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The map label for this gene is relA [H]

Identifier: 197294785

GI number: 197294785

Start: 782074

End: 784251

Strand: Direct

Name: relA [H]

Synonym: PAa_0767

Alternate gene names: 197294785

Gene position: 782074-784251 (Clockwise)

Preceding gene: 197294784

Following gene: 197294788

Centisome position: 88.88

GC content: 29.16

Gene sequence:

>2178_bases
TTGAAAGATTTAATGGATATTATTACCCAAAACATTCATGATGAATCCATTTTAGAAAAAATAGCCAGGGCTTATCATTT
TGCCGAAGAAAAACATTCAGGCCAATTTCGTTTAACAGGAGAGGCTTATATCACTCATCCTTGTGAAGTAACCAAAAATT
TAGCTCTGCTTAACAGTGAACCTAATACTTTAATTGCTGGTTTGTTGCATGATGTTGTAGAAGATACTCCAACAACAATC
GAAGAATTAAGTGATCTTTTTGGTAAAGACGTTGCTTATTTAGTTTATTGTGCCACTAAATTAACAAAAATTGCTTTTTA
CCAAAACAAAAAGAAAGTCGATAACCAACAAAAAATGTTTTTAGCAATGGCCAAAGATATTCGAGTAGTCATTTTAAAAA
TTGCTGATAGATTACATAACATGCAAACTTTAAAATCAATGGATCCTGAAAAACAAAAAATAATAGCTCAAGAAACTTTA
GAAATACACGCCCCTTTAGCCCACCGTTTAGGTCTTTTCCATATGAAATCCGAATTAGAAGATTTAGCCTTAAGATATGT
TTTGCCAAAAGAATATTATCATATTTCTCATTTAATTAAGTTGAAAAAAAAAGAACGCGAAGAATCAGTGAAACGCGTCA
TCAAAGATATTGAAGCTCTTTTTAAAAAAAACAACTTGCAAGATGCAATCATTAAAGGGCGTATTAAAAACATTTACAGT
ATTTATAAAAAAATACACAAAAGAAAAGTTAAATTTGAAGAAATTTTTGATCTTTTAGCTATTCGAATTATTGTTTCTAA
CGTGGATTTATGTTATCAATCTTTAGGAATTATTCACGGGCATTTTTCTCCTTTGCCTTTGCGATTCAAAGATTATATTG
CAGTTCCTAAACCAAACCTTTACCAATCCCTTCATACAACAGTTTTAACTAAAAACGGCTCTTTGTTTGAGATTCAAATT
AGAACCAAAGAAATGGATCAAATCGCTGAACAAGGAATCGCTGCTCATTGGGCTTACAAAGAAAACAAAACTTATTCACA
AGAAGATAAACAAATTGAGATTGCCAAAAAATTGAGATGGTACCAAGAGTTAGTGAAAATCACAAATGATGCCAAAAATC
ACCCCGAAGAAACTTCTAAAGAATTTGTTGATGCTATTAAAAATGATATTTTAAGTGATAACGTTTATGTTTTTACACCT
ACACAAGAAGTTTTTGAACTCCCTAAAGGATCTACTCCTATTGATTTTGCTTTTCGAATTCATACAGAAGTAGCTAATAA
AATTAACGCAGCAATCGTCAACGGTCAAATCGTTACTCTTGATTATCGACTAAAAAACGGCGATATTATCGATATCAAAA
CTAATAAAAATATTTTATCAGTTAACAAAGACTGGTTGCGTATTGTAAAGACTAGTCATGCTAAAAGAAAAATTAAATCT
TTTTTAAAAAAACTTCAAAAAGAAGAAGATTTATTAGCGATTCAAAGAGGGAAAGAAATTCTTGAAAAAGAGTTAGTTTT
GCATAAAATCAAATTAGTTTTAGATCAAAATTTTATTCAAAAGCATTTCGAACGTTATAATATTTTTTCTTTAAACGATT
TTTATGAAGAAATTGGCAGAAAAAAAATAAGCACTAAAACTGTTATTAACAAAATACTGCCCTTAGCTAATCACAATATT
AGTCAAACTAATTTAGAAAAGCAAATGGTTAAATCTCAACAAAAGTTAACTCATCAAAGTGAAAACGGAGTTTTGATTGA
AGGTTTACACAATCCTAAATTAAAATTAGCTAATTGTTGTTCTCCTGTTGCGGGGGATAAAATATCGGGATTTTTGACTA
AGGGGCGTGGCATTATCGTTCATTTGAAAAATTGTATTAATTTAAAAAATTGCGATTTTCAAAGGATAATTGCTGCCTCT
TGGGAAGATGCTGATTTTAAATATTCTGCCTGGCTTAGTTTAATTGCTAATAGCAAAGATAATTTAACCCAACAAATAAT
TAACAAAATTAATGTTTTCAAAATTAATATTTTGGAATTAAAAGTTATCAATAATCAAAAACTAGAAACAATTATTAAAC
TTAGAGTTTTGACTTCTAACATTCAAGAATTAAATAATTTAATCGCCAATTTACAAAAGATCCCTGAAGTGAATCGAATT
AAAAGAGGCAATTATTAA

