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The map label for this gene is HmdIII

Identifier: 20094558

GI number: 20094558

Start: 1096289

End: 1097245

Strand: Direct

Name: HmdIII

Synonym: MK1122

Alternate gene names: NA

Gene position: 1096289-1097245 (Clockwise)

Preceding gene: 20094557

Following gene: 20094560

Centisome position: 64.68

GC content: 63.64

Gene sequence:

>957_bases
TTGGAGGTGCACTACGAACTACCCCTGGGTGGGGCACACCTGGCGTATCGGGCGGCGGAGGCCGGACATGACGTAGTCCT
GTGCGACCCCTCGTTCGACATCTCCGAGGAGTCGATGGAGCGGTTGGAGTCGGCCGGTGTGGAACTCGTGACGGACGATA
CCGCAGGTGTGGAGCACGGTGAGATCCAGATACTGTTCACGCCGTTCGGTCATACGGTGAAGATCGCCCGAGAGTTGCTC
GACGACGTCCGTGAGGGGGCCGTTCTCTGCACGACGTGCACGTGCCCACCGATCGCCCTGTACCACGGCCTGGAGGGGGA
GCTTCGCACGAAAAGGGAGGACGTCGGTGTCTCCTCCTTCCACCCGGCCGGGATCCCGGGGGCGGAGACACAGGACCTGA
TCCTGGTGGCGGACGCGCGGTCCGAGGAGTCGGGGATCGAGCTGGCGTCGGAGGAACAGGTCGAGCGGTGCGTAAACCTC
GCGGAGGACATGGGGTACGACGTTTACGTCCTGGATCCCGAGCTTATCTCATCCATCGGTGACATGTCCGTCGTCCTTAC
CGTGCGTATAGTCCAGGCGATCTGTAACTACTTCTCGGTAGCGAGGATCTGCGGTGCACCCATCGAGATGATCGAGGAAC
AGGTGGAAGAGGTGCTGTCGACCATGGCGTACCTAGTCGGGAGGTACGGGCTGGACGCGTTCGATCGGATGGATGGGAAG
CTGCTGCTGAGGTCGCTGCGGAACATGGCGCTCACGGAGGACGTCGAGCGGGTCGTGGACTTCTTCGAGCGGTGCTACGT
GGACTTGCTGAGCGGTGACCGGGAGAGCATGCGAGAACTGAGCTCCATGATGGTGCCTCCGGACAAGCTGGTGGACCGCG
TCCGGGAGATCGTGGGAGAGGCGCCGGTCCAGTACGCCCGGCGGAGGTTCTTCGAGGAGCGGCGATGGGGCTCGTGA

Upstream 100 bases:

>100_bases
ATCGAAGGGTACCGTCACCGACCGCCGGGGGTGGCGCGGGTGAAGGTCACCGTGTACGGGTGCGGGGACGAGAACATGAT
GGTGAAGCTGATCGAACCAC

Downstream 100 bases:

>100_bases
ACCGCCCTTTCCTCGGGTCGCCATCCACGATCCGGTGCCGGTCGCCCTTTCGGGGGATCCGAACGGTGAGGGAAAAACGG
TCGTGGGTTAGGAAACGCAT

Product: H(2)-dependent methylenetetrahydromethanopterin dehydrogenase-related protein

Products: 5,10-methenyltetrahydromethanopterin; reduced coenzyme F420

Alternate protein names: NA

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MEVHYELPLGGAHLAYRAAEAGHDVVLCDPSFDISEESMERLESAGVELVTDDTAGVEHGEIQILFTPFGHTVKIARELL
DDVREGAVLCTTCTCPPIALYHGLEGELRTKREDVGVSSFHPAGIPGAETQDLILVADARSEESGIELASEEQVERCVNL
AEDMGYDVYVLDPELISSIGDMSVVLTVRIVQAICNYFSVARICGAPIEMIEEQVEEVLSTMAYLVGRYGLDAFDRMDGK
LLLRSLRNMALTEDVERVVDFFERCYVDLLSGDRESMRELSSMMVPPDKLVDRVREIVGEAPVQYARRRFFEERRWGS

