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The map label for this gene is msmR [H]

Identifier: 19745306

GI number: 19745306

Start: 123368

End: 124573

Strand: Reverse

Name: msmR [H]

Synonym: spyM18_0131

Alternate gene names: 19745306

Gene position: 124573-123368 (Counterclockwise)

Preceding gene: 19745308

Following gene: 19745300

Centisome position: 6.57

GC content: 34.25

Gene sequence:

>1206_bases
ATGGCTATATTCGATTTAAAACATGTGCAAACATTACACAGCTTGTCTCAATTACCTATTTCAGTGATGTCACAAGATAA
GGCACTTATTCAAGTATATGGTAATGACGACTATTTATTATGTTACTATCAATTTTTAAAGCATCTAGCTATTCCTCAAG
CCGCACAAGATGTTATTTTTTATGAGGGTTTATTTGAAGAGTCCTTTATGATTTTTCCTCTTTGTCACTACATTATTGCC
ATTGGACCTTTCTACCCTTATTCACTTAATAAAGACTATCAGGAACAATTAGCTAATAATTGTTTAAAACATTCTTCTCA
TCGTAGCAAAGAAGAGCTCTTATCCTATATGGCACTTGTCCCACATTTTCCAATTAATAATGTGCGGAACCTTTTGATAG
CTATTGACGCTTTTTTTGACACACAATTTGAGACGACTTGCCAACAAACAATTCATCAATTGTTGCAGCATTCAAAACAG
ATGACTGCTGATCCTGATATCATTCATCGCCTTAAGCATATTAGCAAAGCATCTAGCCAACTACCGCCTGTTTTAGAGCA
CCTAAATCATATTATGGATCTGGTAAAGCTAGGCAATCCACAATTGCTCAAGCAAGAAATCAATCGCATCCCCTTATCAA
GTATCACCTCATCTTCTATTTCTGCTCTAAGGGCGGAAAAGAACCTCACTGTTATCTATTTAACTAGGTTACTGGAATTC
AGTTTTGTAGAAAATACTGACGTAGCAAAGCATTATAGCCTTGTCAAATACTACATGGCCTTAAATGAAGAAGCGAGTGA
CTTGCTCAAAGTTTTGAGAATTCGCTGTGCAGCTATCATCCATTTTTCCGAATCATTAACCAATAAAAGTATTTCTGATA
AACGTCAAATGTACAATAGTGTGCTTCATTATGTCGATAGTCACCTGTATTCCAAATTAAAGGTATCTGATATCGCTAAG
CGCCTATATGTTTCCGAATCTCACTTACGTTCAGTCTTTAAAAAATACTCAAATGTTTCCTTACAACATTATATTCTAAG
TACAAAAATCAAAGAAGCTCAACTACTCTTAAAACGAGGAATTCCTGTTGGAGAAGTGGCTAAAAGCTTATATTTTTATG
ACACTACCCATTTTCATAAAATTTTTAAAAAATACACGGGTATTTCTTCAAAAGACTATCTTGCTAAATACCGAGATAAT
ATTTAA

Upstream 100 bases:

>100_bases
AGTGTGCCTACCAAATAGGAATTTTCATCATTAACATTTACTAAAGCTTTTACAAGTCTACGGAAAATGATACAACTAAG
GATGGGGGGCAATCTATCAA

Downstream 100 bases:

>100_bases
GAATTCAAGACACTCTTTTCATCAATCATTATCTTATATGGTACAAAAACCTATCAGCATAGAAAAACATCTCCAAAGTC
AAGCAAGACTGTGGAGATGT

Product: multiple sugar metabolism repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 401; Mature: 400

Protein sequence:

>401_residues
MAIFDLKHVQTLHSLSQLPISVMSQDKALIQVYGNDDYLLCYYQFLKHLAIPQAAQDVIFYEGLFEESFMIFPLCHYIIA
IGPFYPYSLNKDYQEQLANNCLKHSSHRSKEELLSYMALVPHFPINNVRNLLIAIDAFFDTQFETTCQQTIHQLLQHSKQ
MTADPDIIHRLKHISKASSQLPPVLEHLNHIMDLVKLGNPQLLKQEINRIPLSSITSSSISALRAEKNLTVIYLTRLLEF
SFVENTDVAKHYSLVKYYMALNEEASDLLKVLRIRCAAIIHFSESLTNKSISDKRQMYNSVLHYVDSHLYSKLKVSDIAK
RLYVSESHLRSVFKKYSNVSLQHYILSTKIKEAQLLLKRGIPVGEVAKSLYFYDTTHFHKIFKKYTGISSKDYLAKYRDN
I

Sequences:

>Translated_401_residues
MAIFDLKHVQTLHSLSQLPISVMSQDKALIQVYGNDDYLLCYYQFLKHLAIPQAAQDVIFYEGLFEESFMIFPLCHYIIA
IGPFYPYSLNKDYQEQLANNCLKHSSHRSKEELLSYMALVPHFPINNVRNLLIAIDAFFDTQFETTCQQTIHQLLQHSKQ
MTADPDIIHRLKHISKASSQLPPVLEHLNHIMDLVKLGNPQLLKQEINRIPLSSITSSSISALRAEKNLTVIYLTRLLEF
SFVENTDVAKHYSLVKYYMALNEEASDLLKVLRIRCAAIIHFSESLTNKSISDKRQMYNSVLHYVDSHLYSKLKVSDIAK
RLYVSESHLRSVFKKYSNVSLQHYILSTKIKEAQLLLKRGIPVGEVAKSLYFYDTTHFHKIFKKYTGISSKDYLAKYRDN
I
>Mature_400_residues
AIFDLKHVQTLHSLSQLPISVMSQDKALIQVYGNDDYLLCYYQFLKHLAIPQAAQDVIFYEGLFEESFMIFPLCHYIIAI
GPFYPYSLNKDYQEQLANNCLKHSSHRSKEELLSYMALVPHFPINNVRNLLIAIDAFFDTQFETTCQQTIHQLLQHSKQM
TADPDIIHRLKHISKASSQLPPVLEHLNHIMDLVKLGNPQLLKQEINRIPLSSITSSSISALRAEKNLTVIYLTRLLEFS
FVENTDVAKHYSLVKYYMALNEEASDLLKVLRIRCAAIIHFSESLTNKSISDKRQMYNSVLHYVDSHLYSKLKVSDIAKR
LYVSESHLRSVFKKYSNVSLQHYILSTKIKEAQLLLKRGIPVGEVAKSLYFYDTTHFHKIFKKYTGISSKDYLAKYRDNI

Specific function: Regulatory protein for the msm operon for multiple sugar metabolism. Activates the transcription of the msmEFGK, aga, dexB and gftA genes [H]

COG id: COG4753

COG function: function code T; Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH araC/xylS-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR003313
- InterPro:   IPR018062
- InterPro:   IPR020449
- InterPro:   IPR018060 [H]

Pfam domain/function: PF02311 AraC_binding; PF00165 HTH_AraC [H]

EC number: NA

Molecular weight: Translated: 46447; Mature: 46316

Theoretical pI: Translated: 9.03; Mature: 9.03

Prosite motif: PS01124 HTH_ARAC_FAMILY_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIFDLKHVQTLHSLSQLPISVMSQDKALIQVYGNDDYLLCYYQFLKHLAIPQAAQDVIF
CCCCHHHHHHHHHHHHHCCHHHHCCCCEEEEEECCCCEEEHHHHHHHHHCCCHHHHHHHH
YEGLFEESFMIFPLCHYIIAIGPFYPYSLNKDYQEQLANNCLKHSSHRSKEELLSYMALV
HHHHHHCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
PHFPINNVRNLLIAIDAFFDTQFETTCQQTIHQLLQHSKQMTADPDIIHRLKHISKASSQ
CCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHC
LPPVLEHLNHIMDLVKLGNPQLLKQEINRIPLSSITSSSISALRAEKNLTVIYLTRLLEF
CCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHH
SFVENTDVAKHYSLVKYYMALNEEASDLLKVLRIRCAAIIHFSESLTNKSISDKRQMYNS
HHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
VLHYVDSHLYSKLKVSDIAKRLYVSESHLRSVFKKYSNVSLQHYILSTKIKEAQLLLKRG
HHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC
IPVGEVAKSLYFYDTTHFHKIFKKYTGISSKDYLAKYRDNI
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCC
>Mature Secondary Structure 
AIFDLKHVQTLHSLSQLPISVMSQDKALIQVYGNDDYLLCYYQFLKHLAIPQAAQDVIF
CCCHHHHHHHHHHHHHCCHHHHCCCCEEEEEECCCCEEEHHHHHHHHHCCCHHHHHHHH
YEGLFEESFMIFPLCHYIIAIGPFYPYSLNKDYQEQLANNCLKHSSHRSKEELLSYMALV
HHHHHHCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
PHFPINNVRNLLIAIDAFFDTQFETTCQQTIHQLLQHSKQMTADPDIIHRLKHISKASSQ
CCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHC
LPPVLEHLNHIMDLVKLGNPQLLKQEINRIPLSSITSSSISALRAEKNLTVIYLTRLLEF
CCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHH
SFVENTDVAKHYSLVKYYMALNEEASDLLKVLRIRCAAIIHFSESLTNKSISDKRQMYNS
HHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
VLHYVDSHLYSKLKVSDIAKRLYVSESHLRSVFKKYSNVSLQHYILSTKIKEAQLLLKRG
HHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC
IPVGEVAKSLYFYDTTHFHKIFKKYTGISSKDYLAKYRDNI
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1537846; 12397186 [H]