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The map label for this gene is HyuA_1

Identifier: 20094527

GI number: 20094527

Start: 1059786

End: 1061828

Strand: Direct

Name: HyuA_1

Synonym: MK1091

Alternate gene names: NA

Gene position: 1059786-1061828 (Clockwise)

Preceding gene: 20094526

Following gene: 20094528

Centisome position: 62.53

GC content: 65.64

Gene sequence:

>2043_bases
ATGGCCGAGCTCGCCGTCGGCATCGACGTGGGCGGCACTTTCACTGACCTGGTGGAGTACGACGGGCGGGAGCTCCGTGT
CCGGAAGGTTCCGTCGTCACCCCGGCGGCCCGAACGGGGCTTCGCGGAAGCTCTTAAAATCGTCGAGACAGACCCGGATG
TTGTCCTTCACGCCACGACCATAGGGACCAACGCGTTTCTGGGTCAGAAGGGGCTTGAACTGCCCGAAGTTGCTCTCGTG
ACGACACTCGGGTTCCGCGACGCGATCGAGATCGGACGGCAGGTTCGTCCCCAGACCTACTCGCTGTCACCCCGAAAACC
CGAACCGCTCGTACCTCGACGGCTCAGGTTCGAGGTTAAGGAGCGTACCTCACCCGACGGTGAGATCATAGTACCGGTCG
ACGAGGACAAGCTCCGTCGTATCGCCCGCCGTATCGCGGTCGAGGACGTCGATGTGGTCGTCGTCGCTTTCCTCCACGCC
TACGCTAACCCGGCCAACGAGTGCAAGGCGAAGGAGGTTCTGGAGGAGGAGCTCGGTGACGTCGAGGTAGTATGTTCGCA
CGAGGTATGCAACGAATACCGCGAGTATGAGCGGACTTCGACGGCCCTCGTCAACGCGGTCTTACGACAGATCGTCACGG
AGTACGTCGAGAGGACCTGGGACGCCGTCCGCGACGCCGGTGCCTCGGAGTACTACCTGATGCAGTCGGACGGATACGCC
GTGCCGGCCGAGCTCACCCTTCACACCCCGGCCAAGCTCATCGAGTCGGGTCCCGCCGCCGGAGTCGTCGCGGCCCGATA
CCTGGGTGAAACGCTGGGTAGGGACCGCCTGGTCTCGTTCGACATGGGTGGAACGACGGCTAAGGCCGGTACGGTCGTCG
AAGGCCGTTACGAGGTGACTAAGGAGTACGAGGTGGGCGGTGAGGTACACAGGGGTCGTAGGGTGCGCGGTTCGGGATAC
CCCGTTCTTCATCGCTTCATCGACCTGACGGAGTGTAGCGCCGGCGGTGGTACGATACTCTGGACCGACGAGGCCGGCGC
GCTCCGGGTGGGACCGCTGAGCGCCGGAGCCGATCCGGGTCCGGTTTGCTACGGGAAGGGAGGTACGGATCCGACGATCA
CCGACGCCAACGTCGTCTTGGGACGCCTCAACCGACGTGCCCTCCTCGGCGGCGAAATGCCCATCGACGCCGAGGCCGCC
GATCGTGCGCTCTCGGAGCTCGCGGACGAGCTCGGACTCGAGCCGGAGGAAGCCGCGTACCAGGCCCTGCGCCTCGCCGT
CGAGGAGATGGCCCGGATCGTGCGTATAGTCACGGTGGAGCGCGGCCACGATCCCCGCGAGTTCTCGCTGGTCGCTTTCG
GTGGTGCGGGACCCTTACACGCGGCGGAGCTGGCCGAGATCTTGGAGGTCGAGGAGGTGATAGTTCCCCTCCATCCCGGC
GTGTTCTCGGCGTACGGGCTCCTAGCGGCCGAGGTCGCCTGGGAACACGTCACCCCGGTCATGAGGACGCTCGAGGAGCT
CGACGATGAGGAGCTGCGCGCGGTCGTGAGAGGTACCGCGGAGAAGGCGGCGGAGCGCCTGCCGAGGGAACCGGACGACG
TCCGGATCGTCGTGGAAGCGAGGTACCGCGGGCAGGCGCATGAGCTCGAGGTTCAGACGGGGCCGGACGTGACGGCGGAC
GAGCTCGAGGAGGCTTTCCACGAGCGGCACCGCGCCGTTCACGGGTTCCAACTTAATGCCCCGGTGGAAATCGTCAACGT
CCGCGCCCTCGCGGTGATCGAGCGGAAGCCACCCGAACCGAGCCCGCTCAAGGAGGGTGGAGAAGGGAACCCCAAGCGTG
CGCTCGTCGAGACCCGGGAGGTGTACTTCAGGGAGGAGGGTTACCTGGAAACTCCCGTGTTCGATAGGGACGCCTTGAGG
GCCGACGACATCGTCGAGGGACCGGCGGTCATCGAGCAGTACGACTCGACCACCCTCGTACCGCCCGGCTGGAGGGCACG
CGTTCACAGGTCGGGTGCTATCCTGCTCCACCGGATCGAGTGA

Upstream 100 bases:

>100_bases
ATAACCAAAACCGACCTCCTGCACTTACTGGTGGAAGAGCTGGAGGCGGCCGGCTAATTCTTAACCTCCACCAACCGCCC
GTCGGACGGGCTCACCCGGG

Downstream 100 bases:

>100_bases
GGCGGGAACACTCCGGACGTGTCCTCGTGCCTGCTCGTTCCCGAGGACACAACCATCGGATGTGGCGGAGCCTTGGTGGG
TCCGTTCCCGCATTGCTGAC

Product: N-methylhydantoinase A

Products: ADP; phosphate; N-carbamoylsarcosine

Alternate protein names: NA

Number of amino acids: Translated: 680; Mature: 679

Protein sequence:

>680_residues
MAELAVGIDVGGTFTDLVEYDGRELRVRKVPSSPRRPERGFAEALKIVETDPDVVLHATTIGTNAFLGQKGLELPEVALV
TTLGFRDAIEIGRQVRPQTYSLSPRKPEPLVPRRLRFEVKERTSPDGEIIVPVDEDKLRRIARRIAVEDVDVVVVAFLHA
YANPANECKAKEVLEEELGDVEVVCSHEVCNEYREYERTSTALVNAVLRQIVTEYVERTWDAVRDAGASEYYLMQSDGYA
VPAELTLHTPAKLIESGPAAGVVAARYLGETLGRDRLVSFDMGGTTAKAGTVVEGRYEVTKEYEVGGEVHRGRRVRGSGY
PVLHRFIDLTECSAGGGTILWTDEAGALRVGPLSAGADPGPVCYGKGGTDPTITDANVVLGRLNRRALLGGEMPIDAEAA
DRALSELADELGLEPEEAAYQALRLAVEEMARIVRIVTVERGHDPREFSLVAFGGAGPLHAAELAEILEVEEVIVPLHPG
VFSAYGLLAAEVAWEHVTPVMRTLEELDDEELRAVVRGTAEKAAERLPREPDDVRIVVEARYRGQAHELEVQTGPDVTAD
ELEEAFHERHRAVHGFQLNAPVEIVNVRALAVIERKPPEPSPLKEGGEGNPKRALVETREVYFREEGYLETPVFDRDALR
ADDIVEGPAVIEQYDSTTLVPPGWRARVHRSGAILLHRIE

Sequences:

>Translated_680_residues
MAELAVGIDVGGTFTDLVEYDGRELRVRKVPSSPRRPERGFAEALKIVETDPDVVLHATTIGTNAFLGQKGLELPEVALV
TTLGFRDAIEIGRQVRPQTYSLSPRKPEPLVPRRLRFEVKERTSPDGEIIVPVDEDKLRRIARRIAVEDVDVVVVAFLHA
YANPANECKAKEVLEEELGDVEVVCSHEVCNEYREYERTSTALVNAVLRQIVTEYVERTWDAVRDAGASEYYLMQSDGYA
VPAELTLHTPAKLIESGPAAGVVAARYLGETLGRDRLVSFDMGGTTAKAGTVVEGRYEVTKEYEVGGEVHRGRRVRGSGY
PVLHRFIDLTECSAGGGTILWTDEAGALRVGPLSAGADPGPVCYGKGGTDPTITDANVVLGRLNRRALLGGEMPIDAEAA
DRALSELADELGLEPEEAAYQALRLAVEEMARIVRIVTVERGHDPREFSLVAFGGAGPLHAAELAEILEVEEVIVPLHPG
VFSAYGLLAAEVAWEHVTPVMRTLEELDDEELRAVVRGTAEKAAERLPREPDDVRIVVEARYRGQAHELEVQTGPDVTAD
ELEEAFHERHRAVHGFQLNAPVEIVNVRALAVIERKPPEPSPLKEGGEGNPKRALVETREVYFREEGYLETPVFDRDALR
ADDIVEGPAVIEQYDSTTLVPPGWRARVHRSGAILLHRIE
>Mature_679_residues
AELAVGIDVGGTFTDLVEYDGRELRVRKVPSSPRRPERGFAEALKIVETDPDVVLHATTIGTNAFLGQKGLELPEVALVT
TLGFRDAIEIGRQVRPQTYSLSPRKPEPLVPRRLRFEVKERTSPDGEIIVPVDEDKLRRIARRIAVEDVDVVVVAFLHAY
ANPANECKAKEVLEEELGDVEVVCSHEVCNEYREYERTSTALVNAVLRQIVTEYVERTWDAVRDAGASEYYLMQSDGYAV
PAELTLHTPAKLIESGPAAGVVAARYLGETLGRDRLVSFDMGGTTAKAGTVVEGRYEVTKEYEVGGEVHRGRRVRGSGYP
VLHRFIDLTECSAGGGTILWTDEAGALRVGPLSAGADPGPVCYGKGGTDPTITDANVVLGRLNRRALLGGEMPIDAEAAD
RALSELADELGLEPEEAAYQALRLAVEEMARIVRIVTVERGHDPREFSLVAFGGAGPLHAAELAEILEVEEVIVPLHPGV
FSAYGLLAAEVAWEHVTPVMRTLEELDDEELRAVVRGTAEKAAERLPREPDDVRIVVEARYRGQAHELEVQTGPDVTADE
LEEAFHERHRAVHGFQLNAPVEIVNVRALAVIERKPPEPSPLKEGGEGNPKRALVETREVYFREEGYLETPVFDRDALRA
DDIVEGPAVIEQYDSTTLVPPGWRARVHRSGAILLHRIE

Specific function: Unknown

COG id: COG0145

COG function: function code EQ; N-methylhydantoinase A/acetone carboxylase, beta subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the oxoprolinase family [H]

Homologues:

Organism=Homo sapiens, GI48314820, Length=750, Percent_Identity=30.8, Blast_Score=195, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI133901900, Length=725, Percent_Identity=24.8275862068966, Blast_Score=143, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6322634, Length=748, Percent_Identity=27.2727272727273, Blast_Score=210, Evalue=8e-55,
Organism=Drosophila melanogaster, GI45550492, Length=746, Percent_Identity=29.6246648793566, Blast_Score=205, Evalue=9e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008040
- InterPro:   IPR002821 [H]

Pfam domain/function: PF05378 Hydant_A_N; PF01968 Hydantoinase_A [H]

EC number: 3.5.2.14

Molecular weight: Translated: 74686; Mature: 74555

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAELAVGIDVGGTFTDLVEYDGRELRVRKVPSSPRRPERGFAEALKIVETDPDVVLHATT
CCCEEEEEECCCHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHCCCCCEEEEEEE
IGTNAFLGQKGLELPEVALVTTLGFRDAIEIGRQVRPQTYSLSPRKPEPLVPRRLRFEVK
ECCCHHCCCCCCCCCHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHH
ERTSPDGEIIVPVDEDKLRRIARRIAVEDVDVVVVAFLHAYANPANECKAKEVLEEELGD
HCCCCCCCEEEECCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCC
VEVVCSHEVCNEYREYERTSTALVNAVLRQIVTEYVERTWDAVRDAGASEYYLMQSDGYA
EEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEE
VPAELTLHTPAKLIESGPAAGVVAARYLGETLGRDRLVSFDMGGTTAKAGTVVEGRYEVT
CCCEEEECCHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCEEECCEEEC
KEYEVGGEVHRGRRVRGSGYPVLHRFIDLTECSAGGGTILWTDEAGALRVGPLSAGADPG
EEHHCCCHHHCCCEECCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCEEECCCCCCCCCC
PVCYGKGGTDPTITDANVVLGRLNRRALLGGEMPIDAEAADRALSELADELGLEPEEAAY
CEEECCCCCCCCCCCHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHHHHCCCHHHHHH
QALRLAVEEMARIVRIVTVERGHDPREFSLVAFGGAGPLHAAELAEILEVEEVIVPLHPG
HHHHHHHHHHHHHHHHEEEECCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHEECCCC
VFSAYGLLAAEVAWEHVTPVMRTLEELDDEELRAVVRGTAEKAAERLPREPDDVRIVVEA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEE
RYRGQAHELEVQTGPDVTADELEEAFHERHRAVHGFQLNAPVEIVNVRALAVIERKPPEP
CCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCEEECCCEEEEEEEEEEEEECCCCCC
SPLKEGGEGNPKRALVETREVYFREEGYLETPVFDRDALRADDIVEGPAVIEQYDSTTLV
CCCCCCCCCCCHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCCCCHHHHHCCCCCCC
PPGWRARVHRSGAILLHRIE
CCCHHHEEECCCEEEEEECC
>Mature Secondary Structure 
AELAVGIDVGGTFTDLVEYDGRELRVRKVPSSPRRPERGFAEALKIVETDPDVVLHATT
CCEEEEEECCCHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHCCCCCEEEEEEE
IGTNAFLGQKGLELPEVALVTTLGFRDAIEIGRQVRPQTYSLSPRKPEPLVPRRLRFEVK
ECCCHHCCCCCCCCCHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHH
ERTSPDGEIIVPVDEDKLRRIARRIAVEDVDVVVVAFLHAYANPANECKAKEVLEEELGD
HCCCCCCCEEEECCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCC
VEVVCSHEVCNEYREYERTSTALVNAVLRQIVTEYVERTWDAVRDAGASEYYLMQSDGYA
EEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEE
VPAELTLHTPAKLIESGPAAGVVAARYLGETLGRDRLVSFDMGGTTAKAGTVVEGRYEVT
CCCEEEECCHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCEEECCEEEC
KEYEVGGEVHRGRRVRGSGYPVLHRFIDLTECSAGGGTILWTDEAGALRVGPLSAGADPG
EEHHCCCHHHCCCEECCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCEEECCCCCCCCCC
PVCYGKGGTDPTITDANVVLGRLNRRALLGGEMPIDAEAADRALSELADELGLEPEEAAY
CEEECCCCCCCCCCCHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHHHHCCCHHHHHH
QALRLAVEEMARIVRIVTVERGHDPREFSLVAFGGAGPLHAAELAEILEVEEVIVPLHPG
HHHHHHHHHHHHHHHHEEEECCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHEECCCC
VFSAYGLLAAEVAWEHVTPVMRTLEELDDEELRAVVRGTAEKAAERLPREPDDVRIVVEA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEE
RYRGQAHELEVQTGPDVTADELEEAFHERHRAVHGFQLNAPVEIVNVRALAVIERKPPEP
CCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCEEECCCEEEEEEEEEEEEECCCCCC
SPLKEGGEGNPKRALVETREVYFREEGYLETPVFDRDALRADDIVEGPAVIEQYDSTTLV
CCCCCCCCCCCHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCCCCHHHHHCCCCCCC
PPGWRARVHRSGAILLHRIE
CCCHHHEEECCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; N-methylimidazolidine-2,4-dione; H2O

Specific reaction: ATP + N-methylimidazolidine-2,4-dione + 2 H2O = ADP + phosphate + N-carbamoylsarcosine

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]