Click here to switch to the map view.

The map label for this gene is adh [H]

Identifier: 19746061

GI number: 19746061

Start: 890011

End: 891060

Strand: Reverse

Name: adh [H]

Synonym: spyM18_1073

Alternate gene names: 19746061

Gene position: 891060-890011 (Counterclockwise)

Preceding gene: 19746068

Following gene: 19746058

Centisome position: 47.02

GC content: 38.48

Gene sequence:

>1050_bases
ATGAAAGCAGCAACTTACCTTTCAACCGGAAATCTACAGCTCATAGACAAACCAAAACCAGTCATTATAAAGCCTACAGA
TGCTATCGTCCAGTTGGTAAAAACCACTATTTGTGGAACTGATTTGCATATCTTAGGTGGGGATGTTCCCGCATGTAAAG
AAGGAACAATCCTTGGTCATGAAGGAATTGGAATTGTTAAGGAGATCGGTGATGCGGTCACTAACTTTAAAATCGGAGAT
AAAGTGATTATTTCTTGCGTCACATCATGTCATACCTGTTATTATTGTAAACGAGGCCTTTCGTCACATTGTGAAGATGG
CGGTTGGATTCTTGGCCATTTAATTAATGGAACACAAGCAGAATATGTCCATATCCCACATGCAGATGGTAGTCTCTATC
ATGCTCCTGATACGATTGATGATGAGGCACTTGTCATGCTTTCTGATATTTTACCAACTTCATATGAAATTGGTGTCTTG
CCATCACATGTCAAGCCTGGAGATAATGTTTGTATTGTTGGTGCCGGTCCAGTAGGACTCGCAGCCTTACTAACCGCTCA
ATTTTTCTCTCCAGCCAATATTATTATGGTCGACTTATCTCAAAATCGCCTTGAAGCAGCTAAAACATTTGGAGCCACAC
ACACGATTTGTTCAGGAAGTAGTGAAGAAGTCAAGACTATCATTGACGATATAACCAATGGACGTGGTGTCGATATTTCC
ATGGAGTGTGTTGGTTATCCCGCGACATTTGATATTTGTCAAAAAATTATATCAGTAGGTGGGCATATTGCTAACGTTGG
GGTTCATGGGAAACCAGTTGATTTCAACCTGGATGAATTATGGATTAAAAATATCACCTTAAACACTGGACTTGTTAATG
CCAATACAACTGAAATGCTACTAAATGTCTTGAAAACTGGAAAGATTGACGCAACAAGACTTATTACACATCATTTTAAA
CTTTCAGAAGTTGAAAAAGCTTATGAAACCTTTAAACATGCTGGTGCAAATAACGCCTTGAAAGTTATTATTGATAATGA
TATTAGCTAA

Upstream 100 bases:

>100_bases
AATCAATTTAAAAAATATTGAAAACCCTTTCTTAAACTATTATAATACCTGTGTAAAAATGAATTGGTTGATTACCTCTC
AACCTTATAAGGAGTTAAAT

Downstream 100 bases:

>100_bases
TCACAAAATAAGTAGAAGCTAGAAATATGCTTCTACTTATTTTGTGATTTAAAGTATAACTTTCTCTTTTTTCATATATT
CTATGATTTAAGGACTACCG

Product: zinc-containing alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MKAATYLSTGNLQLIDKPKPVIIKPTDAIVQLVKTTICGTDLHILGGDVPACKEGTILGHEGIGIVKEIGDAVTNFKIGD
KVIISCVTSCHTCYYCKRGLSSHCEDGGWILGHLINGTQAEYVHIPHADGSLYHAPDTIDDEALVMLSDILPTSYEIGVL
PSHVKPGDNVCIVGAGPVGLAALLTAQFFSPANIIMVDLSQNRLEAAKTFGATHTICSGSSEEVKTIIDDITNGRGVDIS
MECVGYPATFDICQKIISVGGHIANVGVHGKPVDFNLDELWIKNITLNTGLVNANTTEMLLNVLKTGKIDATRLITHHFK
LSEVEKAYETFKHAGANNALKVIIDNDIS

Sequences:

>Translated_349_residues
MKAATYLSTGNLQLIDKPKPVIIKPTDAIVQLVKTTICGTDLHILGGDVPACKEGTILGHEGIGIVKEIGDAVTNFKIGD
KVIISCVTSCHTCYYCKRGLSSHCEDGGWILGHLINGTQAEYVHIPHADGSLYHAPDTIDDEALVMLSDILPTSYEIGVL
PSHVKPGDNVCIVGAGPVGLAALLTAQFFSPANIIMVDLSQNRLEAAKTFGATHTICSGSSEEVKTIIDDITNGRGVDIS
MECVGYPATFDICQKIISVGGHIANVGVHGKPVDFNLDELWIKNITLNTGLVNANTTEMLLNVLKTGKIDATRLITHHFK
LSEVEKAYETFKHAGANNALKVIIDNDIS
>Mature_349_residues
MKAATYLSTGNLQLIDKPKPVIIKPTDAIVQLVKTTICGTDLHILGGDVPACKEGTILGHEGIGIVKEIGDAVTNFKIGD
KVIISCVTSCHTCYYCKRGLSSHCEDGGWILGHLINGTQAEYVHIPHADGSLYHAPDTIDDEALVMLSDILPTSYEIGVL
PSHVKPGDNVCIVGAGPVGLAALLTAQFFSPANIIMVDLSQNRLEAAKTFGATHTICSGSSEEVKTIIDDITNGRGVDIS
MECVGYPATFDICQKIISVGGHIANVGVHGKPVDFNLDELWIKNITLNTGLVNANTTEMLLNVLKTGKIDATRLITHHFK
LSEVEKAYETFKHAGANNALKVIIDNDIS

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI71565154, Length=365, Percent_Identity=26.3013698630137, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI156627571, Length=348, Percent_Identity=25.8620689655172, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI34577061, Length=341, Percent_Identity=26.9794721407625, Blast_Score=95, Evalue=9e-20,
Organism=Homo sapiens, GI4501929, Length=335, Percent_Identity=27.1641791044776, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI4501933, Length=235, Percent_Identity=30.6382978723404, Blast_Score=92, Evalue=9e-19,
Organism=Homo sapiens, GI71743840, Length=334, Percent_Identity=26.3473053892216, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI262073058, Length=334, Percent_Identity=26.3473053892216, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI4501939, Length=360, Percent_Identity=25.2777777777778, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI156523966, Length=360, Percent_Identity=25.2777777777778, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI1786825, Length=377, Percent_Identity=28.6472148541114, Blast_Score=160, Evalue=8e-41,
Organism=Escherichia coli, GI1790045, Length=358, Percent_Identity=27.9329608938547, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1788075, Length=373, Percent_Identity=26.2734584450402, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI87082125, Length=340, Percent_Identity=29.1176470588235, Blast_Score=118, Evalue=6e-28,
Organism=Escherichia coli, GI1787863, Length=333, Percent_Identity=26.4264264264264, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI1788073, Length=333, Percent_Identity=27.9279279279279, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI226510992, Length=333, Percent_Identity=26.1261261261261, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1788407, Length=272, Percent_Identity=25.7352941176471, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87081918, Length=271, Percent_Identity=29.520295202952, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1786552, Length=336, Percent_Identity=27.0833333333333, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1790718, Length=313, Percent_Identity=23.961661341853, Blast_Score=76, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17562878, Length=350, Percent_Identity=28.5714285714286, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17562876, Length=343, Percent_Identity=28.5714285714286, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17565904, Length=352, Percent_Identity=26.7045454545455, Blast_Score=95, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI25146526, Length=369, Percent_Identity=26.5582655826558, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71997431, Length=340, Percent_Identity=27.0588235294118, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6322619, Length=348, Percent_Identity=29.8850574712644, Blast_Score=125, Evalue=8e-30,
Organism=Saccharomyces cerevisiae, GI6319955, Length=348, Percent_Identity=29.8850574712644, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6323099, Length=356, Percent_Identity=26.9662921348315, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6319258, Length=385, Percent_Identity=25.7142857142857, Blast_Score=109, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6319257, Length=350, Percent_Identity=24.8571428571429, Blast_Score=93, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6320033, Length=368, Percent_Identity=24.4565217391304, Blast_Score=89, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6323729, Length=232, Percent_Identity=26.2931034482759, Blast_Score=66, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6323961, Length=132, Percent_Identity=34.8484848484849, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17737897, Length=342, Percent_Identity=30.7017543859649, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI17137530, Length=342, Percent_Identity=29.5321637426901, Blast_Score=131, Evalue=6e-31,
Organism=Drosophila melanogaster, GI17737895, Length=353, Percent_Identity=26.0623229461756, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI45550770, Length=334, Percent_Identity=23.9520958083832, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI45551930, Length=334, Percent_Identity=23.9520958083832, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI221457811, Length=334, Percent_Identity=23.9520958083832, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 37279; Mature: 37279

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAATYLSTGNLQLIDKPKPVIIKPTDAIVQLVKTTICGTDLHILGGDVPACKEGTILGH
CCCCEEEECCCEEEEECCCCEEECCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCEEECC
EGIGIVKEIGDAVTNFKIGDKVIISCVTSCHTCYYCKRGLSSHCEDGGWILGHLINGTQA
CCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCE
EYVHIPHADGSLYHAPDTIDDEALVMLSDILPTSYEIGVLPSHVKPGDNVCIVGAGPVGL
EEEEEECCCCCEEECCCCCCCHHHHHHHHHCCCCEEECCCCCCCCCCCCEEEEECCHHHH
AALLTAQFFSPANIIMVDLSQNRLEAAKTFGATHTICSGSSEEVKTIIDDITNGRGVDIS
HHHHHHHHCCCCEEEEEECCCCHHHHHHHCCCCEEEECCCHHHHHHHHHHCCCCCCCEEE
MECVGYPATFDICQKIISVGGHIANVGVHGKPVDFNLDELWIKNITLNTGLVNANTTEML
EEEECCCHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHEEEEEEEEECCEECCCHHHHH
LNVLKTGKIDATRLITHHFKLSEVEKAYETFKHAGANNALKVIIDNDIS
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCC
>Mature Secondary Structure
MKAATYLSTGNLQLIDKPKPVIIKPTDAIVQLVKTTICGTDLHILGGDVPACKEGTILGH
CCCCEEEECCCEEEEECCCCEEECCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCEEECC
EGIGIVKEIGDAVTNFKIGDKVIISCVTSCHTCYYCKRGLSSHCEDGGWILGHLINGTQA
CCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCE
EYVHIPHADGSLYHAPDTIDDEALVMLSDILPTSYEIGVLPSHVKPGDNVCIVGAGPVGL
EEEEEECCCCCEEECCCCCCCHHHHHHHHHCCCCEEECCCCCCCCCCCCEEEEECCHHHH
AALLTAQFFSPANIIMVDLSQNRLEAAKTFGATHTICSGSSEEVKTIIDDITNGRGVDIS
HHHHHHHHCCCCEEEEEECCCCHHHHHHHCCCCEEEECCCHHHHHHHHHHCCCCCCCEEE
MECVGYPATFDICQKIISVGGHIANVGVHGKPVDFNLDELWIKNITLNTGLVNANTTEML
EEEECCCHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHEEEEEEEEECCEECCCHHHHH
LNVLKTGKIDATRLITHHFKLSEVEKAYETFKHAGANNALKVIIDNDIS
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2846513 [H]