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The map label for this gene is SerA [H]

Identifier: 20093758

GI number: 20093758

Start: 310502

End: 311260

Strand: Reverse

Name: SerA [H]

Synonym: MK0320

Alternate gene names: 20093758

Gene position: 311260-310502 (Counterclockwise)

Preceding gene: 20093762

Following gene: 20093757

Centisome position: 18.36

GC content: 64.43

Gene sequence:

>759_bases
TTGCCCGGGCGGGGGTGCGCGCATGACGAAGATCCTGGTCACGGACCCGTTCATGAGGATGCGTTGCGGAAGCTGGAGGA
GCTTGGTGAGGTGGTGCTTGAGGATGCGGACGAGGAGGGGCTCCGTAGGCACGTAAGGGACGCGGACGCGTGGGTGGTGC
GGAGCGGGACGCAGGTGACGCGGGAGCTGATCGAGGAGGCGGAGAATCTGAAGGTGATCGCGCGGGCCGGGGTTGGTGTG
GACAACATCGATGTGGAGGCGGCGACGGAGCGTGGGATCGTGGTGGTGAACGCGCCGGAGTCGAGCTCGATCTCGGTCGC
GGAGCACACGATGAGTTTGATGCTGGTGCTGGCGCGGCGGATTCCGCAGGCGGACCGGTCGGTGCGACGGGGAGAGTGGG
ATCGGAAGCTGTTCATGGGTGTGGAGCTGGCTGGGAAGGTGCTGGGCGTCATCGAGCTGGGCCGGATCGGTCGGCAGGTG
GCGAAGCGGACGAAGGCCTTCGAGATGGAGGTGATAGCGTTCGACCCGTACATCTCGGAGGAGGTGGCAGAAGGGCTGGA
TGTAGAGCTGGTGGAGGATCTGGACGAGCTGTTGCGGCGTGCGGACGTGGTTACGATTTACGTACCGTTGACGGATGAAA
CGCAGGGGATGATCGGGGAGCGAGAGCTGAAGCTGATGAAGGAGTCGGCGTTTCTGATCAACTGCGCTCGGGGCGAGGTG
GTAGATGAGGAAGCGCTGGTGCGGGCGTGCAGCTGCTGA

Upstream 100 bases:

>100_bases
GGGAACGACGTCATCGCGTGGGACGGTTTCTCGGACCGGAACAATCTGAGGTGTCAGTTGCGGCGAGCGTCCGACGGTCA
CCATCAATATATTTTTCCAC

Downstream 100 bases:

>100_bases
AGGGCAGGTTACGGTCGGTTGTGATCAAGGTGGGTGAGGAGCCGGGCGATCGAGAGCGGGAGGCCCTGAAGCGGGCGATG
CTAAAGGGGTGCTTGGACCG

Product: dehydrogenase related to phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 252; Mature: 251

Protein sequence:

>252_residues
MPGRGCAHDEDPGHGPVHEDALRKLEELGEVVLEDADEEGLRRHVRDADAWVVRSGTQVTRELIEEAENLKVIARAGVGV
DNIDVEAATERGIVVVNAPESSSISVAEHTMSLMLVLARRIPQADRSVRRGEWDRKLFMGVELAGKVLGVIELGRIGRQV
AKRTKAFEMEVIAFDPYISEEVAEGLDVELVEDLDELLRRADVVTIYVPLTDETQGMIGERELKLMKESAFLINCARGEV
VDEEALVRACSC

Sequences:

>Translated_252_residues
MPGRGCAHDEDPGHGPVHEDALRKLEELGEVVLEDADEEGLRRHVRDADAWVVRSGTQVTRELIEEAENLKVIARAGVGV
DNIDVEAATERGIVVVNAPESSSISVAEHTMSLMLVLARRIPQADRSVRRGEWDRKLFMGVELAGKVLGVIELGRIGRQV
AKRTKAFEMEVIAFDPYISEEVAEGLDVELVEDLDELLRRADVVTIYVPLTDETQGMIGERELKLMKESAFLINCARGEV
VDEEALVRACSC
>Mature_251_residues
PGRGCAHDEDPGHGPVHEDALRKLEELGEVVLEDADEEGLRRHVRDADAWVVRSGTQVTRELIEEAENLKVIARAGVGVD
NIDVEAATERGIVVVNAPESSSISVAEHTMSLMLVLARRIPQADRSVRRGEWDRKLFMGVELAGKVLGVIELGRIGRQVA
KRTKAFEMEVIAFDPYISEEVAEGLDVELVEDLDELLRRADVVTIYVPLTDETQGMIGERELKLMKESAFLINCARGEVV
DEEALVRACSC

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=216, Percent_Identity=44.9074074074074, Blast_Score=204, Evalue=9e-53,
Organism=Homo sapiens, GI4557497, Length=198, Percent_Identity=38.3838383838384, Blast_Score=135, Evalue=4e-32,
Organism=Homo sapiens, GI61743967, Length=198, Percent_Identity=38.3838383838384, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI145580578, Length=234, Percent_Identity=35.042735042735, Blast_Score=131, Evalue=6e-31,
Organism=Homo sapiens, GI4557499, Length=234, Percent_Identity=35.042735042735, Blast_Score=131, Evalue=6e-31,
Organism=Homo sapiens, GI145580575, Length=234, Percent_Identity=35.042735042735, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI6912396, Length=231, Percent_Identity=32.9004329004329, Blast_Score=101, Evalue=5e-22,
Organism=Escherichia coli, GI1789279, Length=240, Percent_Identity=36.6666666666667, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI87082289, Length=199, Percent_Identity=35.678391959799, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1787645, Length=192, Percent_Identity=35.4166666666667, Blast_Score=118, Evalue=4e-28,
Organism=Escherichia coli, GI1788660, Length=205, Percent_Identity=30.7317073170732, Blast_Score=76, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=205, Percent_Identity=45.3658536585366, Blast_Score=177, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI25147481, Length=234, Percent_Identity=32.0512820512821, Blast_Score=118, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6320925, Length=238, Percent_Identity=36.1344537815126, Blast_Score=137, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6322116, Length=214, Percent_Identity=35.981308411215, Blast_Score=128, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6324964, Length=202, Percent_Identity=35.1485148514851, Blast_Score=113, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6324055, Length=182, Percent_Identity=31.8681318681319, Blast_Score=94, Evalue=2e-20,
Organism=Drosophila melanogaster, GI19921140, Length=210, Percent_Identity=42.8571428571429, Blast_Score=166, Evalue=1e-41,
Organism=Drosophila melanogaster, GI62472511, Length=202, Percent_Identity=39.6039603960396, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24646446, Length=202, Percent_Identity=39.6039603960396, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24646448, Length=202, Percent_Identity=39.6039603960396, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24646452, Length=202, Percent_Identity=39.6039603960396, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24646450, Length=202, Percent_Identity=39.6039603960396, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI28574286, Length=188, Percent_Identity=29.2553191489362, Blast_Score=98, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24585514, Length=188, Percent_Identity=27.6595744680851, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI28574282, Length=188, Percent_Identity=27.6595744680851, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI45552429, Length=185, Percent_Identity=28.1081081081081, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI45551003, Length=188, Percent_Identity=27.6595744680851, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI28574284, Length=188, Percent_Identity=27.6595744680851, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI28571528, Length=214, Percent_Identity=34.1121495327103, Blast_Score=91, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24585516, Length=180, Percent_Identity=26.1111111111111, Blast_Score=78, Evalue=5e-15,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 27837; Mature: 27706

Theoretical pI: Translated: 4.39; Mature: 4.39

Prosite motif: PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGRGCAHDEDPGHGPVHEDALRKLEELGEVVLEDADEEGLRRHVRDADAWVVRSGTQVT
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEECCHHHH
RELIEEAENLKVIARAGVGVDNIDVEAATERGIVVVNAPESSSISVAEHTMSLMLVLARR
HHHHHHHHCCEEEEECCCCCCCCCCEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHHH
IPQADRSVRRGEWDRKLFMGVELAGKVLGVIELGRIGRQVAKRTKAFEMEVIAFDPYISE
CCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCHHH
EVAEGLDVELVEDLDELLRRADVVTIYVPLTDETQGMIGERELKLMKESAFLINCARGEV
HHHCCCCHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHEEECCCCCC
VDEEALVRACSC
CCHHHHHHHCCC
>Mature Secondary Structure 
PGRGCAHDEDPGHGPVHEDALRKLEELGEVVLEDADEEGLRRHVRDADAWVVRSGTQVT
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEECCHHHH
RELIEEAENLKVIARAGVGVDNIDVEAATERGIVVVNAPESSSISVAEHTMSLMLVLARR
HHHHHHHHCCEEEEECCCCCCCCCCEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHHH
IPQADRSVRRGEWDRKLFMGVELAGKVLGVIELGRIGRQVAKRTKAFEMEVIAFDPYISE
CCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCHHH
EVAEGLDVELVEDLDELLRRADVVTIYVPLTDETQGMIGERELKLMKESAFLINCARGEV
HHHCCCCHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHEEECCCCCC
VDEEALVRACSC
CCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]