BacMap

Definition	Streptococcus pyogenes MGAS8232, complete genome.
Accession	NC_003485
Length	1,895,017

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The map label for this gene is accC [H]

Identifier: 19746702

GI number: 19746702

Start: 1501520

End: 1502884

Strand: Reverse

Name: accC [H]

Synonym: spyM18_1817

Alternate gene names: 19746702

Gene position: 1502884-1501520 (Counterclockwise)

Preceding gene: 19746703

Following gene: 19746701

Centisome position: 79.31

GC content: 42.34

Gene sequence:

>1365_bases
ATGTTTAAAAAAATCTTAATTGCTAATCGTGGTGAAATTGCAGTGCGTATCATTCGTGCTGCACGAGAATTAGGGATTTC
CACAGTTGCAGTTTATTCGGAAGCGGATAAGGAAGCTCTGCACACGATATTGGCGGACGAGGCTATCTGTATTGGCCCTG
CCCGTTCCAAGGAATCCTATCTTAATATGAATTCCGTCTTGTCAGCAGCTATTGTGACAGGAGCCCAAGCGATTCACCCA
GGGTTTGGCTTTTTAAGTGAAAACTCAAAGTTTGCGACCATGTGTGAAGAGATGAATATTAAATTTATCGGTCCATCCGC
ATCGGTTATGGATAAAATGGGTGATAAAATCAATGCTCGTTCTGAAATGATTAAGGCAGGAGTGCCCGTTATTCCAGGGT
CAGATGGTGAAGTTTATAACGCTCAAGAAGCCTTAGCTATTGCCAATAAGATTGGTTATCCTGTCATGCTAAAAGCATCG
GCAGGTGGTGGAGGTAAAGGGATTCGTAAAGTGGAGACAGAAGCAGATTTGGAGGCGGCTTTCAATGCTGCCAGTCAAGA
AGCTTTGGGAGCTTTCGGAAATGGCGCCATGTATTTGGAAAAAGTAATTTACCCAGCTAGACATATTGAGGTGCAAATTT
TAGGAGACGCTTACGGTAACATCATTCACTTGGGAGAACGGGATTGCTCGTTACAGCGTCATAATCAAAAAGTCTTGGAA
GAAAGTCCATCCATTGCTATTGGCAATACCCTCAGACACGAAATGGGGCAAGCAGCGGTTAGAGCAGCTAAAGCTGTAGC
CTATGAAAATGCGGGAACCATTGAGTTTTTGTTGGACGAAGACAGCGAGAAATTCTATTTCATGGAAATGAATACCCGTA
TCCAAGTTGAGCATCCTGTCACCGAATTTGTGACAGGAGTGGATATTGTCAAAGAGCAAATCAAAATTGCAGCAGGTCAG
CCTTTGGCGATTAATCAAGAAGACATCACTATCACGGGACATGCTATTGAATGTCGTATCAATGCTGAAAATACTGCTTT
TAACTTTGCACCGAGTCCAGGAAAGATTACAGACTTGTATATGCCAAGTGGTGGTGTAGGACTACGAGTTGATTCAGCAG
TTTACAATGGCTATGCCATTCCTCCTTATTATGACAGCATGATTGCTAAAATCATCGTTCATGGAAGCAATCGATTTGAC
GCTTTGATGAAAATGCAACGTGCCTTAGTTGAATTGGAAATTGAAGGCATTATCACCAATACAGACTTCCAGCTCGATTT
GATTTCAGATAAGCGAGTGATTGCAGGAGATTATGATACCTCTTTCTTGATGGAAACGTTCCTGCCACATTACAATAAAG
ATTAG

Upstream 100 bases:

>100_bases
GAAGCCAGGGCAGAAGTTGATGGCAAGCTAGCAGCAAGTGGAACATTAACCTTTGCCTGTGGGCAATGAGAATGATTGTT
CTGCGGAGGAAGAAACCCTT

Downstream 100 bases:

>100_bases
GAGAAAATATGGCTTTATTTCGTAAAAAAGATAAATACATCCGTATTACTCCCAATAATTTCCTCAAAGGATCTGTCAGC
CATAATGTCCCAGAAGTTCC

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A 1; ACC 1 [H]

