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The map label for this gene is PurC

Identifier: 20094229

GI number: 20094229

Start: 751904

End: 752647

Strand: Reverse

Name: PurC

Synonym: MK0792

Alternate gene names: 20094229

Gene position: 752647-751904 (Counterclockwise)

Preceding gene: 20094236

Following gene: 20094228

Centisome position: 44.4

GC content: 55.65

Gene sequence:

>744_bases
ATGGAGCGCGGTAGACTCGTCTACGAGGGCAAGGCGAAGAGTCTCTACGAACATCCGGAGGATGAGAACCTGCTCGTGAT
GGAATTCCGAGACGACATCACGGCGTTTAACATGGAGAAAATGGATACCGTCGAAGGCAAGGGAGTTTACAACTGCCTGA
TTTCGGCGCGATTGTTCGAAGTACTCGAAGACGCCGGAATACCCACCCACTACGTGGAACTCGCCGACGAGCGTCGCATG
GTAGTGGAGCGCTTAGACATGTTTAATTTGGAGGTCATCTGTCGCAACATGGCGACGGGCAGTTTGGTGGAGCGACTACC
ATTCGAGGAGGGTGAGAAGCTGGATCCACCGATCGTCGAATTCGACTACAAGAGCGACGAATACGGAGACCCGATGGTGA
ATATGGACCACATCCGAGCGCTAGGTTTGGCTACGGAAGAAGAAGTAGAACGCATGCGGGAGCTGACCCTGCAGGTGAAC
GAAGTGCTCTCCGAGTTCCTGAAGGATTGCGACATCATCCTGGTGGACTTCAAGCTCGAGTTCGGAGTGAACCCGGACGG
AGAAGTCGTAGTGGGAGACGAGATCAGCCCCGACACGTGCCGGTTCTGGGACGCGGAGACCGAAGAGAGCCTGGACAAGG
ACATCTTCAGAAAAGACGAAGGAGACGTTCTGGCGGGTTACAGGGAAGCCGCCGAGAGAATCCTGCGAGGTGATGAGGAG
AAGCTGGCCATGCTACCGGGGTGA

Upstream 100 bases:

>100_bases
CCCCTCCAGCAAGAACGGCATAAGTTAACTTTCCACTCCGTTTGTTGACGCGTTTAGTGTTTATATACAGGTTCGGCCGG
CTAAGGGAGCGGGCACCGCT

Downstream 100 bases:

>100_bases
CACAGTTGGTCACCGTCGAGGTTCGCGTGAGCTTGAAACCGAAGGCATTGGACCCCGAAGGTGAGACTGTGAAGAGGGCG
TTACACCGACTGGGATACGA

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase

Number of amino acids: Translated: 247; Mature: 247

Protein sequence:

>247_residues
MERGRLVYEGKAKSLYEHPEDENLLVMEFRDDITAFNMEKMDTVEGKGVYNCLISARLFEVLEDAGIPTHYVELADERRM
VVERLDMFNLEVICRNMATGSLVERLPFEEGEKLDPPIVEFDYKSDEYGDPMVNMDHIRALGLATEEEVERMRELTLQVN
EVLSEFLKDCDIILVDFKLEFGVNPDGEVVVGDEISPDTCRFWDAETEESLDKDIFRKDEGDVLAGYREAAERILRGDEE
KLAMLPG

Sequences:

>Translated_247_residues
MERGRLVYEGKAKSLYEHPEDENLLVMEFRDDITAFNMEKMDTVEGKGVYNCLISARLFEVLEDAGIPTHYVELADERRM
VVERLDMFNLEVICRNMATGSLVERLPFEEGEKLDPPIVEFDYKSDEYGDPMVNMDHIRALGLATEEEVERMRELTLQVN
EVLSEFLKDCDIILVDFKLEFGVNPDGEVVVGDEISPDTCRFWDAETEESLDKDIFRKDEGDVLAGYREAAERILRGDEE
KLAMLPG
>Mature_247_residues
MERGRLVYEGKAKSLYEHPEDENLLVMEFRDDITAFNMEKMDTVEGKGVYNCLISARLFEVLEDAGIPTHYVELADERRM
VVERLDMFNLEVICRNMATGSLVERLPFEEGEKLDPPIVEFDYKSDEYGDPMVNMDHIRALGLATEEEVERMRELTLQVN
EVLSEFLKDCDIILVDFKLEFGVNPDGEVVVGDEISPDTCRFWDAETEESLDKDIFRKDEGDVLAGYREAAERILRGDEE
KLAMLPG

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family

Homologues:

Organism=Homo sapiens, GI119220557, Length=223, Percent_Identity=31.8385650224215, Blast_Score=117, Evalue=8e-27,
Organism=Homo sapiens, GI5453539, Length=223, Percent_Identity=31.8385650224215, Blast_Score=117, Evalue=8e-27,
Organism=Homo sapiens, GI119220559, Length=230, Percent_Identity=30.4347826086957, Blast_Score=107, Evalue=1e-23,
Organism=Escherichia coli, GI1788820, Length=234, Percent_Identity=42.3076923076923, Blast_Score=186, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17531275, Length=220, Percent_Identity=29.5454545454545, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6319326, Length=255, Percent_Identity=24.7058823529412, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI18860083, Length=222, Percent_Identity=31.981981981982, Blast_Score=116, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24583917, Length=211, Percent_Identity=32.2274881516588, Blast_Score=114, Evalue=6e-26,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): PUR7_METKA (Q8TX83)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_614076.1
- ProteinModelPortal:   Q8TX83
- SMR:   Q8TX83
- GeneID:   1476893
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK0792
- NMPDR:   fig|190192.1.peg.789
- HOGENOM:   HBG306070
- OMA:   THYVELA
- ProtClustDB:   PRK09362
- BioCyc:   MKAN190192:MK0792-MONOMER
- BRENDA:   6.3.2.6
- HAMAP:   MF_00137
- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236
- Gene3D:   G3DSA:3.30.470.20
- PANTHER:   PTHR11609
- TIGRFAMs:   TIGR00081

Pfam domain/function: PF01259 SAICAR_synt

EC number: =6.3.2.6

Molecular weight: Translated: 28405; Mature: 28405

Theoretical pI: Translated: 4.03; Mature: 4.03

Prosite motif: PS01057 SAICAR_SYNTHETASE_1; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERGRLVYEGKAKSLYEHPEDENLLVMEFRDDITAFNMEKMDTVEGKGVYNCLISARLFE
CCCCCEEEECCCHHHHCCCCCCCEEEEEECCCCHHCCHHHHHCCCCCHHHHHHHHHHHHH
VLEDAGIPTHYVELADERRMVVERLDMFNLEVICRNMATGSLVERLPFEEGEKLDPPIVE
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCCCCCCCCEEE
FDYKSDEYGDPMVNMDHIRALGLATEEEVERMRELTLQVNEVLSEFLKDCDIILVDFKLE
EECCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEE
FGVNPDGEVVVGDEISPDTCRFWDAETEESLDKDIFRKDEGDVLAGYREAAERILRGDEE
ECCCCCCCEEECCCCCCCCEECCCCCCHHHHHHHHHHCCCCCEEHHHHHHHHHHHCCCCH
KLAMLPG
HEECCCC
>Mature Secondary Structure
MERGRLVYEGKAKSLYEHPEDENLLVMEFRDDITAFNMEKMDTVEGKGVYNCLISARLFE
CCCCCEEEECCCHHHHCCCCCCCEEEEEECCCCHHCCHHHHHCCCCCHHHHHHHHHHHHH
VLEDAGIPTHYVELADERRMVVERLDMFNLEVICRNMATGSLVERLPFEEGEKLDPPIVE
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCCCCCCCCEEE
FDYKSDEYGDPMVNMDHIRALGLATEEEVERMRELTLQVNEVLSEFLKDCDIILVDFKLE
EECCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEE
FGVNPDGEVVVGDEISPDTCRFWDAETEESLDKDIFRKDEGDVLAGYREAAERILRGDEE
ECCCCCCCEEECCCCCCCCEECCCCCCHHHHHHHHHHCCCCCEEHHHHHHHHHHHCCCCH
KLAMLPG
HEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11930014