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The map label for this gene is glmS [H]

Identifier: 19746203

GI number: 19746203

Start: 1029398

End: 1031212

Strand: Reverse

Name: glmS [H]

Synonym: spyM18_1228

Alternate gene names: 19746203

Gene position: 1031212-1029398 (Counterclockwise)

Preceding gene: 19746204

Following gene: 19746202

Centisome position: 54.42

GC content: 41.27

Gene sequence:

>1815_bases
ATGTGTGGAATTGTTGGAGTTGTTGGAAATCGCAATGCAACGGATATTTTAATGCAAGGCCTTGAAAAGCTTGAATACCG
GGGTTATGATTCAGCAGGAATTTTTGTGGCTAATGCCAATCAAACAAACTTGATTAAATCAGTGGGGCGGATTGCTGATT
TGCGTGCCAAGATTGGCATTGATGTTGCTGGTTCAACAGGGATTGGACACACCCGTTGGGCAACGCATGGCCAATCAACA
GAGGATAATGCCCATCCTCACACGTCACAAACTGGACGTTTTGTACTTGTTCATAATGGTGTGATTGAAAATTACCTTCA
CATTAAAACAGAGTTCCTAGCTGGACATGATTTTAAGGGGCAGACAGATACTGAGATTGCAGTACACTTGATTGGAAAAT
TTGTGGAAGAAGACAAGCTGTCAGTACTGGAAGCTTTTAAAAAAGCTTTAAGCATTATTGAAGGTTCCTATGCCTTTGCG
TTAATGGATAGCCAAGCAACTGATACTATTTATGTGGCTAAAAACAAATCTCCATTGTTGATTGGACTTGGTGAAGGTTA
CAACATGGTTTGTTCAGATGCCATGGCCATGATTCGTGAAACCAGTGAATTTATGGAAATTCATGATAAGGAGCTAGTTA
TTTTAACCAAAGATAAGGTAACTGTTACAGACTACGATGGTAAAGAGCTGATACGAGATTCCTACACTGCTGAATTAGAC
TTATCTGATATTGGCAAAGGGACTTATCCTTTCTATATGCTGAAAGAAATTGATGAGCAACCAACCGTAATGCGTCAATT
AATTTCAACTTATGCAGATGAAACTGGTAACGTACAGGTTGATCCAGCTATCATTACCTCTATCCAAGAGGCTGACCGTC
TTTATATTTTAGCGGCAGGGACTTCCTACCATGCTGGTTTTGCAACAAAAAATATGCTTGAGCAATTGACAGATACACCA
GTTGAGTTGGGAGTGGCTTCTGAGTGGGGTTACCACATGCCTCTGCTTAGCAAGAAACCAATGTTTATTCTACTAAGCCA
ATCAGGAGAAACCGCAGATAGTCGTCAAGTTTTAGTAAAGGCAAATGCTATGGGCATTCCGAGTTTGACAGTAACTAACG
TTCCAGGATCAACCTTATCACGTGAATCAACATACACCATGTTGATTCATGCTGGACCTGAAATTGCTGTTGCGTCTACA
AAAGCTTACACTGCACAAATTGCTGCCCTTGCCTTTTTGGCTAAGGCAGTTGGTGAGGCAAATGGTAAGCAAGAAGCTCT
TGACTTTAACTTGGTACATGAGTTGTCATTGGTTGCCCAATCTATTGAGGCGACTTTGTCTGAAAAAGATCTCGTGGCAG
AAAAGGTTCAAGCTTTGCTAGCTACTACTCGTAATGCTTTTTACATCGGGCGTGGCAATGATTATTACGTTGCGATGGAA
GCTGCTTTGAAATTAAAAGAGATTTCTTATATTCAATGCGAAGGCTTTGCGGCTGGTGAATTGAAACATGGAACCATTTC
ATTAATTGAGGAGGACACGCCAGTAATCGCTTTAATATCGTCTAGTCAGTTGGTTGCCTCTCATACGCGTGGTAATATTC
AAGAAGTTGCTGCCCGTGGGGCTCATGTTTTAACAGTTGTGGAAGAAGGGCTTGACCGTGAGGGAGATGACATTATTGTC
AATAAGGTTCATCCTTTCCTAGCCCCGATTGCTATGGTCATTCCAACTCAACTGATTGCTTACTACGCTTCATTACAACG
TGGACTTGATGTTGATAAGCCACGTAATTTGGCTAAAGCTGTAACAGTAGAATAA

Upstream 100 bases:

>100_bases
TACTGTAAACATAATGTTTTTATCGGTATAATTAGACTATACCAATTATTGAAATTATGAGAGAAAGTAGCAAGTTAACG
AACTTGTTAAGGTAATTAAG

Downstream 100 bases:

>100_bases
ATGATTATAATGGATAAGGCAACCATCTGTTAGGTGGTTGCTTTTTGTTTTTAGGAGAATAGCAGAGCTTAGAAAATGGC
CTTGAGAAAAGCTATACAAG

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 604; Mature: 604

Protein sequence:

>604_residues
MCGIVGVVGNRNATDILMQGLEKLEYRGYDSAGIFVANANQTNLIKSVGRIADLRAKIGIDVAGSTGIGHTRWATHGQST
EDNAHPHTSQTGRFVLVHNGVIENYLHIKTEFLAGHDFKGQTDTEIAVHLIGKFVEEDKLSVLEAFKKALSIIEGSYAFA
LMDSQATDTIYVAKNKSPLLIGLGEGYNMVCSDAMAMIRETSEFMEIHDKELVILTKDKVTVTDYDGKELIRDSYTAELD
LSDIGKGTYPFYMLKEIDEQPTVMRQLISTYADETGNVQVDPAIITSIQEADRLYILAAGTSYHAGFATKNMLEQLTDTP
VELGVASEWGYHMPLLSKKPMFILLSQSGETADSRQVLVKANAMGIPSLTVTNVPGSTLSRESTYTMLIHAGPEIAVAST
KAYTAQIAALAFLAKAVGEANGKQEALDFNLVHELSLVAQSIEATLSEKDLVAEKVQALLATTRNAFYIGRGNDYYVAME
AALKLKEISYIQCEGFAAGELKHGTISLIEEDTPVIALISSSQLVASHTRGNIQEVAARGAHVLTVVEEGLDREGDDIIV
NKVHPFLAPIAMVIPTQLIAYYASLQRGLDVDKPRNLAKAVTVE

Sequences:

>Translated_604_residues
MCGIVGVVGNRNATDILMQGLEKLEYRGYDSAGIFVANANQTNLIKSVGRIADLRAKIGIDVAGSTGIGHTRWATHGQST
EDNAHPHTSQTGRFVLVHNGVIENYLHIKTEFLAGHDFKGQTDTEIAVHLIGKFVEEDKLSVLEAFKKALSIIEGSYAFA
LMDSQATDTIYVAKNKSPLLIGLGEGYNMVCSDAMAMIRETSEFMEIHDKELVILTKDKVTVTDYDGKELIRDSYTAELD
LSDIGKGTYPFYMLKEIDEQPTVMRQLISTYADETGNVQVDPAIITSIQEADRLYILAAGTSYHAGFATKNMLEQLTDTP
VELGVASEWGYHMPLLSKKPMFILLSQSGETADSRQVLVKANAMGIPSLTVTNVPGSTLSRESTYTMLIHAGPEIAVAST
KAYTAQIAALAFLAKAVGEANGKQEALDFNLVHELSLVAQSIEATLSEKDLVAEKVQALLATTRNAFYIGRGNDYYVAME
AALKLKEISYIQCEGFAAGELKHGTISLIEEDTPVIALISSSQLVASHTRGNIQEVAARGAHVLTVVEEGLDREGDDIIV
NKVHPFLAPIAMVIPTQLIAYYASLQRGLDVDKPRNLAKAVTVE
>Mature_604_residues
MCGIVGVVGNRNATDILMQGLEKLEYRGYDSAGIFVANANQTNLIKSVGRIADLRAKIGIDVAGSTGIGHTRWATHGQST
EDNAHPHTSQTGRFVLVHNGVIENYLHIKTEFLAGHDFKGQTDTEIAVHLIGKFVEEDKLSVLEAFKKALSIIEGSYAFA
LMDSQATDTIYVAKNKSPLLIGLGEGYNMVCSDAMAMIRETSEFMEIHDKELVILTKDKVTVTDYDGKELIRDSYTAELD
LSDIGKGTYPFYMLKEIDEQPTVMRQLISTYADETGNVQVDPAIITSIQEADRLYILAAGTSYHAGFATKNMLEQLTDTP
VELGVASEWGYHMPLLSKKPMFILLSQSGETADSRQVLVKANAMGIPSLTVTNVPGSTLSRESTYTMLIHAGPEIAVAST
KAYTAQIAALAFLAKAVGEANGKQEALDFNLVHELSLVAQSIEATLSEKDLVAEKVQALLATTRNAFYIGRGNDYYVAME
AALKLKEISYIQCEGFAAGELKHGTISLIEEDTPVIALISSSQLVASHTRGNIQEVAARGAHVLTVVEEGLDREGDDIIV
NKVHPFLAPIAMVIPTQLIAYYASLQRGLDVDKPRNLAKAVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI205277386, Length=697, Percent_Identity=32.9985652797704, Blast_Score=309, Evalue=5e-84,
Organism=Homo sapiens, GI4826742, Length=696, Percent_Identity=31.7528735632184, Blast_Score=294, Evalue=1e-79,
Organism=Escherichia coli, GI1790167, Length=620, Percent_Identity=38.5483870967742, Blast_Score=416, Evalue=1e-117,
Organism=Escherichia coli, GI1788651, Length=173, Percent_Identity=28.3236994219653, Blast_Score=64, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17539970, Length=426, Percent_Identity=31.924882629108, Blast_Score=209, Evalue=4e-54,
Organism=Caenorhabditis elegans, GI17532899, Length=432, Percent_Identity=32.8703703703704, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17532897, Length=432, Percent_Identity=32.8703703703704, Blast_Score=206, Evalue=3e-53,
Organism=Saccharomyces cerevisiae, GI6322745, Length=476, Percent_Identity=31.3025210084034, Blast_Score=216, Evalue=8e-57,
Organism=Saccharomyces cerevisiae, GI6323731, Length=413, Percent_Identity=27.3607748184019, Blast_Score=149, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6323730, Length=205, Percent_Identity=34.1463414634146, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI21357745, Length=693, Percent_Identity=30.8802308802309, Blast_Score=302, Evalue=5e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 65594; Mature: 65594

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGVVGNRNATDILMQGLEKLEYRGYDSAGIFVANANQTNLIKSVGRIADLRAKIGI
CCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCE
DVAGSTGIGHTRWATHGQSTEDNAHPHTSQTGRFVLVHNGVIENYLHIKTEFLAGHDFKG
EECCCCCCCCCEECCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHEEEEEECCCCCCC
QTDTEIAVHLIGKFVEEDKLSVLEAFKKALSIIEGSYAFALMDSQATDTIYVAKNKSPLL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCCEE
IGLGEGYNMVCSDAMAMIRETSEFMEIHDKELVILTKDKVTVTDYDGKELIRDSYTAELD
EECCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCEEEEECCCCHHHHHCCCCEEEE
LSDIGKGTYPFYMLKEIDEQPTVMRQLISTYADETGNVQVDPAIITSIQEADRLYILAAG
HHHCCCCCCCCHHHHHCCCCHHHHHHHHHHHCCCCCCEEECHHHHHHHHCCCEEEEEEEC
TSYHAGFATKNMLEQLTDTPVELGVASEWGYHMPLLSKKPMFILLSQSGETADSRQVLVK
CCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEE
ANAMGIPSLTVTNVPGSTLSRESTYTMLIHAGPEIAVASTKAYTAQIAALAFLAKAVGEA
ECCCCCCCEEEECCCCCCCCCCCEEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHHCC
NGKQEALDFNLVHELSLVAQSIEATLSEKDLVAEKVQALLATTRNAFYIGRGNDYYVAME
CCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCEEEEECCCCEEEEEE
AALKLKEISYIQCEGFAAGELKHGTISLIEEDTPVIALISSSQLVASHTRGNIQEVAARG
EHHHHHHCCEEEECCEECCCCCCCEEEEEECCCCEEEEEECCCEEEHHCCCCHHHHHHCC
AHVLTVVEEGLDREGDDIIVNKVHPFLAPIAMVIPTQLIAYYASLQRGLDVDKPRNLAKA
CEEEEEEHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHE
VTVE
EECC
>Mature Secondary Structure
MCGIVGVVGNRNATDILMQGLEKLEYRGYDSAGIFVANANQTNLIKSVGRIADLRAKIGI
CCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCE
DVAGSTGIGHTRWATHGQSTEDNAHPHTSQTGRFVLVHNGVIENYLHIKTEFLAGHDFKG
EECCCCCCCCCEECCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHEEEEEECCCCCCC
QTDTEIAVHLIGKFVEEDKLSVLEAFKKALSIIEGSYAFALMDSQATDTIYVAKNKSPLL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCCEE
IGLGEGYNMVCSDAMAMIRETSEFMEIHDKELVILTKDKVTVTDYDGKELIRDSYTAELD
EECCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCEEEEECCCCHHHHHCCCCEEEE
LSDIGKGTYPFYMLKEIDEQPTVMRQLISTYADETGNVQVDPAIITSIQEADRLYILAAG
HHHCCCCCCCCHHHHHCCCCHHHHHHHHHHHCCCCCCEEECHHHHHHHHCCCEEEEEEEC
TSYHAGFATKNMLEQLTDTPVELGVASEWGYHMPLLSKKPMFILLSQSGETADSRQVLVK
CCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEE
ANAMGIPSLTVTNVPGSTLSRESTYTMLIHAGPEIAVASTKAYTAQIAALAFLAKAVGEA
ECCCCCCCEEEECCCCCCCCCCCEEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHHCC
NGKQEALDFNLVHELSLVAQSIEATLSEKDLVAEKVQALLATTRNAFYIGRGNDYYVAME
CCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCEEEEECCCCEEEEEE
AALKLKEISYIQCEGFAAGELKHGTISLIEEDTPVIALISSSQLVASHTRGNIQEVAARG
EHHHHHHCCEEEECCEECCCCCCCEEEEEECCCCEEEEEECCCEEEHHCCCCHHHHHHCC
AHVLTVVEEGLDREGDDIIVNKVHPFLAPIAMVIPTQLIAYYASLQRGLDVDKPRNLAKA
CEEEEEEHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHE
VTVE
EECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]