Click here to switch to the map view.

The map label for this gene is dltA [H]

Identifier: 19746293

GI number: 19746293

Start: 1103110

End: 1104648

Strand: Reverse

Name: dltA [H]

Synonym: spyM18_1324

Alternate gene names: 19746293

Gene position: 1104648-1103110 (Counterclockwise)

Preceding gene: 19746294

Following gene: 19746292

Centisome position: 58.29

GC content: 40.55

Gene sequence:

>1539_bases
ATGATTAAGGATATGATTGACAGTATTGAGCAGTTTGCTCAGACACAGGCGGATTTCCCAGTTTATGATTGTTTAGGGGA
ACGCCGAACTTACGGACAACTCAAAAGAGATTCTGATAGCATTGCTGCATTTATAGATAGCTTAGCTTTACTGGCAAAAT
CTCCAGTTTTGGTTTTTGGGGCGCAAACTTATGATATGTTAGCTACTTTTGTAGCTTTAACCAAATCTGGTCATGCCTAT
ATCCCAGTAGATGTGCATTCAGCACCAGAACGTATTTTAGCGATTATTGAGATTGCAAAGCCCAGTTTAATCATTGCTAT
TGAGGAATTCCCTCTTACTATTGAAGGGATTTCCCTTGTCTCACTATCAGAGATTGAGTCAGCAAAATTAGCAGAAATGC
CCTATGAGCGAACACATTCTGTTAAAGGAGATGATAATTATTACATTATTTTCACCTCTGGAACAACGGGCCAACCAAAA
GGGGTGCAAATTTCACATGACAATCTTTTGAGCTTTACCAACTGGATGATCGAAGATGCAGCATTTGATGTACCTAAACA
GCCACAAATGCTGGCGCAGCCACCCTATTCCTTTGACCTTTCTGTCATGTACTGGGCACCTACCTTGGCTTTAGGTGGAA
CCTTATTTGCACTTCCAAAAGAATTGGTGGCAGACTTTAAACAGTTATTTACAACGATTGCGCAACTTCCAGTTGGCATT
TGGACATCGACTCCTTCATTTGCTGATATGGCCATGCTTAGCGATGATTTTTGCCAGGCTAAGATGCCAGCTTTAACGCA
TTTTTATTTTGATGGCGAAGAATTAACCGTTTCTACGGCTCGAAAACTCTTTGAACGTTTCCCGAGTGCCAAGATCATCA
ATGCCTATGGACCAACAGAAGCGACTGTAGCCTTATCCGCTATTGAAATTACCAGAGAAATGGTGGATAATTATACCCGC
TTGCCGATTGGCTACCCCAAACCAGATTCTCCGACCTATATTATTGATGAAGATGGTAAGGAGTTAGCTTCAGGGGAGCA
GGGTGAAATTATTGTTACAGGGCCTGCTGTGTCAAAAGGTTACCTCAACAATCCTGAGAAAACCGCAGAAGCTTTCTTTA
CTTTTAAAGGACAGCCTGCTTATCATACAGGGGACATTGGCTCACTGACAGAAGATAATATTTTGCTGTATGGTGGGCGT
TTGGATTTTCAGATTAAATATGCTGGTTATCGTATTGAACTAGAAGATGTTTCCCAACAGTTGAATCAATCACCAATGGT
AGCATCGGCTGTGGCTGTTCCAAGGTACAATAAAGAACATAAGGTTCAAAATCTCTTGGCCTATATCGTTGTCAAAGATG
GGGTTAAAGAGCGTTTTGATAGGGAATTGGAGTTAACCAAAGCTATCAAAGCCTCTGTTAAGGATCATATGATGAGTTAT
ATGATGCCTTCTAAGTTTCTTTATCGAGACAGTCTACCATTAACTCCAAATGGTAAGATAGATATTAAAACTTTGATTAA
TGAGGTCAATAACCGATGA

Upstream 100 bases:

>100_bases
TTTTATTTTATCTGATTTTAATGTTGCTGGTCTATTTCTTTGGTTATCTAGGACATGGTCAAAGTAACTTTATTTATAAT
GAATTTTAGGAGATTGACTG

Downstream 100 bases:

>100_bases
TGATGTTTTTTAGCCACATTCCCTACATGGAACCTTACGGTAACCCCATTTACTTTGTCTATCTTATTTTGGCTTTCTTA
CCAGTCATCATTGGGATTTT

Product: D-alanine--poly(phosphoribitol) ligase subunit 1

Products: NA

Alternate protein names: D-alanine-D-alanyl carrier protein ligase; DCL; D-alanine-activating enzyme; DAE [H]

Number of amino acids: Translated: 512; Mature: 512

Protein sequence:

>512_residues
MIKDMIDSIEQFAQTQADFPVYDCLGERRTYGQLKRDSDSIAAFIDSLALLAKSPVLVFGAQTYDMLATFVALTKSGHAY
IPVDVHSAPERILAIIEIAKPSLIIAIEEFPLTIEGISLVSLSEIESAKLAEMPYERTHSVKGDDNYYIIFTSGTTGQPK
GVQISHDNLLSFTNWMIEDAAFDVPKQPQMLAQPPYSFDLSVMYWAPTLALGGTLFALPKELVADFKQLFTTIAQLPVGI
WTSTPSFADMAMLSDDFCQAKMPALTHFYFDGEELTVSTARKLFERFPSAKIINAYGPTEATVALSAIEITREMVDNYTR
LPIGYPKPDSPTYIIDEDGKELASGEQGEIIVTGPAVSKGYLNNPEKTAEAFFTFKGQPAYHTGDIGSLTEDNILLYGGR
LDFQIKYAGYRIELEDVSQQLNQSPMVASAVAVPRYNKEHKVQNLLAYIVVKDGVKERFDRELELTKAIKASVKDHMMSY
MMPSKFLYRDSLPLTPNGKIDIKTLINEVNNR

Sequences:

>Translated_512_residues
MIKDMIDSIEQFAQTQADFPVYDCLGERRTYGQLKRDSDSIAAFIDSLALLAKSPVLVFGAQTYDMLATFVALTKSGHAY
IPVDVHSAPERILAIIEIAKPSLIIAIEEFPLTIEGISLVSLSEIESAKLAEMPYERTHSVKGDDNYYIIFTSGTTGQPK
GVQISHDNLLSFTNWMIEDAAFDVPKQPQMLAQPPYSFDLSVMYWAPTLALGGTLFALPKELVADFKQLFTTIAQLPVGI
WTSTPSFADMAMLSDDFCQAKMPALTHFYFDGEELTVSTARKLFERFPSAKIINAYGPTEATVALSAIEITREMVDNYTR
LPIGYPKPDSPTYIIDEDGKELASGEQGEIIVTGPAVSKGYLNNPEKTAEAFFTFKGQPAYHTGDIGSLTEDNILLYGGR
LDFQIKYAGYRIELEDVSQQLNQSPMVASAVAVPRYNKEHKVQNLLAYIVVKDGVKERFDRELELTKAIKASVKDHMMSY
MMPSKFLYRDSLPLTPNGKIDIKTLINEVNNR
>Mature_512_residues
MIKDMIDSIEQFAQTQADFPVYDCLGERRTYGQLKRDSDSIAAFIDSLALLAKSPVLVFGAQTYDMLATFVALTKSGHAY
IPVDVHSAPERILAIIEIAKPSLIIAIEEFPLTIEGISLVSLSEIESAKLAEMPYERTHSVKGDDNYYIIFTSGTTGQPK
GVQISHDNLLSFTNWMIEDAAFDVPKQPQMLAQPPYSFDLSVMYWAPTLALGGTLFALPKELVADFKQLFTTIAQLPVGI
WTSTPSFADMAMLSDDFCQAKMPALTHFYFDGEELTVSTARKLFERFPSAKIINAYGPTEATVALSAIEITREMVDNYTR
LPIGYPKPDSPTYIIDEDGKELASGEQGEIIVTGPAVSKGYLNNPEKTAEAFFTFKGQPAYHTGDIGSLTEDNILLYGGR
LDFQIKYAGYRIELEDVSQQLNQSPMVASAVAVPRYNKEHKVQNLLAYIVVKDGVKERFDRELELTKAIKASVKDHMMSY
MMPSKFLYRDSLPLTPNGKIDIKTLINEVNNR

Specific function: Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp [H]

COG id: COG1020

COG function: function code Q; Non-ribosomal peptide synthetase modules and related proteins

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family. DltA subfamily [H]

Homologues:

Organism=Homo sapiens, GI115511026, Length=467, Percent_Identity=25.6959314775161, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI42544132, Length=460, Percent_Identity=25, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI187761345, Length=479, Percent_Identity=23.3820459290188, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI187761343, Length=479, Percent_Identity=23.3820459290188, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI45580730, Length=371, Percent_Identity=25.3369272237197, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI156151445, Length=525, Percent_Identity=23.8095238095238, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI38505220, Length=395, Percent_Identity=25.3164556962025, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI58082049, Length=470, Percent_Identity=24.6808510638298, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI157311624, Length=477, Percent_Identity=23.6897274633124, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI157311622, Length=477, Percent_Identity=23.6897274633124, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1786801, Length=449, Percent_Identity=28.2850779510022, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI1786810, Length=527, Percent_Identity=23.5294117647059, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI1788107, Length=578, Percent_Identity=21.7993079584775, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI145693145, Length=402, Percent_Identity=25.1243781094527, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI221142682, Length=518, Percent_Identity=22.7799227799228, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI32563687, Length=496, Percent_Identity=25.2016129032258, Blast_Score=92, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI17556356, Length=498, Percent_Identity=25.9036144578313, Blast_Score=86, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17538037, Length=426, Percent_Identity=26.9953051643192, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71994703, Length=533, Percent_Identity=22.5140712945591, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71994694, Length=363, Percent_Identity=24.7933884297521, Blast_Score=75, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI71994690, Length=363, Percent_Identity=24.7933884297521, Blast_Score=75, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6319591, Length=593, Percent_Identity=25.1264755480607, Blast_Score=139, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6319699, Length=376, Percent_Identity=25.7978723404255, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24648676, Length=459, Percent_Identity=27.2331154684096, Blast_Score=162, Evalue=6e-40,
Organism=Drosophila melanogaster, GI161076582, Length=371, Percent_Identity=26.1455525606469, Blast_Score=79, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24653035, Length=372, Percent_Identity=26.6129032258064, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21355181, Length=463, Percent_Identity=23.7580993520518, Blast_Score=76, Evalue=7e-14,
Organism=Drosophila melanogaster, GI18859661, Length=362, Percent_Identity=24.0331491712707, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21356947, Length=370, Percent_Identity=24.3243243243243, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI20130357, Length=430, Percent_Identity=23.7209302325581, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24648257, Length=473, Percent_Identity=24.7357293868922, Blast_Score=70, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24648260, Length=443, Percent_Identity=21.8961625282167, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21356441, Length=433, Percent_Identity=20.7852193995381, Blast_Score=65, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010071
- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR010072 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.1.1.13 [H]

