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The map label for this gene is fhuB [H]

Identifier: 19745540

GI number: 19745540

Start: 359748

End: 360800

Strand: Reverse

Name: fhuB [H]

Synonym: spyM18_0437

Alternate gene names: 19745540

Gene position: 360800-359748 (Counterclockwise)

Preceding gene: 19745541

Following gene: 19745539

Centisome position: 19.04

GC content: 42.07

Gene sequence:

>1053_bases
GTGAAAACTAAGCATCCCTTTTTGTGTCTCGAGCGTTTTTGCTTAAAAAAAACGCAGATAATCACTAAGTCACATATCTT
TTGGCTTGTCTTTGTGCTACTTAGTTTTAGCTTATGTGTTGCTATTTACTGTCATCTGCGCTTTGGAGCCGTTGCTTTAT
CACATCAGGATCTTAACTCTATTTTATTTGGAAAGCAAAACGGCCATAAAGCCAATGTTTTACTAGCTATACGATTACCG
AGACTTTTTGGTGCTACCTTAACTGGCTCTGCGTTAGCTGTTTCTGGAACTATCATGCAAGCAATCACACGTAATCCTAT
CGCTGAGCCTGGCCTTTTAGGCATTAATGCTGGAGCAGGACTAGCCTTGGTACTGGCTTATGCGTTTGTACCTCACTTGC
ACTATTCCCTCATTATTCTGCTTTCGTTGTTAGGGTCTAGCCTGGCAGCAACCTTAGTCTTTGGCCTTTCTTATCAATCT
GGCAAAGGCTACCATCAGCTCCGCCTTGTCTTAGCAGGAGCTATGGTTTCCATACTGCTATCAGCATTAGGTCAAGGTAT
TACCAATTACTATCATCTGACAAATGCTGTTATCGGCTGGCAAGCAGGAGGTCTTGTCGGGGTCAATTGGCAAATGATCG
GCTATATTGCTCCTCTTATTATTCTTAGTCTTTGTTTAGCCCAGCTATTATCTTATCACCTGACCGTCCTTAGTCTAAGT
GAGTCTCAGGCAAAAGCTCTTGGGCAAAAGACCAACTTGATCAGTGCAGTCTTTATGATTTTGGTTCTTATTTTATCATC
AGCAGCTGTAGCCATTGCTGGAAGCATTTCTTTTATCGGCTTAGTCATTCCTCATCTTATGAAACACTTTACACCTCATC
ATTACCGATACCTTTTGCCGCTTTGTGCAGTTTCTGGCGCTAGTTTCATGGTATGGGTTGATATTGCTTGTCGTAATCTC
AATCCGCCTTATGAAACCCCTCTTGGGGCATTGGTTAGCTTAATTGGTTTTCCATGCTTTTTATGGTTAATAAGAAGAGG
AGGCCGCTATTGA

Upstream 100 bases:

>100_bases
AAACACCATGTGATCAAAGTCAATGCCAATGTCTTTTACTTTACTGATCCTCTTTCTTTAGAATATCAATTAGAGACTTT
ACGAGAGGCAATCTTATCAA

Downstream 100 bases:

>100_bases
AATCTCACCGACACCTTTTAAGGTTATATACTAGCCTGATCCTGCTACTTGTAAGTCTTATGGGATTAGCTTTGTCCCTT
GGAGAATCTCATCTATCTTT

Product: ferrichrome ABC transporter permease

Products: ADP; phosphate; iron dicitrate [Cytoplasm] [C]

Alternate protein names: Ferric hydroxamate uptake protein B; Ferrichrome transport system permease protein fhuB; Iron(III)-hydroxamate import system permease protein fhuB [H]

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MKTKHPFLCLERFCLKKTQIITKSHIFWLVFVLLSFSLCVAIYCHLRFGAVALSHQDLNSILFGKQNGHKANVLLAIRLP
RLFGATLTGSALAVSGTIMQAITRNPIAEPGLLGINAGAGLALVLAYAFVPHLHYSLIILLSLLGSSLAATLVFGLSYQS
GKGYHQLRLVLAGAMVSILLSALGQGITNYYHLTNAVIGWQAGGLVGVNWQMIGYIAPLIILSLCLAQLLSYHLTVLSLS
ESQAKALGQKTNLISAVFMILVLILSSAAVAIAGSISFIGLVIPHLMKHFTPHHYRYLLPLCAVSGASFMVWVDIACRNL
NPPYETPLGALVSLIGFPCFLWLIRRGGRY

Sequences:

>Translated_350_residues
MKTKHPFLCLERFCLKKTQIITKSHIFWLVFVLLSFSLCVAIYCHLRFGAVALSHQDLNSILFGKQNGHKANVLLAIRLP
RLFGATLTGSALAVSGTIMQAITRNPIAEPGLLGINAGAGLALVLAYAFVPHLHYSLIILLSLLGSSLAATLVFGLSYQS
GKGYHQLRLVLAGAMVSILLSALGQGITNYYHLTNAVIGWQAGGLVGVNWQMIGYIAPLIILSLCLAQLLSYHLTVLSLS
ESQAKALGQKTNLISAVFMILVLILSSAAVAIAGSISFIGLVIPHLMKHFTPHHYRYLLPLCAVSGASFMVWVDIACRNL
NPPYETPLGALVSLIGFPCFLWLIRRGGRY
>Mature_350_residues
MKTKHPFLCLERFCLKKTQIITKSHIFWLVFVLLSFSLCVAIYCHLRFGAVALSHQDLNSILFGKQNGHKANVLLAIRLP
RLFGATLTGSALAVSGTIMQAITRNPIAEPGLLGINAGAGLALVLAYAFVPHLHYSLIILLSLLGSSLAATLVFGLSYQS
GKGYHQLRLVLAGAMVSILLSALGQGITNYYHLTNAVIGWQAGGLVGVNWQMIGYIAPLIILSLCLAQLLSYHLTVLSLS
ESQAKALGQKTNLISAVFMILVLILSSAAVAIAGSISFIGLVIPHLMKHFTPHHYRYLLPLCAVSGASFMVWVDIACRNL
NPPYETPLGALVSLIGFPCFLWLIRRGGRY

Specific function: Part of the ABC transporter complex fhuBGCD involved in iron(3+)-hydroxamate import. Responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790740, Length=324, Percent_Identity=34.5679012345679, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1790741, Length=331, Percent_Identity=34.1389728096677, Blast_Score=141, Evalue=7e-35,
Organism=Escherichia coli, GI1788004, Length=280, Percent_Identity=35, Blast_Score=117, Evalue=9e-28,
Organism=Escherichia coli, GI1786805, Length=291, Percent_Identity=31.6151202749141, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1786804, Length=311, Percent_Identity=32.475884244373, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1786347, Length=287, Percent_Identity=27.8745644599303, Blast_Score=88, Evalue=8e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 37876; Mature: 37876

Theoretical pI: Translated: 10.00; Mature: 10.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTKHPFLCLERFCLKKTQIITKSHIFWLVFVLLSFSLCVAIYCHLRFGAVALSHQDLNS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
ILFGKQNGHKANVLLAIRLPRLFGATLTGSALAVSGTIMQAITRNPIAEPGLLGINAGAG
HHCCCCCCCCEEEEEEEECHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEECCCHH
LALVLAYAFVPHLHYSLIILLSLLGSSLAATLVFGLSYQSGKGYHQLRLVLAGAMVSILL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
SALGQGITNYYHLTNAVIGWQAGGLVGVNWQMIGYIAPLIILSLCLAQLLSYHLTVLSLS
HHHHHHHHHHHHHHHHHHEECCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
ESQAKALGQKTNLISAVFMILVLILSSAAVAIAGSISFIGLVIPHLMKHFTPHHYRYLLP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
LCAVSGASFMVWVDIACRNLNPPYETPLGALVSLIGFPCFLWLIRRGGRY
HHHHCCCCEEEEEEEHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKTKHPFLCLERFCLKKTQIITKSHIFWLVFVLLSFSLCVAIYCHLRFGAVALSHQDLNS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
ILFGKQNGHKANVLLAIRLPRLFGATLTGSALAVSGTIMQAITRNPIAEPGLLGINAGAG
HHCCCCCCCCEEEEEEEECHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEECCCHH
LALVLAYAFVPHLHYSLIILLSLLGSSLAATLVFGLSYQSGKGYHQLRLVLAGAMVSILL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
SALGQGITNYYHLTNAVIGWQAGGLVGVNWQMIGYIAPLIILSLCLAQLLSYHLTVLSLS
HHHHHHHHHHHHHHHHHHEECCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
ESQAKALGQKTNLISAVFMILVLILSSAAVAIAGSISFIGLVIPHLMKHFTPHHYRYLLP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
LCAVSGASFMVWVDIACRNLNPPYETPLGALVSLIGFPCFLWLIRRGGRY
HHHHCCCCEEEEEEEHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron dicitrate [Periplasm]; H2O [C]

Specific reaction: ATP + iron dicitrate [Periplasm] + H2O = ADP + phosphate + iron dicitrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377; 8388528 [H]