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The map label for this gene is zosA [H]

Identifier: 19746387

GI number: 19746387

Start: 1203967

End: 1205829

Strand: Reverse

Name: zosA [H]

Synonym: spyM18_1443

Alternate gene names: 19746387

Gene position: 1205829-1203967 (Counterclockwise)

Preceding gene: 19746388

Following gene: 19746386

Centisome position: 63.63

GC content: 40.69

Gene sequence:

>1863_bases
ATGACAATCAGACAATGGATGGCAGACCATCTTCATTTGATGGAGACTTTAGCGTGTTTGGTATTAATAATAATTGGCCT
AGCCTTTTTACACTCATTTCCACAAGTGGCTTCCGCTATTTTCATTACAGCCTTCTTGATTGGAGGATATGCGTCTGCAA
AAACGGGTATATTGGATTTGGTGAAGAACAAACACTTGTCAGTGGATATTTTGATGATTTTGGCAGCTATCGGTGCTGGA
ATTATCGGCTATTGGCTGGAGGGTGCTCTGCTTATTTTTATCTTTTCGTTGTCCAATGCGCTTGAAGAAATGGCCATGGA
AAAAAGTAAGGATGCTATTTCAGCCTTGATGTCCTTGACGCCAGATACAGCTCGTCAATACCAAGAAGATGGCCATATTT
TAGAAGTTGAGACCAGATCCTTGAGTGTTGGTGACCGTTTACAAGTTCGTAAAGGCGAAGCTGTTCCAATTGACGGGCAG
TTGCTTAGTCCTTTTGGTCAATTTGATGAATCTATGGTCACTGGTGAGCCTATCACTGTTGATAAGGCAGAAGGCCAGGA
TCTGATTGGGGGAACCATTAACCAAGGACAAACCATAGATATGTTGGTTACTATTGAAAATGACGATACTCTCTTTGCCA
AGATTATTAATCTGGTGGAATCTGCCCAAGAAAAGAAAAGCAAAACCGCCACCTTTATCGAAAGCTTAGAAGATGGTTAT
GTCAAATTTGTGCTCGTCCTTATTCCTGCCTTTATCCTCTTTAGCCACTTTGTGCTTTCTTGGACTTGGTTGGCTGCTTT
TTACCGAGGGATGATTCTCTTAACAGTAGCTTCACCATGTGCCCTAATTGCCAGTTCCACACCTGCTAGCTTGGCTGCTA
TTTCTCGTGCAGCCAGAAAGGGATTGATTATCAAAGGAGGGGATATTGTCGATAACATGGGAGATATTAAGGCTGTTGTC
ATGGATAAAACGGGAACGCTCACCCAAGGAAAACCTTCTGTTGTGAATGCTCATTATTTGGAAGATGAGTTGCTCGTGAA
TAGACTGGTAAAAGGAGCAGAGGCTGCTAGTACCCATCCTATTTCTAAAGCCCTTCTTGAATACACTGAAAAATTGGAGC
CACTGACCTTTGACCACTTAGAAGAAATTTCTGGGAAAGGTTTTCAGGGCTTCTATCAAGGGCAAGAATGGCGAATTGGC
AAGAAAACCTTCATTTTGGAAAAGGTTCAAGACCTATCAGCTTTTGAAGAAACTATTCAAGTGGAAGAAAATCAAGGGAA
AACCCTAATCTTTGTTTCACGTGACCATCAATTGATAGCTTACTATGCCCTCTTGGATGATATCAAAATAGAATCAAAAC
GTGCTATTAAGTCTCTTCATGCCATGGGAATCAAAACAGTCATGTTAACAGGTGACCAAGAACGAACCGCCAATTATGTG
GCACAAAAACTTGGTATTGATGAAGTGGTAGCCAACTGTATGCCTCAAGATAAGGTGGCTAAGTTAGCAGAATTAAAGAC
CAAATATGGTTTTGTGGCCATGGTAGGAGATGGTATTAATGATGCTCCTGCCCTTGCTCAAGCAGATGTTTCTTATGCTA
TTGGATCAGGAACAGATATTGCAATGGAAAGTGCAGACAGTGTGATTATGGATGACTTGACTCGTATTCCATTTTCGATT
CAACTTTCCCGCAAAATGAAGACCATTATCAAACAAAATATTGTTTTTGCCTTATCTGTGATTACCTTATTGATTTTAGC
CAATGTTTTTCAGGTAGTTAACTTGCCGCTTGGTGTTGTTGGACACGAAGGCTCAACGATTTTAGTGATTTTAAATGGCT
TGCGTTTACTTTCTTTTAAATAA

Upstream 100 bases:

>100_bases
TATTTAGAATGTTTCTAAATTACTTGACTTATTTATTTAGAATTATTATAATTAATATATCTTAAAGATTGAATAACTTT
TAATTGCGAGGGAACTAAAA

Downstream 100 bases:

>100_bases
TTTAGAAACTTGCTTGAAAACTTGAAAGTGTTTATAATAATACTAAGACTTATGAAAGAGAAAACCGCCGTATGTTTACT
ATTATGATCATTGGTTTAGC

Product: heavy metal-transporting ATPase

Products: NA

Alternate protein names: Zn(2+)-translocating P-type ATPase [H]

Number of amino acids: Translated: 620; Mature: 619

Protein sequence:

>620_residues
MTIRQWMADHLHLMETLACLVLIIIGLAFLHSFPQVASAIFITAFLIGGYASAKTGILDLVKNKHLSVDILMILAAIGAG
IIGYWLEGALLIFIFSLSNALEEMAMEKSKDAISALMSLTPDTARQYQEDGHILEVETRSLSVGDRLQVRKGEAVPIDGQ
LLSPFGQFDESMVTGEPITVDKAEGQDLIGGTINQGQTIDMLVTIENDDTLFAKIINLVESAQEKKSKTATFIESLEDGY
VKFVLVLIPAFILFSHFVLSWTWLAAFYRGMILLTVASPCALIASSTPASLAAISRAARKGLIIKGGDIVDNMGDIKAVV
MDKTGTLTQGKPSVVNAHYLEDELLVNRLVKGAEAASTHPISKALLEYTEKLEPLTFDHLEEISGKGFQGFYQGQEWRIG
KKTFILEKVQDLSAFEETIQVEENQGKTLIFVSRDHQLIAYYALLDDIKIESKRAIKSLHAMGIKTVMLTGDQERTANYV
AQKLGIDEVVANCMPQDKVAKLAELKTKYGFVAMVGDGINDAPALAQADVSYAIGSGTDIAMESADSVIMDDLTRIPFSI
QLSRKMKTIIKQNIVFALSVITLLILANVFQVVNLPLGVVGHEGSTILVILNGLRLLSFK

Sequences:

>Translated_620_residues
MTIRQWMADHLHLMETLACLVLIIIGLAFLHSFPQVASAIFITAFLIGGYASAKTGILDLVKNKHLSVDILMILAAIGAG
IIGYWLEGALLIFIFSLSNALEEMAMEKSKDAISALMSLTPDTARQYQEDGHILEVETRSLSVGDRLQVRKGEAVPIDGQ
LLSPFGQFDESMVTGEPITVDKAEGQDLIGGTINQGQTIDMLVTIENDDTLFAKIINLVESAQEKKSKTATFIESLEDGY
VKFVLVLIPAFILFSHFVLSWTWLAAFYRGMILLTVASPCALIASSTPASLAAISRAARKGLIIKGGDIVDNMGDIKAVV
MDKTGTLTQGKPSVVNAHYLEDELLVNRLVKGAEAASTHPISKALLEYTEKLEPLTFDHLEEISGKGFQGFYQGQEWRIG
KKTFILEKVQDLSAFEETIQVEENQGKTLIFVSRDHQLIAYYALLDDIKIESKRAIKSLHAMGIKTVMLTGDQERTANYV
AQKLGIDEVVANCMPQDKVAKLAELKTKYGFVAMVGDGINDAPALAQADVSYAIGSGTDIAMESADSVIMDDLTRIPFSI
QLSRKMKTIIKQNIVFALSVITLLILANVFQVVNLPLGVVGHEGSTILVILNGLRLLSFK
>Mature_619_residues
TIRQWMADHLHLMETLACLVLIIIGLAFLHSFPQVASAIFITAFLIGGYASAKTGILDLVKNKHLSVDILMILAAIGAGI
IGYWLEGALLIFIFSLSNALEEMAMEKSKDAISALMSLTPDTARQYQEDGHILEVETRSLSVGDRLQVRKGEAVPIDGQL
LSPFGQFDESMVTGEPITVDKAEGQDLIGGTINQGQTIDMLVTIENDDTLFAKIINLVESAQEKKSKTATFIESLEDGYV
KFVLVLIPAFILFSHFVLSWTWLAAFYRGMILLTVASPCALIASSTPASLAAISRAARKGLIIKGGDIVDNMGDIKAVVM
DKTGTLTQGKPSVVNAHYLEDELLVNRLVKGAEAASTHPISKALLEYTEKLEPLTFDHLEEISGKGFQGFYQGQEWRIGK
KTFILEKVQDLSAFEETIQVEENQGKTLIFVSRDHQLIAYYALLDDIKIESKRAIKSLHAMGIKTVMLTGDQERTANYVA
QKLGIDEVVANCMPQDKVAKLAELKTKYGFVAMVGDGINDAPALAQADVSYAIGSGTDIAMESADSVIMDDLTRIPFSIQ
LSRKMKTIIKQNIVFALSVITLLILANVFQVVNLPLGVVGHEGSTILVILNGLRLLSFK

Specific function: Couples the hydrolysis of ATP with the transport of zinc into the cell [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=585, Percent_Identity=31.965811965812, Blast_Score=240, Evalue=4e-63,
Organism=Homo sapiens, GI55743073, Length=546, Percent_Identity=32.0512820512821, Blast_Score=224, Evalue=2e-58,
Organism=Homo sapiens, GI115529486, Length=602, Percent_Identity=30.2325581395349, Blast_Score=223, Evalue=6e-58,
Organism=Homo sapiens, GI51944966, Length=310, Percent_Identity=26.4516129032258, Blast_Score=77, Evalue=6e-14,
Organism=Homo sapiens, GI209413709, Length=234, Percent_Identity=26.9230769230769, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI4502285, Length=234, Percent_Identity=26.9230769230769, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI24638454, Length=234, Percent_Identity=26.9230769230769, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI22748667, Length=245, Percent_Identity=27.3469387755102, Blast_Score=71, Evalue=4e-12,
Organism=Homo sapiens, GI48762689, Length=184, Percent_Identity=29.8913043478261, Blast_Score=71, Evalue=4e-12,
Organism=Homo sapiens, GI48762691, Length=184, Percent_Identity=29.8913043478261, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI48762687, Length=184, Percent_Identity=29.8913043478261, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI48762685, Length=184, Percent_Identity=29.8913043478261, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI4502271, Length=369, Percent_Identity=25.7452574525745, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI237681111, Length=249, Percent_Identity=26.1044176706827, Blast_Score=67, Evalue=5e-11,
Organism=Homo sapiens, GI237681109, Length=249, Percent_Identity=26.1044176706827, Blast_Score=67, Evalue=6e-11,
Organism=Homo sapiens, GI21361181, Length=249, Percent_Identity=26.1044176706827, Blast_Score=67, Evalue=6e-11,
Organism=Escherichia coli, GI1789879, Length=625, Percent_Identity=33.92, Blast_Score=313, Evalue=1e-86,
Organism=Escherichia coli, GI1786691, Length=550, Percent_Identity=32.1818181818182, Blast_Score=251, Evalue=9e-68,
Organism=Escherichia coli, GI1786914, Length=508, Percent_Identity=26.7716535433071, Blast_Score=128, Evalue=9e-31,
Organism=Escherichia coli, GI2367363, Length=585, Percent_Identity=25.2991452991453, Blast_Score=114, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17556548, Length=177, Percent_Identity=38.9830508474576, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17559224, Length=271, Percent_Identity=26.9372693726937, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320475, Length=561, Percent_Identity=30.4812834224599, Blast_Score=203, Evalue=8e-53,
Organism=Saccharomyces cerevisiae, GI6319772, Length=608, Percent_Identity=24.0131578947368, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6321430, Length=529, Percent_Identity=24.7637051039698, Blast_Score=120, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6325221, Length=590, Percent_Identity=23.3898305084746, Blast_Score=116, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6320243, Length=273, Percent_Identity=28.5714285714286, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320244, Length=273, Percent_Identity=28.5714285714286, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320245, Length=273, Percent_Identity=28.2051282051282, Blast_Score=78, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6321271, Length=202, Percent_Identity=28.7128712871287, Blast_Score=74, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6321432, Length=182, Percent_Identity=31.8681318681319, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221329854, Length=190, Percent_Identity=38.4210526315789, Blast_Score=124, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR001366
- InterPro:   IPR006404
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR000150 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00702 Hydrolase [H]

EC number: =3.6.3.5 [H]

Molecular weight: Translated: 67657; Mature: 67526

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS00154 ATPASE_E1_E2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIRQWMADHLHLMETLACLVLIIIGLAFLHSFPQVASAIFITAFLIGGYASAKTGILDL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
VKNKHLSVDILMILAAIGAGIIGYWLEGALLIFIFSLSNALEEMAMEKSKDAISALMSLT
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PDTARQYQEDGHILEVETRSLSVGDRLQVRKGEAVPIDGQLLSPFGQFDESMVTGEPITV
CHHHHHHHCCCCEEEEEECCCCCCCCEEECCCCCCCCCCHHHCCHHHHCCCCCCCCCEEE
DKAEGQDLIGGTINQGQTIDMLVTIENDDTLFAKIINLVESAQEKKSKTATFIESLEDGY
ECCCCCCCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VKFVLVLIPAFILFSHFVLSWTWLAAFYRGMILLTVASPCALIASSTPASLAAISRAARK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEHHCCHHHHCCCCCHHHHHHHHHHHC
GLIIKGGDIVDNMGDIKAVVMDKTGTLTQGKPSVVNAHYLEDELLVNRLVKGAEAASTHP
CEEEECCCHHCCCCCEEEEEEECCCCCCCCCCCCEEHHHHHHHHHHHHHHCCCCCCCCCH
ISKALLEYTEKLEPLTFDHLEEISGKGFQGFYQGQEWRIGKKTFILEKVQDLSAFEETIQ
HHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHH
VEENQGKTLIFVSRDHQLIAYYALLDDIKIESKRAIKSLHAMGIKTVMLTGDQERTANYV
EECCCCCEEEEEECCCCEEEHHHHHHHHCHHHHHHHHHHHHCCCEEEEEECCHHHHHHHH
AQKLGIDEVVANCMPQDKVAKLAELKTKYGFVAMVGDGINDAPALAQADVSYAIGSGTDI
HHHCCHHHHHHHCCCHHHHHHHHHHHHHCCEEEEECCCCCCCCHHHHCCCCEECCCCCCH
AMESADSVIMDDLTRIPFSIQLSRKMKTIIKQNIVFALSVITLLILANVFQVVNLPLGVV
HHHCCCHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
GHEGSTILVILNGLRLLSFK
CCCCCEEEEEEECCCHHCCC
>Mature Secondary Structure 
TIRQWMADHLHLMETLACLVLIIIGLAFLHSFPQVASAIFITAFLIGGYASAKTGILDL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
VKNKHLSVDILMILAAIGAGIIGYWLEGALLIFIFSLSNALEEMAMEKSKDAISALMSLT
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PDTARQYQEDGHILEVETRSLSVGDRLQVRKGEAVPIDGQLLSPFGQFDESMVTGEPITV
CHHHHHHHCCCCEEEEEECCCCCCCCEEECCCCCCCCCCHHHCCHHHHCCCCCCCCCEEE
DKAEGQDLIGGTINQGQTIDMLVTIENDDTLFAKIINLVESAQEKKSKTATFIESLEDGY
ECCCCCCCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VKFVLVLIPAFILFSHFVLSWTWLAAFYRGMILLTVASPCALIASSTPASLAAISRAARK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEHHCCHHHHCCCCCHHHHHHHHHHHC
GLIIKGGDIVDNMGDIKAVVMDKTGTLTQGKPSVVNAHYLEDELLVNRLVKGAEAASTHP
CEEEECCCHHCCCCCEEEEEEECCCCCCCCCCCCEEHHHHHHHHHHHHHHCCCCCCCCCH
ISKALLEYTEKLEPLTFDHLEEISGKGFQGFYQGQEWRIGKKTFILEKVQDLSAFEETIQ
HHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHH
VEENQGKTLIFVSRDHQLIAYYALLDDIKIESKRAIKSLHAMGIKTVMLTGDQERTANYV
EECCCCCEEEEEECCCCEEEHHHHHHHHCHHHHHHHHHHHHCCCEEEEEECCHHHHHHHH
AQKLGIDEVVANCMPQDKVAKLAELKTKYGFVAMVGDGINDAPALAQADVSYAIGSGTDI
HHHCCHHHHHHHCCCHHHHHHHHHHHHHCCEEEEECCCCCCCCHHHHCCCCEECCCCCCH
AMESADSVIMDDLTRIPFSIQLSRKMKTIIKQNIVFALSVITLLILANVFQVVNLPLGVV
HHHCCCHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
GHEGSTILVILNGLRLLSFK
CCCCCEEEEEEECCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]