Upstream 100 bases:

>100_bases
TGCCTTGGAGCTGGCGTTATTAAAGAAGTTTATTTTCAAAATCAAAAAAGATTATATACTTAATTTTAAAGATAAGAGGT
GAGAAAAAACAAAAAAAATA

Downstream 100 bases:

>100_bases
TAAATTTAAGATAAAGAAAAGTTATTTTTTAACCTCACAAGTGTTTTTGAATTTTTACACTATAAATTAGTAATTGTTGA
GTTAGTTAGATACAAAGATT

Product: GTP pyrophosphokinase

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 725; Mature: 725

Protein sequence:

>725_residues
MKDLMDIITQNIHDESILEKIARAYHFAEEKHSGQFRLTGEAYITHPCEVTKNLALLNSEPNTLIAGLLHDVVEDTPTTI
EELSDLFGKDVAYLVYCATKLTKIAFYQNKKKVDNQQKMFLAMAKDIRVVILKIADRLHNMQTLKSMDPEKQKIIAQETL
EIHAPLAHRLGLFHMKSELEDLALRYVLPKEYYHISHLIKLKKKEREESVKRVIKDIEALFKKNNLQDAIIKGRIKNIYS
IYKKIHKRKVKFEEIFDLLAIRIIVSNVDLCYQSLGIIHGHFSPLPLRFKDYIAVPKPNLYQSLHTTVLTKNGSLFEIQI
RTKEMDQIAEQGIAAHWAYKENKTYSQEDKQIEIAKKLRWYQELVKITNDAKNHPEETSKEFVDAIKNDILSDNVYVFTP
TQEVFELPKGSTPIDFAFRIHTEVANKINAAIVNGQIVTLDYRLKNGDIIDIKTNKNILSVNKDWLRIVKTSHAKRKIKS
FLKKLQKEEDLLAIQRGKEILEKELVLHKIKLVLDQNFIQKHFERYNIFSLNDFYEEIGRKKISTKTVINKILPLANHNI
SQTNLEKQMVKSQQKLTHQSENGVLIEGLHNPKLKLANCCSPVAGDKISGFLTKGRGIIVHLKNCINLKNCDFQRIIAAS
WEDADFKYSAWLSLIANSKDNLTQQIINKINVFKINILELKVINNQKLETIIKLRVLTSNIQELNNLIANLQKIPEVNRI
KRGNY

Sequences:

