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The map label for this gene is uvrB [H]

Identifier: 19746295

GI number: 19746295

Start: 1105066

End: 1107057

Strand: Reverse

Name: uvrB [H]

Synonym: spyM18_1326

Alternate gene names: 19746295

Gene position: 1107057-1105066 (Counterclockwise)

Preceding gene: 19746298

Following gene: 19746294

Centisome position: 58.42

GC content: 39.16

Gene sequence:

>1992_bases
ATGATTGATAAACGTGATGATAAACCATTTAAACTAAAATCAAAGTATAAACCGTCTGGTGATCAGCCACAAGCTATTGA
AAGCCTAGTTGATAATATCGAGGGCGGAGAAAAAGCTCAGATTCTCCTAGGTGCTACAGGAACGGGAAAAACATACACCA
TGAGCCAAGTAATTAGTAAAGTAAATAAACCTACCTTAGTGATAGCTCACAATAAAACCTTAGCAGGACAATTATATGGT
GAATTTAAAGAATTTTTTCCAGACAATGCTGTGGAATATTTTGTTTCCTATTATGATTACTACCAACCTGAAGCATATGT
CCCATCAAGCGACACCTATATCGAAAAAGATAGTTCAGTCAATGATGAAATCGATAAACTTCGCCATTCAGCCACCTCTT
CTTTACTTGAGCGTAACGATGTCATAGTGGTAGCTTCTGTATCTTGTATTTATGGACTAGGTTCGCCAAAAGAGTACGCA
GATTCAGCAGTCAGTCTACGTCCAGGTCAGGAGATATCACGTGACACTTTGCTAAATCAATTAGTAGATATTCAATTTGA
GCGTAATGATATTGATTTTCAACGCGGCTGTTTTCGTGTACGTGGCGATGTTGTTGAGGTCTTTCCAGCATCCAGGGATG
AACATGCTTTTCGGGTGGAATTTTTCGGGGATGAGATTGACCGTATATGTGAAATCGAAAGTTTAACTGGGAAAACTATT
GGAGAAGTTGACCATTTGGTTTTATTTCCAGCTACTCACTTTGTAACAAATGATGAGCATATGGAGCAATCAATAGCCAA
AATTCAAGCAGAGTTAGCAGAGCAGTTACAGTTATTTGAATCTGAAGGTAAACTACTAGAAGCACAGCGATTACGCCAAA
GAACGGAATATGATATTGAAATGTTACGTGAAATGGGCTATACTAGCGGAGTCGAAAACTATTCCCGTCATATGGATGGC
AGGTCACCAGGAGAACCTCCTTATACCTTGTTAGATTTCTTCCCAGAAGATTTTTTAATTATGATTGATGAAAGTCACAT
GACAATGGGACAAATCAAAGGCATGTATAATGGTGACCAAGCCAGAAAACAAATGCTAGTTGACTATGGTTTTCGATTGC
CATCAGCTCTTGATAATCGTCCCTTAAGACGCAAGGAATTTGAAAGTCATGTGCACCAAATTGTCTATGTTTCAGCAACG
CCTGGTGAATACGAAATGTCACAGACTAATACAATTATTGAGCAAATTATTCGTCCGACTGGGCTACTTGATCCTGAAAT
TGATGTAAGGCCAAGTATGGGGCAAATGGATGATTTGTTGGGAGAAATTAACCAGCGCGTAGCGCGCGATGAACGGACGT
TCATCACAACCTTAACTAAAAAAATGGCAGAAGATTTGACTGATTATCTAAAAGAGATGGGTGTCAAGGTCAAGTATATG
CACAGTGATATTAAAACCTTAGAGCGAACAGAAATTATTCGTGATTTACGACTTGGTGTTTTTGATGTCTTGATTGGAAT
CAATCTGCTCCGTGAAGGGATTGATGTGCCAGAAGTTAGTCTTGTAGCCATTTTGGATGCTGATAAAGAGGGTTTCCTCC
GTAATGAACGCGGCTTGATTCAGACCATCGGTAGAGCAGCTCGAAACGTAGATGGTCATGTCATTATGTATGCGGACAAG
ATGACAGATTCTATGCAGCGAGCTATTGACGAAACGGCTCGTCGTCGTGAGATTCAAATAGCATATAACAAAGCGCACGG
CATCGTTCCACAAACTATAAAAAAAGACATCAGAGGTTTTATTAGTATAAGTAAAACAAGCCACAATGATATATCAAAAG
AAGAGATGGATTATGAAAGTATGTCAAGAGGAGAACGAAAAGAAGCGATCAATGCTCTGCAAAAACAAATGCAAGAGGCA
GCTGAATTACTTGATTTCGAATTGGCAGCTCAAATGCGAGACTTGATTTTAGAACTTAAATTAATGGACTAG

Upstream 100 bases:

>100_bases
AACATGTAAATGACATGTTTTTTTACGCTTATTGGAGGTGATTCTGGCTTATCTATGTTAAAATAGTCTATAAGAGAGTA
AGACTATTAGAGGGTATAAA

Downstream 100 bases:

>100_bases
GTTTTGAATAAAGCTTATATTATACTTATAACATATATAAGTTAAAGTCAAATAATTCTTTTTATTAGGATAATTTTAAG
TTAACTTTTTAAGGTAAAGA

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 663; Mature: 663

Protein sequence:

>663_residues
MIDKRDDKPFKLKSKYKPSGDQPQAIESLVDNIEGGEKAQILLGATGTGKTYTMSQVISKVNKPTLVIAHNKTLAGQLYG
EFKEFFPDNAVEYFVSYYDYYQPEAYVPSSDTYIEKDSSVNDEIDKLRHSATSSLLERNDVIVVASVSCIYGLGSPKEYA
DSAVSLRPGQEISRDTLLNQLVDIQFERNDIDFQRGCFRVRGDVVEVFPASRDEHAFRVEFFGDEIDRICEIESLTGKTI
GEVDHLVLFPATHFVTNDEHMEQSIAKIQAELAEQLQLFESEGKLLEAQRLRQRTEYDIEMLREMGYTSGVENYSRHMDG
RSPGEPPYTLLDFFPEDFLIMIDESHMTMGQIKGMYNGDQARKQMLVDYGFRLPSALDNRPLRRKEFESHVHQIVYVSAT
PGEYEMSQTNTIIEQIIRPTGLLDPEIDVRPSMGQMDDLLGEINQRVARDERTFITTLTKKMAEDLTDYLKEMGVKVKYM
HSDIKTLERTEIIRDLRLGVFDVLIGINLLREGIDVPEVSLVAILDADKEGFLRNERGLIQTIGRAARNVDGHVIMYADK
MTDSMQRAIDETARRREIQIAYNKAHGIVPQTIKKDIRGFISISKTSHNDISKEEMDYESMSRGERKEAINALQKQMQEA
AELLDFELAAQMRDLILELKLMD

Sequences:

>Translated_663_residues
MIDKRDDKPFKLKSKYKPSGDQPQAIESLVDNIEGGEKAQILLGATGTGKTYTMSQVISKVNKPTLVIAHNKTLAGQLYG
EFKEFFPDNAVEYFVSYYDYYQPEAYVPSSDTYIEKDSSVNDEIDKLRHSATSSLLERNDVIVVASVSCIYGLGSPKEYA
DSAVSLRPGQEISRDTLLNQLVDIQFERNDIDFQRGCFRVRGDVVEVFPASRDEHAFRVEFFGDEIDRICEIESLTGKTI
GEVDHLVLFPATHFVTNDEHMEQSIAKIQAELAEQLQLFESEGKLLEAQRLRQRTEYDIEMLREMGYTSGVENYSRHMDG
RSPGEPPYTLLDFFPEDFLIMIDESHMTMGQIKGMYNGDQARKQMLVDYGFRLPSALDNRPLRRKEFESHVHQIVYVSAT
PGEYEMSQTNTIIEQIIRPTGLLDPEIDVRPSMGQMDDLLGEINQRVARDERTFITTLTKKMAEDLTDYLKEMGVKVKYM
HSDIKTLERTEIIRDLRLGVFDVLIGINLLREGIDVPEVSLVAILDADKEGFLRNERGLIQTIGRAARNVDGHVIMYADK
MTDSMQRAIDETARRREIQIAYNKAHGIVPQTIKKDIRGFISISKTSHNDISKEEMDYESMSRGERKEAINALQKQMQEA
AELLDFELAAQMRDLILELKLMD
>Mature_663_residues
MIDKRDDKPFKLKSKYKPSGDQPQAIESLVDNIEGGEKAQILLGATGTGKTYTMSQVISKVNKPTLVIAHNKTLAGQLYG
EFKEFFPDNAVEYFVSYYDYYQPEAYVPSSDTYIEKDSSVNDEIDKLRHSATSSLLERNDVIVVASVSCIYGLGSPKEYA
DSAVSLRPGQEISRDTLLNQLVDIQFERNDIDFQRGCFRVRGDVVEVFPASRDEHAFRVEFFGDEIDRICEIESLTGKTI
GEVDHLVLFPATHFVTNDEHMEQSIAKIQAELAEQLQLFESEGKLLEAQRLRQRTEYDIEMLREMGYTSGVENYSRHMDG
RSPGEPPYTLLDFFPEDFLIMIDESHMTMGQIKGMYNGDQARKQMLVDYGFRLPSALDNRPLRRKEFESHVHQIVYVSAT
PGEYEMSQTNTIIEQIIRPTGLLDPEIDVRPSMGQMDDLLGEINQRVARDERTFITTLTKKMAEDLTDYLKEMGVKVKYM
HSDIKTLERTEIIRDLRLGVFDVLIGINLLREGIDVPEVSLVAILDADKEGFLRNERGLIQTIGRAARNVDGHVIMYADK
MTDSMQRAIDETARRREIQIAYNKAHGIVPQTIKKDIRGFISISKTSHNDISKEEMDYESMSRGERKEAINALQKQMQEA
AELLDFELAAQMRDLILELKLMD

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=664, Percent_Identity=56.4759036144578, Blast_Score=748, Evalue=0.0,
Organism=Escherichia coli, GI1787357, Length=235, Percent_Identity=24.6808510638298, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 75699; Mature: 75699

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDKRDDKPFKLKSKYKPSGDQPQAIESLVDNIEGGEKAQILLGATGTGKTYTMSQVISK
CCCCCCCCCCEECCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEEECCCCCEEEHHHHHHH
VNKPTLVIAHNKTLAGQLYGEFKEFFPDNAVEYFVSYYDYYQPEAYVPSSDTYIEKDSSV
CCCCEEEEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCC
NDEIDKLRHSATSSLLERNDVIVVASVSCIYGLGSPKEYADSAVSLRPGQEISRDTLLNQ
CHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHCCCCCHHHHCCCCCCCCCCHHHHHHHHHH
LVDIQFERNDIDFQRGCFRVRGDVVEVFPASRDEHAFRVEFFGDEIDRICEIESLTGKTI
HHHCEECCCCCCHHHHHHHHCCCEEEECCCCCCCCEEEEEECCHHHHHHHHHHHHCCCHH
GEVDHLVLFPATHFVTNDEHMEQSIAKIQAELAEQLQLFESEGKLLEAQRLRQRTEYDIE
HCCCCEEEECCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
MLREMGYTSGVENYSRHMDGRSPGEPPYTLLDFFPEDFLIMIDESHMTMGQIKGMYNGDQ
HHHHCCCCCCHHHHHHHCCCCCCCCCCHHHHHHCCCCEEEEEECCCCCHHHHCCCCCCHH
ARKQMLVDYGFRLPSALDNRPLRRKEFESHVHQIVYVSATPGEYEMSQTNTIIEQIIRPT
HHHHHHHHHCCCCCHHHCCCCCHHHHHHHHHHEEEEEEECCCCCCHHHHHHHHHHHHHHC
GLLDPEIDVRPSMGQMDDLLGEINQRVARDERTFITTLTKKMAEDLTDYLKEMGVKVKYM
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEH
HSDIKTLERTEIIRDLRLGVFDVLIGINLLREGIDVPEVSLVAILDADKEGFLRNERGLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCCCHHH
QTIGRAARNVDGHVIMYADKMTDSMQRAIDETARRREIQIAYNKAHGIVPQTIKKDIRGF
HHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHCEEEEEEECCCCCCHHHHHHHHHHH
ISISKTSHNDISKEEMDYESMSRGERKEAINALQKQMQEAAELLDFELAAQMRDLILELK
EEEECCCCCCCCHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMD
CCC
>Mature Secondary Structure
MIDKRDDKPFKLKSKYKPSGDQPQAIESLVDNIEGGEKAQILLGATGTGKTYTMSQVISK
CCCCCCCCCCEECCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEEECCCCCEEEHHHHHHH
VNKPTLVIAHNKTLAGQLYGEFKEFFPDNAVEYFVSYYDYYQPEAYVPSSDTYIEKDSSV
CCCCEEEEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCC
NDEIDKLRHSATSSLLERNDVIVVASVSCIYGLGSPKEYADSAVSLRPGQEISRDTLLNQ
CHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHCCCCCHHHHCCCCCCCCCCHHHHHHHHHH
LVDIQFERNDIDFQRGCFRVRGDVVEVFPASRDEHAFRVEFFGDEIDRICEIESLTGKTI
HHHCEECCCCCCHHHHHHHHCCCEEEECCCCCCCCEEEEEECCHHHHHHHHHHHHCCCHH
GEVDHLVLFPATHFVTNDEHMEQSIAKIQAELAEQLQLFESEGKLLEAQRLRQRTEYDIE
HCCCCEEEECCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
MLREMGYTSGVENYSRHMDGRSPGEPPYTLLDFFPEDFLIMIDESHMTMGQIKGMYNGDQ
HHHHCCCCCCHHHHHHHCCCCCCCCCCHHHHHHCCCCEEEEEECCCCCHHHHCCCCCCHH
ARKQMLVDYGFRLPSALDNRPLRRKEFESHVHQIVYVSATPGEYEMSQTNTIIEQIIRPT
HHHHHHHHHCCCCCHHHCCCCCHHHHHHHHHHEEEEEEECCCCCCHHHHHHHHHHHHHHC
GLLDPEIDVRPSMGQMDDLLGEINQRVARDERTFITTLTKKMAEDLTDYLKEMGVKVKYM
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEH
HSDIKTLERTEIIRDLRLGVFDVLIGINLLREGIDVPEVSLVAILDADKEGFLRNERGLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCCCHHH
QTIGRAARNVDGHVIMYADKMTDSMQRAIDETARRREIQIAYNKAHGIVPQTIKKDIRGF
HHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHCEEEEEEECCCCCCHHHHHHHHHHH
ISISKTSHNDISKEEMDYESMSRGERKEAINALQKQMQEAAELLDFELAAQMRDLILELK
EEEECCCCCCCCHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMD
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA