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The map label for this gene is malR [H]

Identifier: 19746057

GI number: 19746057

Start: 885054

End: 885719

Strand: Reverse

Name: malR [H]

Synonym: spyM18_1068

Alternate gene names: 19746057

Gene position: 885719-885054 (Counterclockwise)

Preceding gene: 19746058

Following gene: 19746046

Centisome position: 46.74

GC content: 37.39

Gene sequence:

>666_bases
ATGAACGTTTTAATCATTGAAGATGATCCCATGGTGGATTTTATCCATCGCAATTACCTCGAAAAACTAAATCTTTTTGA
TCGCATTATATCCAGCGACTCTATGAAAGCTGTTCAAAGCATACTTACTGATTACGCAATTGACCTCATTTTACTGGATA
TTCATATTACAGATGGCAATGGGATTCAATTTTTGGAGAAATTGCGTGCTCAGCATATTCCTTGCGAAGTCATTATTATT
TCAGCCGCAAATGATGGGAATATTATCCGAGATGGTTTTCATTTAGGAATTATCGACTACCTCATCAAGCCCTTTACCTT
TGAACGCTTTCAAGAAAGCATCCAACAGTTTGTTACGCATCGAGAACATTTGGCCAATCAGCAACTAGAGCAGGCCCAAA
TTGACCAACTGAAATGTTTGACTAGCAAAAAAGACACTAAAAACAAACAATTGTTAGAAAAAGGCTTATCTGAATCCACT
TTCCAGTGGATTATAGAAAATATCAAAGCCTTTGATCAACCTTTTACTATCCAAGAATTAGCTTCCGCTTGTCACTTATC
CCATGTCTCTGTCCGTAAATACATTGCTTATTTAGAAGAAAATAAGCAACTGAACAGCCAACAAATTTTTACCAAGGTTG
GCCGTCCCTATCGCGTGTACTGGTGA

Upstream 100 bases:

>100_bases
TTTCAACAGCTCTTGACCGATACAAATTCCCAATTCCATCAACATCAAACCGTAACCGAGTTACAGTTCTCAGTGACAAC
ACCTTATGTAGGAGGGCAAC

Downstream 100 bases:

>100_bases
CGTCATCTGTCGATACATTAAAAAGGCTGGAGAAATACCAGCCTTTTTGAGTGCTTATTTGCGATACATTTTAAATTGGA
GGTATAAATCATTATAAATC

Product: two-component response regulator

Products: NA

Alternate protein names: Malate response regulator [H]

Number of amino acids: Translated: 221; Mature: 221

Protein sequence:

>221_residues
MNVLIIEDDPMVDFIHRNYLEKLNLFDRIISSDSMKAVQSILTDYAIDLILLDIHITDGNGIQFLEKLRAQHIPCEVIII
SAANDGNIIRDGFHLGIIDYLIKPFTFERFQESIQQFVTHREHLANQQLEQAQIDQLKCLTSKKDTKNKQLLEKGLSEST
FQWIIENIKAFDQPFTIQELASACHLSHVSVRKYIAYLEENKQLNSQQIFTKVGRPYRVYW

Sequences:

>Translated_221_residues
MNVLIIEDDPMVDFIHRNYLEKLNLFDRIISSDSMKAVQSILTDYAIDLILLDIHITDGNGIQFLEKLRAQHIPCEVIII
SAANDGNIIRDGFHLGIIDYLIKPFTFERFQESIQQFVTHREHLANQQLEQAQIDQLKCLTSKKDTKNKQLLEKGLSEST
FQWIIENIKAFDQPFTIQELASACHLSHVSVRKYIAYLEENKQLNSQQIFTKVGRPYRVYW
>Mature_221_residues
MNVLIIEDDPMVDFIHRNYLEKLNLFDRIISSDSMKAVQSILTDYAIDLILLDIHITDGNGIQFLEKLRAQHIPCEVIII
SAANDGNIIRDGFHLGIIDYLIKPFTFERFQESIQQFVTHREHLANQQLEQAQIDQLKCLTSKKDTKNKQLLEKGLSEST
FQWIIENIKAFDQPFTIQELASACHLSHVSVRKYIAYLEENKQLNSQQIFTKVGRPYRVYW

Specific function: Member of a two-component regulatory system malK/malR. Activates transcription of maeA, maeN and yflS in presence of malate by binding to their promoter region [H]

COG id: COG4565

COG function: function code KT; Response regulator of citrate/malate metabolism

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790566, Length=231, Percent_Identity=35.0649350649351, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1786838, Length=222, Percent_Identity=27.027027027027, Blast_Score=107, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789 [H]

Pfam domain/function: PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 25767; Mature: 25767

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVLIIEDDPMVDFIHRNYLEKLNLFDRIISSDSMKAVQSILTDYAIDLILLDIHITDGN
CEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHEEEEEEEEECCC
GIQFLEKLRAQHIPCEVIIISAANDGNIIRDGFHLGIIDYLIKPFTFERFQESIQQFVTH
CHHHHHHHHHHCCCEEEEEEEECCCCCEEECCHHHHHHHHHHCCCCHHHHHHHHHHHHHH
REHLANQQLEQAQIDQLKCLTSKKDTKNKQLLEKGLSESTFQWIIENIKAFDQPFTIQEL
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHH
ASACHLSHVSVRKYIAYLEENKQLNSQQIFTKVGRPYRVYW
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCEEECC
>Mature Secondary Structure
MNVLIIEDDPMVDFIHRNYLEKLNLFDRIISSDSMKAVQSILTDYAIDLILLDIHITDGN
CEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHEEEEEEEEECCC
GIQFLEKLRAQHIPCEVIIISAANDGNIIRDGFHLGIIDYLIKPFTFERFQESIQQFVTH
CHHHHHHHHHHCCCEEEEEEEECCCCCEEECCHHHHHHHHHHCCCCHHHHHHHHHHHHHH
REHLANQQLEQAQIDQLKCLTSKKDTKNKQLLEKGLSESTFQWIIENIKAFDQPFTIQEL
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHH
ASACHLSHVSVRKYIAYLEENKQLNSQQIFTKVGRPYRVYW
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9274030; 9384377; 12949159; 12949160 [H]