Click here to switch to the map view.

The map label for this gene is HdrA_2

Identifier: 20093705

GI number: 20093705

Start: 253054

End: 255024

Strand: Reverse

Name: HdrA_2

Synonym: MK0265

Alternate gene names: 20093705

Gene position: 255024-253054 (Counterclockwise)

Preceding gene: 20093706

Following gene: 20093700

Centisome position: 15.05

GC content: 62.4

Gene sequence:

>1971_bases
TTGGCGGAGGAAGAGCCGCGCATCGGCGTCTACGTGTGCCACTGCGGCGTGAACATCGCCGGCGTCGTCGACGTCAAGGA
AGTGGCCGAGTTCGCCAAGACGCTGAAGAACGTGGTCGTGGCGCGCGATTACAAGTACGTGTGCTCCGACCCGGGTCAAG
AGATCATTCAACGCGACATCGAGAAGTACGATCTGAACCGTGTCGTCGTGGCGGCCTGTTCGCCCAGGCTACATGAGCCC
ACGTTCCGACGGTGCGTCGAGGAGGCCGGGTTGAACCCCTACTGCTTCGAGATGGCGAACATCAGGGAGCACTGCTCATG
GGTTCACATGGACGATCCGGCCAGGGCCACGGAGAAAGCTAAGGACCTCGTCCGCATGGCGGTGGCCAAGGCCCGGCTGC
TCGAGTCCCTCGAGACCATCAAGGTGGACGTGACCGACCGCGCCCTGGTCATCGGGGGCGGAGTCTCCGGGATTCAGGCG
GCCCTGGACCTCGCGGACATGGGCTTCGAGGTCATCCTGGTCGAGAAGGAGCCGTCCATCGGGGGCAGGATGGCCCAGCT
GGACAAGACGTTCCCCACGAACGACTGCTCCATCTGCATCTTGGCACCGAAGATGGTGGACGTGTCCAAGCATCCCAACA
TCAAGATGTACACCTACGCCGAGGTCGTCGAGGTGGACGGGTACGTGGGCAACTTCACGGTGAAGATCGAGAAGAAGCCG
CGGTACGTGGACGAGGACGCGTGCACGGGCTGCGGCGCGTGCGCGGAGGTCTGCCCGATCGAGGTGCCCAACGAGTTCGA
CGAGGGCCTGGGGATGAGGAAGGCCATCTACAAGCCGTTCCCGCAGGCGGTCCCGTCGGTGTTCACGATCGACGAGGAGC
ACTGCATCCGATGCGGTCTCTGCGAAGAGGTATGCGACGCCGACGCGATAGACTTCGATCAGGAGCCCGAGATCGTCGAG
GAAGAGGTCGGTGCTATCATCTGCGCCATCGGATACGACACGTGCGACCCGACCGAGCGCGAGGAGTACGGGTACGGCGT
CTACGACAACGTGATCACGTCGATAGAGCTGGAGAGGCTCATCAACGCCTCGGGACCCACCGGTGGCAAGGTGGTGAGGC
CCAGTGATGGAAAGAAACCGAAACGTATTGCATTCATCCAGTGCGTTGGCTCACGTGACCCGCACAGGACCAATCCGTAC
TGCTCCAACGTTTGCTGCATGTACGCGATGAAGTTGGCGCAGCTGATCCGGGAGAAGTACCCGGAGACACAGATCGATAT
CTACTACATGGACGTGCGGGCGTTCGGTAAGGGTTACGAGGAGTACTACGAACGCTCGCAGAAGCAGTACGGCATCCGGT
TCATCCGCGGCCGGCCCGCGGAGATAGTCGAGGACCCGGAGACCAAGAACCTCATCGTGCGTGCCGAGGATACGCTGCTC
GGCGACGTGGTCGAAAGGGAGTACGACTTGGTGGTGTTGTCCGTAGGTATGGTGCCGCGGGACTCGGCCGACGTCATCCA
GGAGGTCCTCAGTATTTCACGTTCGCCGGACGGTTTCTTCATGGAAGCACATCCGAAGTTGCGGCCCGTGGACACGGCGA
TCGACGGTATCTTCCTGGCCGGAGCGTGTCAAGGTCCGAAGGACATACCCTCCTCGGTCGCCCAGGGTTCTGCCGCCGCG
GCTCGCGCCGCCACGGCATTGGCGGCCGGTGAGGTGGCCGTAGAGCCCATAGTATCGGAGGTGGACGAGGAGATCTGCGG
CGGTTGTGGTACCTGCGTGGAACTCTGTCCGTACGGTGCCATAGAACTCGTCGAGAAGGACGGGAAGCTCGTGGCCGAAG
TCACGGCCGCTTTGTGCAAGGGATGCGGGACCTGCGCGGCGGCGTGCCCGAGCGGTGCCATGGAGCAGAACCACTTCAAG
ACCGAGCAGTTGTACAAGCAGATCGAGGGGGCCTTCAGGGACCCCGCTTAG

