| Definition | Streptococcus pyogenes MGAS8232, complete genome. |
|---|---|
| Accession | NC_003485 |
| Length | 1,895,017 |
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The map label for this gene is scrA [H]
Identifier: 19746751
GI number: 19746751
Start: 1560447
End: 1562330
Strand: Reverse
Name: scrA [H]
Synonym: spyM18_1881
Alternate gene names: 19746751
Gene position: 1562330-1560447 (Counterclockwise)
Preceding gene: 19746754
Following gene: 19746750
Centisome position: 82.44
GC content: 43.42
Gene sequence:
>1884_bases ATGGATAATCGTCAGATTGCAGCTGAAGTGATTGAGGCTTTAGGTGGCCGAGAAAATGTGAGGAGTGTTGCCCACTGTGC AACTCGCCTTCGCGTGATGGTTTATGATGAAGGAAAGATTGATAAGGAAAAAGCAGAAGCTATTGACAAGGTTAAAGGAG CATTCTTTAACTCTGGTCAATATCAGATGATTTTTGGAACTGGTACCGTTAATAACATTTATGACGAAGTTGTTGCTCTT GGTTTACCCACGTCATCAACCAGTGAGCAAAAAGCAGAAGCAGGCAAACAAGGCAATATCTTCCAACGGGCGATTCGTAC GTTTGGAGATGTGTTTGTTCCCATTATTCCAGCTATTGTAGCAACGGGTCTCTTTATGGGGGTTCGTGGTTTGGCGACCC AGCCAGCTATTATGGATTTATTTGGGGTGCATGAGTACGGGGAAAATTTTCTCATGTACACTCGTATTCTAACGGATACA GCCTTTGTCTACTTGCCAGCTTTGGTGGCTTGGTCAGCCTTTAGGGTCTTTGGGGGTAATCCTATTATCGGTATTGTTTT AGGCTTGATGTTGGTGTCCAATGAATTGCCAAACGCCTGGGTAGTTGCCTCTGGTGGAGATGTTAAGCCGCTAACCTTCT TTGGATTTGTTCCTGTTGTTGGTTATCAAGGTACCGTTTTACCTGCCTTCTTTGTTGGTCTGGTAGGAGCTAAGTTGGAG AAATGGTTGCACAAAAAGGTTCCAGAAGCTTTGGACTTATTGGTCACACCGTTTTTAACGTTTGCTATTATGAGTATCTT GGGATTATTTGTGATTGGACCAGTCTTCCATTCTCTTGAAAACCTTGTTCTGGCTGGGACACAGGCCGTTTTGCATTTGC CGTTTGGTATTGCAGGCTTGATTGTTGGGGGAATCCAACAATTAATCGTAGTGACTGGTATTCACCATATCTTTAACTTC TTGGAAGCGCAGCTGATTGCCAATACCGGAAAAGATCCTTTCAATGCTTACCTAACAGCAGCAACAGTTGCTCAAGCTGG AGCTACCTTAGCTGTTGCTGTAAAAACCAAATCACCAAAATTAAAAGGTCTGGCTTTTCCATCGACCTTATCAGCTCTTT TAGGGATTACTGAACCAGCTATTTTTGGGGTCAACCTCCGTTATCCAAAAGTCTTTGTTTCAGGTCTTATTGGTGGTGCC TTAGGTGGTTGGGTCGCTGGGCTCTTTGGCATTGCAGGAACTGGTCTTGGGATTACGGTCTTACCAGGAACTCTCCTTTA CTTGAATGGCCAATTATTACAATACCTTGTGACTATGCTTGTCGGTCTTGGGGTAGCCTTTGGAATTGCTTATACTTGGG GTTATCAAGATAGAGAAACCCTTCCGTTACCAGCTGTCGAAGTTGATCAAACGGCTGATCAGCCAGCCTTAGCAGAGGAA ACTTTATATAGTCCTTTGAATGGAACAGTTGTAGACTTATCTGCGGTTTCAGACCCTGTCTTTTCATCAGGTGCTATGGG TCAAGGCTTAGCAATTAAGCCAGAAGATAATACCCTATACTCACCAGTTGATGGTAAAGTTGAAATTGTCTTTGAAACAG GTCATGCCTATGCTATAACGTCAAGTCAAGGAGCAGAAGTGTTACTTCATATTGGTATTGATACCGTGTCGATGGCAGGA GATGGCTTTGAATCTCTTGTAGCAGTAGGTCAGGCGGTTAAAAAAGGTGATCTTCTTGGACACTTTGATCCTAGTAAGAT TGCAGAAGCTGGACTAGATGACACCACCATGATGATTGTGACCAATAGCGCTGACTATCAAAGCGTGGACATTCTTGCTC AAGGACATGTTTTGATTGGTGATCAAGTGGCACTTATCAAATAA
Upstream 100 bases:
>100_bases GTGAAGCGGATTCACTAGCGTTGGTCCTGCACATTCTTAGCCACAAAGCTGGCAGAATGGATGGGGGAATAACACCAAAT GAAAAAGGAGACTTTTAGGC
Downstream 100 bases:
>100_bases GGACAAAAGAGCTAACTAAGCAGCTCTTTTGTCCTGCCATGAATGGCAGGTTGGCAAAAAAATGAGAAAAGCCTAAAAAC CTTAAATTTGTGTTATTTTA
Product: PTS system, sucrose-specific IIABC component
Products: NA
Alternate protein names: EIIBCA-Scr; EII-Scr; Sucrose-specific phosphotransferase enzyme IIB component; PTS system sucrose-specific EIIB component; Sucrose permease IIC component; PTS system sucrose-specific EIIC component; Sucrose-specific phosphotransferase enzyme IIA component; PTS system sucrose-specific EIIA component [H]
Number of amino acids: Translated: 627; Mature: 627
Protein sequence:
>627_residues MDNRQIAAEVIEALGGRENVRSVAHCATRLRVMVYDEGKIDKEKAEAIDKVKGAFFNSGQYQMIFGTGTVNNIYDEVVAL GLPTSSTSEQKAEAGKQGNIFQRAIRTFGDVFVPIIPAIVATGLFMGVRGLATQPAIMDLFGVHEYGENFLMYTRILTDT AFVYLPALVAWSAFRVFGGNPIIGIVLGLMLVSNELPNAWVVASGGDVKPLTFFGFVPVVGYQGTVLPAFFVGLVGAKLE KWLHKKVPEALDLLVTPFLTFAIMSILGLFVIGPVFHSLENLVLAGTQAVLHLPFGIAGLIVGGIQQLIVVTGIHHIFNF LEAQLIANTGKDPFNAYLTAATVAQAGATLAVAVKTKSPKLKGLAFPSTLSALLGITEPAIFGVNLRYPKVFVSGLIGGA LGGWVAGLFGIAGTGLGITVLPGTLLYLNGQLLQYLVTMLVGLGVAFGIAYTWGYQDRETLPLPAVEVDQTADQPALAEE TLYSPLNGTVVDLSAVSDPVFSSGAMGQGLAIKPEDNTLYSPVDGKVEIVFETGHAYAITSSQGAEVLLHIGIDTVSMAG DGFESLVAVGQAVKKGDLLGHFDPSKIAEAGLDDTTMMIVTNSADYQSVDILAQGHVLIGDQVALIK
Sequences:
>Translated_627_residues MDNRQIAAEVIEALGGRENVRSVAHCATRLRVMVYDEGKIDKEKAEAIDKVKGAFFNSGQYQMIFGTGTVNNIYDEVVAL GLPTSSTSEQKAEAGKQGNIFQRAIRTFGDVFVPIIPAIVATGLFMGVRGLATQPAIMDLFGVHEYGENFLMYTRILTDT AFVYLPALVAWSAFRVFGGNPIIGIVLGLMLVSNELPNAWVVASGGDVKPLTFFGFVPVVGYQGTVLPAFFVGLVGAKLE KWLHKKVPEALDLLVTPFLTFAIMSILGLFVIGPVFHSLENLVLAGTQAVLHLPFGIAGLIVGGIQQLIVVTGIHHIFNF LEAQLIANTGKDPFNAYLTAATVAQAGATLAVAVKTKSPKLKGLAFPSTLSALLGITEPAIFGVNLRYPKVFVSGLIGGA LGGWVAGLFGIAGTGLGITVLPGTLLYLNGQLLQYLVTMLVGLGVAFGIAYTWGYQDRETLPLPAVEVDQTADQPALAEE TLYSPLNGTVVDLSAVSDPVFSSGAMGQGLAIKPEDNTLYSPVDGKVEIVFETGHAYAITSSQGAEVLLHIGIDTVSMAG DGFESLVAVGQAVKKGDLLGHFDPSKIAEAGLDDTTMMIVTNSADYQSVDILAQGHVLIGDQVALIK >Mature_627_residues MDNRQIAAEVIEALGGRENVRSVAHCATRLRVMVYDEGKIDKEKAEAIDKVKGAFFNSGQYQMIFGTGTVNNIYDEVVAL GLPTSSTSEQKAEAGKQGNIFQRAIRTFGDVFVPIIPAIVATGLFMGVRGLATQPAIMDLFGVHEYGENFLMYTRILTDT AFVYLPALVAWSAFRVFGGNPIIGIVLGLMLVSNELPNAWVVASGGDVKPLTFFGFVPVVGYQGTVLPAFFVGLVGAKLE KWLHKKVPEALDLLVTPFLTFAIMSILGLFVIGPVFHSLENLVLAGTQAVLHLPFGIAGLIVGGIQQLIVVTGIHHIFNF LEAQLIANTGKDPFNAYLTAATVAQAGATLAVAVKTKSPKLKGLAFPSTLSALLGITEPAIFGVNLRYPKVFVSGLIGGA LGGWVAGLFGIAGTGLGITVLPGTLLYLNGQLLQYLVTMLVGLGVAFGIAYTWGYQDRETLPLPAVEVDQTADQPALAEE TLYSPLNGTVVDLSAVSDPVFSSGAMGQGLAIKPEDNTLYSPVDGKVEIVFETGHAYAITSSQGAEVLLHIGIDTVSMAG DGFESLVAVGQAVKKGDLLGHFDPSKIAEAGLDDTTMMIVTNSADYQSVDILAQGHVLIGDQVALIK
Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This
COG id: COG1263
COG function: function code G; Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific
Gene ontology:
Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 PTS EIIC type-1 domain [H]
Homologues:
Organism=Escherichia coli, GI1790159, Length=627, Percent_Identity=29.9840510366826, Blast_Score=258, Evalue=8e-70, Organism=Escherichia coli, GI2367362, Length=427, Percent_Identity=30.9133489461358, Blast_Score=206, Evalue=4e-54, Organism=Escherichia coli, GI48994906, Length=487, Percent_Identity=28.5420944558522, Blast_Score=150, Evalue=2e-37, Organism=Escherichia coli, GI1788769, Length=439, Percent_Identity=27.1070615034169, Blast_Score=118, Evalue=1e-27, Organism=Escherichia coli, GI1786894, Length=146, Percent_Identity=35.6164383561644, Blast_Score=102, Evalue=7e-23, Organism=Escherichia coli, GI1788757, Length=140, Percent_Identity=37.1428571428571, Blast_Score=102, Evalue=9e-23,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR011055 - InterPro: IPR018113 - InterPro: IPR001127 - InterPro: IPR001996 - InterPro: IPR003352 - InterPro: IPR013013 - InterPro: IPR011535 - InterPro: IPR010973 [H]
Pfam domain/function: PF00358 PTS_EIIA_1; PF00367 PTS_EIIB; PF02378 PTS_EIIC [H]
EC number: =2.7.1.69 [H]
Molecular weight: Translated: 66231; Mature: 66231
Theoretical pI: Translated: 4.82; Mature: 4.82
Prosite motif: PS00371 PTS_EIIA_TYPE_1_HIS ; PS51093 PTS_EIIA_TYPE_1 ; PS01035 PTS_EIIB_TYPE_1_CYS ; PS51098 PTS_EIIB_TYPE_1 ; PS51103 PTS_EIIC_TYPE_1
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.2 %Cys (Translated Protein) 2.1 %Met (Translated Protein) 2.2 %Cys+Met (Translated Protein) 0.2 %Cys (Mature Protein) 2.1 %Met (Mature Protein) 2.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MDNRQIAAEVIEALGGRENVRSVAHCATRLRVMVYDEGKIDKEKAEAIDKVKGAFFNSGQ CCCHHHHHHHHHHHCCHHHHHHHHHHHHHEEEEEEECCCCCHHHHHHHHHHHHHHCCCCC YQMIFGTGTVNNIYDEVVALGLPTSSTSEQKAEAGKQGNIFQRAIRTFGDVFVPIIPAIV EEEEEECCCHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH ATGLFMGVRGLATQPAIMDLFGVHEYGENFLMYTRILTDTAFVYLPALVAWSAFRVFGGN HHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC PIIGIVLGLMLVSNELPNAWVVASGGDVKPLTFFGFVPVVGYQGTVLPAFFVGLVGAKLE CHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEHCCHHHHCCCCCCHHHHHHHHHHHHHHH KWLHKKVPEALDLLVTPFLTFAIMSILGLFVIGPVFHSLENLVLAGTQAVLHLPFGIAGL HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEECCHHHHHH IVGGIQQLIVVTGIHHIFNFLEAQLIANTGKDPFNAYLTAATVAQAGATLAVAVKTKSPK HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCC LKGLAFPSTLSALLGITEPAIFGVNLRYPKVFVSGLIGGALGGWVAGLFGIAGTGLGITV CCCCCCHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE LPGTLLYLNGQLLQYLVTMLVGLGVAFGIAYTWGYQDRETLPLPAVEVDQTADQPALAEE CCCEEEEECHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCEECCCCCCCCCHHHH TLYSPLNGTVVDLSAVSDPVFSSGAMGQGLAIKPEDNTLYSPVDGKVEIVFETGHAYAIT HHCCCCCCCEEEECCCCCCCCCCCCCCCCEEECCCCCCEECCCCCEEEEEEECCCEEEEE SSQGAEVLLHIGIDTVSMAGDGFESLVAVGQAVKKGDLLGHFDPSKIAEAGLDDTTMMIV CCCCCEEEEEECCCEEECCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCCEEEEE TNSADYQSVDILAQGHVLIGDQVALIK ECCCCCCEEEEEECCCEEECCCEEECC >Mature Secondary Structure MDNRQIAAEVIEALGGRENVRSVAHCATRLRVMVYDEGKIDKEKAEAIDKVKGAFFNSGQ CCCHHHHHHHHHHHCCHHHHHHHHHHHHHEEEEEEECCCCCHHHHHHHHHHHHHHCCCCC YQMIFGTGTVNNIYDEVVALGLPTSSTSEQKAEAGKQGNIFQRAIRTFGDVFVPIIPAIV EEEEEECCCHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH ATGLFMGVRGLATQPAIMDLFGVHEYGENFLMYTRILTDTAFVYLPALVAWSAFRVFGGN HHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC PIIGIVLGLMLVSNELPNAWVVASGGDVKPLTFFGFVPVVGYQGTVLPAFFVGLVGAKLE CHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEHCCHHHHCCCCCCHHHHHHHHHHHHHHH KWLHKKVPEALDLLVTPFLTFAIMSILGLFVIGPVFHSLENLVLAGTQAVLHLPFGIAGL HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEECCHHHHHH IVGGIQQLIVVTGIHHIFNFLEAQLIANTGKDPFNAYLTAATVAQAGATLAVAVKTKSPK HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCC LKGLAFPSTLSALLGITEPAIFGVNLRYPKVFVSGLIGGALGGWVAGLFGIAGTGLGITV CCCCCCHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE LPGTLLYLNGQLLQYLVTMLVGLGVAFGIAYTWGYQDRETLPLPAVEVDQTADQPALAEE CCCEEEEECHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCEECCCCCCCCCHHHH TLYSPLNGTVVDLSAVSDPVFSSGAMGQGLAIKPEDNTLYSPVDGKVEIVFETGHAYAIT HHCCCCCCCEEEECCCCCCCCCCCCCCCCEEECCCCCCEECCCCCEEEEEEECCCEEEEE SSQGAEVLLHIGIDTVSMAGDGFESLVAVGQAVKKGDLLGHFDPSKIAEAGLDDTTMMIV CCCCCEEEEEECCCEEECCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCCEEEEE TNSADYQSVDILAQGHVLIGDQVALIK ECCCCCCEEEEEECCCEEECCCEEECC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: 2536656; 12397186; 8336109 [H]