Click here to switch to the map view.

The map label for this gene is IlvC

Identifier: 20094268

GI number: 20094268

Start: 791741

End: 792721

Strand: Reverse

Name: IlvC

Synonym: MK0832

Alternate gene names: 20094268

Gene position: 792721-791741 (Counterclockwise)

Preceding gene: 20094269

Following gene: 20094267

Centisome position: 46.77

GC content: 60.24

Gene sequence:

>981_bases
GTGGCCAAGATCTACGGCGATGAGGACGCCTCCCTCGAACCCCTCGAGGACAAAACGGTGGCGGTAATCGGGTACGGATC
GCAGGGTGAGGCCCAAGCGAAGAACCTCCGGGACTCCGGTATAGACGTTATCATCGGCGTACGTGAGGGAGGACCATCCT
GGGAGCGGGCCAAGAAGGACGGTTTCGAAGTGCTGCCGATCCCGGAAGCCGCCGAGGCCGGCGACGTGGTCCACATACTG
ATCCCCGACGAGGTACAGCCGCAGGTTTACCGCGAGCACATCCACGACAATCTGGAGAAGGGGAACGCGCTCGGCTTCAG
CCACGCCTACAACATCCACTACGGCCTCATCGAGCCCCCGGAGTACGTCGACGTCATCCTGGTGGCCCCGAAAGGGCCGG
GACACATGGTCCGCAAGCTGTACACCGAAGGATTCGGTACTCCGGCCCTAGTGGCCGTACACCAAGACTACACCGGCGAG
GCGATGGACCTGGCCCTCGCCATGGCCAAGGCGATGGGGTTCACCCGCGCCGGCGTGATCAAGACGACGTTCCGGGAGGA
AGTGGAGACCGACCTTTTCGGCGAGCAGGTAGACCTAGTCGGTGGAGTCCTGTACATGATCCTCTACGCGTTCGAGACCC
TAGTCGAAGCGGGTTACCAGCCCGAGGTCGCCTACTTCGAGACGTTACACGAGCTGAAGCTCATCGTCGACCTGATCTAC
GAGAAAGGCCTCAGTGGAATGCTCGATAACGTCTCCAACACTGCGGAGTACGGCGGGCTCACTAGAGGCAAGCGCATCAT
CAACAAGGAGGAGATGCGGAAGGTGTTGGAAGAAATCCGAAGCGGTGAGTTCGCCCGTGAGTGGACACTCGAGAACGAGT
CCGGTCGTATCGTCATGAAGCGTCTCCGGGAGGAGATAGAGAACCACGAAATCGAGAAGGTAGGCGAGCGGTTGAGGAAG
ATGATGGGGTTTGAGGACTAG

Upstream 100 bases:

>100_bases
GGCGCGTCCGACGAGGAGGTCAAGGAGGCGCTGGAGGAAGCCGGCCTCCTGGACCTCATGAAGGAAGGCATCGTGAGTGG
GTCGTGAGGGGGACCACAGG

Downstream 100 bases:

>100_bases
GCCCATGCCGAAAATTCCCAAAAAGGTAATATAACGCCCCGGACCACCGGAGGCTGGGGGTGAAACCGCCGTGAAGCGCG
TGCTTCTGGCGCTGGCCGTG

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 326; Mature: 325

Protein sequence:

>326_residues
MAKIYGDEDASLEPLEDKTVAVIGYGSQGEAQAKNLRDSGIDVIIGVREGGPSWERAKKDGFEVLPIPEAAEAGDVVHIL
IPDEVQPQVYREHIHDNLEKGNALGFSHAYNIHYGLIEPPEYVDVILVAPKGPGHMVRKLYTEGFGTPALVAVHQDYTGE
AMDLALAMAKAMGFTRAGVIKTTFREEVETDLFGEQVDLVGGVLYMILYAFETLVEAGYQPEVAYFETLHELKLIVDLIY
EKGLSGMLDNVSNTAEYGGLTRGKRIINKEEMRKVLEEIRSGEFAREWTLENESGRIVMKRLREEIENHEIEKVGERLRK
MMGFED

Sequences:

>Translated_326_residues
MAKIYGDEDASLEPLEDKTVAVIGYGSQGEAQAKNLRDSGIDVIIGVREGGPSWERAKKDGFEVLPIPEAAEAGDVVHIL
IPDEVQPQVYREHIHDNLEKGNALGFSHAYNIHYGLIEPPEYVDVILVAPKGPGHMVRKLYTEGFGTPALVAVHQDYTGE
AMDLALAMAKAMGFTRAGVIKTTFREEVETDLFGEQVDLVGGVLYMILYAFETLVEAGYQPEVAYFETLHELKLIVDLIY
EKGLSGMLDNVSNTAEYGGLTRGKRIINKEEMRKVLEEIRSGEFAREWTLENESGRIVMKRLREEIENHEIEKVGERLRK
MMGFED
>Mature_325_residues
AKIYGDEDASLEPLEDKTVAVIGYGSQGEAQAKNLRDSGIDVIIGVREGGPSWERAKKDGFEVLPIPEAAEAGDVVHILI
PDEVQPQVYREHIHDNLEKGNALGFSHAYNIHYGLIEPPEYVDVILVAPKGPGHMVRKLYTEGFGTPALVAVHQDYTGEA
MDLALAMAKAMGFTRAGVIKTTFREEVETDLFGEQVDLVGGVLYMILYAFETLVEAGYQPEVAYFETLHELKLIVDLIYE
KGLSGMLDNVSNTAEYGGLTRGKRIINKEEMRKVLEEIRSGEFAREWTLENESGRIVMKRLREEIENHEIEKVGERLRKM
MGFED

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=282, Percent_Identity=36.8794326241135, Blast_Score=149, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6323387, Length=323, Percent_Identity=38.0804953560372, Blast_Score=159, Evalue=8e-40,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_METKA (Q8TX44)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_614115.1
- ProteinModelPortal:   Q8TX44
- SMR:   Q8TX44
- GeneID:   1476933
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK0832
- NMPDR:   fig|190192.1.peg.828
- HOGENOM:   HBG286525
- OMA:   AMKQCLK
- ProtClustDB:   PRK05479
- BioCyc:   MKAN190192:MK0832-MONOMER
- BRENDA:   1.1.1.86
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 36461; Mature: 36330

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: NA

Important sites: ACT_SITE 108-108

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIYGDEDASLEPLEDKTVAVIGYGSQGEAQAKNLRDSGIDVIIGVREGGPSWERAKKD
CCCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHCCCCCEEEEEECCCCCCHHHHHHC
GFEVLPIPEAAEAGDVVHILIPDEVQPQVYREHIHDNLEKGNALGFSHAYNIHYGLIEPP
CCEEECCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCC
EYVDVILVAPKGPGHMVRKLYTEGFGTPALVAVHQDYTGEAMDLALAMAKAMGFTRAGVI
CCEEEEEECCCCCHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCHHCCHH
KTTFREEVETDLFGEQVDLVGGVLYMILYAFETLVEAGYQPEVAYFETLHELKLIVDLIY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
EKGLSGMLDNVSNTAEYGGLTRGKRIINKEEMRKVLEEIRSGEFAREWTLENESGRIVMK
HHCHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHCCCCEEHCCCCCCCCHHHHH
RLREEIENHEIEKVGERLRKMMGFED
HHHHHHHCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AKIYGDEDASLEPLEDKTVAVIGYGSQGEAQAKNLRDSGIDVIIGVREGGPSWERAKKD
CCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHCCCCCEEEEEECCCCCCHHHHHHC
GFEVLPIPEAAEAGDVVHILIPDEVQPQVYREHIHDNLEKGNALGFSHAYNIHYGLIEPP
CCEEECCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCC
EYVDVILVAPKGPGHMVRKLYTEGFGTPALVAVHQDYTGEAMDLALAMAKAMGFTRAGVI
CCEEEEEECCCCCHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCHHCCHH
KTTFREEVETDLFGEQVDLVGGVLYMILYAFETLVEAGYQPEVAYFETLHELKLIVDLIY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
EKGLSGMLDNVSNTAEYGGLTRGKRIINKEEMRKVLEEIRSGEFAREWTLENESGRIVMK
HHCHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHCCCCEEHCCCCCCCCHHHHH
RLREEIENHEIEKVGERLRKMMGFED
HHHHHHHCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11930014