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The map label for this gene is czcD [H]

Identifier: 19745920

GI number: 19745920

Start: 739241

End: 740116

Strand: Reverse

Name: czcD [H]

Synonym: spyM18_0905

Alternate gene names: 19745920

Gene position: 740116-739241 (Counterclockwise)

Preceding gene: 19745932

Following gene: 19745895

Centisome position: 39.06

GC content: 33.45

Gene sequence:

>876_bases
ATGCCAGCAAGTAAAAAAGTCATCATTATTTTTATATTAAATCTTAGTTTTTCCCTCATTGAATTTATTTTTGGGACATT
ATTCTTTTCGGGTGCTATTTTAGCAGATGCTGTCCACGATTTTGGAGATGCCATTGCTATTGGTATCTCAGCTATCTTAG
AAAGAAAGGCTGTTAAAAAAGAGAGTTCAAATTTTTCACTAGGCTATAAGCGATTTAGCCTTTTAGGAGCACTAACAACA
AATCTAATACTTATTAGCGGGTCATTATTAGTAATGATTGAAACGATACCAAAATTATGGCATCCTACTATTGTTAATTA
TGACGGTATGTTCGTTTTAGCTATTTTTGCAATTATAATCAATGGATTTGCTAGCTTCATCATTCACTCTAACCAGACAA
AAAATGAAGAAATATTAAGCCTTCACTTTTTAGAAGATATCCTTGGGTGGTTAGCCATTATCATACTGTCACTGATCTTA
AAATGGAAACCTTGGTACATTCTTGATCCTTTATTATCAATTGCCATTGCTTCTTTTATATTATCTAAAGCTCTTCCAAA
GTTAGTAGCAACTGCTAACATTTTTTTAGATGGTGTTCCTGATTCGATAGACTATTGCGCTTTGCACCATGAACTCAGCC
AACTTCCTCATATAGTGTCTGTTAATCAGCTTAATGTTTGGTCGATGGATGGTATTGATCATAGAGCAACTATACATTGC
TGCTTGAGAGAATCTACCACTGAAAAACATTGCAAAAAATCTATTAGACTGATTTGTCAAAGGTACAATATAAACTCAGT
CACTGTGGAAATCGATACTTCTTTAAACGAACACCAACATCACTGTTCTTCTCTTTCTAGTATTGAAGTCAACTAA

Upstream 100 bases:

>100_bases
AGGTGCTCATTTTTGGTTATAGTAATTGTATTTTAACTTTTAGATAATAGAATAAAGAATTCTACTATACATATTACCAG
TATAACAAAAGGAGAAAATT

Downstream 100 bases:

>100_bases
TTGAAGTCAATTAATGTGCTATAAGTCTATTGAAAACTTATTAGGTGCAGTTATCTATAAATATTAAGAGTACCTAATAA
GCATACCCCTTTTTACAACA

Product: cation-efflux system membrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 291; Mature: 290

Protein sequence:

>291_residues
MPASKKVIIIFILNLSFSLIEFIFGTLFFSGAILADAVHDFGDAIAIGISAILERKAVKKESSNFSLGYKRFSLLGALTT
NLILISGSLLVMIETIPKLWHPTIVNYDGMFVLAIFAIIINGFASFIIHSNQTKNEEILSLHFLEDILGWLAIIILSLIL
KWKPWYILDPLLSIAIASFILSKALPKLVATANIFLDGVPDSIDYCALHHELSQLPHIVSVNQLNVWSMDGIDHRATIHC
CLRESTTEKHCKKSIRLICQRYNINSVTVEIDTSLNEHQHHCSSLSSIEVN

Sequences:

>Translated_291_residues
MPASKKVIIIFILNLSFSLIEFIFGTLFFSGAILADAVHDFGDAIAIGISAILERKAVKKESSNFSLGYKRFSLLGALTT
NLILISGSLLVMIETIPKLWHPTIVNYDGMFVLAIFAIIINGFASFIIHSNQTKNEEILSLHFLEDILGWLAIIILSLIL
KWKPWYILDPLLSIAIASFILSKALPKLVATANIFLDGVPDSIDYCALHHELSQLPHIVSVNQLNVWSMDGIDHRATIHC
CLRESTTEKHCKKSIRLICQRYNINSVTVEIDTSLNEHQHHCSSLSSIEVN
>Mature_290_residues
PASKKVIIIFILNLSFSLIEFIFGTLFFSGAILADAVHDFGDAIAIGISAILERKAVKKESSNFSLGYKRFSLLGALTTN
LILISGSLLVMIETIPKLWHPTIVNYDGMFVLAIFAIIINGFASFIIHSNQTKNEEILSLHFLEDILGWLAIIILSLILK
WKPWYILDPLLSIAIASFILSKALPKLVATANIFLDGVPDSIDYCALHHELSQLPHIVSVNQLNVWSMDGIDHRATIHCC
LRESTTEKHCKKSIRLICQRYNINSVTVEIDTSLNEHQHHCSSLSSIEVN

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI21359890, Length=314, Percent_Identity=21.9745222929936, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI1786966, Length=280, Percent_Identity=25.7142857142857, Blast_Score=75, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI32564488, Length=303, Percent_Identity=21.4521452145215, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI193210990, Length=294, Percent_Identity=22.108843537415, Blast_Score=71, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17555794, Length=310, Percent_Identity=22.258064516129, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17555796, Length=310, Percent_Identity=22.258064516129, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 32467; Mature: 32335

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: PS00307 LECTIN_LEGUME_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPASKKVIIIFILNLSFSLIEFIFGTLFFSGAILADAVHDFGDAIAIGISAILERKAVKK
CCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ESSNFSLGYKRFSLLGALTTNLILISGSLLVMIETIPKLWHPTIVNYDGMFVLAIFAIII
CCCCCCHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHCCCEECCCCHHHHHHHHHHH
NGFASFIIHSNQTKNEEILSLHFLEDILGWLAIIILSLILKWKPWYILDPLLSIAIASFI
HHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
LSKALPKLVATANIFLDGVPDSIDYCALHHELSQLPHIVSVNQLNVWSMDGIDHRATIHC
HHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHCCCEEEECCCCEEECCCCCCHHHHHE
CLRESTTEKHCKKSIRLICQRYNINSVTVEIDTSLNEHQHHCSSLSSIEVN
EHHCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHCCCCCCCCC
>Mature Secondary Structure 
PASKKVIIIFILNLSFSLIEFIFGTLFFSGAILADAVHDFGDAIAIGISAILERKAVKK
CCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ESSNFSLGYKRFSLLGALTTNLILISGSLLVMIETIPKLWHPTIVNYDGMFVLAIFAIII
CCCCCCHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHCCCEECCCCHHHHHHHHHHH
NGFASFIIHSNQTKNEEILSLHFLEDILGWLAIIILSLILKWKPWYILDPLLSIAIASFI
HHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
LSKALPKLVATANIFLDGVPDSIDYCALHHELSQLPHIVSVNQLNVWSMDGIDHRATIHC
HHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHCCCEEEECCCCEEECCCCCCHHHHHE
CLRESTTEKHCKKSIRLICQRYNINSVTVEIDTSLNEHQHHCSSLSSIEVN
EHHCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA