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The map label for this gene is ispA [H]

Identifier: 19746452

GI number: 19746452

Start: 1248425

End: 1249297

Strand: Reverse

Name: ispA [H]

Synonym: spyM18_1516

Alternate gene names: 19746452

Gene position: 1249297-1248425 (Counterclockwise)

Preceding gene: 19746453

Following gene: 19746451

Centisome position: 65.93

GC content: 40.89

Gene sequence:

>873_bases
ATGGACAAATTAGCTAGAATTGACGAAGCCATTCGTCGCTACTATAAGACGACTAGTAACGGTGTATCTGAAGAGTTGAT
TGATGCTATCTTGTATTCTGTTGACAGTGGTGGCAAGCGCATTCGCCCACTTATCTTATTAGAGATGATTGAGGGATTTG
GGGTATCGTTACAGAATGCTCATTTTGATTTGGCTGCAGCCCTTGAAATGATTCATACAGGAAGTCTGATTCACGATGAT
TTGCCAGCCATGGATAATGATGATTACCGACGTGGTAGACTGACCAATCACAAACAATTTGGAGAGGCTACTGCTATTTT
GGCGGGAGATAGCTTATTTTTAGACCCCTTTGGGTTAATAGCTCAAGCTGAATTAAATAGCGAGGTTAAAGTAGCCTTAA
TCCAAGAACTTTCCCTAGCTTCAGGAACTTTTGGCATGGTTGGTGGTCAGATGCTAGATATGAAAGGGGAAAATCAAGCT
TTGAGTCTCTCTCAGTTGTCACTGATTCACCTCAATAAAACCGGAAAATTATTAACTTTTCCTTTTAAAGCAGCAGCTCT
TGTAACAGAACAGGCTATTACTGTTCGTCAACAACTAGAGCAGGCGGGAATGCTCATCGGGCATGCCTTTCAGATTAGGG
ATGATATTTTAGACGTGACAGCTAGCTTTGAAGATCTTGGAAAAACGCCTAAAAAGGACTTATTCGCAGAAAAAGCTACT
TACCCAAGTTTACTGGGGTTAGAAGCCTCTTACCAACTGTTGACAGAGAGTTTAGATCAGGCTTTGACGATTTTTCAGAC
ACTAGAAAGCGATGTAGGCTTTAAGCCTCAAATAATTACAAAACTGATAGAAGGGTTACGACTTAATGCCTAA

Upstream 100 bases:

>100_bases
TGCTTCTCTCAAAAGAACTTCAAAAGACCTTACAAGCGGCAGAAAAAACACTCGTCAAAGTGATGCAAGCTGATGGCACA
GAAGTAGATATGGATGATTA

Downstream 100 bases:

>100_bases
AGAAAGAGTAGATGTGTTAGCCTATAAGCAAGGATTATTTGAGACCAGAGAGCAAGCTAAGCGTGGTGTCATGGCAGGCT
TAGTGGTCTCTGTGATTAAT

Product: geranyltranstransferase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MDKLARIDEAIRRYYKTTSNGVSEELIDAILYSVDSGGKRIRPLILLEMIEGFGVSLQNAHFDLAAALEMIHTGSLIHDD
LPAMDNDDYRRGRLTNHKQFGEATAILAGDSLFLDPFGLIAQAELNSEVKVALIQELSLASGTFGMVGGQMLDMKGENQA
LSLSQLSLIHLNKTGKLLTFPFKAAALVTEQAITVRQQLEQAGMLIGHAFQIRDDILDVTASFEDLGKTPKKDLFAEKAT
YPSLLGLEASYQLLTESLDQALTIFQTLESDVGFKPQIITKLIEGLRLNA

Sequences:

>Translated_290_residues
MDKLARIDEAIRRYYKTTSNGVSEELIDAILYSVDSGGKRIRPLILLEMIEGFGVSLQNAHFDLAAALEMIHTGSLIHDD
LPAMDNDDYRRGRLTNHKQFGEATAILAGDSLFLDPFGLIAQAELNSEVKVALIQELSLASGTFGMVGGQMLDMKGENQA
LSLSQLSLIHLNKTGKLLTFPFKAAALVTEQAITVRQQLEQAGMLIGHAFQIRDDILDVTASFEDLGKTPKKDLFAEKAT
YPSLLGLEASYQLLTESLDQALTIFQTLESDVGFKPQIITKLIEGLRLNA
>Mature_290_residues
MDKLARIDEAIRRYYKTTSNGVSEELIDAILYSVDSGGKRIRPLILLEMIEGFGVSLQNAHFDLAAALEMIHTGSLIHDD
LPAMDNDDYRRGRLTNHKQFGEATAILAGDSLFLDPFGLIAQAELNSEVKVALIQELSLASGTFGMVGGQMLDMKGENQA
LSLSQLSLIHLNKTGKLLTFPFKAAALVTEQAITVRQQLEQAGMLIGHAFQIRDDILDVTASFEDLGKTPKKDLFAEKAT
YPSLLGLEASYQLLTESLDQALTIFQTLESDVGFKPQIITKLIEGLRLNA

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=234, Percent_Identity=30.3418803418803, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI1786623, Length=243, Percent_Identity=42.3868312757202, Blast_Score=138, Evalue=4e-34,
Organism=Escherichia coli, GI1789578, Length=215, Percent_Identity=30.6976744186047, Blast_Score=96, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24651612, Length=262, Percent_Identity=30.1526717557252, Blast_Score=89, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 31813; Mature: 31813

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKLARIDEAIRRYYKTTSNGVSEELIDAILYSVDSGGKRIRPLILLEMIEGFGVSLQNA
CCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEECCC
HFDLAAALEMIHTGSLIHDDLPAMDNDDYRRGRLTNHKQFGEATAILAGDSLFLDPFGLI
HHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCCCCHHHCCEEEEEECCCEEECCHHHH
AQAELNSEVKVALIQELSLASGTFGMVGGQMLDMKGENQALSLSQLSLIHLNKTGKLLTF
HHHCCCCCHHHHHHHHHHHCCCCHHHCCCEEEECCCCCCEEEHHHEEEEEECCCCCEEEE
PFKAAALVTEQAITVRQQLEQAGMLIGHAFQIRDDILDVTASFEDLGKTPKKDLFAEKAT
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCHHHHHHHHCC
YPSLLGLEASYQLLTESLDQALTIFQTLESDVGFKPQIITKLIEGLRLNA
CCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDKLARIDEAIRRYYKTTSNGVSEELIDAILYSVDSGGKRIRPLILLEMIEGFGVSLQNA
CCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEECCC
HFDLAAALEMIHTGSLIHDDLPAMDNDDYRRGRLTNHKQFGEATAILAGDSLFLDPFGLI
HHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCCCCHHHCCEEEEEECCCEEECCHHHH
AQAELNSEVKVALIQELSLASGTFGMVGGQMLDMKGENQALSLSQLSLIHLNKTGKLLTF
HHHCCCCCHHHHHHHHHHHCCCCHHHCCCEEEECCCCCCEEEHHHEEEEEECCCCCEEEE
PFKAAALVTEQAITVRQQLEQAGMLIGHAFQIRDDILDVTASFEDLGKTPKKDLFAEKAT
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCHHHHHHHHCC
YPSLLGLEASYQLLTESLDQALTIFQTLESDVGFKPQIITKLIEGLRLNA
CCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9515931 [H]