCGTGCATTTCTCAGAACGTTTCCGGACCGTGAGATCACCGTCGAGGCGGTGAGCG
TCGACCCAGGGGTACCACCT

Product: phosphopantetheine adenylyltransferase

Products: NA

Alternate protein names: Dephospho-CoA pyrophosphorylase; Pantetheine-phosphate adenylyltransferase; PPAT

Number of amino acids: Translated: 157; Mature: 156

Protein sequence:

>157_residues
MTPLARFRKVVVGGTFDRLHLGHQRLLSVALELGDRVVIGVTTDSFVREEGKKGVEPFEERVRAVRRFVEEKGASDRVEI
VPLEDRYGTTLEDDEMDAIVVSPETEPVALEINELRRKRGFPPLSIVVIPFVLDGDGRKISSSRLRGEVDEGPCRDD

Sequences:

>Translated_157_residues
MTPLARFRKVVVGGTFDRLHLGHQRLLSVALELGDRVVIGVTTDSFVREEGKKGVEPFEERVRAVRRFVEEKGASDRVEI
VPLEDRYGTTLEDDEMDAIVVSPETEPVALEINELRRKRGFPPLSIVVIPFVLDGDGRKISSSRLRGEVDEGPCRDD
>Mature_156_residues
TPLARFRKVVVGGTFDRLHLGHQRLLSVALELGDRVVIGVTTDSFVREEGKKGVEPFEERVRAVRRFVEEKGASDRVEIV
PLEDRYGTTLEDDEMDAIVVSPETEPVALEINELRRKRGFPPLSIVVIPFVLDGDGRKISSSRLRGEVDEGPCRDD

Specific function: Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate

COG id: COG1019

COG function: function code R; Predicted nucleotidyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eukaryotic CoaD family

Homologues:

Organism=Homo sapiens, GI110227605, Length=151, Percent_Identity=31.7880794701987, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI110227603, Length=151, Percent_Identity=31.7880794701987, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI110227601, Length=151, Percent_Identity=31.7880794701987, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI205277394, Length=151, Percent_Identity=31.7880794701987, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI25143409, Length=145, Percent_Identity=37.9310344827586, Blast_Score=80, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6321716, Length=147, Percent_Identity=34.6938775510204, Blast_Score=85, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24658602, Length=149, Percent_Identity=39.5973154362416, Blast_Score=82, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAD_METKA (Q8TGY4)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_614787.1
- ProteinModelPortal:   Q8TGY4
- SMR:   Q8TGY4
- GeneID:   1478099
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK1504
- NMPDR:   fig|190192.1.peg.1500
- HOGENOM:   HBG593121
- OMA:   ISTTRIR
- ProtClustDB:   PRK00777
- BioCyc:   MKAN190192:MK1504-MONOMER
- BRENDA:   2.7.7.3
- GO:   GO:0005737
- HAMAP:   MF_00647
- InterPro:   IPR004821
- InterPro:   IPR004820
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- TIGRFAMs:   TIGR00125

Pfam domain/function: PF01467 CTP_transf_2

EC number: =2.7.7.3

Molecular weight: Translated: 17612; Mature: 17481

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPLARFRKVVVGGTFDRLHLGHQRLLSVALELGDRVVIGVTTDSFVREEGKKGVEPFEE
CCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHCCCCCCHHHH
RVRAVRRFVEEKGASDRVEIVPLEDRYGTTLEDDEMDAIVVSPETEPVALEINELRRKRG
HHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCEEEECCCCCCEEEEHHHHHHHCC
FPPLSIVVIPFVLDGDGRKISSSRLRGEVDEGPCRDD
CCCEEEEEEEEEECCCCCEECCHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TPLARFRKVVVGGTFDRLHLGHQRLLSVALELGDRVVIGVTTDSFVREEGKKGVEPFEE
CCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHCCCCCCHHHH
RVRAVRRFVEEKGASDRVEIVPLEDRYGTTLEDDEMDAIVVSPETEPVALEINELRRKRG
HHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCEEEECCCCCCEEEEHHHHHHHCC
FPPLSIVVIPFVLDGDGRKISSSRLRGEVDEGPCRDD
CCCEEEEEEEEEECCCCCEECCHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11930014