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The map label for this gene is pepP [H]

Identifier: 19746758

GI number: 19746758

Start: 1567151

End: 1568224

Strand: Reverse

Name: pepP [H]

Synonym: spyM18_1889

Alternate gene names: 19746758

Gene position: 1568224-1567151 (Counterclockwise)

Preceding gene: 19746759

Following gene: 19746757

Centisome position: 82.76

GC content: 43.39

Gene sequence:

>1074_bases
ATGTCAGGATTTTTAGAGCAACGATTAGGTCACTGCCTAAGGCAGATGGCAGAGAAGGGGCTAGAGGCTCTTCTAGTCAC
CCATTTAACCAATAGTTATTACTTGACAGGTTTTTCTGGAACTGCAGCAACTGTTTTGATAACGGCCAAACGTCGTGTTT
TGATCACAGATTCACGTTATACCTTGCTTGCTAAAGCTAGTGTTGAGGGATTTGATATTATCGAAAGCCGCACGCCCCTG
AAGGTTGTGGCAGAATTGTTAGGGGCTGATCAAATAGATTGCCTTGGTTTTGAGGACCAGGTATCGTTTTCTTTTTATCA
GGCCATGCAAGCAGAACTGTCAGGAATAACCTTGCTTGCTCAGTCAGGCTTTGTGGAGCATTTACGTCTTATTAAGGACG
TCTCTGAAATTGAGACCATTGCTAAAGCGTGCTCGATCTCAGACAAAGCATTTGAAGATGCTCTTGATTTTATTAAACCA
GGGACAACCACTGAACGTGACCTGGCTAATTTTTTAGATTTTCGCATGCGTCAGTATGGTGCCAGCGGCACATCATTTGA
TATCATTGTAGCTTCAGGCTATCGCTCTGCCATGCCTCATGGACGTGCCAGTGACAAGGTTATCCAGAATAAAGAGAGCT
TGACCATGGACTTTGGGTGTTACTACAATCACTATGTTAGTGATATGACGAGGACCATTCATATTGGCCAAGTTACTGAT
GAAGAACGTGAGATTTATGCTCTTGTTTTTGCTGCTAATAAGGCTTTAATTGCTAAAGCTAGCGCTGGCATGACTTATAG
TGACTTTGACGGTATTCCGCGCCAACTCATCACTGAGGCGGGTTATGGTAGTCACTTCACACATGGCATTGGTCATGGTA
TCGGGCTTGACATCCATGAGAATCCATTTTTTGGGAAATCTGAGCAACTTCTCCAAGCTGGAATGGTGGTCACAGACGAG
CCAGGTATCTATTTGGATAACAAATATGGTGTCCGTATCGAAGACGACTTGGTTATCACAAAAACTGGTTGTCAAGTCTT
GACCTTGGCACCCAAAGAATTAATTGTATTGTAA

Upstream 100 bases:

>100_bases
TGAGCTCCTTTTTAATCTTTTAAATGCTCTCAAATCATGGTAAACTTAAAGTAGTTTTTTCATGCTACAATATTCTCAAA
AGTTACCAAAGGAGTTCGCG

Downstream 100 bases:

>100_bases
AAGAATGGTTCAGGAAAGGATTAGGGGAGAAGCAATGACAAATCGTTTATCATGGCAAGACTATTTTATGGCCAATGCAG
AGCTGATTTCCAAGCGCTCT

Product: Xaa-Pro dipeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 357; Mature: 356

Protein sequence:

>357_residues
MSGFLEQRLGHCLRQMAEKGLEALLVTHLTNSYYLTGFSGTAATVLITAKRRVLITDSRYTLLAKASVEGFDIIESRTPL
KVVAELLGADQIDCLGFEDQVSFSFYQAMQAELSGITLLAQSGFVEHLRLIKDVSEIETIAKACSISDKAFEDALDFIKP
GTTTERDLANFLDFRMRQYGASGTSFDIIVASGYRSAMPHGRASDKVIQNKESLTMDFGCYYNHYVSDMTRTIHIGQVTD
EEREIYALVFAANKALIAKASAGMTYSDFDGIPRQLITEAGYGSHFTHGIGHGIGLDIHENPFFGKSEQLLQAGMVVTDE
PGIYLDNKYGVRIEDDLVITKTGCQVLTLAPKELIVL

Sequences:

