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The map label for this gene is glgC [C]

Identifier: 20094353

GI number: 20094353

Start: 874490

End: 875560

Strand: Reverse

Name: glgC [C]

Synonym: MK0917

Alternate gene names: 20094353

Gene position: 875560-874490 (Counterclockwise)

Preceding gene: 20094354

Following gene: 20094352

Centisome position: 51.66

GC content: 59.94

Gene sequence:

>1071_bases
TTGAACGTGGACGCGGTGGTGCTCGCGGGCGGGTTCGGCACAAGACTGCGCCCCCTGACCTGGGATACGCCTAAACCCCT
GGTTCCCATCCTGGGTAAGCCGCTCATCGAGTGGGTGATCCGCTCCCTACCCCGTGACGTCGTTCACGTTCACATCGCCG
CCGGTTTCAGCTCCGAGAAGCTCGAGCGGTACGTCGAGTCCGATCCCCTCCCCAGGAAGCTTCACCTGAAGGTAGAACCC
AAGCCACTCGACACCGCCGGTGCGATCAAGTTCGCGTGCCGAGACTCCACGGCCGACGCCTTCGTAGCGTTCAACGGGGA
CATAGTCTCCTCGCTCGACGTACGCCAGATGTTGAAGTTCCACCGTGAGCACGACGGGATCGCCACGATAGCCCTGTATC
CAGTACCCGAAGACGAAGTCTCACGCTTCGGTGTAGTGGACCTGGACGATGACGACCGCATCCTCGACTTCGTCGAGAAG
CCCGAGCCGGAGGAGGCTCCCTCGAACCTCATCAATGCCGGCGCGTACGTGCTGGACCGGGAGGTGCTGGACTACATACC
CGAAGGGCGCCCCGTATCGATCGAGCGCGAGATCTTCCCGAAACTCGCCGAGGAAGGCCTGCTATACGGGTTCAAGTTCG
AAGGATACTGGGTGGACGTGGGCCTCCCCGAAACTTACCTCGAAGCACATCGCGTTCTGATGGAGCATGAATGTTCTGGG
AAGTCCGTGGTAGGAGCACGGATCACCGATACCGACTTGAAGCCACCGGTAGTAGCCGCACCGATGACCGAGCTCCGATC
CTCAGAGATCGGACCGTACGTGTACGTGGGTGAGAGGACAGAAATTAACGGATCAGTAATCGAGAACTCCGTCATCCTAG
ACGATGTAGAGATCATCGACTCTGAGGTCCGCAACACCATCGTAGCCGAAGGGTGTAAGATCGAGAACGCACGGCTCGAC
GGGTGTGTGCTGGGTCATGATGCCGAGGTGTGTGGTTGCAACCTCAAGGGTGTTCGGGTGGCTCCCGGTAAGGAAGCCGA
GCGGGACCTCGAGGATGAGTGGGTGATCTGA

Upstream 100 bases:

>100_bases
CGTGCTGTACCTCCTGGTCGACGAGGCTTACGGTCCCGTGGACACCACGGAAGCACGAAGCTGGTGGAACCACGTGTAGC
GCGTCAGGGGAGGTCGAACG

Downstream 100 bases:

>100_bases
ACATGAAGATCGAAGCGGGTGAGGCCGTTAGAATCCTCGCCTATCTGTTCTTCCTGTTCTTCGTCCTCCCCGTGCTAATC
GCAGCCATCGTGCTGACGCT

Product: translation initiation factor eIF2B subunit

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MNVDAVVLAGGFGTRLRPLTWDTPKPLVPILGKPLIEWVIRSLPRDVVHVHIAAGFSSEKLERYVESDPLPRKLHLKVEP
KPLDTAGAIKFACRDSTADAFVAFNGDIVSSLDVRQMLKFHREHDGIATIALYPVPEDEVSRFGVVDLDDDDRILDFVEK
PEPEEAPSNLINAGAYVLDREVLDYIPEGRPVSIEREIFPKLAEEGLLYGFKFEGYWVDVGLPETYLEAHRVLMEHECSG
KSVVGARITDTDLKPPVVAAPMTELRSSEIGPYVYVGERTEINGSVIENSVILDDVEIIDSEVRNTIVAEGCKIENARLD
GCVLGHDAEVCGCNLKGVRVAPGKEAERDLEDEWVI

Sequences:

>Translated_356_residues
MNVDAVVLAGGFGTRLRPLTWDTPKPLVPILGKPLIEWVIRSLPRDVVHVHIAAGFSSEKLERYVESDPLPRKLHLKVEP
KPLDTAGAIKFACRDSTADAFVAFNGDIVSSLDVRQMLKFHREHDGIATIALYPVPEDEVSRFGVVDLDDDDRILDFVEK
PEPEEAPSNLINAGAYVLDREVLDYIPEGRPVSIEREIFPKLAEEGLLYGFKFEGYWVDVGLPETYLEAHRVLMEHECSG
KSVVGARITDTDLKPPVVAAPMTELRSSEIGPYVYVGERTEINGSVIENSVILDDVEIIDSEVRNTIVAEGCKIENARLD
GCVLGHDAEVCGCNLKGVRVAPGKEAERDLEDEWVI
>Mature_356_residues
MNVDAVVLAGGFGTRLRPLTWDTPKPLVPILGKPLIEWVIRSLPRDVVHVHIAAGFSSEKLERYVESDPLPRKLHLKVEP
KPLDTAGAIKFACRDSTADAFVAFNGDIVSSLDVRQMLKFHREHDGIATIALYPVPEDEVSRFGVVDLDDDDRILDFVEK
PEPEEAPSNLINAGAYVLDREVLDYIPEGRPVSIEREIFPKLAEEGLLYGFKFEGYWVDVGLPETYLEAHRVLMEHECSG
KSVVGARITDTDLKPPVVAAPMTELRSSEIGPYVYVGERTEINGSVIENSVILDDVEIIDSEVRNTIVAEGCKIENARLD
GCVLGHDAEVCGCNLKGVRVAPGKEAERDLEDEWVI

