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The map label for this gene is uppS [H]

Identifier: 19746875

GI number: 19746875

Start: 1693344

End: 1694093

Strand: Reverse

Name: uppS [H]

Synonym: spyM18_2033

Alternate gene names: 19746875

Gene position: 1694093-1693344 (Counterclockwise)

Preceding gene: 19746876

Following gene: 19746874

Centisome position: 89.4

GC content: 40.67

Gene sequence:

>750_bases
ATGTTTGGATTAAAAGCGAAATCAACAAAAAAAGTTTTGGGGAGTATCCCAAAGCATATTGGAATTATCATGGATGGTAA
TGGACGTTGGGCCAAAAAAAGACTAAAACCTAGAGTGTTTGGGCATAAAGCTGGGATGGATGCTTTACAAGAAGTAACGA
TTACTGCATCTGAGTTGGGGGTTAAAGTTCTGACAGTCTATGCCTTTTCGACAGAAAACTGGTCCAGACCCCAAGATGAG
GTATCTTTTATCATGAATTTACCAGTAGCCTTCTTTGACAAATATGTGCCTGTGCTTCATGAGAACAATGTAAAGATTCA
AATGATTGGAGAGACTAGTCGTTTACCTGAAGATACCTTGGCAGCGCTAAATGCAGCCATCGACAAAACAAAACGTAATA
CGGGTTTAATTTTGAATTTTGCTCTCAATTATGGAGGACGTGCTGAGATTACCAGTGCTGTTCGCTTTATTGCTCAAGAT
GTCTTAGATGCCAAATTAAATCCAGGAGATATTACGGAGGATTTGATTGCTAATTACTTGATGACAGACCATCTGCCATA
TCTCTACCGAGACCCCGATTTGATTATTCGCACCAGTGGTGAGCTGCGTTTGAGCAATTTCTTGCCTTGGCAATCAGCTT
ATAGTGAATTTTATTTCACACCAGTCTTGTGGCCTGATTTTAAAAAGGCAGAGCTACTAAAGGCCATTGCGGATTATAAC
CGCCGCCAACGTCGTTTTGGCAAGGTCTAA

Upstream 100 bases:

>100_bases
AACATTTTGTGAAGATAAGATCTAATTGATAAAAAACAAGCCAAAAGGCGTGAAATATGATAAAATATGAGATAAGTATG
CTTATCAATAAGGAAAAAAC

Downstream 100 bases:

>100_bases
AAGGAGATAGTTATGAAAGAACGTGTTGTTTGGGGGGGAGTAGCAGTAGCTATTTTCCTACCTTTTCTCATAATAGGAAA
TCTACCATTCCAATTATTTG

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 249; Mature: 249

Protein sequence:

>249_residues
MFGLKAKSTKKVLGSIPKHIGIIMDGNGRWAKKRLKPRVFGHKAGMDALQEVTITASELGVKVLTVYAFSTENWSRPQDE
VSFIMNLPVAFFDKYVPVLHENNVKIQMIGETSRLPEDTLAALNAAIDKTKRNTGLILNFALNYGGRAEITSAVRFIAQD
VLDAKLNPGDITEDLIANYLMTDHLPYLYRDPDLIIRTSGELRLSNFLPWQSAYSEFYFTPVLWPDFKKAELLKAIADYN
RRQRRFGKV

Sequences:

>Translated_249_residues
MFGLKAKSTKKVLGSIPKHIGIIMDGNGRWAKKRLKPRVFGHKAGMDALQEVTITASELGVKVLTVYAFSTENWSRPQDE
VSFIMNLPVAFFDKYVPVLHENNVKIQMIGETSRLPEDTLAALNAAIDKTKRNTGLILNFALNYGGRAEITSAVRFIAQD
VLDAKLNPGDITEDLIANYLMTDHLPYLYRDPDLIIRTSGELRLSNFLPWQSAYSEFYFTPVLWPDFKKAELLKAIADYN
RRQRRFGKV
>Mature_249_residues
MFGLKAKSTKKVLGSIPKHIGIIMDGNGRWAKKRLKPRVFGHKAGMDALQEVTITASELGVKVLTVYAFSTENWSRPQDE
VSFIMNLPVAFFDKYVPVLHENNVKIQMIGETSRLPEDTLAALNAAIDKTKRNTGLILNFALNYGGRAEITSAVRFIAQD
VLDAKLNPGDITEDLIANYLMTDHLPYLYRDPDLIIRTSGELRLSNFLPWQSAYSEFYFTPVLWPDFKKAELLKAIADYN
RRQRRFGKV

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=230, Percent_Identity=39.5652173913043, Blast_Score=164, Evalue=6e-41,
Organism=Homo sapiens, GI45580742, Length=230, Percent_Identity=39.5652173913043, Blast_Score=164, Evalue=6e-41,
Organism=Escherichia coli, GI1786371, Length=239, Percent_Identity=44.7698744769874, Blast_Score=213, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI71993029, Length=230, Percent_Identity=36.5217391304348, Blast_Score=137, Evalue=8e-33,
Organism=Saccharomyces cerevisiae, GI6319474, Length=224, Percent_Identity=33.4821428571429, Blast_Score=109, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6323748, Length=224, Percent_Identity=29.9107142857143, Blast_Score=102, Evalue=4e-23,
Organism=Drosophila melanogaster, GI18857969, Length=243, Percent_Identity=37.037037037037, Blast_Score=151, Evalue=5e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 28227; Mature: 28227

Theoretical pI: Translated: 9.94; Mature: 9.94

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFGLKAKSTKKVLGSIPKHIGIIMDGNGRWAKKRLKPRVFGHKAGMDALQEVTITASELG
CCCCCCCHHHHHHHCCHHHEEEEECCCCCHHHHHCCCHHHCCHHHHHHHHHHHHHHHHCC
VKVLTVYAFSTENWSRPQDEVSFIMNLPVAFFDKYVPVLHENNVKIQMIGETSRLPEDTL
EEEEEEEEECCCCCCCCHHHHHHHHHCCHHHHHHHCCCEECCCEEEEEECCCCCCCHHHH
AALNAAIDKTKRNTGLILNFALNYGGRAEITSAVRFIAQDVLDAKLNPGDITEDLIANYL
HHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
MTDHLPYLYRDPDLIIRTSGELRLSNFLPWQSAYSEFYFTPVLWPDFKKAELLKAIADYN
HHHCCCCEEECCCEEEECCCCEEECCCCCHHHHHHHEEECCCCCCCCHHHHHHHHHHHHH
RRQRRFGKV
HHHHHHCCC
>Mature Secondary Structure
MFGLKAKSTKKVLGSIPKHIGIIMDGNGRWAKKRLKPRVFGHKAGMDALQEVTITASELG
CCCCCCCHHHHHHHCCHHHEEEEECCCCCHHHHHCCCHHHCCHHHHHHHHHHHHHHHHCC
VKVLTVYAFSTENWSRPQDEVSFIMNLPVAFFDKYVPVLHENNVKIQMIGETSRLPEDTL
EEEEEEEEECCCCCCCCHHHHHHHHHCCHHHHHHHCCCEECCCEEEEEECCCCCCCHHHH
AALNAAIDKTKRNTGLILNFALNYGGRAEITSAVRFIAQDVLDAKLNPGDITEDLIANYL
HHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
MTDHLPYLYRDPDLIIRTSGELRLSNFLPWQSAYSEFYFTPVLWPDFKKAELLKAIADYN
HHHCCCCEEECCCEEEECCCCEEECCCCCHHHHHHHEEECCCCCCCCHHHHHHHHHHHHH
RRQRRFGKV
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]