>Translated_357_residues
MSGFLEQRLGHCLRQMAEKGLEALLVTHLTNSYYLTGFSGTAATVLITAKRRVLITDSRYTLLAKASVEGFDIIESRTPL
KVVAELLGADQIDCLGFEDQVSFSFYQAMQAELSGITLLAQSGFVEHLRLIKDVSEIETIAKACSISDKAFEDALDFIKP
GTTTERDLANFLDFRMRQYGASGTSFDIIVASGYRSAMPHGRASDKVIQNKESLTMDFGCYYNHYVSDMTRTIHIGQVTD
EEREIYALVFAANKALIAKASAGMTYSDFDGIPRQLITEAGYGSHFTHGIGHGIGLDIHENPFFGKSEQLLQAGMVVTDE
PGIYLDNKYGVRIEDDLVITKTGCQVLTLAPKELIVL
>Mature_356_residues
SGFLEQRLGHCLRQMAEKGLEALLVTHLTNSYYLTGFSGTAATVLITAKRRVLITDSRYTLLAKASVEGFDIIESRTPLK
VVAELLGADQIDCLGFEDQVSFSFYQAMQAELSGITLLAQSGFVEHLRLIKDVSEIETIAKACSISDKAFEDALDFIKPG
TTTERDLANFLDFRMRQYGASGTSFDIIVASGYRSAMPHGRASDKVIQNKESLTMDFGCYYNHYVSDMTRTIHIGQVTDE
EREIYALVFAANKALIAKASAGMTYSDFDGIPRQLITEAGYGSHFTHGIGHGIGLDIHENPFFGKSEQLLQAGMVVTDEP
GIYLDNKYGVRIEDDLVITKTGCQVLTLAPKELIVL

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=260, Percent_Identity=30.3846153846154, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI93141226, Length=189, Percent_Identity=32.2751322751323, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI264681563, Length=177, Percent_Identity=31.638418079096, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI260593665, Length=311, Percent_Identity=24.1157556270096, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI149589008, Length=311, Percent_Identity=24.1157556270096, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI264681565, Length=174, Percent_Identity=30.4597701149425, Blast_Score=76, Evalue=5e-14,
Organism=Escherichia coli, GI1788728, Length=346, Percent_Identity=38.150289017341, Blast_Score=225, Evalue=3e-60,
Organism=Escherichia coli, GI1789275, Length=274, Percent_Identity=28.8321167883212, Blast_Score=108, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17508215, Length=292, Percent_Identity=27.3972602739726, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI71989583, Length=288, Percent_Identity=24.3055555555556, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17509539, Length=185, Percent_Identity=32.4324324324324, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6321118, Length=284, Percent_Identity=25.7042253521127, Blast_Score=97, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6322999, Length=183, Percent_Identity=32.7868852459016, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320922, Length=268, Percent_Identity=29.1044776119403, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI19920384, Length=272, Percent_Identity=26.8382352941176, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI21357079, Length=288, Percent_Identity=27.7777777777778, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI17137632, Length=171, Percent_Identity=29.2397660818713, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: 3.4.-.- [C]

Molecular weight: Translated: 39317; Mature: 39186

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGFLEQRLGHCLRQMAEKGLEALLVTHLTNSYYLTGFSGTAATVLITAKRRVLITDSRY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEEEEECCEEEEECCCE
TLLAKASVEGFDIIESRTPLKVVAELLGADQIDCLGFEDQVSFSFYQAMQAELSGITLLA
EEEEECCCCCCCHHCCCCCHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHCCEEEEE
QSGFVEHLRLIKDVSEIETIAKACSISDKAFEDALDFIKPGTTTERDLANFLDFRMRQYG
CCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHC
ASGTSFDIIVASGYRSAMPHGRASDKVIQNKESLTMDFGCYYNHYVSDMTRTIHIGQVTD
CCCCEEEEEEECCCHHCCCCCCCCCHHHCCCCCEEEEECHHHHHHHHHHHHEEEECCCCC
EEREIYALVFAANKALIAKASAGMTYSDFDGIPRQLITEAGYGSHFTHGIGHGIGLDIHE
CCCEEEEEEEECCCEEEEECCCCCEEHHCCCCHHHHHHHCCCCCCHHHHCCCCCCCEECC
NPFFGKSEQLLQAGMVVTDEPGIYLDNKYGVRIEDDLVITKTGCQVLTLAPKELIVL
CCCCCCHHHHHHCCCEEECCCCEEECCCCCEEEECCEEEEECCCEEEEECCHHEEEC
>Mature Secondary Structure 
SGFLEQRLGHCLRQMAEKGLEALLVTHLTNSYYLTGFSGTAATVLITAKRRVLITDSRY
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEEEEECCEEEEECCCE
TLLAKASVEGFDIIESRTPLKVVAELLGADQIDCLGFEDQVSFSFYQAMQAELSGITLLA
EEEEECCCCCCCHHCCCCCHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHCCEEEEE
QSGFVEHLRLIKDVSEIETIAKACSISDKAFEDALDFIKPGTTTERDLANFLDFRMRQYG
CCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHC
ASGTSFDIIVASGYRSAMPHGRASDKVIQNKESLTMDFGCYYNHYVSDMTRTIHIGQVTD
CCCCEEEEEEECCCHHCCCCCCCCCHHHCCCCCEEEEECHHHHHHHHHHHHEEEECCCCC
EEREIYALVFAANKALIAKASAGMTYSDFDGIPRQLITEAGYGSHFTHGIGHGIGLDIHE
CCCEEEEEEEECCCEEEEECCCCCEEHHCCCCHHHHHHHCCCCCCHHHHCCCCCCCEECC
NPFFGKSEQLLQAGMVVTDEPGIYLDNKYGVRIEDDLVITKTGCQVLTLAPKELIVL
CCCCCCHHHHHHCCCEEECCCCEEECCCCCEEEECCEEEEECCCEEEEECCHHEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]