>Translated_725_residues
MKDLMDIITQNIHDESILEKIARAYHFAEEKHSGQFRLTGEAYITHPCEVTKNLALLNSEPNTLIAGLLHDVVEDTPTTI
EELSDLFGKDVAYLVYCATKLTKIAFYQNKKKVDNQQKMFLAMAKDIRVVILKIADRLHNMQTLKSMDPEKQKIIAQETL
EIHAPLAHRLGLFHMKSELEDLALRYVLPKEYYHISHLIKLKKKEREESVKRVIKDIEALFKKNNLQDAIIKGRIKNIYS
IYKKIHKRKVKFEEIFDLLAIRIIVSNVDLCYQSLGIIHGHFSPLPLRFKDYIAVPKPNLYQSLHTTVLTKNGSLFEIQI
RTKEMDQIAEQGIAAHWAYKENKTYSQEDKQIEIAKKLRWYQELVKITNDAKNHPEETSKEFVDAIKNDILSDNVYVFTP
TQEVFELPKGSTPIDFAFRIHTEVANKINAAIVNGQIVTLDYRLKNGDIIDIKTNKNILSVNKDWLRIVKTSHAKRKIKS
FLKKLQKEEDLLAIQRGKEILEKELVLHKIKLVLDQNFIQKHFERYNIFSLNDFYEEIGRKKISTKTVINKILPLANHNI
SQTNLEKQMVKSQQKLTHQSENGVLIEGLHNPKLKLANCCSPVAGDKISGFLTKGRGIIVHLKNCINLKNCDFQRIIAAS
WEDADFKYSAWLSLIANSKDNLTQQIINKINVFKINILELKVINNQKLETIIKLRVLTSNIQELNNLIANLQKIPEVNRI
KRGNY
>Mature_725_residues
MKDLMDIITQNIHDESILEKIARAYHFAEEKHSGQFRLTGEAYITHPCEVTKNLALLNSEPNTLIAGLLHDVVEDTPTTI
EELSDLFGKDVAYLVYCATKLTKIAFYQNKKKVDNQQKMFLAMAKDIRVVILKIADRLHNMQTLKSMDPEKQKIIAQETL
EIHAPLAHRLGLFHMKSELEDLALRYVLPKEYYHISHLIKLKKKEREESVKRVIKDIEALFKKNNLQDAIIKGRIKNIYS
IYKKIHKRKVKFEEIFDLLAIRIIVSNVDLCYQSLGIIHGHFSPLPLRFKDYIAVPKPNLYQSLHTTVLTKNGSLFEIQI
RTKEMDQIAEQGIAAHWAYKENKTYSQEDKQIEIAKKLRWYQELVKITNDAKNHPEETSKEFVDAIKNDILSDNVYVFTP
TQEVFELPKGSTPIDFAFRIHTEVANKINAAIVNGQIVTLDYRLKNGDIIDIKTNKNILSVNKDWLRIVKTSHAKRKIKS
FLKKLQKEEDLLAIQRGKEILEKELVLHKIKLVLDQNFIQKHFERYNIFSLNDFYEEIGRKKISTKTVINKILPLANHNI
SQTNLEKQMVKSQQKLTHQSENGVLIEGLHNPKLKLANCCSPVAGDKISGFLTKGRGIIVHLKNCINLKNCDFQRIIAAS
WEDADFKYSAWLSLIANSKDNLTQQIINKINVFKINILELKVINNQKLETIIKLRVLTSNIQELNNLIANLQKIPEVNRI
KRGNY

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Escherichia coli, GI1790082, Length=638, Percent_Identity=37.1473354231975, Blast_Score=445, Evalue=1e-126,
Organism=Escherichia coli, GI1789147, Length=705, Percent_Identity=32.9078014184397, Blast_Score=389, Evalue=1e-109,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 83872; Mature: 83872

Theoretical pI: Translated: 9.87; Mature: 9.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDLMDIITQNIHDESILEKIARAYHFAEEKHSGQFRLTGEAYITHPCEVTKNLALLNSE
CCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCEEEECCHHHHCCEEEECCC
PNTLIAGLLHDVVEDTPTTIEELSDLFGKDVAYLVYCATKLTKIAFYQNKKKVDNQQKMF
CHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCHHHCCHHHHHH
LAMAKDIRVVILKIADRLHNMQTLKSMDPEKQKIIAQETLEIHAPLAHRLGLFHMKSELE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
DLALRYVLPKEYYHISHLIKLKKKEREESVKRVIKDIEALFKKNNLQDAIIKGRIKNIYS
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
IYKKIHKRKVKFEEIFDLLAIRIIVSNVDLCYQSLGIIHGHFSPLPLRFKDYIAVPKPNL
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCEECCCCCHH
YQSLHTTVLTKNGSLFEIQIRTKEMDQIAEQGIAAHWAYKENKTYSQEDKQIEIAKKLRW
HHHHHHHHEECCCCEEEEEECHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHH
YQELVKITNDAKNHPEETSKEFVDAIKNDILSDNVYVFTPTQEVFELPKGSTPIDFAFRI
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHCCCCCCCCEEEEEE
HTEVANKINAAIVNGQIVTLDYRLKNGDIIDIKTNKNILSVNKDWLRIVKTSHAKRKIKS
HHHHHHHHHHEEECCEEEEEEEEECCCCEEEEECCCCEEECCHHHHHHHHHHHHHHHHHH
FLKKLQKEEDLLAIQRGKEILEKELVLHKIKLVLDQNFIQKHFERYNIFSLNDFYEEIGR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCH
KKISTKTVINKILPLANHNISQTNLEKQMVKSQQKLTHQSENGVLIEGLHNPKLKLANCC
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHCC
SPVAGDKISGFLTKGRGIIVHLKNCINLKNCDFQRIIAASWEDADFKYSAWLSLIANSKD
CCCCCCHHHHHHCCCCEEEEEEHHHCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHCCCH
NLTQQIINKINVFKINILELKVINNQKLETIIKLRVLTSNIQELNNLIANLQKIPEVNRI
HHHHHHHHCCCEEEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
KRGNY
CCCCC
>Mature Secondary Structure
MKDLMDIITQNIHDESILEKIARAYHFAEEKHSGQFRLTGEAYITHPCEVTKNLALLNSE
CCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCEEEECCHHHHCCEEEECCC
PNTLIAGLLHDVVEDTPTTIEELSDLFGKDVAYLVYCATKLTKIAFYQNKKKVDNQQKMF
CHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCHHHCCHHHHHH
LAMAKDIRVVILKIADRLHNMQTLKSMDPEKQKIIAQETLEIHAPLAHRLGLFHMKSELE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
DLALRYVLPKEYYHISHLIKLKKKEREESVKRVIKDIEALFKKNNLQDAIIKGRIKNIYS
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
IYKKIHKRKVKFEEIFDLLAIRIIVSNVDLCYQSLGIIHGHFSPLPLRFKDYIAVPKPNL
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCEECCCCCHH
YQSLHTTVLTKNGSLFEIQIRTKEMDQIAEQGIAAHWAYKENKTYSQEDKQIEIAKKLRW
HHHHHHHHEECCCCEEEEEECHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHH
YQELVKITNDAKNHPEETSKEFVDAIKNDILSDNVYVFTPTQEVFELPKGSTPIDFAFRI
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHCCCCCCCCEEEEEE
HTEVANKINAAIVNGQIVTLDYRLKNGDIIDIKTNKNILSVNKDWLRIVKTSHAKRKIKS
HHHHHHHHHHEEECCEEEEEEEEECCCCEEEEECCCCEEECCHHHHHHHHHHHHHHHHHH
FLKKLQKEEDLLAIQRGKEILEKELVLHKIKLVLDQNFIQKHFERYNIFSLNDFYEEIGR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCH
KKISTKTVINKILPLANHNISQTNLEKQMVKSQQKLTHQSENGVLIEGLHNPKLKLANCC
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHCC
SPVAGDKISGFLTKGRGIIVHLKNCINLKNCDFQRIIAASWEDADFKYSAWLSLIANSKD
CCCCCCHHHHHHCCCCEEEEEEHHHCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHCCCH
NLTQQIINKINVFKINILELKVINNQKLETIIKLRVLTSNIQELNNLIANLQKIPEVNRI
HHHHHHHHCCCEEEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
KRGNY
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9383190; 9384377 [H]