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The map label for this gene is HtpX

Identifier: 20093611

GI number: 20093611

Start: 167695

End: 168651

Strand: Direct

Name: HtpX

Synonym: MK0171

Alternate gene names: 20093611

Gene position: 167695-168651 (Clockwise)

Preceding gene: 20093610

Following gene: 20093614

Centisome position: 9.89

GC content: 63.11

Gene sequence:

>957_bases
TTGCTGGAAGCCGCCGGTGCCGTGCTTCTGGGTTCGGCCGCGCTCCTGATGGTTGGCAGATTGGGTAACCGCGGGTTCTT
CTTGTGGCTCCGTACCGTCGGTATCTTAGGTCTGTTGGTCGGAATACTGTCCCTGGCGCTGGCCGCCCTGACGGGGAGTG
CGATCGCGGGGCTGGTCGTAGGAGTCATCACTGCCGCGATGATGTACCTATTCTCCTCCCGTATAGTGCGCATCCAGATG
GGAGCCGTAGACGCCGAGGAGTTCCTCCGGTACAAGCCGGAGTACGCGGACAAGTTACGCAGAGTGCAGGAGATGGTGTC
GAAGCTAGCGTCCAAGGCTGGGCTTCCGGAACCCGAGCTGGTGGTAGTTCCGGAAGAGACCGGTGTCGGCGGGTACCCCA
ACGCCTTCGCCACCGGACGCCGGTCGAAGCCCACGGTGGGAGTTACAGAGGGGCTCCTGAGGCACCTGGACGACGACGAG
ATATACGGAGTACTGGGTCACGAGCTCGCTCACGTGAAGAACCGCGACACGCTCGTCATGACCGTAGCTGCGGCCGTGAG
CACCGCCATCGCGTACGCGTTCGACCCGTGGCTGAACGCCATGTACACCGAGGACTGGGAGGACATAGCTTTCCTGGTGC
TGGCGGGCATGTTGGCCTCGCTGATCTCGACGCTGCTCGTGGCCGCCATAAGCCGGTCGCGGGAGTACTTGGCCGACGAG
GAGGGAGCTAAGCTCTCGGGGAACCCCATGGCGCTGGCCGAGGCCTTGGAGAAGATCGAGGCGATAGTCAAGTCCAACCC
CGCGCCCGCTAGGTCGTTGTCCGAAGTCTCAACGGCGCACCTGTGGATCGAGAACCCGTTCCGCGGAGGCCTACTCCGAC
TGTTCAGCACTCATCCGCCGGTCGAGAAGAGGGTCGAACGTCTCAGGCGCCTCGCGAGAGAGTTGCAAGGACCGTAA

Upstream 100 bases:

>100_bases
CAGAGTTGCGCAAAACGTACAAGGAGTACGACATCGTGTACGTAACGAAGGCCGGTGTCCTGGCCGGAAAAGTGATCTAC
GAAAGGGAGTGAGGGAAAGC

Downstream 100 bases:

>100_bases
CCTCGGCCCAGGCGTCCTCGAGGTAACGCTGCACCTCCAGGGGGCTCCAGGGATCGATCCTTCGGACGCGGCGGAGGAGC
CGCTTCTTGACCTTAGCCAC

Product: Zn-dependent protease with chaperone function

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MLEAAGAVLLGSAALLMVGRLGNRGFFLWLRTVGILGLLVGILSLALAALTGSAIAGLVVGVITAAMMYLFSSRIVRIQM
GAVDAEEFLRYKPEYADKLRRVQEMVSKLASKAGLPEPELVVVPEETGVGGYPNAFATGRRSKPTVGVTEGLLRHLDDDE
IYGVLGHELAHVKNRDTLVMTVAAAVSTAIAYAFDPWLNAMYTEDWEDIAFLVLAGMLASLISTLLVAAISRSREYLADE
EGAKLSGNPMALAEALEKIEAIVKSNPAPARSLSEVSTAHLWIENPFRGGLLRLFSTHPPVEKRVERLRRLARELQGP

Sequences:

>Translated_318_residues
MLEAAGAVLLGSAALLMVGRLGNRGFFLWLRTVGILGLLVGILSLALAALTGSAIAGLVVGVITAAMMYLFSSRIVRIQM
GAVDAEEFLRYKPEYADKLRRVQEMVSKLASKAGLPEPELVVVPEETGVGGYPNAFATGRRSKPTVGVTEGLLRHLDDDE
IYGVLGHELAHVKNRDTLVMTVAAAVSTAIAYAFDPWLNAMYTEDWEDIAFLVLAGMLASLISTLLVAAISRSREYLADE
EGAKLSGNPMALAEALEKIEAIVKSNPAPARSLSEVSTAHLWIENPFRGGLLRLFSTHPPVEKRVERLRRLARELQGP
>Mature_318_residues
MLEAAGAVLLGSAALLMVGRLGNRGFFLWLRTVGILGLLVGILSLALAALTGSAIAGLVVGVITAAMMYLFSSRIVRIQM
GAVDAEEFLRYKPEYADKLRRVQEMVSKLASKAGLPEPELVVVPEETGVGGYPNAFATGRRSKPTVGVTEGLLRHLDDDE
IYGVLGHELAHVKNRDTLVMTVAAAVSTAIAYAFDPWLNAMYTEDWEDIAFLVLAGMLASLISTLLVAAISRSREYLADE
EGAKLSGNPMALAEALEKIEAIVKSNPAPARSLSEVSTAHLWIENPFRGGLLRLFSTHPPVEKRVERLRRLARELQGP

Specific function: Unknown Function. Overexpression Of A Truncated Form Of The Htpx Protein Leads To An Increase In The Degradation Of Abnormal Proteins. [C]

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family

Homologues:

Organism=Escherichia coli, GI1788133, Length=295, Percent_Identity=28.8135593220339, Blast_Score=78, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HTPX_METKA (Q8TYX0)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_613458.1
- ProteinModelPortal:   Q8TYX0
- MEROPS:   M48.004
- GeneID:   1477474
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK0171
- NMPDR:   fig|190192.1.peg.171
- HOGENOM:   HBG739460
- OMA:   MISATAF
- BioCyc:   MKAN190192:MK0171-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_00188
- InterPro:   IPR022919
- InterPro:   IPR001915

Pfam domain/function: PF01435 Peptidase_M48

EC number: 3.4.24.- [C]

Molecular weight: Translated: 34304; Mature: 34304

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: ACT_SITE 168-168

Signals:

None

Transmembrane regions:

HASH(0x91f9ed4)-; HASH(0xbc7700c)-; HASH(0xbce0b10)-; HASH(0xbc729c0)-; HASH(0xbc91140)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEAAGAVLLGSAALLMVGRLGNRGFFLWLRTVGILGLLVGILSLALAALTGSAIAGLVV
CCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVITAAMMYLFSSRIVRIQMGAVDAEEFLRYKPEYADKLRRVQEMVSKLASKAGLPEPEL
HHHHHHHHHHHHCCCEEEEECCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCE
VVVPEETGVGGYPNAFATGRRSKPTVGVTEGLLRHLDDDEIYGVLGHELAHVKNRDTLVM
EEEECCCCCCCCCCHHCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHH
TVAAAVSTAIAYAFDPWLNAMYTEDWEDIAFLVLAGMLASLISTLLVAAISRSREYLADE
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
EGAKLSGNPMALAEALEKIEAIVKSNPAPARSLSEVSTAHLWIENPFRGGLLRLFSTHPP
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHEEECCCCCCHHHHHHCCCCC
VEKRVERLRRLARELQGP
HHHHHHHHHHHHHHHCCH
>Mature Secondary Structure
MLEAAGAVLLGSAALLMVGRLGNRGFFLWLRTVGILGLLVGILSLALAALTGSAIAGLVV
CCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVITAAMMYLFSSRIVRIQMGAVDAEEFLRYKPEYADKLRRVQEMVSKLASKAGLPEPEL
HHHHHHHHHHHHCCCEEEEECCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCE
VVVPEETGVGGYPNAFATGRRSKPTVGVTEGLLRHLDDDEIYGVLGHELAHVKNRDTLVM
EEEECCCCCCCCCCHHCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHH
TVAAAVSTAIAYAFDPWLNAMYTEDWEDIAFLVLAGMLASLISTLLVAAISRSREYLADE
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
EGAKLSGNPMALAEALEKIEAIVKSNPAPARSLSEVSTAHLWIENPFRGGLLRLFSTHPP
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHEEECCCCCCHHHHHHCCCCC
VEKRVERLRRLARELQGP
HHHHHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11930014