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The map label for this gene is dinP [H]

Identifier: 19746777

GI number: 19746777

Start: 1586129

End: 1587223

Strand: Reverse

Name: dinP [H]

Synonym: spyM18_1910

Alternate gene names: 19746777

Gene position: 1587223-1586129 (Counterclockwise)

Preceding gene: 19746779

Following gene: 19746772

Centisome position: 83.76

GC content: 41.37

Gene sequence:

>1095_bases
ATGCTTATTTTTCCACTGATTAATGACACGTCACGAAAAATCATCCATATTGACATGGATGCCTTTTTTGCTGCAGTTGA
GGAAAGGGATAACCCTGCTTTAAAAGGAAAGCCTGTTGTGATTGGGAAAGATCCAAGAGAAACAGGTGGTCGTGGAGTTG
TTTCCACTTGTAATTACGAAGCGAGAAAATATGGCATTCATTCGGCCATGAGCTCTAAAGAAGCTTATGAGCGTTGTCCC
AAAGCCATTTTTATTTCAGGAAATTATGAAAAGTATCGAACAGTTGGGGACCAGATCCGCCGTATTTTTAAGCGTTATAC
TGATTTGGTTGAACCTATGTCTATTGACGAGGCTTACCTTGATGTGACTGATAATAAGTTGGGGATTAAATCAGCCGTCA
AAATAGCCAAGCTGATTCAGCATGATATCTGGAAAGAAGTAGGATTGACCTGTTCAGCAGGTGTGTCTTATAACAAATTT
TTGGCTAAATTGGCTAGTGATTTTGAAAAACCTCATGGCCTCACCCTAGTCTTGAAAGAAGATGCCCTGTGCTTTTTAGC
CAAACTCCCCATTGAAAAGTTTCATGGTGTTGGTAAAAAATCAGTTGAAAAACTGCATGACATGGGGATTTATACAGGAC
AGGATTTGTTGGCAGTTCCTGAAATGACCTTGATTGATCATTTTGGTCGGTTTGGTTTTGACCTTTACCGTAAAGCGAGA
GGCATCAGCAATTCTCCTGTCAAGTCTGATCGGATACGCAAGTCAATTGGCAGTGAGAGAACCTACGCTAAACTGCTTTA
TCAAGAAACAGACATCAAGGCAGAGATCAGTAAAAATGCTAAGCGCGTGGCCGCTCTCTTACAAGACCATAAAAAGTTAG
GCAAGACCATTGTGCTCAAAGTGCGTTATGCTGATTTTACCACCTTGACAAAACGTGTCACCTTGCCAGAATTAACCAGA
AATGCCGCACAAATTGAGCAAGTAGCTGGGGATATTTTTGACAGCTTAAGTGAAAATCCTGCTGGTATCCGCCTGTTAGG
GGTAACCATGACCAATTTGGAGGATAAGGTAGCTGATATTTCCTTGGACCTATAG

Upstream 100 bases:

>100_bases
TTTTATAATACAGATTGTTGAAACAGTCACAAACTGTATTAGAATGTATTTTTTTTGGCTTTAGATAGCCTAAAAGGTAT
AATAGAGAAAGGAGGGACTT

Downstream 100 bases:

>100_bases
GAGAAAGAGTGCTCTATCCGTCCGCCTCATTTTGGAGAAAAAAGAAGCTGATTAGGGATTTCCCTAATCAGCTTCTTTGG
TCCATTATTTTATTACAGCA

Product: DNA polymerase IV

Products: NA

Alternate protein names: Pol IV [H]

Number of amino acids: Translated: 364; Mature: 364

Protein sequence:

>364_residues
MLIFPLINDTSRKIIHIDMDAFFAAVEERDNPALKGKPVVIGKDPRETGGRGVVSTCNYEARKYGIHSAMSSKEAYERCP
KAIFISGNYEKYRTVGDQIRRIFKRYTDLVEPMSIDEAYLDVTDNKLGIKSAVKIAKLIQHDIWKEVGLTCSAGVSYNKF
LAKLASDFEKPHGLTLVLKEDALCFLAKLPIEKFHGVGKKSVEKLHDMGIYTGQDLLAVPEMTLIDHFGRFGFDLYRKAR
GISNSPVKSDRIRKSIGSERTYAKLLYQETDIKAEISKNAKRVAALLQDHKKLGKTIVLKVRYADFTTLTKRVTLPELTR
NAAQIEQVAGDIFDSLSENPAGIRLLGVTMTNLEDKVADISLDL

Sequences:

>Translated_364_residues
MLIFPLINDTSRKIIHIDMDAFFAAVEERDNPALKGKPVVIGKDPRETGGRGVVSTCNYEARKYGIHSAMSSKEAYERCP
KAIFISGNYEKYRTVGDQIRRIFKRYTDLVEPMSIDEAYLDVTDNKLGIKSAVKIAKLIQHDIWKEVGLTCSAGVSYNKF
LAKLASDFEKPHGLTLVLKEDALCFLAKLPIEKFHGVGKKSVEKLHDMGIYTGQDLLAVPEMTLIDHFGRFGFDLYRKAR
GISNSPVKSDRIRKSIGSERTYAKLLYQETDIKAEISKNAKRVAALLQDHKKLGKTIVLKVRYADFTTLTKRVTLPELTR
NAAQIEQVAGDIFDSLSENPAGIRLLGVTMTNLEDKVADISLDL
>Mature_364_residues
MLIFPLINDTSRKIIHIDMDAFFAAVEERDNPALKGKPVVIGKDPRETGGRGVVSTCNYEARKYGIHSAMSSKEAYERCP
KAIFISGNYEKYRTVGDQIRRIFKRYTDLVEPMSIDEAYLDVTDNKLGIKSAVKIAKLIQHDIWKEVGLTCSAGVSYNKF
LAKLASDFEKPHGLTLVLKEDALCFLAKLPIEKFHGVGKKSVEKLHDMGIYTGQDLLAVPEMTLIDHFGRFGFDLYRKAR
GISNSPVKSDRIRKSIGSERTYAKLLYQETDIKAEISKNAKRVAALLQDHKKLGKTIVLKVRYADFTTLTKRVTLPELTR
NAAQIEQVAGDIFDSLSENPAGIRLLGVTMTNLEDKVADISLDL

Specific function: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits

COG id: COG0389

COG function: function code L; Nucleotidyltransferase/DNA polymerase involved in DNA repair

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 umuC domain [H]

Homologues:

Organism=Homo sapiens, GI84043967, Length=405, Percent_Identity=25.679012345679, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI7706681, Length=406, Percent_Identity=25.615763546798, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI154350220, Length=343, Percent_Identity=27.6967930029155, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI5729982, Length=321, Percent_Identity=27.1028037383178, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI7705344, Length=113, Percent_Identity=44.2477876106195, Blast_Score=106, Evalue=4e-23,
Organism=Escherichia coli, GI1786425, Length=349, Percent_Identity=40.974212034384, Blast_Score=244, Evalue=5e-66,
Organism=Escherichia coli, GI1787432, Length=303, Percent_Identity=25.0825082508251, Blast_Score=82, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI193205700, Length=417, Percent_Identity=29.4964028776978, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17537959, Length=383, Percent_Identity=25.065274151436, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI193205702, Length=347, Percent_Identity=27.0893371757925, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI115534089, Length=123, Percent_Identity=36.5853658536585, Blast_Score=82, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6324921, Length=208, Percent_Identity=27.4038461538462, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI19923006, Length=415, Percent_Identity=24.3373493975904, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI21355641, Length=291, Percent_Identity=28.5223367697594, Blast_Score=108, Evalue=7e-24,
Organism=Drosophila melanogaster, GI24644984, Length=291, Percent_Identity=28.5223367697594, Blast_Score=108, Evalue=7e-24,
Organism=Drosophila melanogaster, GI24668444, Length=127, Percent_Identity=33.0708661417323, Blast_Score=82, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017962
- InterPro:   IPR017961
- InterPro:   IPR001126
- InterPro:   IPR017963
- InterPro:   IPR022880 [H]

Pfam domain/function: PF00817 IMS [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 40776; Mature: 40776

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: PS50173 UMUC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIFPLINDTSRKIIHIDMDAFFAAVEERDNPALKGKPVVIGKDPRETGGRGVVSTCNYE
CEEEEEECCCCCEEEEEEHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCEEEECCCH
ARKYGIHSAMSSKEAYERCPKAIFISGNYEKYRTVGDQIRRIFKRYTDLVEPMSIDEAYL
HHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHE
DVTDNKLGIKSAVKIAKLIQHDIWKEVGLTCSAGVSYNKFLAKLASDFEKPHGLTLVLKE
EECCCCCCHHHHHHHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHCCCCCEEEEECC
DALCFLAKLPIEKFHGVGKKSVEKLHDMGIYTGQDLLAVPEMTLIDHFGRFGFDLYRKAR
CCHHHHHHCCHHHHHCCCHHHHHHHHHCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHC
GISNSPVKSDRIRKSIGSERTYAKLLYQETDIKAEISKNAKRVAALLQDHKKLGKTIVLK
CCCCCCCCHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEE
VRYADFTTLTKRVTLPELTRNAAQIEQVAGDIFDSLSENPAGIRLLGVTMTNLEDKVADI
EEECCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCHHHHHHHC
SLDL
EECC
>Mature Secondary Structure
MLIFPLINDTSRKIIHIDMDAFFAAVEERDNPALKGKPVVIGKDPRETGGRGVVSTCNYE
CEEEEEECCCCCEEEEEEHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCEEEECCCH
ARKYGIHSAMSSKEAYERCPKAIFISGNYEKYRTVGDQIRRIFKRYTDLVEPMSIDEAYL
HHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHE
DVTDNKLGIKSAVKIAKLIQHDIWKEVGLTCSAGVSYNKFLAKLASDFEKPHGLTLVLKE
EECCCCCCHHHHHHHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHCCCCCEEEEECC
DALCFLAKLPIEKFHGVGKKSVEKLHDMGIYTGQDLLAVPEMTLIDHFGRFGFDLYRKAR
CCHHHHHHCCHHHHHCCCHHHHHHHHHCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHC
GISNSPVKSDRIRKSIGSERTYAKLLYQETDIKAEISKNAKRVAALLQDHKKLGKTIVLK
CCCCCCCCHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEE
VRYADFTTLTKRVTLPELTRNAAQIEQVAGDIFDSLSENPAGIRLLGVTMTNLEDKVADI
EEECCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCHHHHHHHC
SLDL
EECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12122206; 12799345 [H]