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The map label for this gene is Tmk

Identifier: 20093541

GI number: 20093541

Start: 93378

End: 93962

Strand: Direct

Name: Tmk

Synonym: MK0101

Alternate gene names: 20093541

Gene position: 93378-93962 (Clockwise)

Preceding gene: 20093540

Following gene: 20093542

Centisome position: 5.51

GC content: 63.25

Gene sequence:

>585_bases
ATGGGACTGTACCTGGGGGTCGAGGGCATTGACGGCGTCGGCAAGTCGTCCGTGGTGAACCTAGCCGCGGAGTTCCTCGA
GATCCACGGGCTCGAGGTCACCACCGTGAGGGAGCCTTCCACCGACATCGGACGTGAAGCCTTGGAGTGGGACGACCCCT
ACCTCCAAGCCCTGGCCTTCACCCTCGACCGTATGCTCACACTTAAACGGGTGGACTTCGAGGCGGCCGACGTCGTCCTG
TCCGACCGTACGTTCCTCAGCACGCTCGCCTATCAGTCCGCACTGGGCGCCGACATGCGGTGGCTGCTGGAACTCCAACG
CCCGGTCCCTAAGCCCGACGTCGTGTACATCATCGATCGAGAACCGCTGGCGGAGGACGCGACGTTCGATAAGGAGTTCC
TGGAGCGCGTGCGGAACCGCTACCGGGAGGCGGCGCGACTCATCGAGGAAGAGTTCGACGTCGAAATAAAATGGATCGAG
GCAGAGGATATGGACAAGGAGGAGATCGCCGAGCTGATCGTAGCCGACGCACGCCGGAGACTGGACGACCCGCTGGGGAT
TCCCGACGACCTCCTCGAGGGGTGA

Upstream 100 bases:

>100_bases
ACCCCGCCCCGCTGCCGGCCATACGGGCTTACGACCGTGGGATTACATGAATTTTTCGGGCCTCGAAAACCCCGATACCA
CCCGAGCGGGGAGGATGCGT

Downstream 100 bases:

>100_bases
CGGACGGTGAGCTACCGACGTGGCGCCGACTTCGAGCGTCAACTGGTACGCTACCTCCGAGAGCACGGGGGTGAGGCCGT
CAGGGTGGCCGGATCCGGGG

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 194; Mature: 193

Protein sequence:

>194_residues
MGLYLGVEGIDGVGKSSVVNLAAEFLEIHGLEVTTVREPSTDIGREALEWDDPYLQALAFTLDRMLTLKRVDFEAADVVL
SDRTFLSTLAYQSALGADMRWLLELQRPVPKPDVVYIIDREPLAEDATFDKEFLERVRNRYREAARLIEEEFDVEIKWIE
AEDMDKEEIAELIVADARRRLDDPLGIPDDLLEG

Sequences:

>Translated_194_residues
MGLYLGVEGIDGVGKSSVVNLAAEFLEIHGLEVTTVREPSTDIGREALEWDDPYLQALAFTLDRMLTLKRVDFEAADVVL
SDRTFLSTLAYQSALGADMRWLLELQRPVPKPDVVYIIDREPLAEDATFDKEFLERVRNRYREAARLIEEEFDVEIKWIE
AEDMDKEEIAELIVADARRRLDDPLGIPDDLLEG
>Mature_193_residues
GLYLGVEGIDGVGKSSVVNLAAEFLEIHGLEVTTVREPSTDIGREALEWDDPYLQALAFTLDRMLTLKRVDFEAADVVLS
DRTFLSTLAYQSALGADMRWLLELQRPVPKPDVVYIIDREPLAEDATFDKEFLERVRNRYREAARLIEEEFDVEIKWIEA
EDMDKEEIAELIVADARRRLDDPLGIPDDLLEG

Specific function: Unknown

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_METKA (Q8TZ38)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_613388.1
- ProteinModelPortal:   Q8TZ38
- SMR:   Q8TZ38
- GeneID:   1477404
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK0101
- NMPDR:   fig|190192.1.peg.101
- HOGENOM:   HBG626009
- OMA:   REALEWD
- BioCyc:   MKAN190192:MK0101-MONOMER
- BRENDA:   2.7.4.9
- HAMAP:   MF_00165
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 22113; Mature: 21982

Theoretical pI: Translated: 4.04; Mature: 4.04

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLYLGVEGIDGVGKSSVVNLAAEFLEIHGLEVTTVREPSTDIGREALEWDDPYLQALAF
CCEEECCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHCCCCHHHHHHHH
TLDRMLTLKRVDFEAADVVLSDRTFLSTLAYQSALGADMRWLLELQRPVPKPDVVYIIDR
HHHHHHHHHHCCCHHHHEEECCHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCEEEEECC
EPLAEDATFDKEFLERVRNRYREAARLIEEEFDVEIKWIEAEDMDKEEIAELIVADARRR
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHH
LDDPLGIPDDLLEG
CCCCCCCCHHHHCC
>Mature Secondary Structure 
GLYLGVEGIDGVGKSSVVNLAAEFLEIHGLEVTTVREPSTDIGREALEWDDPYLQALAF
CEEECCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHCCCCHHHHHHHH
TLDRMLTLKRVDFEAADVVLSDRTFLSTLAYQSALGADMRWLLELQRPVPKPDVVYIIDR
HHHHHHHHHHCCCHHHHEEECCHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCEEEEECC
EPLAEDATFDKEFLERVRNRYREAARLIEEEFDVEIKWIEAEDMDKEEIAELIVADARRR
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHH
LDDPLGIPDDLLEG
CCCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11930014