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The map label for this gene is serA [H]

Identifier: 20093737

GI number: 20093737

Start: 285628

End: 287196

Strand: Reverse

Name: serA [H]

Synonym: MK0297

Alternate gene names: 20093737

Gene position: 287196-285628 (Counterclockwise)

Preceding gene: 20093738

Following gene: 20093736

Centisome position: 16.94

GC content: 66.09

Gene sequence:

>1569_bases
GTGGCCAAGATTCTGGTTACGGACCCTATCCACGAGGACGCGCTGAGGAAGCTCGAGGAGCTCGGAGAGGTCGTCGTGCT
GGAGGACGCCGACGAGGAGGAGATCCGTGAGCACGTGCGGGACGCGGACGCCTGGGTGGTGAGGAGCGGGACGCGGGTGA
CGAGGGAGCTGATCGAGGAGGCTAAGAATCTCAAGGTCATCGCCCGGGCGGGTGTGGGCGTCGACAACATCGACGTGAAG
GCCGCGACGGAACGCGGTATCATCGTCGTCAACGCGCCCGAGTCGAGCTCGATCTCGGTAGCCGAGCACACGATGGGTCT
CATCCTGGCGTTGGCCCGAAAGATACCGCAGGCGGACAGGTCGGTGCGCCGCGGGGAGTGGGACAGGAAGCGGTTCATGG
GCGTCGAGCTGGCCGGAAAGACGTTGGGTCTCATAGGACTGGGTAGGATAGGTCAGCAGGTGGCCAAGCGTGCGAAGGCG
TTCGAGATGGAGGTGACAGCGTACGACCCGTACATACCGGAGAAGGTGGCGGAGGAGCTCGGGGTGGAGCTCGTCGACGA
GCTCGAGGAGCTGCTGGAGCGCGCTGACGTCGTCTCGATCCACGTGCCCCTGACCGAGGAGACGGAGGGGATGATCGGCG
AGGAGGAGCTGAAGCGGATGAAGAGCTCGGCGTTCCTGGTCAACTGCGCGCGCGGTAAGATCGTGGACGAGGAGGCGCTG
ATCAAGGCGCTGAAGGAGGGCTGGATCGCGGGCGCCGCCCTCGACGTGTTCGCCGAGGAGCCACCCGGTGAGGACCACCC
GCTGTACGAGCTGGATAACGTGGTCCTCACGCCGCACATCGGCGGTTCGACCGGCGAGGCGCAGCGGGCCGCGGGTCTGA
TCGTAGCCCGCGAGATCGAGAGGGTGTTGAAGGGCGAGATCCCGGAGAACGTGGTCAACCTGCCGTTGGCCGGTGTGCCG
GACGACGTGAGGGAGCTGATGGAGGTCGGTGAAAGGCTGGCCGACGCCGCCGCCCAGGTACTCGAGGAGCGCCTGAGGTG
GGTACAGGTTAAGGTGGGTGGTGAGCTCGAGGACCGTGAAAAGGAGGCGCTGAAGCGGGCCGTCCTGAAAGGGTGTCTGG
ACCGAGTGTTGACGGAGCCCGTCACCATGGTCAACGCTGTAGACGTCGCCGAGCGGAGGGGGATCGAGTTCGAGTTCACG
GTCTCGGACGAGCTCGAGGGAGGAGAGGTGGAGGTGGTCGTCCGCTCGGACGAGGACGAGATCTCGCTCAGGGGCGAGCT
GGTCGAGGATCGGGTGTACCTGACGTCGGTGAACGGGTACGAGGTACGGTTCAAGCTCAGCGGTCCGACGCTCTTCGTGT
GGCACGTGGACAGGCCGGGGGTCATCGGGGAGGTCGGGATAATCCTGGGCGAGCACCGCGTGAACGTGGCCGCGATGGAG
GTAGGACGCCGGGAGCGCGGCGGCGAGGCGATCATGGTCATACGGATGGACGAGGAGCCGCCCGAGGAGTGCCTGCGGGC
CATCGACGAGGTCGAACCGGTCCGCCGGGTGGAGCTGGTCAGGTGCTGA

Upstream 100 bases:

