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The map label for this gene is Dfp [H]

Identifier: 20094150

GI number: 20094150

Start: 678478

End: 679608

Strand: Reverse

Name: Dfp [H]

Synonym: MK0713

Alternate gene names: 20094150

Gene position: 679608-678478 (Counterclockwise)

Preceding gene: 20094151

Following gene: 20094149

Centisome position: 40.1

GC content: 64.99

Gene sequence:

>1131_bases
TTGGTTAACGTGGTCGTATGCGTGACGGGTAGCGTAGCCGCGTATCGCGCCCCGGACGTTTGCCGGGAACTGGTACGTCG
GGGTCATCGCGTCCGGGTCGTCGCATCGGAGGAGGCCCTGAGGTTCGTAGGTAAGGACGCACTGGGGTTCGCGGCCGAGG
AGGTCATCTTCCGGCTCACATCACGGGCGGAGCACGTAGAGCTGGCCGAGTGGGCCGACGTGGTGGCGGTAGTACCGGCC
ACGCTGAACACCCTCGCCAAGATCGCGCGCGGGGTAGCTGACGCCCCCGTCCCCCTCACGGCCGTGACATCGTTAGGGGC
CGGAAAACGATTAGTCGTCGCCCCCGCGATGTCCCTGCACATGTACCGGTCGCCACCGGCTCGGGAGATCCTACGCCAGC
TGGAGGATATGGGCGTCACCGTCGTGGGACCTGTAATCGAGGAAGGGAAGGCCAAACTGGCCTCGATAGAGGAAATAGTA
GAGGCCGTGGAGGGAGAGCTGTCGGGCTTTAGGGTCCTGGTCACCGGCGGGCCGACGATGGAGCCCTTGGACGATGTCCG
GGTGATCACCAACCGGAGCTCGGGACGGACGGCGTGTGAGATCTGCCGCGAGCTCCGTGCGCGTGGGGCCGAGGTCGTGT
TCGTCCATGGGCCGCTCCGAGTGGACCCGCCCCCGATGGACGAGCGTGTGGAGGTGGAAACCACCCGCGAAATGCTCGAG
GAGGTCGTGAAGAGGATCGACGACGTGGACGCTATCGTGATGGCGGCGGCACCGTCGGACTTCCGACCGGCGGAGCGTGC
CGACGGGAAGCTGGACTCGCGACGTGAGCACGAGATCCGTCTGATCCCTACCGAGAAGATAGTACGGGAAGTGTTTCCGG
ATTTCGACGGAGTTAGGGTGGCATTCAAGCTAGATCCCGAGCCGGTGGAAGGGGCCCGACGGCTTCTGGACGAAGTCCCG
TGTGAGCTCGTCGTCGCCAATCCTCCGGAGACCGCCGGTGCCGAGGGATCGGAGTGGTGGATATTGGACGGAGACGGCGA
GGTCATCGAGCGGGTGAAAGGGGACAAGCGGGAGCTGGCCAGGAAGTTGGTAGACGCTCTCTCGAAACTGCTCCGGGGTG
ACCGCGGGTGA

Upstream 100 bases:

>100_bases
GCGGTGATCCATCACCGGGACCGGCACCGCGTGCCCGCGGACACCGAGGAGCTCGAGAAGGCCGTGAAGGAGCTCACGGG
GATGGAGGTGGAGGTAACCT

Downstream 100 bases:

>100_bases
AGATACCACCCGATCACCCCAGGGCGGAGGCGTTGAAGATCCGTGAGCGCCTCGTGCGGGGGTTCGAGGACGGCTACGTG
GTGCCTCAAGGACTGATCGC

Product: phosphopantothenoylcysteine synthetase/decarboxylase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 376; Mature: 376

Protein sequence:

>376_residues
MVNVVVCVTGSVAAYRAPDVCRELVRRGHRVRVVASEEALRFVGKDALGFAAEEVIFRLTSRAEHVELAEWADVVAVVPA
TLNTLAKIARGVADAPVPLTAVTSLGAGKRLVVAPAMSLHMYRSPPAREILRQLEDMGVTVVGPVIEEGKAKLASIEEIV
EAVEGELSGFRVLVTGGPTMEPLDDVRVITNRSSGRTACEICRELRARGAEVVFVHGPLRVDPPPMDERVEVETTREMLE
EVVKRIDDVDAIVMAAAPSDFRPAERADGKLDSRREHEIRLIPTEKIVREVFPDFDGVRVAFKLDPEPVEGARRLLDEVP
CELVVANPPETAGAEGSEWWILDGDGEVIERVKGDKRELARKLVDALSKLLRGDRG

Sequences:

>Translated_376_residues
MVNVVVCVTGSVAAYRAPDVCRELVRRGHRVRVVASEEALRFVGKDALGFAAEEVIFRLTSRAEHVELAEWADVVAVVPA
TLNTLAKIARGVADAPVPLTAVTSLGAGKRLVVAPAMSLHMYRSPPAREILRQLEDMGVTVVGPVIEEGKAKLASIEEIV
EAVEGELSGFRVLVTGGPTMEPLDDVRVITNRSSGRTACEICRELRARGAEVVFVHGPLRVDPPPMDERVEVETTREMLE
EVVKRIDDVDAIVMAAAPSDFRPAERADGKLDSRREHEIRLIPTEKIVREVFPDFDGVRVAFKLDPEPVEGARRLLDEVP
CELVVANPPETAGAEGSEWWILDGDGEVIERVKGDKRELARKLVDALSKLLRGDRG
>Mature_376_residues
MVNVVVCVTGSVAAYRAPDVCRELVRRGHRVRVVASEEALRFVGKDALGFAAEEVIFRLTSRAEHVELAEWADVVAVVPA
TLNTLAKIARGVADAPVPLTAVTSLGAGKRLVVAPAMSLHMYRSPPAREILRQLEDMGVTVVGPVIEEGKAKLASIEEIV
EAVEGELSGFRVLVTGGPTMEPLDDVRVITNRSSGRTACEICRELRARGAEVVFVHGPLRVDPPPMDERVEVETTREMLE
EVVKRIDDVDAIVMAAAPSDFRPAERADGKLDSRREHEIRLIPTEKIVREVFPDFDGVRVAFKLDPEPVEGARRLLDEVP
CELVVANPPETAGAEGSEWWILDGDGEVIERVKGDKRELARKLVDALSKLLRGDRG

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Escherichia coli, GI87082301, Length=374, Percent_Identity=29.144385026738, Blast_Score=127, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17560194, Length=184, Percent_Identity=28.2608695652174, Blast_Score=71, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24657262, Length=188, Percent_Identity=28.7234042553192, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 41102; Mature: 41102

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVNVVVCVTGSVAAYRAPDVCRELVRRGHRVRVVASEEALRFVGKDALGFAAEEVIFRLT
CCEEEEEECCCCHHCCCHHHHHHHHHCCCEEEEEECHHHHHHHCCHHHHHHHHHHHHHHH
SRAEHVELAEWADVVAVVPATLNTLAKIARGVADAPVPLTAVTSLGAGKRLVVAPAMSLH
HCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCEEEEECHHHHH
MYRSPPAREILRQLEDMGVTVVGPVIEEGKAKLASIEEIVEAVEGELSGFRVLVTGGPTM
CCCCCCHHHHHHHHHHCCEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCC
EPLDDVRVITNRSSGRTACEICRELRARGAEVVFVHGPLRVDPPPMDERVEVETTREMLE
CCHHHHHEEECCCCCCHHHHHHHHHHHCCCEEEEEECCEECCCCCCCCCCHHHHHHHHHH
EVVKRIDDVDAIVMAAAPSDFRPAERADGKLDSRREHEIRLIPTEKIVREVFPDFDGVRV
HHHHHHCCCCEEEEEECCCCCCCCHHCCCCCCCCCCCCEEEECHHHHHHHHCCCCCCEEE
AFKLDPEPVEGARRLLDEVPCELVVANPPETAGAEGSEWWILDGDGEVIERVKGDKRELA
EEEECCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCCEEEEECCCHHHHHHHCCCHHHHH
RKLVDALSKLLRGDRG
HHHHHHHHHHHCCCCC
>Mature Secondary Structure
MVNVVVCVTGSVAAYRAPDVCRELVRRGHRVRVVASEEALRFVGKDALGFAAEEVIFRLT
CCEEEEEECCCCHHCCCHHHHHHHHHCCCEEEEEECHHHHHHHCCHHHHHHHHHHHHHHH
SRAEHVELAEWADVVAVVPATLNTLAKIARGVADAPVPLTAVTSLGAGKRLVVAPAMSLH
HCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCEEEEECHHHHH
MYRSPPAREILRQLEDMGVTVVGPVIEEGKAKLASIEEIVEAVEGELSGFRVLVTGGPTM
CCCCCCHHHHHHHHHHCCEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCC
EPLDDVRVITNRSSGRTACEICRELRARGAEVVFVHGPLRVDPPPMDERVEVETTREMLE
CCHHHHHEEECCCCCCHHHHHHHHHHHCCCEEEEEECCEECCCCCCCCCCHHHHHHHHHH
EVVKRIDDVDAIVMAAAPSDFRPAERADGKLDSRREHEIRLIPTEKIVREVFPDFDGVRV
HHHHHHCCCCEEEEEECCCCCCCCHHCCCCCCCCCCCCEEEECHHHHHHHHCCCCCCEEE
AFKLDPEPVEGARRLLDEVPCELVVANPPETAGAEGSEWWILDGDGEVIERVKGDKRELA
EEEECCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCCEEEEECCCHHHHHHHCCCHHHHH
RKLVDALSKLLRGDRG
HHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]