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The map label for this gene is SPT15

Identifier: 20094275

GI number: 20094275

Start: 799566

End: 800123

Strand: Reverse

Name: SPT15

Synonym: MK0839

Alternate gene names: 20094275

Gene position: 800123-799566 (Counterclockwise)

Preceding gene: 20094276

Following gene: 20094273

Centisome position: 47.21

GC content: 54.66

Gene sequence:

>558_bases
GTGGAGATCCAGAACATCGTAGCATCCGTCGACCTCAAAGGAGAGGTGAACTTGGACGAGTGCTCCGTAATACTCCAAGG
GGAGTACGAACCGGAACAGTTTCCGGGACTCGTATACAGGCTCGAAGACATCGGTACTGTGGTATTGATCTTCAGATCCG
GGAAAATGGTGTGTACCGGTGCCAAGAATCGGGAGCAGATTTACAAGAGCGTCGAGAGGGTCAGGGAAGACCTGGAGAAG
AAGTGCGGAGTGAAGTTCCACGGAGAACCCGAAGTGGAGATCCAGAACATCGTAGCGTCGATCGACTTCCACGTACCACT
GGACCTGGACACGATCGCGGAGGTCTTGGTGGGAGACGAAGACGTCGAAGGGATCGAGTACGAACCGGAGCAGTTTCCAG
GGCTGGTACTGAGACTGAGGGAACCCAAGGTGGCGATGCTATTGTTCTACTCCGGTAAGGCCGTATGTACGGGGGCTAAG
ACCGAAGAGGAGCCCGAGAAAGCCGTGAAGAAGATCGCGGAGAAGATCGAGAAATACGGGCTGAAGCTCACGGGGTAA

Upstream 100 bases:

>100_bases
GGCCTCCGGTACTTGGAGGGGGAACCCGTCCCGGCACTGCCGTGTGAGGGGGGAACCGGACGTGGCGGAAAAACGTGAGG
AGGGTGTACCAGAACCCGAA

Downstream 100 bases:

>100_bases
CGGGTCGAGCTATTACTATCGGGACGTGCTCAAAGCCGTTCAGGAACTCTTCATCCAGCGATTCTGGATCGCCCACTTCT
TCCAAGGCGTCATAGACCGT

Product: transcription factor

Products: NA

Alternate protein names: Box A-binding protein; BAP; TATA sequence-binding protein; TBP; TATA-box factor

Number of amino acids: Translated: 185; Mature: 185

Protein sequence:

>185_residues
MEIQNIVASVDLKGEVNLDECSVILQGEYEPEQFPGLVYRLEDIGTVVLIFRSGKMVCTGAKNREQIYKSVERVREDLEK
KCGVKFHGEPEVEIQNIVASIDFHVPLDLDTIAEVLVGDEDVEGIEYEPEQFPGLVLRLREPKVAMLLFYSGKAVCTGAK
TEEEPEKAVKKIAEKIEKYGLKLTG

Sequences:

>Translated_185_residues
MEIQNIVASVDLKGEVNLDECSVILQGEYEPEQFPGLVYRLEDIGTVVLIFRSGKMVCTGAKNREQIYKSVERVREDLEK
KCGVKFHGEPEVEIQNIVASIDFHVPLDLDTIAEVLVGDEDVEGIEYEPEQFPGLVLRLREPKVAMLLFYSGKAVCTGAK
TEEEPEKAVKKIAEKIEKYGLKLTG
>Mature_185_residues
MEIQNIVASVDLKGEVNLDECSVILQGEYEPEQFPGLVYRLEDIGTVVLIFRSGKMVCTGAKNREQIYKSVERVREDLEK
KCGVKFHGEPEVEIQNIVASIDFHVPLDLDTIAEVLVGDEDVEGIEYEPEQFPGLVLRLREPKVAMLLFYSGKAVCTGAK
TEEEPEKAVKKIAEKIEKYGLKLTG

Specific function: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation

COG id: COG2101

COG function: function code K; TATA-box binding protein (TBP), component of TFIID and TFIIIB

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TBP family

Homologues:

Organism=Homo sapiens, GI285026520, Length=174, Percent_Identity=37.9310344827586, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI4507379, Length=174, Percent_Identity=37.9310344827586, Blast_Score=104, Evalue=4e-23,
Organism=Homo sapiens, GI39930602, Length=173, Percent_Identity=36.4161849710983, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17555358, Length=173, Percent_Identity=36.9942196531792, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6320996, Length=173, Percent_Identity=39.3063583815029, Blast_Score=101, Evalue=5e-23,
Organism=Drosophila melanogaster, GI17136834, Length=166, Percent_Identity=35.5421686746988, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI17647997, Length=180, Percent_Identity=35.5555555555556, Blast_Score=103, Evalue=5e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TBP_METKA (Q8TX38)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_614122.1
- ProteinModelPortal:   Q8TX38
- SMR:   Q8TX38
- GeneID:   1476940
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK0839
- NMPDR:   fig|190192.1.peg.835
- HOGENOM:   HBG499930
- OMA:   MERSVPN
- ProtClustDB:   PRK00394
- BioCyc:   MKAN190192:MK0839-MONOMER
- HAMAP:   MF_00408
- InterPro:   IPR012295
- InterPro:   IPR000814
- InterPro:   IPR012294
- Gene3D:   G3DSA:3.30.310.10
- PANTHER:   PTHR10126
- PRINTS:   PR00686

Pfam domain/function: PF00352 TBP; SSF55945 TFIID_C/glycos_N

EC number: NA

Molecular weight: Translated: 20730; Mature: 20730

Theoretical pI: Translated: 4.42; Mature: 4.42

Prosite motif: PS00351 TFIID

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIQNIVASVDLKGEVNLDECSVILQGEYEPEQFPGLVYRLEDIGTVVLIFRSGKMVCTG
CCHHHEEEEECCCCCCCHHHEEEEEECCCCCCCCCCCEEEECCCCEEEEEEECCCEEEEC
AKNREQIYKSVERVREDLEKKCGVKFHGEPEVEIQNIVASIDFHVPLDLDTIAEVLVGDE
CCCHHHHHHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHHCCEECCCCHHHHHHHHCCCC
DVEGIEYEPEQFPGLVLRLREPKVAMLLFYSGKAVCTGAKTEEEPEKAVKKIAEKIEKYG
CCCCCCCCCCCCCCEEEEECCCCEEEEEEECCCEEEECCCCCCCHHHHHHHHHHHHHHCC
LKLTG
CEECC
>Mature Secondary Structure
MEIQNIVASVDLKGEVNLDECSVILQGEYEPEQFPGLVYRLEDIGTVVLIFRSGKMVCTG
CCHHHEEEEECCCCCCCHHHEEEEEECCCCCCCCCCCEEEECCCCEEEEEEECCCEEEEC
AKNREQIYKSVERVREDLEKKCGVKFHGEPEVEIQNIVASIDFHVPLDLDTIAEVLVGDE
CCCHHHHHHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHHCCEECCCCHHHHHHHHCCCC
DVEGIEYEPEQFPGLVLRLREPKVAMLLFYSGKAVCTGAKTEEEPEKAVKKIAEKIEKYG
CCCCCCCCCCCCCCEEEEECCCCEEEEEEECCCEEEECCCCCCCHHHHHHHHHHHHHHCC
LKLTG
CEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11930014