Upstream 100 bases:

>100_bases
CCTGTCTTGTGCGACCCACGTACTCGGCGAGCGTCCCAGGCTCACGCTCGAGGTTCACCGCGCCGGTAGGCTAGTTCGGA
TTGTGGAGGGGTGATGGTGG

Downstream 100 bases:

>100_bases
CCTCCTCACTCCCTCAGTTCTTCGCACAGGGCCTCCGGTATCGCCCTGGTGAGCTCGTGTATCCTAGTTGTCGGAGTCGC
GTTCGCGATTTCACCGAGCC

Product: heterodisulfide reductase, subunit A, polyferredoxin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 656; Mature: 655

Protein sequence:

>656_residues
MAEEEPRIGVYVCHCGVNIAGVVDVKEVAEFAKTLKNVVVARDYKYVCSDPGQEIIQRDIEKYDLNRVVVAACSPRLHEP
TFRRCVEEAGLNPYCFEMANIREHCSWVHMDDPARATEKAKDLVRMAVAKARLLESLETIKVDVTDRALVIGGGVSGIQA
ALDLADMGFEVILVEKEPSIGGRMAQLDKTFPTNDCSICILAPKMVDVSKHPNIKMYTYAEVVEVDGYVGNFTVKIEKKP
RYVDEDACTGCGACAEVCPIEVPNEFDEGLGMRKAIYKPFPQAVPSVFTIDEEHCIRCGLCEEVCDADAIDFDQEPEIVE
EEVGAIICAIGYDTCDPTEREEYGYGVYDNVITSIELERLINASGPTGGKVVRPSDGKKPKRIAFIQCVGSRDPHRTNPY
CSNVCCMYAMKLAQLIREKYPETQIDIYYMDVRAFGKGYEEYYERSQKQYGIRFIRGRPAEIVEDPETKNLIVRAEDTLL
GDVVEREYDLVVLSVGMVPRDSADVIQEVLSISRSPDGFFMEAHPKLRPVDTAIDGIFLAGACQGPKDIPSSVAQGSAAA
ARAATALAAGEVAVEPIVSEVDEEICGGCGTCVELCPYGAIELVEKDGKLVAEVTAALCKGCGTCAAACPSGAMEQNHFK
TEQLYKQIEGAFRDPA

Sequences:

>Translated_656_residues
MAEEEPRIGVYVCHCGVNIAGVVDVKEVAEFAKTLKNVVVARDYKYVCSDPGQEIIQRDIEKYDLNRVVVAACSPRLHEP
TFRRCVEEAGLNPYCFEMANIREHCSWVHMDDPARATEKAKDLVRMAVAKARLLESLETIKVDVTDRALVIGGGVSGIQA
ALDLADMGFEVILVEKEPSIGGRMAQLDKTFPTNDCSICILAPKMVDVSKHPNIKMYTYAEVVEVDGYVGNFTVKIEKKP
RYVDEDACTGCGACAEVCPIEVPNEFDEGLGMRKAIYKPFPQAVPSVFTIDEEHCIRCGLCEEVCDADAIDFDQEPEIVE
EEVGAIICAIGYDTCDPTEREEYGYGVYDNVITSIELERLINASGPTGGKVVRPSDGKKPKRIAFIQCVGSRDPHRTNPY
CSNVCCMYAMKLAQLIREKYPETQIDIYYMDVRAFGKGYEEYYERSQKQYGIRFIRGRPAEIVEDPETKNLIVRAEDTLL
GDVVEREYDLVVLSVGMVPRDSADVIQEVLSISRSPDGFFMEAHPKLRPVDTAIDGIFLAGACQGPKDIPSSVAQGSAAA
ARAATALAAGEVAVEPIVSEVDEEICGGCGTCVELCPYGAIELVEKDGKLVAEVTAALCKGCGTCAAACPSGAMEQNHFK
TEQLYKQIEGAFRDPA
>Mature_655_residues
AEEEPRIGVYVCHCGVNIAGVVDVKEVAEFAKTLKNVVVARDYKYVCSDPGQEIIQRDIEKYDLNRVVVAACSPRLHEPT
FRRCVEEAGLNPYCFEMANIREHCSWVHMDDPARATEKAKDLVRMAVAKARLLESLETIKVDVTDRALVIGGGVSGIQAA
LDLADMGFEVILVEKEPSIGGRMAQLDKTFPTNDCSICILAPKMVDVSKHPNIKMYTYAEVVEVDGYVGNFTVKIEKKPR
YVDEDACTGCGACAEVCPIEVPNEFDEGLGMRKAIYKPFPQAVPSVFTIDEEHCIRCGLCEEVCDADAIDFDQEPEIVEE
EVGAIICAIGYDTCDPTEREEYGYGVYDNVITSIELERLINASGPTGGKVVRPSDGKKPKRIAFIQCVGSRDPHRTNPYC
SNVCCMYAMKLAQLIREKYPETQIDIYYMDVRAFGKGYEEYYERSQKQYGIRFIRGRPAEIVEDPETKNLIVRAEDTLLG
DVVEREYDLVVLSVGMVPRDSADVIQEVLSISRSPDGFFMEAHPKLRPVDTAIDGIFLAGACQGPKDIPSSVAQGSAAAA
RAATALAAGEVAVEPIVSEVDEEICGGCGTCVELCPYGAIELVEKDGKLVAEVTAALCKGCGTCAAACPSGAMEQNHFKT
EQLYKQIEGAFRDPA

Specific function: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). May act as the catalytic subunit

COG id: COG1148

COG function: function code C; Heterodisulfide reductase, subunit A and related polyferredoxins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 4 4Fe-4S ferredoxin-type domains

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HDRA2_METKA (P96801)

Other databases:

- EMBL:   Y09871
- EMBL:   AE009439
- RefSeq:   NP_613552.1
- ProteinModelPortal:   P96801
- GeneID:   1477568
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK0265
- NMPDR:   fig|190192.1.peg.265
- HOGENOM:   HBG452010
- OMA:   ACSPRMH
- ProtClustDB:   CLSK876667
- BioCyc:   MKAN190192:MK0265-MONOMER
- BRENDA:   1.8.98.1
- GO:   GO:0015948
- InterPro:   IPR001450
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR003953
- InterPro:   IPR012285
- Gene3D:   G3DSA:1.10.1060.10