>100_bases
TGGCGGACCCGTTGGCACCATCGGGGCGACGGGGCCGGCCCCGGAGGAGACCCAGTCAACATATTTTCGGGGCTATCCGT
GCCCGGCCGGGGGTGTCTCC

Downstream 100 bases:

>100_bases
GGAGCGTGGCCGTGGCGGGCGACCTGGACCGGTTCGGGGAGGTGGTCGAGGAGAGGGGTTGGCCGGAGTACTCTCCTAAC
CCCGCCACAGGCCTTCTCAC

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 522; Mature: 521

Protein sequence:

>522_residues
MAKILVTDPIHEDALRKLEELGEVVVLEDADEEEIREHVRDADAWVVRSGTRVTRELIEEAKNLKVIARAGVGVDNIDVK
AATERGIIVVNAPESSSISVAEHTMGLILALARKIPQADRSVRRGEWDRKRFMGVELAGKTLGLIGLGRIGQQVAKRAKA
FEMEVTAYDPYIPEKVAEELGVELVDELEELLERADVVSIHVPLTEETEGMIGEEELKRMKSSAFLVNCARGKIVDEEAL
IKALKEGWIAGAALDVFAEEPPGEDHPLYELDNVVLTPHIGGSTGEAQRAAGLIVAREIERVLKGEIPENVVNLPLAGVP
DDVRELMEVGERLADAAAQVLEERLRWVQVKVGGELEDREKEALKRAVLKGCLDRVLTEPVTMVNAVDVAERRGIEFEFT
VSDELEGGEVEVVVRSDEDEISLRGELVEDRVYLTSVNGYEVRFKLSGPTLFVWHVDRPGVIGEVGIILGEHRVNVAAME
VGRRERGGEAIMVIRMDEEPPEECLRAIDEVEPVRRVELVRC

Sequences:

>Translated_522_residues
MAKILVTDPIHEDALRKLEELGEVVVLEDADEEEIREHVRDADAWVVRSGTRVTRELIEEAKNLKVIARAGVGVDNIDVK
AATERGIIVVNAPESSSISVAEHTMGLILALARKIPQADRSVRRGEWDRKRFMGVELAGKTLGLIGLGRIGQQVAKRAKA
FEMEVTAYDPYIPEKVAEELGVELVDELEELLERADVVSIHVPLTEETEGMIGEEELKRMKSSAFLVNCARGKIVDEEAL
IKALKEGWIAGAALDVFAEEPPGEDHPLYELDNVVLTPHIGGSTGEAQRAAGLIVAREIERVLKGEIPENVVNLPLAGVP
DDVRELMEVGERLADAAAQVLEERLRWVQVKVGGELEDREKEALKRAVLKGCLDRVLTEPVTMVNAVDVAERRGIEFEFT
VSDELEGGEVEVVVRSDEDEISLRGELVEDRVYLTSVNGYEVRFKLSGPTLFVWHVDRPGVIGEVGIILGEHRVNVAAME
VGRRERGGEAIMVIRMDEEPPEECLRAIDEVEPVRRVELVRC
>Mature_521_residues
AKILVTDPIHEDALRKLEELGEVVVLEDADEEEIREHVRDADAWVVRSGTRVTRELIEEAKNLKVIARAGVGVDNIDVKA
ATERGIIVVNAPESSSISVAEHTMGLILALARKIPQADRSVRRGEWDRKRFMGVELAGKTLGLIGLGRIGQQVAKRAKAF
EMEVTAYDPYIPEKVAEELGVELVDELEELLERADVVSIHVPLTEETEGMIGEEELKRMKSSAFLVNCARGKIVDEEALI
KALKEGWIAGAALDVFAEEPPGEDHPLYELDNVVLTPHIGGSTGEAQRAAGLIVAREIERVLKGEIPENVVNLPLAGVPD
DVRELMEVGERLADAAAQVLEERLRWVQVKVGGELEDREKEALKRAVLKGCLDRVLTEPVTMVNAVDVAERRGIEFEFTV
SDELEGGEVEVVVRSDEDEISLRGELVEDRVYLTSVNGYEVRFKLSGPTLFVWHVDRPGVIGEVGIILGEHRVNVAAMEV
GRRERGGEAIMVIRMDEEPPEECLRAIDEVEPVRRVELVRC

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=312, Percent_Identity=44.5512820512821, Blast_Score=276, Evalue=5e-74,
Organism=Homo sapiens, GI145580578, Length=310, Percent_Identity=40, Blast_Score=196, Evalue=4e-50,
Organism=Homo sapiens, GI4557499, Length=310, Percent_Identity=40, Blast_Score=196, Evalue=4e-50,
Organism=Homo sapiens, GI61743967, Length=309, Percent_Identity=39.1585760517799, Blast_Score=195, Evalue=9e-50,
Organism=Homo sapiens, GI4557497, Length=309, Percent_Identity=39.1585760517799, Blast_Score=195, Evalue=1e-49,
Organism=Homo sapiens, GI145580575, Length=310, Percent_Identity=40, Blast_Score=193, Evalue=4e-49,
Organism=Homo sapiens, GI6912396, Length=287, Percent_Identity=33.4494773519164, Blast_Score=153, Evalue=3e-37,
Organism=Escherichia coli, GI1789279, Length=339, Percent_Identity=38.9380530973451, Blast_Score=203, Evalue=2e-53,
Organism=Escherichia coli, GI87082289, Length=269, Percent_Identity=37.546468401487, Blast_Score=178, Evalue=6e-46,
Organism=Escherichia coli, GI1787645, Length=272, Percent_Identity=34.5588235294118, Blast_Score=148, Evalue=8e-37,
Organism=Escherichia coli, GI87081824, Length=254, Percent_Identity=26.7716535433071, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788660, Length=252, Percent_Identity=29.7619047619048, Blast_Score=83, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17532191, Length=311, Percent_Identity=42.443729903537, Blast_Score=234, Evalue=8e-62,
Organism=Caenorhabditis elegans, GI25147481, Length=307, Percent_Identity=33.5504885993485, Blast_Score=167, Evalue=8e-42,
Organism=Saccharomyces cerevisiae, GI6320925, Length=330, Percent_Identity=39.3939393939394, Blast_Score=204, Evalue=4e-53,
Organism=Saccharomyces cerevisiae, GI6322116, Length=330, Percent_Identity=37.8787878787879, Blast_Score=199, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6324964, Length=261, Percent_Identity=35.2490421455939, Blast_Score=146, Evalue=7e-36,
Organism=Saccharomyces cerevisiae, GI6324055, Length=323, Percent_Identity=30.6501547987616, Blast_Score=133, Evalue=9e-32,
Organism=Saccharomyces cerevisiae, GI6324980, Length=174, Percent_Identity=32.183908045977, Blast_Score=94, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6325144, Length=169, Percent_Identity=26.6272189349112, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6321253, Length=294, Percent_Identity=26.530612244898, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI19921140, Length=290, Percent_Identity=43.448275862069, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI24646446, Length=312, Percent_Identity=40.0641025641026, Blast_Score=191, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24646448, Length=312, Percent_Identity=40.0641025641026, Blast_Score=191, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24646452, Length=312, Percent_Identity=40.0641025641026, Blast_Score=191, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24646450, Length=312, Percent_Identity=40.0641025641026, Blast_Score=191, Evalue=1e-48,
Organism=Drosophila melanogaster, GI62472511, Length=312, Percent_Identity=40.0641025641026, Blast_Score=189, Evalue=3e-48,
Organism=Drosophila melanogaster, GI28574286, Length=298, Percent_Identity=32.8859060402685, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI45552429, Length=313, Percent_Identity=31.629392971246, Blast_Score=148, Evalue=7e-36,
Organism=Drosophila melanogaster, GI24585514, Length=313, Percent_Identity=31.629392971246, Blast_Score=148, Evalue=1e-35,
Organism=Drosophila melanogaster, GI28574282, Length=313, Percent_Identity=31.629392971246, Blast_Score=148, Evalue=1e-35,
Organism=Drosophila melanogaster, GI45551003, Length=313, Percent_Identity=31.629392971246, Blast_Score=148, Evalue=1e-35,
Organism=Drosophila melanogaster, GI28574284, Length=313, Percent_Identity=31.629392971246, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI28571528, Length=313, Percent_Identity=34.5047923322684, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24585516, Length=312, Percent_Identity=27.5641025641026, Blast_Score=121, Evalue=1e-27,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 57777; Mature: 57646

Theoretical pI: Translated: 4.39; Mature: 4.39

Prosite motif: PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKILVTDPIHEDALRKLEELGEVVVLEDADEEEIREHVRDADAWVVRSGTRVTRELIEE
CCEEEEECCCCHHHHHHHHHCCCEEEEECCCHHHHHHHHCCCCCEEEECCHHHHHHHHHH
AKNLKVIARAGVGVDNIDVKAATERGIIVVNAPESSSISVAEHTMGLILALARKIPQADR
HHCCEEEEECCCCCCCCEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCHHHH
SVRRGEWDRKRFMGVELAGKTLGLIGLGRIGQQVAKRAKAFEMEVTAYDPYIPEKVAEEL
HHHCCCCHHHHHCCEEECCCEECCEEHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHH
GVELVDELEELLERADVVSIHVPLTEETEGMIGEEELKRMKSSAFLVNCARGKIVDEEAL
CHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCHHHHHHHHCCCEEEEECCCCEECHHHH
IKALKEGWIAGAALDVFAEEPPGEDHPLYELDNVVLTPHIGGSTGEAQRAAGLIVAREIE
HHHHHHCCCCCHHHHHHCCCCCCCCCCCEEECCEEEECCCCCCCCCHHHHHHHHHHHHHH
RVLKGEIPENVVNLPLAGVPDDVRELMEVGERLADAAAQVLEERLRWVQVKVGGELEDRE
HHHCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCHHH
KEALKRAVLKGCLDRVLTEPVTMVNAVDVAERRGIEFEFTVSDELEGGEVEVVVRSDEDE
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCEEEEEECCCCCCCEEEEEEECCCCC
ISLRGELVEDRVYLTSVNGYEVRFKLSGPTLFVWHVDRPGVIGEVGIILGEHRVNVAAME
EEECCEEEECEEEEEECCCEEEEEEECCCEEEEEECCCCCCEEEHHEEECCCCCCHHHHH
VGRRERGGEAIMVIRMDEEPPEECLRAIDEVEPVRRVELVRC
HCCCCCCCCEEEEEEECCCCHHHHHHHHHHCCHHHHHHHCCC
>Mature Secondary Structure 
AKILVTDPIHEDALRKLEELGEVVVLEDADEEEIREHVRDADAWVVRSGTRVTRELIEE
CEEEEECCCCHHHHHHHHHCCCEEEEECCCHHHHHHHHCCCCCEEEECCHHHHHHHHHH
AKNLKVIARAGVGVDNIDVKAATERGIIVVNAPESSSISVAEHTMGLILALARKIPQADR
HHCCEEEEECCCCCCCCEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCHHHH
SVRRGEWDRKRFMGVELAGKTLGLIGLGRIGQQVAKRAKAFEMEVTAYDPYIPEKVAEEL
HHHCCCCHHHHHCCEEECCCEECCEEHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHH
GVELVDELEELLERADVVSIHVPLTEETEGMIGEEELKRMKSSAFLVNCARGKIVDEEAL
CHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCHHHHHHHHCCCEEEEECCCCEECHHHH
IKALKEGWIAGAALDVFAEEPPGEDHPLYELDNVVLTPHIGGSTGEAQRAAGLIVAREIE
HHHHHHCCCCCHHHHHHCCCCCCCCCCCEEECCEEEECCCCCCCCCHHHHHHHHHHHHHH
RVLKGEIPENVVNLPLAGVPDDVRELMEVGERLADAAAQVLEERLRWVQVKVGGELEDRE
HHHCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCHHH
KEALKRAVLKGCLDRVLTEPVTMVNAVDVAERRGIEFEFTVSDELEGGEVEVVVRSDEDE
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCEEEEEECCCCCCCEEEEEEECCCCC
ISLRGELVEDRVYLTSVNGYEVRFKLSGPTLFVWHVDRPGVIGEVGIILGEHRVNVAAME
EEECCEEEECEEEEEECCCEEEEEEECCCEEEEEECCCCCCEEEHHEEECCCCCCHHHHH
VGRRERGGEAIMVIRMDEEPPEECLRAIDEVEPVRRVELVRC
HCCCCCCCCEEEEEEECCCCHHHHHHHHHHCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]