Sequences:

>Translated_318_residues
MEVHYELPLGGAHLAYRAAEAGHDVVLCDPSFDISEESMERLESAGVELVTDDTAGVEHGEIQILFTPFGHTVKIARELL
DDVREGAVLCTTCTCPPIALYHGLEGELRTKREDVGVSSFHPAGIPGAETQDLILVADARSEESGIELASEEQVERCVNL
AEDMGYDVYVLDPELISSIGDMSVVLTVRIVQAICNYFSVARICGAPIEMIEEQVEEVLSTMAYLVGRYGLDAFDRMDGK
LLLRSLRNMALTEDVERVVDFFERCYVDLLSGDRESMRELSSMMVPPDKLVDRVREIVGEAPVQYARRRFFEERRWGS
>Mature_318_residues
MEVHYELPLGGAHLAYRAAEAGHDVVLCDPSFDISEESMERLESAGVELVTDDTAGVEHGEIQILFTPFGHTVKIARELL
DDVREGAVLCTTCTCPPIALYHGLEGELRTKREDVGVSSFHPAGIPGAETQDLILVADARSEESGIELASEEQVERCVNL
AEDMGYDVYVLDPELISSIGDMSVVLTVRIVQAICNYFSVARICGAPIEMIEEQVEEVLSTMAYLVGRYGLDAFDRMDGK
LLLRSLRNMALTEDVERVVDFFERCYVDLLSGDRESMRELSSMMVPPDKLVDRVREIVGEAPVQYARRRFFEERRWGS

Specific function: Unknown

COG id: COG4007

COG function: function code R; Predicted dehydrogenase related to H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMD family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR010063
- InterPro:   IPR004889
- InterPro:   IPR016040 [H]

Pfam domain/function: PF03201 HMD [H]

EC number: 1.5.99.9

Molecular weight: Translated: 35460; Mature: 35460

Theoretical pI: Translated: 4.19; Mature: 4.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVHYELPLGGAHLAYRAAEAGHDVVLCDPSFDISEESMERLESAGVELVTDDTAGVEHG
CCEEEECCCCCHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHCCCEEEECCCCCCCCC
EIQILFTPFGHTVKIARELLDDVREGAVLCTTCTCPPIALYHGLEGELRTKREDVGVSSF
EEEEEEECCCHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHCCCCCHHHHHHHHCCCCCC
HPAGIPGAETQDLILVADARSEESGIELASEEQVERCVNLAEDMGYDVYVLDPELISSIG
CCCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECHHHHHHHC
DMSVVLTVRIVQAICNYFSVARICGAPIEMIEEQVEEVLSTMAYLVGRYGLDAFDRMDGK
CHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHH
LLLRSLRNMALTEDVERVVDFFERCYVDLLSGDRESMRELSSMMVPPDKLVDRVREIVGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHCC
APVQYARRRFFEERRWGS
CHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MEVHYELPLGGAHLAYRAAEAGHDVVLCDPSFDISEESMERLESAGVELVTDDTAGVEHG
CCEEEECCCCCHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHCCCEEEECCCCCCCCC
EIQILFTPFGHTVKIARELLDDVREGAVLCTTCTCPPIALYHGLEGELRTKREDVGVSSF
EEEEEEECCCHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHCCCCCHHHHHHHHCCCCCC
HPAGIPGAETQDLILVADARSEESGIELASEEQVERCVNLAEDMGYDVYVLDPELISSIG
CCCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECHHHHHHHC
DMSVVLTVRIVQAICNYFSVARICGAPIEMIEEQVEEVLSTMAYLVGRYGLDAFDRMDGK
CHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHH
LLLRSLRNMALTEDVERVVDFFERCYVDLLSGDRESMRELSSMMVPPDKLVDRVREIVGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHCC
APVQYARRRFFEERRWGS
CHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 5,10-methylenetetrahydromethanopterin; coenzyme F420

Specific reaction: 5,10-methylenetetrahydromethanopterin + coenzyme F420 = 5,10-methenyltetrahydromethanopterin + reduced coenzyme F420

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]