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The map label for this gene is gmk [H]

Identifier: 19746556

GI number: 19746556

Start: 1366500

End: 1367135

Strand: Reverse

Name: gmk [H]

Synonym: spyM18_1642

Alternate gene names: 19746556

Gene position: 1367135-1366500 (Counterclockwise)

Preceding gene: 19746557

Following gene: 19746555

Centisome position: 72.14

GC content: 39.31

Gene sequence:

>636_bases
ATGTCTGAACGCGGTTTGTTAATCGTCTTTTCTGGCCCTTCAGGTGTCGGAAAAGGAACGGTGAGACAAGAAATTTTTTC
AACGCCAGATCATAAATTTGAATATTCGGTTTCAATGACGACTCGTCCGCAAAGACCGGGCGAGGTTGATGGGGTTGATT
ATTTCTTCCGCACACGAGAAGAATTTGAAGAACTCATTAAAACTGGTCAAATGCTAGAGTATGCTGAATATGTTGGTAAT
TACTATGGCACCCCTTTAACTTATGTTAATGAGACTCTTGATAAGGGAATTGATGTCTTTTTAGAAATTGAAGTTCAAGG
AGCTCTTCAGGTTAAGTCAAAAGTACCAGATGGTGTTTTTGTTTTTTTAACACCACCAGATTTAGATGAATTAGAAGACC
GCCTGGTTGGTCGTGGTACAGATAGTCAAGAAGTCATAGCTCAACGTATTGAAAGAGCAAAAGAAGAAATTGCCCTTATG
CGCGAATACGATTATGCAGTTGTTAATGATGAAGTTGCCTTGGCAGCTGAGCGGGTTAAGCGTATCATTGAGACAGAACA
CTTTCGTGTGGAGCGCGTGATTGGTCGTTATGATAAAATGATTAAAATAACAAAAAATCCCTTTAAAGCTAAATAG

Upstream 100 bases:

>100_bases
AATTATCCTCTTTTTCTTTATGACTTGCCTTTGAAAATGTTCTTGAAAAAGACTAGCCTTTTTGATAAACTATTAAAAAG
CAACTAATAAGGAGAATACA

Downstream 100 bases:

>100_bases
AAAAGAGTAAGCATTATGATGTTAAAACCTTCCATTGATACCTTATTAGATAAAGTACCATCCAAGTATTCACTTGTGAT
TTTACAAGCCAAACGTGCCC

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 211; Mature: 210

Protein sequence:

>211_residues
MSERGLLIVFSGPSGVGKGTVRQEIFSTPDHKFEYSVSMTTRPQRPGEVDGVDYFFRTREEFEELIKTGQMLEYAEYVGN
YYGTPLTYVNETLDKGIDVFLEIEVQGALQVKSKVPDGVFVFLTPPDLDELEDRLVGRGTDSQEVIAQRIERAKEEIALM
REYDYAVVNDEVALAAERVKRIIETEHFRVERVIGRYDKMIKITKNPFKAK

Sequences:

>Translated_211_residues
MSERGLLIVFSGPSGVGKGTVRQEIFSTPDHKFEYSVSMTTRPQRPGEVDGVDYFFRTREEFEELIKTGQMLEYAEYVGN
YYGTPLTYVNETLDKGIDVFLEIEVQGALQVKSKVPDGVFVFLTPPDLDELEDRLVGRGTDSQEVIAQRIERAKEEIALM
REYDYAVVNDEVALAAERVKRIIETEHFRVERVIGRYDKMIKITKNPFKAK
>Mature_210_residues
SERGLLIVFSGPSGVGKGTVRQEIFSTPDHKFEYSVSMTTRPQRPGEVDGVDYFFRTREEFEELIKTGQMLEYAEYVGNY
YGTPLTYVNETLDKGIDVFLEIEVQGALQVKSKVPDGVFVFLTPPDLDELEDRLVGRGTDSQEVIAQRIERAKEEIALMR
EYDYAVVNDEVALAAERVKRIIETEHFRVERVIGRYDKMIKITKNPFKAK

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874831, Length=189, Percent_Identity=32.8042328042328, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI226874833, Length=188, Percent_Identity=32.9787234042553, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI4504221, Length=188, Percent_Identity=32.9787234042553, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI38570142, Length=178, Percent_Identity=28.6516853932584, Blast_Score=85, Evalue=5e-17,
Organism=Homo sapiens, GI14780902, Length=198, Percent_Identity=27.7777777777778, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI4505237, Length=167, Percent_Identity=29.940119760479, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI262118259, Length=167, Percent_Identity=29.940119760479, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI262118263, Length=167, Percent_Identity=29.940119760479, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI262118255, Length=167, Percent_Identity=29.940119760479, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI21361598, Length=185, Percent_Identity=27.027027027027, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI21536464, Length=123, Percent_Identity=27.6422764227642, Blast_Score=64, Evalue=1e-10,
Organism=Escherichia coli, GI1790080, Length=199, Percent_Identity=44.7236180904523, Blast_Score=171, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI17508835, Length=172, Percent_Identity=36.046511627907, Blast_Score=118, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI193203132, Length=172, Percent_Identity=36.046511627907, Blast_Score=117, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17556244, Length=121, Percent_Identity=34.7107438016529, Blast_Score=84, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71988041, Length=182, Percent_Identity=24.7252747252747, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71988048, Length=182, Percent_Identity=24.7252747252747, Blast_Score=68, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6320662, Length=183, Percent_Identity=38.7978142076503, Blast_Score=135, Evalue=4e-33,
Organism=Drosophila melanogaster, GI21356141, Length=150, Percent_Identity=38, Blast_Score=107, Evalue=5e-24,
Organism=Drosophila melanogaster, GI161077626, Length=176, Percent_Identity=29.5454545454545, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24640542, Length=176, Percent_Identity=29.5454545454545, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI45554489, Length=176, Percent_Identity=29.5454545454545, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI45554481, Length=176, Percent_Identity=29.5454545454545, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI85724806, Length=176, Percent_Identity=29.5454545454545, Blast_Score=77, Evalue=6e-15,
Organism=Drosophila melanogaster, GI116007136, Length=176, Percent_Identity=29.5454545454545, Blast_Score=77, Evalue=6e-15,
Organism=Drosophila melanogaster, GI221330166, Length=125, Percent_Identity=32.8, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI221330164, Length=125, Percent_Identity=32.8, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI221330162, Length=125, Percent_Identity=32.8, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI85816106, Length=127, Percent_Identity=31.496062992126, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI85816281, Length=127, Percent_Identity=31.496062992126, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI45551002, Length=127, Percent_Identity=31.496062992126, Blast_Score=74, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24648808, Length=185, Percent_Identity=23.7837837837838, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI281362230, Length=185, Percent_Identity=23.7837837837838, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI161078487, Length=185, Percent_Identity=23.7837837837838, Blast_Score=64, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 24187; Mature: 24056

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSERGLLIVFSGPSGVGKGTVRQEIFSTPDHKFEYSVSMTTRPQRPGEVDGVDYFFRTRE
CCCCCEEEEECCCCCCCCCHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHH
EFEELIKTGQMLEYAEYVGNYYGTPLTYVNETLDKGIDVFLEIEVQGALQVKSKVPDGVF
HHHHHHHHCHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEEEEECCEEEECCCCCCCEE
VFLTPPDLDELEDRLVGRGTDSQEVIAQRIERAKEEIALMREYDYAVVNDEVALAAERVK
EEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHHHH
RIIETEHFRVERVIGRYDKMIKITKNPFKAK
HHHHHHHHHHHHHHHHHHHEEEEECCCCCCC
>Mature Secondary Structure 
SERGLLIVFSGPSGVGKGTVRQEIFSTPDHKFEYSVSMTTRPQRPGEVDGVDYFFRTRE
CCCCEEEEECCCCCCCCCHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHH
EFEELIKTGQMLEYAEYVGNYYGTPLTYVNETLDKGIDVFLEIEVQGALQVKSKVPDGVF
HHHHHHHHCHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEEEEECCEEEECCCCCCCEE
VFLTPPDLDELEDRLVGRGTDSQEVIAQRIERAKEEIALMREYDYAVVNDEVALAAERVK
EEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHHHH
RIIETEHFRVERVIGRYDKMIKITKNPFKAK
HHHHHHHHHHHHHHHHHHHEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]