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The map label for this gene is SecY [H]

Identifier: 20093466

GI number: 20093466

Start: 22954

End: 24330

Strand: Reverse

Name: SecY [H]

Synonym: MK0026

Alternate gene names: 20093466

Gene position: 24330-22954 (Counterclockwise)

Preceding gene: 20093467

Following gene: 20093465

Centisome position: 1.44

GC content: 57.95

Gene sequence:

>1377_bases
TTGGCGGATGACTGGCTGGAGAGGTTAAGGCCGATCCTGGAGAGGCTCCCTGAGGTTAAGGTTCCGGACAGGCACGTACC
TTTCAACGAGAAGCTGTTCAAGTACACAGGAATACCGCTCATCCTTTACTTCATACTGTGTGAAATTCCGCTCTATGGTC
TCTCACCGCAGGCTGTGGACTACTTCGCGAATTTGCGTGCCGTCCTGGCCGGAAACTTCGGTTCGATCCTCACCCTGGGT
ATCGGTCCTATCGTTACCGCTTCGATCCTCTTGCAGCTCCTCGTCGGAGGCGACCTAATCAAGTTGGATCTGACGAATCC
TGAGGATCGAAGACTCTTCCAAGGTCTCCAAAAGCTGCTCGCGATCGTCCTGTGCTTCTTCGAAGGTGTGATGATGGTGT
TCAGCGGTGCCGCGCCGCCGGCCGAGCCGAGTATCTTGCTCGAAATCCTGCTCATCTTACAGTTGGCGCTCGGTGGCATT
TTGGTCATCTTCTTGGACGAGGTCGTCAGCAAGTGGGGTATAGGATCTGGTGTCGGACTATTCATCGTCGCTGGGGTTTC
GTCACAGATTATCATCGGAGCGTTCAACCCGCTCCCGAGCCCGCAGCAGCCCGGGCGCCCCGCGGGTGCCGTCTGGGCGT
TCCTGTACTCGGCGATGCAAGGGACGCCGGATTGGACGCTACTCGCCCCAGTCATCGGGGCCATCATCACGTTCCTCATA
GTGCTTTACGTTGAGGGTATGAGGGTCGAGATCCCGATCGCGTTCGCCGGAATTCGGGGTGCTCGAGGCCGCTTCCCAGT
CCGTCTACTCTACACGTCCAACATCCCCGTGATCCTGGCCTCGGCGCTGTTCATGAACGTTCGACTGTGGGCGCTGGCTT
TCCAACGGATGGGTGTACCGATACTGGGGAAGCTCGATCCGCGCGGTCAACCGATATCCGGACTCGTGTACTACCTATCG
CCCCCTAACAGTATCGTGAAGACGCTATCAGACCCCTTGCAAGCGCTGGGCTACATGATGGCCATGGTGATAGCGTCCGT
GTTCTTCGCGGTCCTGTGGGTCGAGTTGACCGGTATGGGACCACGTGAGATCGCCAGACACCTGCACCGCGCTGGCCTGC
ACATCCCGGGCTTCCGTCGAGATATCAGGGTGTTGGAGAAGCGGCTCCAGAAGTACATCTACCCCGTGACCGTGATGGGT
GGAGCCTTCGTAGGATTCCTCGCCGCGGGTGCCGACTTGATGGGCGCGCTGGGTGGAGGTACAGGCGTACTCCTGACAGT
ATCAATCCTCTACAACATGTACGAAGAGATCAAGCAAGAGCGCCTCATGGAGGCACACCCCGTCGTGCGGAAATTCCTCG
AAAAGACCTTGAGGTAG

Upstream 100 bases:

>100_bases
AGAGGAAGCAGGTGGGGAAGCCCGGGAAGCATAGTGCCCGCCGGTTTTTTCAAGGCTCGGCGTCCCAGTCGCCACCAAAC
GCTTCTGGGAGGAGACGACG

Downstream 100 bases:

>100_bases
CGTAGAGGGGTGGATTTGGATGGGTTATGTGATCGTAGCGACGGGAGTACCCGGAGTCGGAGCCACGACCGTTACCACCG
AGGCCGTAAAGGAGCTCGAG

Product: preprotein translocase subunit SecY

Products: NA

Alternate protein names: Protein transport protein SEC61 subunit alpha homolog [H]

Number of amino acids: Translated: 458; Mature: 457

Protein sequence:

>458_residues
MADDWLERLRPILERLPEVKVPDRHVPFNEKLFKYTGIPLILYFILCEIPLYGLSPQAVDYFANLRAVLAGNFGSILTLG
IGPIVTASILLQLLVGGDLIKLDLTNPEDRRLFQGLQKLLAIVLCFFEGVMMVFSGAAPPAEPSILLEILLILQLALGGI
LVIFLDEVVSKWGIGSGVGLFIVAGVSSQIIIGAFNPLPSPQQPGRPAGAVWAFLYSAMQGTPDWTLLAPVIGAIITFLI
VLYVEGMRVEIPIAFAGIRGARGRFPVRLLYTSNIPVILASALFMNVRLWALAFQRMGVPILGKLDPRGQPISGLVYYLS
PPNSIVKTLSDPLQALGYMMAMVIASVFFAVLWVELTGMGPREIARHLHRAGLHIPGFRRDIRVLEKRLQKYIYPVTVMG
GAFVGFLAAGADLMGALGGGTGVLLTVSILYNMYEEIKQERLMEAHPVVRKFLEKTLR

Sequences:

>Translated_458_residues
MADDWLERLRPILERLPEVKVPDRHVPFNEKLFKYTGIPLILYFILCEIPLYGLSPQAVDYFANLRAVLAGNFGSILTLG
IGPIVTASILLQLLVGGDLIKLDLTNPEDRRLFQGLQKLLAIVLCFFEGVMMVFSGAAPPAEPSILLEILLILQLALGGI
LVIFLDEVVSKWGIGSGVGLFIVAGVSSQIIIGAFNPLPSPQQPGRPAGAVWAFLYSAMQGTPDWTLLAPVIGAIITFLI
VLYVEGMRVEIPIAFAGIRGARGRFPVRLLYTSNIPVILASALFMNVRLWALAFQRMGVPILGKLDPRGQPISGLVYYLS
PPNSIVKTLSDPLQALGYMMAMVIASVFFAVLWVELTGMGPREIARHLHRAGLHIPGFRRDIRVLEKRLQKYIYPVTVMG
GAFVGFLAAGADLMGALGGGTGVLLTVSILYNMYEEIKQERLMEAHPVVRKFLEKTLR
>Mature_457_residues
ADDWLERLRPILERLPEVKVPDRHVPFNEKLFKYTGIPLILYFILCEIPLYGLSPQAVDYFANLRAVLAGNFGSILTLGI
GPIVTASILLQLLVGGDLIKLDLTNPEDRRLFQGLQKLLAIVLCFFEGVMMVFSGAAPPAEPSILLEILLILQLALGGIL
VIFLDEVVSKWGIGSGVGLFIVAGVSSQIIIGAFNPLPSPQQPGRPAGAVWAFLYSAMQGTPDWTLLAPVIGAIITFLIV
LYVEGMRVEIPIAFAGIRGARGRFPVRLLYTSNIPVILASALFMNVRLWALAFQRMGVPILGKLDPRGQPISGLVYYLSP
PNSIVKTLSDPLQALGYMMAMVIASVFFAVLWVELTGMGPREIARHLHRAGLHIPGFRRDIRVLEKRLQKYIYPVTVMGG
AFVGFLAAGADLMGALGGGTGVLLTVSILYNMYEEIKQERLMEAHPVVRKFLEKTLR

Specific function: Involved in protein export. Interacts with secE to allow the translocation of proteins across the plasma membrane, by forming part of a channel [H]

COG id: COG0201

COG function: function code U; Preprotein translocase subunit SecY

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the secY/SEC61-alpha family [H]

Homologues:

Organism=Homo sapiens, GI7019415, Length=472, Percent_Identity=34.5338983050847, Blast_Score=254, Evalue=2e-67,
Organism=Homo sapiens, GI14589847, Length=472, Percent_Identity=34.5338983050847, Blast_Score=251, Evalue=9e-67,
Organism=Homo sapiens, GI217330618, Length=472, Percent_Identity=33.0508474576271, Blast_Score=222, Evalue=5e-58,
Organism=Homo sapiens, GI217330616, Length=417, Percent_Identity=33.5731414868106, Blast_Score=214, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI17543770, Length=471, Percent_Identity=34.3949044585987, Blast_Score=250, Evalue=1e-66,
Organism=Saccharomyces cerevisiae, GI6323411, Length=466, Percent_Identity=34.7639484978541, Blast_Score=255, Evalue=8e-69,
Organism=Saccharomyces cerevisiae, GI6319760, Length=474, Percent_Identity=24.8945147679325, Blast_Score=117, Evalue=3e-27,
Organism=Drosophila melanogaster, GI19920826, Length=470, Percent_Identity=35.3191489361702, Blast_Score=257, Evalue=1e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002208
- InterPro:   IPR023201
- InterPro:   IPR019561 [H]

Pfam domain/function: PF10559 Plug_translocon; PF00344 SecY [H]

EC number: NA

Molecular weight: Translated: 50199; Mature: 50068

Theoretical pI: Translated: 9.48; Mature: 9.48

Prosite motif: PS00318 HMG_COA_REDUCTASE_2 ; PS00755 SECY_1 ; PS00756 SECY_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADDWLERLRPILERLPEVKVPDRHVPFNEKLFKYTGIPLILYFILCEIPLYGLSPQAVD
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHH
YFANLRAVLAGNFGSILTLGIGPIVTASILLQLLVGGDLIKLDLTNPEDRRLFQGLQKLL
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHH
AIVLCFFEGVMMVFSGAAPPAEPSILLEILLILQLALGGILVIFLDEVVSKWGIGSGVGL
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
FIVAGVSSQIIIGAFNPLPSPQQPGRPAGAVWAFLYSAMQGTPDWTLLAPVIGAIITFLI
EEEECCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
VLYVEGMRVEIPIAFAGIRGARGRFPVRLLYTSNIPVILASALFMNVRLWALAFQRMGVP
HHHHCCCEEEEEEEEECCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCC
ILGKLDPRGQPISGLVYYLSPPNSIVKTLSDPLQALGYMMAMVIASVFFAVLWVELTGMG
CEECCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PREIARHLHRAGLHIPGFRRDIRVLEKRLQKYIYPVTVMGGAFVGFLAAGADLMGALGGG
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCC
TGVLLTVSILYNMYEEIKQERLMEAHPVVRKFLEKTLR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ADDWLERLRPILERLPEVKVPDRHVPFNEKLFKYTGIPLILYFILCEIPLYGLSPQAVD
CHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHH
YFANLRAVLAGNFGSILTLGIGPIVTASILLQLLVGGDLIKLDLTNPEDRRLFQGLQKLL
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHH
AIVLCFFEGVMMVFSGAAPPAEPSILLEILLILQLALGGILVIFLDEVVSKWGIGSGVGL
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
FIVAGVSSQIIIGAFNPLPSPQQPGRPAGAVWAFLYSAMQGTPDWTLLAPVIGAIITFLI
EEEECCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
VLYVEGMRVEIPIAFAGIRGARGRFPVRLLYTSNIPVILASALFMNVRLWALAFQRMGVP
HHHHCCCEEEEEEEEECCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCC
ILGKLDPRGQPISGLVYYLSPPNSIVKTLSDPLQALGYMMAMVIASVFFAVLWVELTGMG
CEECCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PREIARHLHRAGLHIPGFRRDIRVLEKRLQKYIYPVTVMGGAFVGFLAAGADLMGALGGG
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCC
TGVLLTVSILYNMYEEIKQERLMEAHPVVRKFLEKTLR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]