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The map label for this gene is trxA [H]

Identifier: 19746768

GI number: 19746768

Start: 1577046

End: 1577360

Strand: Reverse

Name: trxA [H]

Synonym: spyM18_1901

Alternate gene names: 19746768

Gene position: 1577360-1577046 (Counterclockwise)

Preceding gene: 19746769

Following gene: 19746765

Centisome position: 83.24

GC content: 34.92

Gene sequence:

>315_bases
ATGGCATTAGAAGTAACAGATGCTACATTTGTAGAAGAAACTAAAGAAGGTTTAGTACTCATTGATTTTTGGGCAACTTG
GTGTGGTCCATGTCGTATGCAAACACCAATCTTAGAACAGTTATCTCAAGAAATCGATGAAGATGAACTCAAAATTTTGA
AAATGGATGTTGATGAAAATCCGGAAACTGCTCGTCAGTTTGGTATTATGTCAATTCCAACATTGATGTTTAAAAAAGAC
GGAGAAGTGGTTAAACAAGTTGCAGGTGTTCATACTAAAGACCAACTGAAAGCTATTATTGCTGAATTGAGTTAA

Upstream 100 bases:

>100_bases
GGCTTTGTTTATTGATTTAGCGAGTTCGTAGCAAATAGTTTCAAAAACAACTAAATTCTTGTACAATAGGCTTATCATTA
AGATGAAATGGAGAAAAAAG

Downstream 100 bases:

>100_bases
CTAAAATAAAGCCCAGCGTCACGCTGAGCTTTATTTTATTATCTACTAACTTCAATGGAATAACCATGTAAACATAAAAC
GACTTGCAAAAAAGATGGCA

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 104; Mature: 103

Protein sequence:

>104_residues
MALEVTDATFVEETKEGLVLIDFWATWCGPCRMQTPILEQLSQEIDEDELKILKMDVDENPETARQFGIMSIPTLMFKKD
GEVVKQVAGVHTKDQLKAIIAELS

Sequences:

>Translated_104_residues
MALEVTDATFVEETKEGLVLIDFWATWCGPCRMQTPILEQLSQEIDEDELKILKMDVDENPETARQFGIMSIPTLMFKKD
GEVVKQVAGVHTKDQLKAIIAELS
>Mature_103_residues
ALEVTDATFVEETKEGLVLIDFWATWCGPCRMQTPILEQLSQEIDEDELKILKMDVDENPETARQFGIMSIPTLMFKKDG
EVVKQVAGVHTKDQLKAIIAELS

Specific function: Component of the thioredoxin-thioredoxin reductase system. Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI148727319, Length=93, Percent_Identity=40.8602150537634, Blast_Score=67, Evalue=2e-12,
Organism=Homo sapiens, GI42516570, Length=93, Percent_Identity=40.8602150537634, Blast_Score=67, Evalue=3e-12,
Organism=Homo sapiens, GI50592994, Length=86, Percent_Identity=38.3720930232558, Blast_Score=66, Evalue=8e-12,
Organism=Homo sapiens, GI21361403, Length=90, Percent_Identity=32.2222222222222, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI87082331, Length=97, Percent_Identity=42.2680412371134, Blast_Score=92, Evalue=8e-21,
Organism=Escherichia coli, GI1788936, Length=84, Percent_Identity=40.4761904761905, Blast_Score=73, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17507705, Length=76, Percent_Identity=38.1578947368421, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17509965, Length=84, Percent_Identity=39.2857142857143, Blast_Score=62, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI71980565, Length=104, Percent_Identity=27.8846153846154, Blast_Score=62, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI71980562, Length=92, Percent_Identity=28.2608695652174, Blast_Score=61, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=86, Percent_Identity=37.2093023255814, Blast_Score=72, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323072, Length=89, Percent_Identity=35.9550561797753, Blast_Score=70, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6319925, Length=73, Percent_Identity=38.3561643835616, Blast_Score=70, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6321022, Length=82, Percent_Identity=29.2682926829268, Blast_Score=64, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17648013, Length=86, Percent_Identity=45.3488372093023, Blast_Score=77, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24583090, Length=86, Percent_Identity=45.3488372093023, Blast_Score=77, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24639826, Length=79, Percent_Identity=37.9746835443038, Blast_Score=73, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24664269, Length=71, Percent_Identity=43.6619718309859, Blast_Score=65, Evalue=8e-12,
Organism=Drosophila melanogaster, GI28573567, Length=79, Percent_Identity=34.1772151898734, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11741; Mature: 11610

Theoretical pI: Translated: 4.13; Mature: 4.13

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALEVTDATFVEETKEGLVLIDFWATWCGPCRMQTPILEQLSQEIDEDELKILKMDVDEN
CEEECCCHHHHHHHCCCEEEEEEHHHHCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCC
PETARQFGIMSIPTLMFKKDGEVVKQVAGVHTKDQLKAIIAELS
HHHHHHHCCCCCCHHHHCCCCHHHHHHHCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
ALEVTDATFVEETKEGLVLIDFWATWCGPCRMQTPILEQLSQEIDEDELKILKMDVDEN
EEECCCHHHHHHHCCCEEEEEEHHHHCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCC
PETARQFGIMSIPTLMFKKDGEVVKQVAGVHTKDQLKAIIAELS
HHHHHHHCCCCCCHHHHCCCCHHHHHHHCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]