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The map label for this gene is ffh [H]

Identifier: 197294839

GI number: 197294839

Start: 852988

End: 854349

Strand: Reverse

Name: ffh [H]

Synonym: PAa_0826

Alternate gene names: 197294839

Gene position: 854349-852988 (Counterclockwise)

Preceding gene: 197294840

Following gene: 197294838

Centisome position: 97.09

GC content: 31.2

Gene sequence:

>1362_bases
ATGAGTATATTAGGAGATGGATTTCAAAAAATCATTAATAAAATCAGAGGCAAAAAAATAATTGAATCTCGAGATATTGA
AAACATTATGGAAGATATTCGATTATCTTTGATCGAAGCAGACGTTAATATAAAAGTTATCGATACTTTTCATGAACTTA
TTAGTAAAAAAAGCCTAAAACAAGAAGTTTTAAAAGGTTTAAAACCAAAAGAACACATTATTAAAATCATTAATGAAACT
TTAACCCAAATTTTGGGTTCCACTCGGTCTGATTTAGTTGTCCAACCAAAACCCCATTTAAATGCCATGATGTTGATTGG
TTTGCAAGGGAGCGGTAAAACTACTACAGCAGGAAAACTAGCTCTTTGGTTAAGAAAAAAAAACCATCAAAAAGTTTTGT
TAATTGCTTGTGACATTTATCGTCCTGGGGCAGTTGAACAATTAAAAGTTATTGGCCGACAAATTAAAATTGATGTTTTT
TCCCAAGGAAACACTCCAGTTATAGAAATTGTTGAACTAGGTTTGCAATATGCTCAAAAAAACGGTTATGATGCAATTGT
TATTGACACTGCAGGGAGATTAACAATTGACGAAAAAATGATGCAAGAATTGAAAGAAATTAAGAGTAAGTGTGATTTTT
CAGAAGTTTTATTAGTTATTGATGCTTTAACAGGGCAACAATCCGCAAAAAACACTCAAACTTTTCACCAACAAGTGGGA
GCAACTGGGGTTATTTTGACTAAAATGGATGCAGACACTAAAGGAGGCGCTTCTTTATCTGTTAGAGTGATGACGGAATT
GCCTTTAAAGTTTATTTCATCATCTGAGTCAATTGATCTTTTAGAACCTTTTAATCCTGATAGGATGGCTTCCAGACTTT
TGGGGATGGGCGATGTTTTAACTTTGATTGAGACAGTAACTGATAAAATTGATGCCGACCAAGGTAAAAAAATGATGGAT
CGTTTGTTAGATGATAATTATAATTATCATGATTTTCAAAAGCAATTAAAAACTTTGAAAAAAATAGGTTCATTTAGTAA
AATATTAAGCTTTATTCCTGGGTTAGGTAATAAAATGAAGCAACTTTCTTCAGGGATTAACGATGATAATTTAAAAAAAT
TTGAAGTTTTAATCCAAAGTATGACTAAAGAAGAACGTAAAAAACCGCGTTTAATTGCTTTAAGTGGTCGCAGAAGAATG
CGGATTGCTAAAGGTTCTGGTAATCAATTAAGCGATGTTTCTCAATTGATGACTTTGTTAGAACAGCAAAAAAAGTTAGC
TAAACAAATGAAAAATTTTGATGATGCAGATATTAATAAATTACAAGAAGACCCTTTATCCTTTTTTAATCATTTGAAAT
AA

Upstream 100 bases:

>100_bases
AAAACCCGAAGATTTAGTCGATTTTGATATTCAAAATTATCTTTTTCATTTATTTAACAATTTTTTTCTGAAAAATATTT
AAAGGAGTAAAGCTATTCAA

Downstream 100 bases:

>100_bases
CAATTAAAAACTTTGAAAAAAATAGGTTCATTTAGTAAAATATTTAAGCTTTATTTCCTGATTAGGCAATAAAATGAAAC
AACTTTCTTCAGGGATTAAC

Product: Signal recognition particle GTPase

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 453; Mature: 452

Protein sequence:

>453_residues
MSILGDGFQKIINKIRGKKIIESRDIENIMEDIRLSLIEADVNIKVIDTFHELISKKSLKQEVLKGLKPKEHIIKIINET
LTQILGSTRSDLVVQPKPHLNAMMLIGLQGSGKTTTAGKLALWLRKKNHQKVLLIACDIYRPGAVEQLKVIGRQIKIDVF
SQGNTPVIEIVELGLQYAQKNGYDAIVIDTAGRLTIDEKMMQELKEIKSKCDFSEVLLVIDALTGQQSAKNTQTFHQQVG
ATGVILTKMDADTKGGASLSVRVMTELPLKFISSSESIDLLEPFNPDRMASRLLGMGDVLTLIETVTDKIDADQGKKMMD
RLLDDNYNYHDFQKQLKTLKKIGSFSKILSFIPGLGNKMKQLSSGINDDNLKKFEVLIQSMTKEERKKPRLIALSGRRRM
RIAKGSGNQLSDVSQLMTLLEQQKKLAKQMKNFDDADINKLQEDPLSFFNHLK

Sequences:

>Translated_453_residues
MSILGDGFQKIINKIRGKKIIESRDIENIMEDIRLSLIEADVNIKVIDTFHELISKKSLKQEVLKGLKPKEHIIKIINET
LTQILGSTRSDLVVQPKPHLNAMMLIGLQGSGKTTTAGKLALWLRKKNHQKVLLIACDIYRPGAVEQLKVIGRQIKIDVF
SQGNTPVIEIVELGLQYAQKNGYDAIVIDTAGRLTIDEKMMQELKEIKSKCDFSEVLLVIDALTGQQSAKNTQTFHQQVG
ATGVILTKMDADTKGGASLSVRVMTELPLKFISSSESIDLLEPFNPDRMASRLLGMGDVLTLIETVTDKIDADQGKKMMD
RLLDDNYNYHDFQKQLKTLKKIGSFSKILSFIPGLGNKMKQLSSGINDDNLKKFEVLIQSMTKEERKKPRLIALSGRRRM
RIAKGSGNQLSDVSQLMTLLEQQKKLAKQMKNFDDADINKLQEDPLSFFNHLK
>Mature_452_residues
SILGDGFQKIINKIRGKKIIESRDIENIMEDIRLSLIEADVNIKVIDTFHELISKKSLKQEVLKGLKPKEHIIKIINETL
TQILGSTRSDLVVQPKPHLNAMMLIGLQGSGKTTTAGKLALWLRKKNHQKVLLIACDIYRPGAVEQLKVIGRQIKIDVFS
QGNTPVIEIVELGLQYAQKNGYDAIVIDTAGRLTIDEKMMQELKEIKSKCDFSEVLLVIDALTGQQSAKNTQTFHQQVGA
TGVILTKMDADTKGGASLSVRVMTELPLKFISSSESIDLLEPFNPDRMASRLLGMGDVLTLIETVTDKIDADQGKKMMDR
LLDDNYNYHDFQKQLKTLKKIGSFSKILSFIPGLGNKMKQLSSGINDDNLKKFEVLIQSMTKEERKKPRLIALSGRRRMR
IAKGSGNQLSDVSQLMTLLEQQKKLAKQMKNFDDADINKLQEDPLSFFNHLK