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP- GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1- P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcN

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=362, Percent_Identity=34.5303867403315, Blast_Score=164, Evalue=9e-41,
Organism=Homo sapiens, GI11761619, Length=326, Percent_Identity=34.6625766871166, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI31881779, Length=366, Percent_Identity=24.5901639344262, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI45447090, Length=366, Percent_Identity=24.5901639344262, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI1789837, Length=387, Percent_Identity=28.9405684754522, Blast_Score=102, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI133931050, Length=358, Percent_Identity=38.268156424581, Blast_Score=188, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI17509979, Length=321, Percent_Identity=28.6604361370716, Blast_Score=94, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17509981, Length=306, Percent_Identity=27.4509803921569, Blast_Score=85, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6320148, Length=371, Percent_Identity=34.7708894878706, Blast_Score=160, Evalue=2e-40,
Organism=Drosophila melanogaster, GI21355443, Length=337, Percent_Identity=32.6409495548961, Blast_Score=154, Evalue=9e-38,
Organism=Drosophila melanogaster, GI24644084, Length=337, Percent_Identity=32.6409495548961, Blast_Score=154, Evalue=9e-38,
Organism=Drosophila melanogaster, GI24653912, Length=373, Percent_Identity=24.6648793565684, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 39435; Mature: 39435

Theoretical pI: Translated: 4.38; Mature: 4.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVDAVVLAGGFGTRLRPLTWDTPKPLVPILGKPLIEWVIRSLPRDVVHVHIAAGFSSEK
CCCCEEEEECCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHCCCCEEEEEEECCCCHHH
LERYVESDPLPRKLHLKVEPKPLDTAGAIKFACRDSTADAFVAFNGDIVSSLDVRQMLKF
HHHHHHCCCCCCEEEEEECCCCCCCCCCEEEEECCCCCCEEEEECCCHHCHHHHHHHHHH
HREHDGIATIALYPVPEDEVSRFGVVDLDDDDRILDFVEKPEPEEAPSNLINAGAYVLDR
HHHCCCEEEEEEEECCHHHHHHCCEEEECCCCHHHHHHCCCCCCHHHHHHHHCCHHHHHH
EVLDYIPEGRPVSIEREIFPKLAEEGLLYGFKFEGYWVDVGLPETYLEAHRVLMEHECSG
HHHHHCCCCCCEEEHHHHHHHHHHCCCEEEEEECCEEEECCCCHHHHHHHHHHHHHCCCC
KSVVGARITDTDLKPPVVAAPMTELRSSEIGPYVYVGERTEINGSVIENSVILDDVEIID
CEEEEEEEECCCCCCCEEECCHHHHHHCCCCCEEEECCCEECCCCEECCCEEEHHHHHHH
SEVRNTIVAEGCKIENARLDGCVLGHDAEVCGCNLKGVRVAPGKEAERDLEDEWVI
HHHHHHHHHCCCEECCCCCCEEEECCCCCEECCCCCCEEECCCCCHHHCCCCCCCC
>Mature Secondary Structure
MNVDAVVLAGGFGTRLRPLTWDTPKPLVPILGKPLIEWVIRSLPRDVVHVHIAAGFSSEK
CCCCEEEEECCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHCCCCEEEEEEECCCCHHH
LERYVESDPLPRKLHLKVEPKPLDTAGAIKFACRDSTADAFVAFNGDIVSSLDVRQMLKF
HHHHHHCCCCCCEEEEEECCCCCCCCCCEEEEECCCCCCEEEEECCCHHCHHHHHHHHHH
HREHDGIATIALYPVPEDEVSRFGVVDLDDDDRILDFVEKPEPEEAPSNLINAGAYVLDR
HHHCCCEEEEEEEECCHHHHHHCCEEEECCCCHHHHHHCCCCCCHHHHHHHHCCHHHHHH
EVLDYIPEGRPVSIEREIFPKLAEEGLLYGFKFEGYWVDVGLPETYLEAHRVLMEHECSG
HHHHHCCCCCCEEEHHHHHHHHHHCCCEEEEEECCEEEECCCCHHHHHHHHHHHHHCCCC
KSVVGARITDTDLKPPVVAAPMTELRSSEIGPYVYVGERTEINGSVIENSVILDDVEIID
CEEEEEEEECCCCCCCEEECCHHHHHHCCCCCEEEECCCEECCCCEECCCEEEHHHHHHH
SEVRNTIVAEGCKIENARLDGCVLGHDAEVCGCNLKGVRVAPGKEAERDLEDEWVI
HHHHHHHHHCCCEECCCCCCEEEECCCCCEECCCCCCEEECCCCCHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA