Click here to switch to the map view.

The map label for this gene is MurE_1 [H]

Identifier: 20094189

GI number: 20094189

Start: 712425

End: 713867

Strand: Reverse

Name: MurE_1 [H]

Synonym: MK0752

Alternate gene names: 20094189

Gene position: 713867-712425 (Counterclockwise)

Preceding gene: 20094190

Following gene: 20094188

Centisome position: 42.12

GC content: 59.53

Gene sequence:

>1443_bases
CTGAAGCTCACGGTGAGGGAGCTGGCTGAGAATGTGGAAGGGGAAATACGCTCAGGCGACCCGGATAGTATGATCGCCGG
ATGGTTCTCCACGTTAGGAAGGGCGAAAGAAGGAGATGTAGTGATCCGATGGTGGTTGGACGATAAAGGTGCCGAGATCG
CGTCGGAGAGAGGCGTGGCATGTCTGGTGACTGAACACCCGCGCGGCAAGCTGATCGAGAGATGCGACGAGCTCGGAATC
CCCTTGATCCTGACGGAGGTGGATCGGGCGAACGAGTACGCTCTGCGCGTAGCCCGTGAGAAGTGCGCCCCTGACGCTAC
CGCGATCTGCGTGACGGGAACTAACGGTAAGTCGACTACGAATCACTTGCTTCACCACATCCTCGATACCGCCGGCTTCG
ATGCTTACTGCAACACGGATTTCCGTTCCGAGAAGAACACCCTCATAGACCCCGTGGTCGCGATGGAGTTGCGCGAGGAA
CGGCCGGAAGATTACCTGTGCGTGGAGGTATCTGAGGTACAAGGCTTACCTACGGGTCGAATAATGGAGGACCACGCCTA
CCGGATGGCGAAGGCCCTCAAATGCGAGCTGGCGGTCGTGACGAACGTCGGGGTGGACCACACGAACCTGGTTTCCTCTC
TGGAAGAGATGGTTGACGCTGTATACGGTGTCGTGCGGGCCCTACGAAAGGGAGGTATCGCGGTGCTCAACCGTGACGAT
CGGTACGTACGGCGGATGACCAGGGAAGGTGTGGAGACGGTATGGTACGGATGGGACGAAGGATACTCCCACATTGAGGA
ACGCGACGGGGAGGAGTGGATAGTACTGGACGAAGAACCCCTAATACCCGTCCGGGAGTTCCCCCTACCGGTGGACCACT
TCCTGTACAACGCGTTGGCCGCCGTAGCCGCCGCGGGAGCTCTAGGAATAGATCGGGAGGATATCGCCGAAGGCTTGAGG
ACGTACCAACCCTTGAAGCGGAGGTTCGAACGCCTGTGCGACGACCCGCTGATTTACGACGATTTCTGCCACAATCCCGA
CGGAGTACTCGCCACTGTTCGCGCCCTGCGACGGTTGGGTCGCTCCAAGGTGATTGTTGTGTTCGCGATCCGCGGGTCGC
GTGGCGTCGACATTAACCGTCAAATCGCTCGGGCGCTGGCTGAAGGCGCGAAGGATCTACAGGACGAGGGAATCCACGTC
CACGTGATCGCGACCTCATCAGAGGGCCTCGTGGACGATGCTAACGTAGTGCGGCCTGAGGAGCGGAGGGCGTTCCTGGA
GGAACTGGAGCGCTCCGGCATCGACTACGAGCACTACGATCGGTTAGAAGACGCTTTGGAGCGCGCACTGGACTTGGCGG
ACGACGACACCGTGATTCTACTGGGAGGAGCCCAAGGAATGGAACCTGCTCGAGAGGTCCTGCGCGATATGGGGGCGATC
TAG

Upstream 100 bases:

>100_bases
GTACGACCTACCCGAACCCGTGGTTGTGGCGCTCCATTGGACCGCCGGAGCGGTGTTCGCCGCCGTGGCACTCTGGATCT
CCGTGGGGTGAGGGGCGCTG

Downstream 100 bases:

>100_bases
CGGTGGAAGAGGAAAGGAAGAGGAAGTGGATCAAACCGTGGCCCGTTTCCCGGCGTAACCTGGCGATCATGCTGATGGGT
GCTCTACTCCTCAGCATCGG

Product: UDP-N-acetylmuramyl tripeptide synthase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase [H]

Number of amino acids: Translated: 480; Mature: 480

Protein sequence:

>480_residues
MKLTVRELAENVEGEIRSGDPDSMIAGWFSTLGRAKEGDVVIRWWLDDKGAEIASERGVACLVTEHPRGKLIERCDELGI
PLILTEVDRANEYALRVAREKCAPDATAICVTGTNGKSTTNHLLHHILDTAGFDAYCNTDFRSEKNTLIDPVVAMELREE
RPEDYLCVEVSEVQGLPTGRIMEDHAYRMAKALKCELAVVTNVGVDHTNLVSSLEEMVDAVYGVVRALRKGGIAVLNRDD
RYVRRMTREGVETVWYGWDEGYSHIEERDGEEWIVLDEEPLIPVREFPLPVDHFLYNALAAVAAAGALGIDREDIAEGLR
TYQPLKRRFERLCDDPLIYDDFCHNPDGVLATVRALRRLGRSKVIVVFAIRGSRGVDINRQIARALAEGAKDLQDEGIHV
HVIATSSEGLVDDANVVRPEERRAFLEELERSGIDYEHYDRLEDALERALDLADDDTVILLGGAQGMEPAREVLRDMGAI

Sequences:

>Translated_480_residues
MKLTVRELAENVEGEIRSGDPDSMIAGWFSTLGRAKEGDVVIRWWLDDKGAEIASERGVACLVTEHPRGKLIERCDELGI
PLILTEVDRANEYALRVAREKCAPDATAICVTGTNGKSTTNHLLHHILDTAGFDAYCNTDFRSEKNTLIDPVVAMELREE
RPEDYLCVEVSEVQGLPTGRIMEDHAYRMAKALKCELAVVTNVGVDHTNLVSSLEEMVDAVYGVVRALRKGGIAVLNRDD
RYVRRMTREGVETVWYGWDEGYSHIEERDGEEWIVLDEEPLIPVREFPLPVDHFLYNALAAVAAAGALGIDREDIAEGLR
TYQPLKRRFERLCDDPLIYDDFCHNPDGVLATVRALRRLGRSKVIVVFAIRGSRGVDINRQIARALAEGAKDLQDEGIHV
HVIATSSEGLVDDANVVRPEERRAFLEELERSGIDYEHYDRLEDALERALDLADDDTVILLGGAQGMEPAREVLRDMGAI
>Mature_480_residues
MKLTVRELAENVEGEIRSGDPDSMIAGWFSTLGRAKEGDVVIRWWLDDKGAEIASERGVACLVTEHPRGKLIERCDELGI
PLILTEVDRANEYALRVAREKCAPDATAICVTGTNGKSTTNHLLHHILDTAGFDAYCNTDFRSEKNTLIDPVVAMELREE
RPEDYLCVEVSEVQGLPTGRIMEDHAYRMAKALKCELAVVTNVGVDHTNLVSSLEEMVDAVYGVVRALRKGGIAVLNRDD
RYVRRMTREGVETVWYGWDEGYSHIEERDGEEWIVLDEEPLIPVREFPLPVDHFLYNALAAVAAAGALGIDREDIAEGLR
TYQPLKRRFERLCDDPLIYDDFCHNPDGVLATVRALRRLGRSKVIVVFAIRGSRGVDINRQIARALAEGAKDLQDEGIHV
HVIATSSEGLVDDANVVRPEERRAFLEELERSGIDYEHYDRLEDALERALDLADDDTVILLGGAQGMEPAREVLRDMGAI

Specific function: Cell wall formation [H]

COG id: COG0769

COG function: function code M; UDP-N-acetylmuramyl tripeptide synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family [H]

Homologues:

Organism=Escherichia coli, GI1790680, Length=292, Percent_Identity=25, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758 [H]

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.8 [H]

Molecular weight: Translated: 53657; Mature: 53657

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: PS01011 FOLYLPOLYGLU_SYNT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLTVRELAENVEGEIRSGDPDSMIAGWFSTLGRAKEGDVVIRWWLDDKGAEIASERGVA
CCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHCCCCE
CLVTEHPRGKLIERCDELGIPLILTEVDRANEYALRVAREKCAPDATAICVTGTNGKSTT
EEEECCCCCHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCHH
NHLLHHILDTAGFDAYCNTDFRSEKNTLIDPVVAMELREERPEDYLCVEVSEVQGLPTGR
HHHHHHHHHHCCCCCEECCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEHHHHCCCCCCC
IMEDHAYRMAKALKCELAVVTNVGVDHTNLVSSLEEMVDAVYGVVRALRKGGIAVLNRDD
HHHHHHHHHHHHHHHEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCH
RYVRRMTREGVETVWYGWDEGYSHIEERDGEEWIVLDEEPLIPVREFPLPVDHFLYNALA
HHHHHHHHHCHHEEEECCHHHHHHHHHCCCCEEEEECCCCCCCHHHCCCCHHHHHHHHHH
AVAAAGALGIDREDIAEGLRTYQPLKRRFERLCDDPLIYDDFCHNPDGVLATVRALRRLG
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHCCCCCHHHHHHHHHHHCC
RSKVIVVFAIRGSRGVDINRQIARALAEGAKDLQDEGIHVHVIATSSEGLVDDANVVRPE
CCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCCCCCH
ERRAFLEELERSGIDYEHYDRLEDALERALDLADDDTVILLGGAQGMEPAREVLRDMGAI
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MKLTVRELAENVEGEIRSGDPDSMIAGWFSTLGRAKEGDVVIRWWLDDKGAEIASERGVA
CCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHCCCCE
CLVTEHPRGKLIERCDELGIPLILTEVDRANEYALRVAREKCAPDATAICVTGTNGKSTT
EEEECCCCCHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCHH
NHLLHHILDTAGFDAYCNTDFRSEKNTLIDPVVAMELREERPEDYLCVEVSEVQGLPTGR
HHHHHHHHHHCCCCCEECCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEHHHHCCCCCCC
IMEDHAYRMAKALKCELAVVTNVGVDHTNLVSSLEEMVDAVYGVVRALRKGGIAVLNRDD
HHHHHHHHHHHHHHHEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCH
RYVRRMTREGVETVWYGWDEGYSHIEERDGEEWIVLDEEPLIPVREFPLPVDHFLYNALA
HHHHHHHHHCHHEEEECCHHHHHHHHHCCCCEEEEECCCCCCCHHHCCCCHHHHHHHHHH
AVAAAGALGIDREDIAEGLRTYQPLKRRFERLCDDPLIYDDFCHNPDGVLATVRALRRLG
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHCCCCCHHHHHHHHHHHCC
RSKVIVVFAIRGSRGVDINRQIARALAEGAKDLQDEGIHVHVIATSSEGLVDDANVVRPE
CCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCCCCCH
ERRAFLEELERSGIDYEHYDRLEDALERALDLADDDTVILLGGAQGMEPAREVLRDMGAI
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA