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The map label for this gene is Map [H]

Identifier: 20094051

GI number: 20094051

Start: 570239

End: 571111

Strand: Reverse

Name: Map [H]

Synonym: MK0613

Alternate gene names: 20094051

Gene position: 571111-570239 (Counterclockwise)

Preceding gene: 20094053

Following gene: 20094049

Centisome position: 33.69

GC content: 61.28

Gene sequence:

>873_bases
GTGGACGATGAGTTCCAGGAAGCCGGAAAGGTGGTCAAAAGGGTCCTCCGTAGGGCTGCCCGGGAGATCGACATCGGAGA
CCGACTGCTGGAAATAGCCGAATACCTCGAGGAGTGCGTGAGGGATCAAGGGGCAGAACCGGCGTTTCCGGTAAACCTAT
CGCTGAACGAGGTGGCTGCTCATTACACGCCGAGCCCGGACGACGAGGTCGAGGTATCGCCCGGGGACATCCTGAAGGTC
GACATAGGCGCTCACGTTAACGGCGCCATCGGGGACGCGGCGATCACGCTGTCCTTCGACAACGACTTAGGGGAGCGATT
GGCGGAGGCCGCCCGCGAGGCCCTCGAAGCGGCCATAGAGACGATCCGACCGGGCGTCGAGTGTCGCGAGGTCGGGAGGG
CCATCGGTGAGGTGTGTCGAGATCGCGGTTTCAAGCCGGTTATCGGACTCACAGGACATCAGATCGAACCGTGGAACCTA
CACGCCGGCGTTTCGATCCCCAACGACGACCTACCAGGGTACGAAGACAAGCTCGAGGAGGGAATGGTACTGGCAGTCGA
ACCGTTCGTAACCACTGAGGACGGAGAGGGAGACGTGAAACCCGGCTCGACCGTCGAGATTTTCTCAGTGCGGAACCCTA
ATCAACGATCCCGCCTGAACCTGCACCGGATCTACGAGGACCGGAAGTCACTGCCTTTCGCCCGACGTTGGGTGGGGAAG
GCTCCGAGGGTGAAGTTCGAACTGCTGAGACTTAGTAAGCTGGGAGCCGTGAAGGCTTACCCCGAGCTCGTCGAGGTGAA
CGGGGAACCGGTGGCCCAGTGGGAGCATACGGTAGTGGTCACCGAGCGCGGGTGTCGCGTGCTGACGGAATAA

Upstream 100 bases:

>100_bases
TCGAAAACGCTTAGGGCCGCGACGTCCGCGATGCGTCGCACTACGTCCAGCACGGATATTCTAACCGTTTCCACGGAGCG
TCTCCCCCGGGGGACCGGAC

Downstream 100 bases:

>100_bases
CGCGGGTAAGTTCCCTGTACCCGGTGTGAGGGTCACGTCCACGCTCGAGGCGTGCGTTCAACCGGAGCAGCACCAACTCC
ACGGTGGTGTAAACCTCGAA

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MDDEFQEAGKVVKRVLRRAAREIDIGDRLLEIAEYLEECVRDQGAEPAFPVNLSLNEVAAHYTPSPDDEVEVSPGDILKV
DIGAHVNGAIGDAAITLSFDNDLGERLAEAAREALEAAIETIRPGVECREVGRAIGEVCRDRGFKPVIGLTGHQIEPWNL
HAGVSIPNDDLPGYEDKLEEGMVLAVEPFVTTEDGEGDVKPGSTVEIFSVRNPNQRSRLNLHRIYEDRKSLPFARRWVGK
APRVKFELLRLSKLGAVKAYPELVEVNGEPVAQWEHTVVVTERGCRVLTE

Sequences:

>Translated_290_residues
MDDEFQEAGKVVKRVLRRAAREIDIGDRLLEIAEYLEECVRDQGAEPAFPVNLSLNEVAAHYTPSPDDEVEVSPGDILKV
DIGAHVNGAIGDAAITLSFDNDLGERLAEAAREALEAAIETIRPGVECREVGRAIGEVCRDRGFKPVIGLTGHQIEPWNL
HAGVSIPNDDLPGYEDKLEEGMVLAVEPFVTTEDGEGDVKPGSTVEIFSVRNPNQRSRLNLHRIYEDRKSLPFARRWVGK
APRVKFELLRLSKLGAVKAYPELVEVNGEPVAQWEHTVVVTERGCRVLTE
>Mature_290_residues
MDDEFQEAGKVVKRVLRRAAREIDIGDRLLEIAEYLEECVRDQGAEPAFPVNLSLNEVAAHYTPSPDDEVEVSPGDILKV
DIGAHVNGAIGDAAITLSFDNDLGERLAEAAREALEAAIETIRPGVECREVGRAIGEVCRDRGFKPVIGLTGHQIEPWNL
HAGVSIPNDDLPGYEDKLEEGMVLAVEPFVTTEDGEGDVKPGSTVEIFSVRNPNQRSRLNLHRIYEDRKSLPFARRWVGK
APRVKFELLRLSKLGAVKAYPELVEVNGEPVAQWEHTVVVTERGCRVLTE

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI5803092, Length=302, Percent_Identity=33.112582781457, Blast_Score=140, Evalue=9e-34,
Organism=Homo sapiens, GI124494254, Length=257, Percent_Identity=25.6809338521401, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI40385867, Length=205, Percent_Identity=27.8048780487805, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1786364, Length=148, Percent_Identity=31.7567567567568, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17544396, Length=302, Percent_Identity=32.1192052980132, Blast_Score=136, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17542840, Length=310, Percent_Identity=26.4516129032258, Blast_Score=92, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6319380, Length=317, Percent_Identity=33.1230283911672, Blast_Score=130, Evalue=3e-31,
Organism=Drosophila melanogaster, GI17137568, Length=299, Percent_Identity=31.438127090301, Blast_Score=130, Evalue=7e-31,
Organism=Drosophila melanogaster, GI24658585, Length=260, Percent_Identity=25.3846153846154, Blast_Score=84, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24583427, Length=201, Percent_Identity=26.865671641791, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21355531, Length=205, Percent_Identity=26.8292682926829, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002468
- InterPro:   IPR018349
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 32064; Mature: 32064

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: PS01202 MAP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDEFQEAGKVVKRVLRRAAREIDIGDRLLEIAEYLEECVRDQGAEPAFPVNLSLNEVAA
CCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCEEECCCHHHHHH
HYTPSPDDEVEVSPGDILKVDIGAHVNGAIGDAAITLSFDNDLGERLAEAAREALEAAIE
CCCCCCCCCEEECCCCEEEEEECCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHH
TIRPGVECREVGRAIGEVCRDRGFKPVIGLTGHQIEPWNLHAGVSIPNDDLPGYEDKLEE
HHCCCHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCEEEECCCCCCCCCCCHHHHHHC
GMVLAVEPFVTTEDGEGDVKPGSTVEIFSVRNPNQRSRLNLHRIYEDRKSLPFARRWVGK
CEEEEEECEEECCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCHHHHHCCC
APRVKFELLRLSKLGAVKAYPELVEVNGEPVAQWEHTVVVTERGCRVLTE
CCCHHHHHHHHHHHCCHHHCCHHHCCCCCCCCCCCEEEEEECCCCEECCC
>Mature Secondary Structure
MDDEFQEAGKVVKRVLRRAAREIDIGDRLLEIAEYLEECVRDQGAEPAFPVNLSLNEVAA
CCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCEEECCCHHHHHH
HYTPSPDDEVEVSPGDILKVDIGAHVNGAIGDAAITLSFDNDLGERLAEAAREALEAAIE
CCCCCCCCCEEECCCCEEEEEECCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHH
TIRPGVECREVGRAIGEVCRDRGFKPVIGLTGHQIEPWNLHAGVSIPNDDLPGYEDKLEE
HHCCCHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCEEEECCCCCCCCCCCHHHHHHC
GMVLAVEPFVTTEDGEGDVKPGSTVEIFSVRNPNQRSRLNLHRIYEDRKSLPFARRWVGK
CEEEEEECEEECCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCHHHHHCCC
APRVKFELLRLSKLGAVKAYPELVEVNGEPVAQWEHTVVVTERGCRVLTE
CCCHHHHHHHHHHHCCHHHCCHHHCCCCCCCCCCCEEEEEECCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]