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The map label for this gene is yesM [H]

Identifier: 19746521

GI number: 19746521

Start: 1321254

End: 1322978

Strand: Reverse

Name: yesM [H]

Synonym: spyM18_1596

Alternate gene names: 19746521

Gene position: 1322978-1321254 (Counterclockwise)

Preceding gene: 19746522

Following gene: 19746520

Centisome position: 69.81

GC content: 40.35

Gene sequence:

>1725_bases
ATGAGTGTTAAAACATTGGGAAGGTATGTGACTAACCACTTTAAGCAGGGTTTTTTGATTAATCGACTGATGAAATTATA
TAGCCTGCTAATTGTAAGTTTTTTCACTTTATCAGCTATTGGCTTGAGCAGTTATTCTATTAGTAGTACTTATAAAAGGG
TGGATGCTGAGGCGCAGATGCGACTGGAGGAGACTCTAGGTAGATTGCAGTCACAAAACGATATTACCCTACGGGTTTTA
GACCAGTTGGTTGGCCGTTCAGAAGATTACCATAATCTCTATCAATACATGACGTTAACCCCAAACCAATATTTTTCAAA
CGTTTTTGAAGACTGGGAAAAAGGAAAAGACACGGACCTATTTTCTGAAGAGGTGAGGCGTCTTTTTGACTTGTACCCTG
ATGTGACTTCTATGACCCTACTGCTAGAGGACAGTAGTGCTTATCTGTACGCCGATAGGGTCATTAAGACGGGTCGTTTG
CTTTATAGCAAGCCTGAAAAAGTAACCGGAAATGTTTTAGTTCGCTCTATTCGAAATCCAGAATCAGGAGATGTGACAGG
TCGTCTTTACCTGACCTTTGACAAACCACCGACTTTGGTAGAGACACAGCAGGATCACTATTTAGCTACTTTTGCTTTTG
ATTACTATGGCCGCAAACTCTTCCATCAAGGAGGTCGGAGATTTCCTCATTTAGAGGCTGAGGTTAAAAAGGCTATCAAG
GCAGATCGGGCAGCTGATCTTAGTAATCTTAGCAAGGCTTATCGGATGCAGTACAATCGCTCGGGAGACCTCTTAGCTTA
TGTGGCTGTCAGAAAATCCTATTTATTAGCGGAAGCTGTCAGGACAGTTTTTGTGTATGGCCTTGTTTCTCTACTTTTAG
CTTGGCTGTTATTGCAGTTGCTCTTTAGGGTTTTCCGAAATTATATCCAGCAGGTTTCTGAAATTACGGATACTGTTGAA
ATGGTTGCAGCAGGCGATTTGTCTTTAACCATCGACAACAGTCACATGGAATTGGAACTGTATCATATTTCAGAAGCCAT
TAATCAGATGTTGGCCAGCATTAAAGCTTATATTGACGAAGTTTATGTGTTAGAGGTAGAGCAACGAGATGCCCAAATGA
GAGCTCTGCAGTCTCAAATCAACCCTCATTTTTTATACAACACGTTAGAGTATATTCGGATGTACGCCCTTAGTTGTCAA
CAAGAAGAATTAGCAGATGTCATTTATGCCTTTGCGAGTCTGCTTCGCAACAATATTAGCCAAGATAAGATGACCACCTT
AAAAGAAGAACTGGCTTTTTGTGAAAAGTACATTTACCTTTATCAAATGCGGTATCCAGATAGCTTCGCTTATCATGTAA
AAATTGATGAGAGTATTGCTGATTTAGCCATTCCTAAATTTGTCATTCAACCTCTCGTTGAAAATTATTTTGTGCATGGG
ATTGATTATAGTCGCCATGACAATGCACTAAGCATCAAGGCTTTAGATGAGACGGATCATCTCTTGATTCAGGTGCTTGA
TAATGGACGTGGTATTAGTCAAGAGCGCTTAGCAGATATGGAAAAAAGGCTTCAAGAGCACCAAACAACAGGCAATAGCT
CTATTGGTTTGCAAAATGTTTACCTCCGTCTTTTCCATCATTTTCGAGACAGGGTTTCTTGGTCCATGGCTAAGGAGCCA
AATGGTGGCTTTATCATTCAAATTAGGATTAGAAAGGATGCTTGA

Upstream 100 bases:

>100_bases
CAATACAAAGGCCTTTATCTCTTTTTAACCTTCGGAACTCTAGTCTTTTGCTTGGACTTTGTCACTAAGGCTAATCGTCG
ACTAGTAGATGGAGTGATTG

Downstream 100 bases:

>100_bases
TGTATAAGGTACTATTAGTTGACGATGAATACATGATTTTACAAGGGCTCACCATGATTATTGATTGGCAGGCACTTGGA
TTTGAAGTGGTTCAAACAGC

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 574; Mature: 573

Protein sequence:

>574_residues
MSVKTLGRYVTNHFKQGFLINRLMKLYSLLIVSFFTLSAIGLSSYSISSTYKRVDAEAQMRLEETLGRLQSQNDITLRVL
DQLVGRSEDYHNLYQYMTLTPNQYFSNVFEDWEKGKDTDLFSEEVRRLFDLYPDVTSMTLLLEDSSAYLYADRVIKTGRL
LYSKPEKVTGNVLVRSIRNPESGDVTGRLYLTFDKPPTLVETQQDHYLATFAFDYYGRKLFHQGGRRFPHLEAEVKKAIK
ADRAADLSNLSKAYRMQYNRSGDLLAYVAVRKSYLLAEAVRTVFVYGLVSLLLAWLLLQLLFRVFRNYIQQVSEITDTVE
MVAAGDLSLTIDNSHMELELYHISEAINQMLASIKAYIDEVYVLEVEQRDAQMRALQSQINPHFLYNTLEYIRMYALSCQ
QEELADVIYAFASLLRNNISQDKMTTLKEELAFCEKYIYLYQMRYPDSFAYHVKIDESIADLAIPKFVIQPLVENYFVHG
IDYSRHDNALSIKALDETDHLLIQVLDNGRGISQERLADMEKRLQEHQTTGNSSIGLQNVYLRLFHHFRDRVSWSMAKEP
NGGFIIQIRIRKDA

Sequences:

>Translated_574_residues
MSVKTLGRYVTNHFKQGFLINRLMKLYSLLIVSFFTLSAIGLSSYSISSTYKRVDAEAQMRLEETLGRLQSQNDITLRVL
DQLVGRSEDYHNLYQYMTLTPNQYFSNVFEDWEKGKDTDLFSEEVRRLFDLYPDVTSMTLLLEDSSAYLYADRVIKTGRL
LYSKPEKVTGNVLVRSIRNPESGDVTGRLYLTFDKPPTLVETQQDHYLATFAFDYYGRKLFHQGGRRFPHLEAEVKKAIK
ADRAADLSNLSKAYRMQYNRSGDLLAYVAVRKSYLLAEAVRTVFVYGLVSLLLAWLLLQLLFRVFRNYIQQVSEITDTVE
MVAAGDLSLTIDNSHMELELYHISEAINQMLASIKAYIDEVYVLEVEQRDAQMRALQSQINPHFLYNTLEYIRMYALSCQ
QEELADVIYAFASLLRNNISQDKMTTLKEELAFCEKYIYLYQMRYPDSFAYHVKIDESIADLAIPKFVIQPLVENYFVHG
IDYSRHDNALSIKALDETDHLLIQVLDNGRGISQERLADMEKRLQEHQTTGNSSIGLQNVYLRLFHHFRDRVSWSMAKEP
NGGFIIQIRIRKDA
>Mature_573_residues
SVKTLGRYVTNHFKQGFLINRLMKLYSLLIVSFFTLSAIGLSSYSISSTYKRVDAEAQMRLEETLGRLQSQNDITLRVLD
QLVGRSEDYHNLYQYMTLTPNQYFSNVFEDWEKGKDTDLFSEEVRRLFDLYPDVTSMTLLLEDSSAYLYADRVIKTGRLL
YSKPEKVTGNVLVRSIRNPESGDVTGRLYLTFDKPPTLVETQQDHYLATFAFDYYGRKLFHQGGRRFPHLEAEVKKAIKA
DRAADLSNLSKAYRMQYNRSGDLLAYVAVRKSYLLAEAVRTVFVYGLVSLLLAWLLLQLLFRVFRNYIQQVSEITDTVEM
VAAGDLSLTIDNSHMELELYHISEAINQMLASIKAYIDEVYVLEVEQRDAQMRALQSQINPHFLYNTLEYIRMYALSCQQ
EELADVIYAFASLLRNNISQDKMTTLKEELAFCEKYIYLYQMRYPDSFAYHVKIDESIADLAIPKFVIQPLVENYFVHGI
DYSRHDNALSIKALDETDHLLIQVLDNGRGISQERLADMEKRLQEHQTTGNSSIGLQNVYLRLFHHFRDRVSWSMAKEPN
GGFIIQIRIRKDA