Pfam domain/function: PF00890 FAD_binding_2; PF00037 Fer4

EC number: =1.8.98.1

Molecular weight: Translated: 71926; Mature: 71795

Theoretical pI: Translated: 4.45; Mature: 4.45

Prosite motif: PS00198 4FE4S_FER_1; PS51379 4FE4S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
4.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEEEPRIGVYVCHCGVNIAGVVDVKEVAEFAKTLKNVVVARDYKYVCSDPGQEIIQRDI
CCCCCCCCEEEEEEECCCEEEEECHHHHHHHHHHHHHHHHHCCCHHCCCCCHHHHHHHHH
EKYDLNRVVVAACSPRLHEPTFRRCVEEAGLNPYCFEMANIREHCSWVHMDDPARATEKA
HHHCCCEEEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCEEECCCCHHHHHHH
KDLVRMAVAKARLLESLETIKVDVTDRALVIGGGVSGIQAALDLADMGFEVILVEKEPSI
HHHHHHHHHHHHHHHHHHHEEEEECCCEEEEECCHHHHHHHHHHHHCCEEEEEEECCCCC
GGRMAQLDKTFPTNDCSICILAPKMVDVSKHPNIKMYTYAEVVEVDGYVGNFTVKIEKKP
CCHHHHHCCCCCCCCCEEEEEECCEECCCCCCCEEEEEEEEEEEECCEEEEEEEEEECCC
RYVDEDACTGCGACAEVCPIEVPNEFDEGLGMRKAIYKPFPQAVPSVFTIDEEHCIRCGL
CCCCCHHCCCCCHHHHHCCCCCCCHHHHCCCHHHHHHCCCHHHCCCEEEECHHHHHHHCC
CEEVCDADAIDFDQEPEIVEEEVGAIICAIGYDTCDPTEREEYGYGVYDNVITSIELERL
HHHHHCCCCCCCCCCCHHHHHHHCEEEEEECCCCCCCCCHHHCCCCHHHHHHHHHHHHHH
INASGPTGGKVVRPSDGKKPKRIAFIQCVGSRDPHRTNPYCSNVCCMYAMKLAQLIREKY
HCCCCCCCCEEECCCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
PETQIDIYYMDVRAFGKGYEEYYERSQKQYGIRFIRGRPAEIVEDPETKNLIVRAEDTLL
CCCEEEEEEEEHHHHCCCHHHHHHHHHHHCCEEEECCCCHHHCCCCCCCCEEEEECHHHH
GDVVEREYDLVVLSVGMVPRDSADVIQEVLSISRSPDGFFMEAHPKLRPVDTAIDGIFLA
HHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCEEECCCCCCCHHHHHCCEEEE
GACQGPKDIPSSVAQGSAAAARAATALAAGEVAVEPIVSEVDEEICGGCGTCVELCPYGA
CCCCCCHHHHHHHHCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCHHHHHCCCCC
IELVEKDGKLVAEVTAALCKGCGTCAAACPSGAMEQNHFKTEQLYKQIEGAFRDPA
EEEECCCCHHHHHHHHHHHHCCCHHHHHCCCCCCHHHCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AEEEPRIGVYVCHCGVNIAGVVDVKEVAEFAKTLKNVVVARDYKYVCSDPGQEIIQRDI
CCCCCCCEEEEEEECCCEEEEECHHHHHHHHHHHHHHHHHCCCHHCCCCCHHHHHHHHH
EKYDLNRVVVAACSPRLHEPTFRRCVEEAGLNPYCFEMANIREHCSWVHMDDPARATEKA
HHHCCCEEEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCEEECCCCHHHHHHH
KDLVRMAVAKARLLESLETIKVDVTDRALVIGGGVSGIQAALDLADMGFEVILVEKEPSI
HHHHHHHHHHHHHHHHHHHEEEEECCCEEEEECCHHHHHHHHHHHHCCEEEEEEECCCCC
GGRMAQLDKTFPTNDCSICILAPKMVDVSKHPNIKMYTYAEVVEVDGYVGNFTVKIEKKP
CCHHHHHCCCCCCCCCEEEEEECCEECCCCCCCEEEEEEEEEEEECCEEEEEEEEEECCC
RYVDEDACTGCGACAEVCPIEVPNEFDEGLGMRKAIYKPFPQAVPSVFTIDEEHCIRCGL
CCCCCHHCCCCCHHHHHCCCCCCCHHHHCCCHHHHHHCCCHHHCCCEEEECHHHHHHHCC
CEEVCDADAIDFDQEPEIVEEEVGAIICAIGYDTCDPTEREEYGYGVYDNVITSIELERL
HHHHHCCCCCCCCCCCHHHHHHHCEEEEEECCCCCCCCCHHHCCCCHHHHHHHHHHHHHH
INASGPTGGKVVRPSDGKKPKRIAFIQCVGSRDPHRTNPYCSNVCCMYAMKLAQLIREKY
HCCCCCCCCEEECCCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
PETQIDIYYMDVRAFGKGYEEYYERSQKQYGIRFIRGRPAEIVEDPETKNLIVRAEDTLL
CCCEEEEEEEEHHHHCCCHHHHHHHHHHHCCEEEECCCCHHHCCCCCCCCEEEEECHHHH
GDVVEREYDLVVLSVGMVPRDSADVIQEVLSISRSPDGFFMEAHPKLRPVDTAIDGIFLA
HHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCEEECCCCCCCHHHHHCCEEEE
GACQGPKDIPSSVAQGSAAAARAATALAAGEVAVEPIVSEVDEEICGGCGTCVELCPYGA
CCCCCCHHHHHHHHCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCHHHHHCCCCC
IELVEKDGKLVAEVTAALCKGCGTCAAACPSGAMEQNHFKTEQLYKQIEGAFRDPA
EEEECCCCHHHHHHHHHHHHCCCHHHHHCCCCCCHHHCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9063468; 11930014