Molecular weight: Translated: 56972; Mature: 56972

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKDMIDSIEQFAQTQADFPVYDCLGERRTYGQLKRDSDSIAAFIDSLALLAKSPVLVFG
CCHHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHCCCCCHHHHHHHHHHHHHHCCCEEEEE
AQTYDMLATFVALTKSGHAYIPVDVHSAPERILAIIEIAKPSLIIAIEEFPLTIEGISLV
CCHHHHHHHHHHHHCCCCEEEEEECCCCHHHHEEHHEECCCEEEEEEECCCEEECCEEEE
SLSEIESAKLAEMPYERTHSVKGDDNYYIIFTSGTTGQPKGVQISHDNLLSFTNWMIEDA
EHHHHCHHHHHHCCHHHHCCCCCCCCEEEEEECCCCCCCCCEEECCCCHHHHHHHHHHHH
AFDVPKQPQMLAQPPYSFDLSVMYWAPTLALGGTLFALPKELVADFKQLFTTIAQLPVGI
HCCCCCCCHHHCCCCCCCCEEEEEECHHHHHCCHHHHCHHHHHHHHHHHHHHHHHCCCEE
WTSTPSFADMAMLSDDFCQAKMPALTHFYFDGEELTVSTARKLFERFPSAKIINAYGPTE
EECCCCHHHHHHHHHHHHHHCCCCEEEEEECCCEEEHHHHHHHHHHCCCCEEEECCCCCC
ATVALSAIEITREMVDNYTRLPIGYPKPDSPTYIIDEDGKELASGEQGEIIVTGPAVSKG
HHHHHHHHHHHHHHHCCCEECCCCCCCCCCCEEEECCCCHHHHCCCCCCEEEECCCCCCC
YLNNPEKTAEAFFTFKGQPAYHTGDIGSLTEDNILLYGGRLDFQIKYAGYRIELEDVSQQ
CCCCCHHHHHEEEEECCCCCCCCCCCCCCCCCCEEEECCEEEEEEEEEEEEEEHHHHHHH
LNQSPMVASAVAVPRYNKEHKVQNLLAYIVVKDGVKERFDRELELTKAIKASVKDHMMSY
HCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
MMPSKFLYRDSLPLTPNGKIDIKTLINEVNNR
HCCCHHHCCCCCCCCCCCCEEHHHHHHHHCCC
>Mature Secondary Structure
MIKDMIDSIEQFAQTQADFPVYDCLGERRTYGQLKRDSDSIAAFIDSLALLAKSPVLVFG
CCHHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHCCCCCHHHHHHHHHHHHHHCCCEEEEE
AQTYDMLATFVALTKSGHAYIPVDVHSAPERILAIIEIAKPSLIIAIEEFPLTIEGISLV
CCHHHHHHHHHHHHCCCCEEEEEECCCCHHHHEEHHEECCCEEEEEEECCCEEECCEEEE
SLSEIESAKLAEMPYERTHSVKGDDNYYIIFTSGTTGQPKGVQISHDNLLSFTNWMIEDA
EHHHHCHHHHHHCCHHHHCCCCCCCCEEEEEECCCCCCCCCEEECCCCHHHHHHHHHHHH
AFDVPKQPQMLAQPPYSFDLSVMYWAPTLALGGTLFALPKELVADFKQLFTTIAQLPVGI
HCCCCCCCHHHCCCCCCCCEEEEEECHHHHHCCHHHHCHHHHHHHHHHHHHHHHHCCCEE
WTSTPSFADMAMLSDDFCQAKMPALTHFYFDGEELTVSTARKLFERFPSAKIINAYGPTE
EECCCCHHHHHHHHHHHHHHCCCCEEEEEECCCEEEHHHHHHHHHHCCCCEEEECCCCCC
ATVALSAIEITREMVDNYTRLPIGYPKPDSPTYIIDEDGKELASGEQGEIIVTGPAVSKG
HHHHHHHHHHHHHHHCCCEECCCCCCCCCCCEEEECCCCHHHHCCCCCCEEEECCCCCCC
YLNNPEKTAEAFFTFKGQPAYHTGDIGSLTEDNILLYGGRLDFQIKYAGYRIELEDVSQQ
CCCCCHHHHHEEEEECCCCCCCCCCCCCCCCCCEEEECCEEEEEEEEEEEEEEHHHHHHH
LNQSPMVASAVAVPRYNKEHKVQNLLAYIVVKDGVKERFDRELELTKAIKASVKDHMMSY
HCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
MMPSKFLYRDSLPLTPNGKIDIKTLINEVNNR
HCCCHHHCCCCCCCCCCCCEEHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]