| Definition | Streptococcus pyogenes MGAS8232, complete genome. |
|---|---|
| Accession | NC_003485 |
| Length | 1,895,017 |
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The map label for this gene is npr [H]
Identifier: 19746593
GI number: 19746593
Start: 1407473
End: 1408819
Strand: Reverse
Name: npr [H]
Synonym: spyM18_1693
Alternate gene names: 19746593
Gene position: 1408819-1407473 (Counterclockwise)
Preceding gene: 19746594
Following gene: 19746592
Centisome position: 74.34
GC content: 41.87
Gene sequence:
>1347_bases ATGACATTAACGACAAAGACCATACATGTTATCGGGGCATCCTTTGCTGGTCTAGCCTTTGTTGATAAATATAAGGACCT CAATCCAGATTCCCAAATCATTCTCATTGATAAGGAAAGCTGTCCCAATTATATTCCAAATGGTATCAACCAATTATTCA GAGGAGACATTCAAGACCTGTCTGATGCTATGTGGGGAAGGGCCTGCCTAGCAGCACAAATAGAATCTAACCACCGGTTT ATTCAAGCAGAAGTGTTAGCTATCGAAGCTCCCTCAAACACCTTGCTTCTCAAAGACAGTCAAGGACGAGTTTTTGAAGA AGGTTATGAAACGCTTGTTTGTGCCATGGGTGCTAGCCCCCAGTCTCATTATATTGAGACGTCACAGACCAACAAAGTTT TGGTAACTAAATATTATGAAGAAAGCCAAGCTAGTTTAAAACTGATTGAGGCTAGCCAAGAGGTCTTGGTTATTGGTGCC GGCTTGATTGGCTTAGACCTTGCCTACAGTTTGTCCTTACAAGGCAAACGGGTCAAACTGATTGAAGCAGCCGAACGTCC AGATTTCTATCAGACTGACGCAGAACTGATAGCCCCTGTAATGGCAGAAATGTCCACTCACCATGTCACCTTTATTAATA ATAAGCGTGTTACGGCTATCCATGAGATAGAGGGAAAAGTTGTCGCTCATACCGAGCAAGGGGACACCTTCCAAGGTGAT TTGGCTATTTTAGCCATTAACTTTAGGCCAAATACACACCTTTTGCAAGGACAAGTGGCTTGTGCTCTGGATAAGACCAT TTTGGTCAATGAAAACTTACAGACCAGCCAGGCTAATATCTATGCCATTGGAGACATGGTTTCATTGCATTTTGGTATAT TGGGAATGGATTACTATACACCTTTGATTAACCAAGCAATGAAGACAGGTCAGGCTCTGGCTCTGCATTTAGCTGGATAT CCTATTCCTCCATTACAGACGGTCAAGGTATTAGGAAGTTCTCACTTTGGTTATTATCGCGCGAGTGTTGGTGTGACAGA AGAAGAAGCAGAGCTTTATATGGATACTTGTAGCTATTTGTACCAAAATGGGGATTCTAAAAACCTCTTTTGGCTGAAAT TAATAGCTAGAAAAACGGATGGGATTTTAATAGGCGCTCAGCTCCTATCCAAAACCAATGCTCTTGTCATCGCCAATCAA TTAGGTCAGGCTCTGGCTCTGAAAGTTACAGACGGTGACTTAGCATTTCAAGATTTTCTCTTTTTACAAGGTCACAGTGA TTTGGCTTATCATCTTCATGAAGCTTGTCTCAAATTATTTGAAAAGAGGCTCCGCCATGAAGATTGA
Upstream 100 bases:
>100_bases AAAGGGGTTGGCTATCATAGGCCAGCTCCTTTGCTTTTTCTTTATAGGATTAGGTAAAACGCTTTCATATCTTAAAAACA ACTGCTATAATAATACTATT
Downstream 100 bases:
>100_bases AGACTTAATGGATAAGGAACGAAGGGCCCAATATCGTCTCTTGGTGACCCTTTATCATGCTAAAGAAACGTTAAGGCTAA AAGACCTAATGAGGCTATCA
Product: NADH peroxidase
Products: NA
Alternate protein names: NPXase; Npx [H]
Number of amino acids: Translated: 448; Mature: 447
Protein sequence:
>448_residues MTLTTKTIHVIGASFAGLAFVDKYKDLNPDSQIILIDKESCPNYIPNGINQLFRGDIQDLSDAMWGRACLAAQIESNHRF IQAEVLAIEAPSNTLLLKDSQGRVFEEGYETLVCAMGASPQSHYIETSQTNKVLVTKYYEESQASLKLIEASQEVLVIGA GLIGLDLAYSLSLQGKRVKLIEAAERPDFYQTDAELIAPVMAEMSTHHVTFINNKRVTAIHEIEGKVVAHTEQGDTFQGD LAILAINFRPNTHLLQGQVACALDKTILVNENLQTSQANIYAIGDMVSLHFGILGMDYYTPLINQAMKTGQALALHLAGY PIPPLQTVKVLGSSHFGYYRASVGVTEEEAELYMDTCSYLYQNGDSKNLFWLKLIARKTDGILIGAQLLSKTNALVIANQ LGQALALKVTDGDLAFQDFLFLQGHSDLAYHLHEACLKLFEKRLRHED
Sequences:
>Translated_448_residues MTLTTKTIHVIGASFAGLAFVDKYKDLNPDSQIILIDKESCPNYIPNGINQLFRGDIQDLSDAMWGRACLAAQIESNHRF IQAEVLAIEAPSNTLLLKDSQGRVFEEGYETLVCAMGASPQSHYIETSQTNKVLVTKYYEESQASLKLIEASQEVLVIGA GLIGLDLAYSLSLQGKRVKLIEAAERPDFYQTDAELIAPVMAEMSTHHVTFINNKRVTAIHEIEGKVVAHTEQGDTFQGD LAILAINFRPNTHLLQGQVACALDKTILVNENLQTSQANIYAIGDMVSLHFGILGMDYYTPLINQAMKTGQALALHLAGY PIPPLQTVKVLGSSHFGYYRASVGVTEEEAELYMDTCSYLYQNGDSKNLFWLKLIARKTDGILIGAQLLSKTNALVIANQ LGQALALKVTDGDLAFQDFLFLQGHSDLAYHLHEACLKLFEKRLRHED >Mature_447_residues TLTTKTIHVIGASFAGLAFVDKYKDLNPDSQIILIDKESCPNYIPNGINQLFRGDIQDLSDAMWGRACLAAQIESNHRFI QAEVLAIEAPSNTLLLKDSQGRVFEEGYETLVCAMGASPQSHYIETSQTNKVLVTKYYEESQASLKLIEASQEVLVIGAG LIGLDLAYSLSLQGKRVKLIEAAERPDFYQTDAELIAPVMAEMSTHHVTFINNKRVTAIHEIEGKVVAHTEQGDTFQGDL AILAINFRPNTHLLQGQVACALDKTILVNENLQTSQANIYAIGDMVSLHFGILGMDYYTPLINQAMKTGQALALHLAGYP IPPLQTVKVLGSSHFGYYRASVGVTEEEAELYMDTCSYLYQNGDSKNLFWLKLIARKTDGILIGAQLLSKTNALVIANQL GQALALKVTDGDLAFQDFLFLQGHSDLAYHLHEACLKLFEKRLRHED
Specific function: Peroxidase whose active site is a redox-active cysteine- sulfenic acid [H]
COG id: COG0446
COG function: function code R; Uncharacterized NAD(FAD)-dependent dehydrogenases
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Unknown [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family [H]
Homologues:
Organism=Escherichia coli, GI1789065, Length=336, Percent_Identity=25, Blast_Score=71, Evalue=1e-13,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR016156 - InterPro: IPR013027 - InterPro: IPR004099 - InterPro: IPR001327 [H]
Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]
EC number: =1.11.1.1 [H]
Molecular weight: Translated: 49483; Mature: 49352
Theoretical pI: Translated: 5.25; Mature: 5.25
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.3 %Cys (Translated Protein) 2.0 %Met (Translated Protein) 3.3 %Cys+Met (Translated Protein) 1.3 %Cys (Mature Protein) 1.8 %Met (Mature Protein) 3.1 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MTLTTKTIHVIGASFAGLAFVDKYKDLNPDSQIILIDKESCPNYIPNGINQLFRGDIQDL CCEEEEEEEEECCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCHHHHHHHCCCHHHH SDAMWGRACLAAQIESNHRFIQAEVLAIEAPSNTLLLKDSQGRVFEEGYETLVCAMGASP HHHHHHHHHHEEEECCCCEEEEEEEEEEECCCCEEEEECCCCCHHHHCHHEEEEEECCCC QSHYIETSQTNKVLVTKYYEESQASLKLIEASQEVLVIGAGLIGLDLAYSLSLQGKRVKL CCCEEECCCCCEEEEEEEECCCCCCEEEEECCCEEEEEECCHHHEEEEEEEECCCCEEEE IEAAERPDFYQTDAELIAPVMAEMSTHHVTFINNKRVTAIHEIEGKVVAHTEQGDTFQGD EECCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCEEEEEEECCCEEEEEECCCCCEECC LAILAINFRPNTHLLQGQVACALDKTILVNENLQTSQANIYAIGDMVSLHFGILGMDYYT EEEEEEEECCCCEEECCEEEEEECCEEEEECCCCCCCCEEEEECCHHHHHHHHCCHHHHH PLINQAMKTGQALALHLAGYPIPPLQTVKVLGSSHFGYYRASVGVTEEEAELYMDTCSYL HHHHHHHHCCCEEEEEECCCCCCCHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHH YQNGDSKNLFWLKLIARKTDGILIGAQLLSKTNALVIANQLGQALALKVTDGDLAFQDFL HHCCCCCCEEEEEEEECCCCCEEEEHHHHCCCCEEEEEECCCCEEEEEEECCCEEEEEEE FLQGHSDLAYHLHEACLKLFEKRLRHED EEECCCHHHHHHHHHHHHHHHHHHCCCC >Mature Secondary Structure TLTTKTIHVIGASFAGLAFVDKYKDLNPDSQIILIDKESCPNYIPNGINQLFRGDIQDL CEEEEEEEEECCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCHHHHHHHCCCHHHH SDAMWGRACLAAQIESNHRFIQAEVLAIEAPSNTLLLKDSQGRVFEEGYETLVCAMGASP HHHHHHHHHHEEEECCCCEEEEEEEEEEECCCCEEEEECCCCCHHHHCHHEEEEEECCCC QSHYIETSQTNKVLVTKYYEESQASLKLIEASQEVLVIGAGLIGLDLAYSLSLQGKRVKL CCCEEECCCCCEEEEEEEECCCCCCEEEEECCCEEEEEECCHHHEEEEEEEECCCCEEEE IEAAERPDFYQTDAELIAPVMAEMSTHHVTFINNKRVTAIHEIEGKVVAHTEQGDTFQGD EECCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCEEEEEEECCCEEEEEECCCCCEECC LAILAINFRPNTHLLQGQVACALDKTILVNENLQTSQANIYAIGDMVSLHFGILGMDYYT EEEEEEEECCCCEEECCEEEEEECCEEEEECCCCCCCCEEEEECCHHHHHHHHCCHHHHH PLINQAMKTGQALALHLAGYPIPPLQTVKVLGSSHFGYYRASVGVTEEEAELYMDTCSYL HHHHHHHHCCCEEEEEECCCCCCCHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHH YQNGDSKNLFWLKLIARKTDGILIGAQLLSKTNALVIANQLGQALALKVTDGDLAFQDFL HHCCCCCCEEEEEEEECCCCCEEEEHHHHCCCCEEEEEECCCCEEEEEEECCCEEEEEEE FLQGHSDLAYHLHEACLKLFEKRLRHED EEECCCHHHHHHHHHHHHHHHHHHCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 1719212; 12663927; 2501302; 1942054; 8425532; 8756456; 9214307 [H]