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MFKKILIANRGEIAVRIIRAARELGISTVAVYSEADKEALHTILADEAICIGPARSKESYLNMNSVLSAAIVTGAQAIHP
GFGFLSENSKFATMCEEMNIKFIGPSASVMDKMGDKINARSEMIKAGVPVIPGSDGEVYNAQEALAIANKIGYPVMLKAS
AGGGGKGIRKVETEADLEAAFNAASQEALGAFGNGAMYLEKVIYPARHIEVQILGDAYGNIIHLGERDCSLQRHNQKVLE
ESPSIAIGNTLRHEMGQAAVRAAKAVAYENAGTIEFLLDEDSEKFYFMEMNTRIQVEHPVTEFVTGVDIVKEQIKIAAGQ
PLAINQEDITITGHAIECRINAENTAFNFAPSPGKITDLYMPSGGVGLRVDSAVYNGYAIPPYYDSMIAKIIVHGSNRFD
ALMKMQRALVELEIEGIITNTDFQLDLISDKRVIAGDYDTSFLMETFLPHYNKD

Sequences:

>Translated_454_residues
MFKKILIANRGEIAVRIIRAARELGISTVAVYSEADKEALHTILADEAICIGPARSKESYLNMNSVLSAAIVTGAQAIHP
GFGFLSENSKFATMCEEMNIKFIGPSASVMDKMGDKINARSEMIKAGVPVIPGSDGEVYNAQEALAIANKIGYPVMLKAS
AGGGGKGIRKVETEADLEAAFNAASQEALGAFGNGAMYLEKVIYPARHIEVQILGDAYGNIIHLGERDCSLQRHNQKVLE
ESPSIAIGNTLRHEMGQAAVRAAKAVAYENAGTIEFLLDEDSEKFYFMEMNTRIQVEHPVTEFVTGVDIVKEQIKIAAGQ
PLAINQEDITITGHAIECRINAENTAFNFAPSPGKITDLYMPSGGVGLRVDSAVYNGYAIPPYYDSMIAKIIVHGSNRFD
ALMKMQRALVELEIEGIITNTDFQLDLISDKRVIAGDYDTSFLMETFLPHYNKD
>Mature_454_residues
MFKKILIANRGEIAVRIIRAARELGISTVAVYSEADKEALHTILADEAICIGPARSKESYLNMNSVLSAAIVTGAQAIHP
GFGFLSENSKFATMCEEMNIKFIGPSASVMDKMGDKINARSEMIKAGVPVIPGSDGEVYNAQEALAIANKIGYPVMLKAS
AGGGGKGIRKVETEADLEAAFNAASQEALGAFGNGAMYLEKVIYPARHIEVQILGDAYGNIIHLGERDCSLQRHNQKVLE
ESPSIAIGNTLRHEMGQAAVRAAKAVAYENAGTIEFLLDEDSEKFYFMEMNTRIQVEHPVTEFVTGVDIVKEQIKIAAGQ
PLAINQEDITITGHAIECRINAENTAFNFAPSPGKITDLYMPSGGVGLRVDSAVYNGYAIPPYYDSMIAKIIVHGSNRFD
ALMKMQRALVELEIEGIITNTDFQLDLISDKRVIAGDYDTSFLMETFLPHYNKD

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=450, Percent_Identity=47.5555555555556, Blast_Score=431, Evalue=1e-121,
Organism=Homo sapiens, GI189095269, Length=447, Percent_Identity=48.5458612975391, Blast_Score=423, Evalue=1e-118,
Organism=Homo sapiens, GI295821183, Length=447, Percent_Identity=48.5458612975391, Blast_Score=422, Evalue=1e-118,
Organism=Homo sapiens, GI65506442, Length=447, Percent_Identity=48.5458612975391, Blast_Score=422, Evalue=1e-118,
Organism=Homo sapiens, GI106049528, Length=448, Percent_Identity=46.6517857142857, Blast_Score=405, Evalue=1e-113,
Organism=Homo sapiens, GI106049295, Length=448, Percent_Identity=46.6517857142857, Blast_Score=405, Evalue=1e-113,
Organism=Homo sapiens, GI106049292, Length=448, Percent_Identity=46.6517857142857, Blast_Score=405, Evalue=1e-113,
Organism=Homo sapiens, GI38679960, Length=509, Percent_Identity=32.0235756385069, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI38679977, Length=509, Percent_Identity=32.0235756385069, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI38679967, Length=509, Percent_Identity=32.0235756385069, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI38679974, Length=509, Percent_Identity=32.0235756385069, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI38679971, Length=509, Percent_Identity=32.0235756385069, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI134142062, Length=506, Percent_Identity=32.0158102766798, Blast_Score=230, Evalue=2e-60,
Organism=Escherichia coli, GI1789654, Length=444, Percent_Identity=52.9279279279279, Blast_Score=457, Evalue=1e-130,
Organism=Caenorhabditis elegans, GI17567343, Length=447, Percent_Identity=46.9798657718121, Blast_Score=414, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI71987519, Length=442, Percent_Identity=45.4751131221719, Blast_Score=387, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI17562816, Length=462, Percent_Identity=44.5887445887446, Blast_Score=384, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI71997168, Length=504, Percent_Identity=32.5396825396825, Blast_Score=239, Evalue=3e-63,
Organism=Caenorhabditis elegans, GI71997163, Length=504, Percent_Identity=32.5396825396825, Blast_Score=238, Evalue=4e-63,
Organism=Caenorhabditis elegans, GI133931226, Length=485, Percent_Identity=30.5154639175258, Blast_Score=224, Evalue=7e-59,
Organism=Saccharomyces cerevisiae, GI6319685, Length=429, Percent_Identity=45.2214452214452, Blast_Score=388, Evalue=1e-109,
Organism=Saccharomyces cerevisiae, GI6319695, Length=450, Percent_Identity=44.8888888888889, Blast_Score=366, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6321376, Length=450, Percent_Identity=45.7777777777778, Blast_Score=352, Evalue=5e-98,
Organism=Saccharomyces cerevisiae, GI6324343, Length=485, Percent_Identity=35.2577319587629, Blast_Score=238, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6323863, Length=459, Percent_Identity=33.3333333333333, Blast_Score=236, Evalue=4e-63,
Organism=Drosophila melanogaster, GI24651757, Length=444, Percent_Identity=47.2972972972973, Blast_Score=421, Evalue=1e-118,
Organism=Drosophila melanogaster, GI281363050, Length=461, Percent_Identity=47.0715835140998, Blast_Score=401, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652224, Length=461, Percent_Identity=47.0715835140998, Blast_Score=401, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652222, Length=461, Percent_Identity=47.0715835140998, Blast_Score=401, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652220, Length=461, Percent_Identity=47.0715835140998, Blast_Score=401, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652218, Length=461, Percent_Identity=47.0715835140998, Blast_Score=401, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652212, Length=461, Percent_Identity=47.0715835140998, Blast_Score=401, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652210, Length=461, Percent_Identity=47.0715835140998, Blast_Score=401, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652214, Length=461, Percent_Identity=47.0715835140998, Blast_Score=401, Evalue=1e-112,
Organism=Drosophila melanogaster, GI19921944, Length=461, Percent_Identity=47.0715835140998, Blast_Score=401, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652216, Length=461, Percent_Identity=47.0715835140998, Blast_Score=401, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24651759, Length=408, Percent_Identity=45.8333333333333, Blast_Score=373, Evalue=1e-103,
Organism=Drosophila melanogaster, GI161076409, Length=499, Percent_Identity=32.8657314629259, Blast_Score=244, Evalue=1e-64,
Organism=Drosophila melanogaster, GI161076407, Length=496, Percent_Identity=33.0645161290323, Blast_Score=243, Evalue=1e-64,
Organism=Drosophila melanogaster, GI24586460, Length=496, Percent_Identity=33.0645161290323, Blast_Score=243, Evalue=1e-64,
Organism=Drosophila melanogaster, GI24586458, Length=496, Percent_Identity=33.0645161290323, Blast_Score=243, Evalue=1e-64,
Organism=Drosophila melanogaster, GI24642586, Length=251, Percent_Identity=24.7011952191235, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI45555749, Length=251, Percent_Identity=24.7011952191235, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 49367; Mature: 49367

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC ; PS00238 OPSIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKKILIANRGEIAVRIIRAARELGISTVAVYSEADKEALHTILADEAICIGPARSKESY
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHCCEEEECCCCCCHHH
LNMNSVLSAAIVTGAQAIHPGFGFLSENSKFATMCEEMNIKFIGPSASVMDKMGDKINAR
CCHHHHHHHHHHHCCHHHCCCCCEECCCCHHHHHHHHCCEEEECCCHHHHHHCCCCCCHH
SEMIKAGVPVIPGSDGEVYNAQEALAIANKIGYPVMLKASAGGGGKGIRKVETEADLEAA
HHHHHCCCCCCCCCCCCEECHHHHHHHHHHCCCCEEEEECCCCCCCCCEEECCHHHHHHH
FNAASQEALGAFGNGAMYLEKVIYPARHIEVQILGDAYGNIIHLGERDCSLQRHNQKVLE
HHHHHHHHHHCCCCCHHHHHHHHCCCCEEEEEEECCCCCCEEEECCCCCHHHHHHHHHHH
ESPSIAIGNTLRHEMGQAAVRAAKAVAYENAGTIEFLLDEDSEKFYFMEMNTRIQVEHPV
CCCCEEECHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEEECCEEEEECCH
TEFVTGVDIVKEQIKIAAGQPLAINQEDITITGHAIECRINAENTAFNFAPSPGKITDLY
HHHHHHHHHHHHHHHHCCCCCEEECCCCEEEEEEEEEEEEECCCCEEEECCCCCCEEEEE
MPSGGVGLRVDSAVYNGYAIPPYYDSMIAKIIVHGSNRFDALMKMQRALVELEIEGIITN
ECCCCCCEEECCCEECCEECCCHHHHHHHHHEEECCCHHHHHHHHHHHHHEEEEEEEEEC
TDFQLDLISDKRVIAGDYDTSFLMETFLPHYNKD
CCEEEEEECCCEEEECCCCHHHHHHHHCCCCCCC
>Mature Secondary Structure
MFKKILIANRGEIAVRIIRAARELGISTVAVYSEADKEALHTILADEAICIGPARSKESY
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHCCEEEECCCCCCHHH
LNMNSVLSAAIVTGAQAIHPGFGFLSENSKFATMCEEMNIKFIGPSASVMDKMGDKINAR
CCHHHHHHHHHHHCCHHHCCCCCEECCCCHHHHHHHHCCEEEECCCHHHHHHCCCCCCHH
SEMIKAGVPVIPGSDGEVYNAQEALAIANKIGYPVMLKASAGGGGKGIRKVETEADLEAA
HHHHHCCCCCCCCCCCCEECHHHHHHHHHHCCCCEEEEECCCCCCCCCEEECCHHHHHHH
FNAASQEALGAFGNGAMYLEKVIYPARHIEVQILGDAYGNIIHLGERDCSLQRHNQKVLE
HHHHHHHHHHCCCCCHHHHHHHHCCCCEEEEEEECCCCCCEEEECCCCCHHHHHHHHHHH
ESPSIAIGNTLRHEMGQAAVRAAKAVAYENAGTIEFLLDEDSEKFYFMEMNTRIQVEHPV
CCCCEEECHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEEECCEEEEECCH
TEFVTGVDIVKEQIKIAAGQPLAINQEDITITGHAIECRINAENTAFNFAPSPGKITDLY
HHHHHHHHHHHHHHHHCCCCCEEECCCCEEEEEEEEEEEEECCCCEEEECCCCCCEEEEE
MPSGGVGLRVDSAVYNGYAIPPYYDSMIAKIIVHGSNRFDALMKMQRALVELEIEGIITN
ECCCCCCEEECCCEECCEECCCHHHHHHHHHEEECCCHHHHHHHHHHHHHEEEEEEEEEC
TDFQLDLISDKRVIAGDYDTSFLMETFLPHYNKD
CCEEEEEECCCEEEECCCCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7592499; 8969508; 9384377 [H]