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=453, Percent_Identity=29.5805739514349, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI226371618, Length=352, Percent_Identity=31.8181818181818, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI23308697, Length=316, Percent_Identity=25.3164556962025, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI295424842, Length=316, Percent_Identity=25.3164556962025, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI89061728, Length=157, Percent_Identity=31.8471337579618, Blast_Score=92, Evalue=9e-19,
Organism=Escherichia coli, GI1788963, Length=417, Percent_Identity=38.3693045563549, Blast_Score=318, Evalue=4e-88,
Organism=Escherichia coli, GI1789874, Length=307, Percent_Identity=35.5048859934853, Blast_Score=131, Evalue=8e-32,
Organism=Caenorhabditis elegans, GI17539958, Length=460, Percent_Identity=29.5652173913043, Blast_Score=203, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI193206261, Length=317, Percent_Identity=25.8675078864353, Blast_Score=87, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6325345, Length=412, Percent_Identity=32.5242718446602, Blast_Score=203, Evalue=5e-53,
Organism=Saccharomyces cerevisiae, GI6320498, Length=303, Percent_Identity=25.0825082508251, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI17647949, Length=423, Percent_Identity=27.8959810874704, Blast_Score=181, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24641198, Length=298, Percent_Identity=25.503355704698, Blast_Score=92, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 50886; Mature: 50755

Theoretical pI: Translated: 10.05; Mature: 10.05

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSILGDGFQKIINKIRGKKIIESRDIENIMEDIRLSLIEADVNIKVIDTFHELISKKSLK
CCCCCHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHH
QEVLKGLKPKEHIIKIINETLTQILGSTRSDLVVQPKPHLNAMMLIGLQGSGKTTTAGKL
HHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCEEEEEEECCCCCCCCHHHH
ALWLRKKNHQKVLLIACDIYRPGAVEQLKVIGRQIKIDVFSQGNTPVIEIVELGLQYAQK
EEEEECCCCCEEEEEEEECCCCCHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHC
NGYDAIVIDTAGRLTIDEKMMQELKEIKSKCDFSEVLLVIDALTGQQSAKNTQTFHQQVG
CCCCEEEEECCCCEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHC
ATGVILTKMDADTKGGASLSVRVMTELPLKFISSSESIDLLEPFNPDRMASRLLGMGDVL
CCEEEEEEECCCCCCCCEEEEEEHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCHHHH
TLIETVTDKIDADQGKKMMDRLLDDNYNYHDFQKQLKTLKKIGSFSKILSFIPGLGNKMK
HHHHHHHHHHCHHCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHH
QLSSGINDDNLKKFEVLIQSMTKEERKKPRLIALSGRRRMRIAKGSGNQLSDVSQLMTLL
HHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEEECCCCCCHHHHHHHHHHH
EQQKKLAKQMKNFDDADINKLQEDPLSFFNHLK
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SILGDGFQKIINKIRGKKIIESRDIENIMEDIRLSLIEADVNIKVIDTFHELISKKSLK
CCCCHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHH
QEVLKGLKPKEHIIKIINETLTQILGSTRSDLVVQPKPHLNAMMLIGLQGSGKTTTAGKL
HHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCEEEEEEECCCCCCCCHHHH
ALWLRKKNHQKVLLIACDIYRPGAVEQLKVIGRQIKIDVFSQGNTPVIEIVELGLQYAQK
EEEEECCCCCEEEEEEEECCCCCHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHC
NGYDAIVIDTAGRLTIDEKMMQELKEIKSKCDFSEVLLVIDALTGQQSAKNTQTFHQQVG
CCCCEEEEECCCCEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHC
ATGVILTKMDADTKGGASLSVRVMTELPLKFISSSESIDLLEPFNPDRMASRLLGMGDVL
CCEEEEEEECCCCCCCCEEEEEEHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCHHHH
TLIETVTDKIDADQGKKMMDRLLDDNYNYHDFQKQLKTLKKIGSFSKILSFIPGLGNKMK
HHHHHHHHHHCHHCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHH
QLSSGINDDNLKKFEVLIQSMTKEERKKPRLIALSGRRRMRIAKGSGNQLSDVSQLMTLL
HHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEEECCCCCCHHHHHHHHHHH
EQQKKLAKQMKNFDDADINKLQEDPLSFFNHLK
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8335643; 9384377; 7511896 [H]