Specific function: Member of the two-component regulatory system yesM/yesN. Probably activates yesN by phosphorylation [H]

COG id: COG2972

COG function: function code T; Predicted signal transduction protein with a C-terminal ATPase domain

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788723, Length=176, Percent_Identity=34.6590909090909, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1788446, Length=201, Percent_Identity=25.3731343283582, Blast_Score=79, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR010559
- InterPro:   IPR005467 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF06580 His_kinase [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 66609; Mature: 66478

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: PS50885 HAMP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVKTLGRYVTNHFKQGFLINRLMKLYSLLIVSFFTLSAIGLSSYSISSTYKRVDAEAQM
CCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
RLEETLGRLQSQNDITLRVLDQLVGRSEDYHNLYQYMTLTPNQYFSNVFEDWEKGKDTDL
HHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCH
FSEEVRRLFDLYPDVTSMTLLLEDSSAYLYADRVIKTGRLLYSKPEKVTGNVLVRSIRNP
HHHHHHHHHHHCCCHHHEEEEEECCCCEEEHHHHHHHCHHHCCCCCHHHHHHHHHHCCCC
ESGDVTGRLYLTFDKPPTLVETQQDHYLATFAFDYYGRKLFHQGGRRFPHLEAEVKKAIK
CCCCCEEEEEEEECCCCCCCCCCCCCEEEEEHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
ADRAADLSNLSKAYRMQYNRSGDLLAYVAVRKSYLLAEAVRTVFVYGLVSLLLAWLLLQL
HHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFRVFRNYIQQVSEITDTVEMVAAGDLSLTIDNSHMELELYHISEAINQMLASIKAYIDE
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHH
VYVLEVEQRDAQMRALQSQINPHFLYNTLEYIRMYALSCQQEELADVIYAFASLLRNNIS
EEEEEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCC
QDKMTTLKEELAFCEKYIYLYQMRYPDSFAYHVKIDESIADLAIPKFVIQPLVENYFVHG
HHHHHHHHHHHHHHHHHHHHHEEECCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHEEC
IDYSRHDNALSIKALDETDHLLIQVLDNGRGISQERLADMEKRLQEHQTTGNSSIGLQNV
CCCCCCCCEEEEEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHH
YLRLFHHFRDRVSWSMAKEPNGGFIIQIRIRKDA
HHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCC
>Mature Secondary Structure 
SVKTLGRYVTNHFKQGFLINRLMKLYSLLIVSFFTLSAIGLSSYSISSTYKRVDAEAQM
CHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
RLEETLGRLQSQNDITLRVLDQLVGRSEDYHNLYQYMTLTPNQYFSNVFEDWEKGKDTDL
HHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCH
FSEEVRRLFDLYPDVTSMTLLLEDSSAYLYADRVIKTGRLLYSKPEKVTGNVLVRSIRNP
HHHHHHHHHHHCCCHHHEEEEEECCCCEEEHHHHHHHCHHHCCCCCHHHHHHHHHHCCCC
ESGDVTGRLYLTFDKPPTLVETQQDHYLATFAFDYYGRKLFHQGGRRFPHLEAEVKKAIK
CCCCCEEEEEEEECCCCCCCCCCCCCEEEEEHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
ADRAADLSNLSKAYRMQYNRSGDLLAYVAVRKSYLLAEAVRTVFVYGLVSLLLAWLLLQL
HHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFRVFRNYIQQVSEITDTVEMVAAGDLSLTIDNSHMELELYHISEAINQMLASIKAYIDE
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHH
VYVLEVEQRDAQMRALQSQINPHFLYNTLEYIRMYALSCQQEELADVIYAFASLLRNNIS
EEEEEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCC
QDKMTTLKEELAFCEKYIYLYQMRYPDSFAYHVKIDESIADLAIPKFVIQPLVENYFVHG
HHHHHHHHHHHHHHHHHHHHHEEECCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHEEC
IDYSRHDNALSIKALDETDHLLIQVLDNGRGISQERLADMEKRLQEHQTTGNSSIGLQNV
CCCCCCCCEEEEEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHH
YLRLFHHFRDRVSWSMAKEPNGGFIIQIRIRKDA
HHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]