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The map label for this gene is pepP [H]

Identifier: 197294713

GI number: 197294713

Start: 688097

End: 689359

Strand: Reverse

Name: pepP [H]

Synonym: PAa_0679

Alternate gene names: 197294713

Gene position: 689359-688097 (Counterclockwise)

Preceding gene: 197294714

Following gene: 197294712

Centisome position: 78.34

GC content: 29.06

Gene sequence:

>1263_bases
ATGTTTTTACAAAATAGAGACAACTTGATTCAAAAAATGGAACAAAACACAGCTGCTGTATTTTTTTCTGGTAAAAAGAT
TGTGAAAAGTGGTGATCAATTTTTCCCTTTTGAAGTCGATCATAATTTTTATTATTTAACAGGAATTAATCAACCTAATT
CAATTTTATTCATTAAAAAAACTGCTTCCGGTTCTCAAGTGTTTTTATTTTTAGATGAACGCGACCCGCAAAAAGCTTTA
TGGGATGGCGATCTTTTAAGTTTTTCTGAAGCTTCTAAAATATCTTGCCTTAAAGAAGAAAAGATTCAAAAAAATACCCT
TTTTAATTCTTTTTTATTAGAAACCATCAACCCTTTAAGAAGTTTTTCCACTGCTTCGATTGATGCTTTTTATTTTGATT
TATCAAGTAGCTCCCGTAATTTAACACAAGAAAATAATCAAGCTTTAATGTTTTGTCAAAAACTTTTGTCTTTGTATCCT
TTTTTAAAAATTAAAAACAGCTCTCCTTTTTTATTGGCTTTGCGTCAATCTAAAAATCTTTATGAACAAACCCAAATTAA
AAAAGCTTTAGAAATCAACGCTCAATCCTTAACTCAACTAATGACTCAAATTAAACCTTTAAATAATGAAAATGATGTAG
CTTCTTTTTTCCGTTATTTTTTAGAAAAAAACCAAACCAAAGAAGCTTTTGATACTATTGCTGCCTCAGGCAAAAATGCT
TTGGTTTTACATTATATTCGCAATTCTGCGCAATTAAATCATAATGAAGTTTTGTTATTTGATGCGGGAGTTAATTATAA
TCATTACTCTTCTGATATTACTCGTTGTTATCCTATTGGTGGCGTTTTTACTCCTTTTCAAAAGCAAATTTATAATTTAG
TTTTAAAAGCCAATAAAGCAATTATCTCTTTTGTAAGACCGCATCACACCTTAGCACAATTAAATCACTATGGTAAAAAT
ATTTTAGCAGAAGGCTTGAAAGAGTTATCTCTTTGGCAAGAAAACGACCGTATTGATAATTATTGTTATCATGGTTTATG
TCATCATTTAGGACTAGACGTTCATGACGTTTGTAATTATTCTGATATTATTGGAGAAAACAGTGTTATCACTGTGGAAC
CAGGTCTTTATTTCCAAAAATTTAATCTCGGCATTAGAATCGAAGACGATATTTTAGTGACTAAAAATGGTGCAATTAAT
TTATCTCAAAAAATCCCTAAAGAAATTACAGAAATTGAAGCTTTAATGAAATCTTTTTGTTAA

Upstream 100 bases:

>100_bases
TTTTCTAGAACGAACGTTTTGCATCGCGAAAAAAAATAATTTTTTCTTTTTGAGATTTAATATGATTAATTTTATCATTT
TTTAAGGGAGATAAGCTTTT

Downstream 100 bases:

>100_bases
TTTTTTTTGTGGCCCTGTAGCCAAGTGGTAAGGCATGGCTCTGCAAAAGCTTGATCATCGGTTCAAATCCGTTCAGGGCC
TCCATTTATTTTTATTTTCT

Product: Xaa-Pro aminopeptidase

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MFLQNRDNLIQKMEQNTAAVFFSGKKIVKSGDQFFPFEVDHNFYYLTGINQPNSILFIKKTASGSQVFLFLDERDPQKAL
WDGDLLSFSEASKISCLKEEKIQKNTLFNSFLLETINPLRSFSTASIDAFYFDLSSSSRNLTQENNQALMFCQKLLSLYP
FLKIKNSSPFLLALRQSKNLYEQTQIKKALEINAQSLTQLMTQIKPLNNENDVASFFRYFLEKNQTKEAFDTIAASGKNA
LVLHYIRNSAQLNHNEVLLFDAGVNYNHYSSDITRCYPIGGVFTPFQKQIYNLVLKANKAIISFVRPHHTLAQLNHYGKN
ILAEGLKELSLWQENDRIDNYCYHGLCHHLGLDVHDVCNYSDIIGENSVITVEPGLYFQKFNLGIRIEDDILVTKNGAIN
LSQKIPKEITEIEALMKSFC

Sequences:

>Translated_420_residues
MFLQNRDNLIQKMEQNTAAVFFSGKKIVKSGDQFFPFEVDHNFYYLTGINQPNSILFIKKTASGSQVFLFLDERDPQKAL
WDGDLLSFSEASKISCLKEEKIQKNTLFNSFLLETINPLRSFSTASIDAFYFDLSSSSRNLTQENNQALMFCQKLLSLYP
FLKIKNSSPFLLALRQSKNLYEQTQIKKALEINAQSLTQLMTQIKPLNNENDVASFFRYFLEKNQTKEAFDTIAASGKNA
LVLHYIRNSAQLNHNEVLLFDAGVNYNHYSSDITRCYPIGGVFTPFQKQIYNLVLKANKAIISFVRPHHTLAQLNHYGKN
ILAEGLKELSLWQENDRIDNYCYHGLCHHLGLDVHDVCNYSDIIGENSVITVEPGLYFQKFNLGIRIEDDILVTKNGAIN
LSQKIPKEITEIEALMKSFC
>Mature_420_residues
MFLQNRDNLIQKMEQNTAAVFFSGKKIVKSGDQFFPFEVDHNFYYLTGINQPNSILFIKKTASGSQVFLFLDERDPQKAL
WDGDLLSFSEASKISCLKEEKIQKNTLFNSFLLETINPLRSFSTASIDAFYFDLSSSSRNLTQENNQALMFCQKLLSLYP
FLKIKNSSPFLLALRQSKNLYEQTQIKKALEINAQSLTQLMTQIKPLNNENDVASFFRYFLEKNQTKEAFDTIAASGKNA
LVLHYIRNSAQLNHNEVLLFDAGVNYNHYSSDITRCYPIGGVFTPFQKQIYNLVLKANKAIISFVRPHHTLAQLNHYGKN
ILAEGLKELSLWQENDRIDNYCYHGLCHHLGLDVHDVCNYSDIIGENSVITVEPGLYFQKFNLGIRIEDDILVTKNGAIN
LSQKIPKEITEIEALMKSFC

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=435, Percent_Identity=27.5862068965517, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI149589008, Length=486, Percent_Identity=22.8395061728395, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI260593665, Length=307, Percent_Identity=26.3843648208469, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI260593663, Length=245, Percent_Identity=28.9795918367347, Blast_Score=102, Evalue=9e-22,
Organism=Escherichia coli, GI1789275, Length=448, Percent_Identity=29.6875, Blast_Score=196, Evalue=3e-51,
Organism=Escherichia coli, GI1788728, Length=245, Percent_Identity=27.3469387755102, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1790282, Length=290, Percent_Identity=24.4827586206897, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71989583, Length=375, Percent_Identity=27.7333333333333, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17508215, Length=492, Percent_Identity=25.8130081300813, Blast_Score=127, Evalue=9e-30,
Organism=Saccharomyces cerevisiae, GI6320922, Length=449, Percent_Identity=26.5033407572383, Blast_Score=148, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6321118, Length=464, Percent_Identity=29.0948275862069, Blast_Score=147, Evalue=3e-36,
Organism=Drosophila melanogaster, GI19920384, Length=432, Percent_Identity=28.7037037037037, Blast_Score=158, Evalue=7e-39,
Organism=Drosophila melanogaster, GI21357079, Length=449, Percent_Identity=25.3897550111359, Blast_Score=114, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 48090; Mature: 48090

Theoretical pI: Translated: 7.31; Mature: 7.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLQNRDNLIQKMEQNTAAVFFSGKKIVKSGDQFFPFEVDHNFYYLTGINQPNSILFIKK
CCCCCHHHHHHHHHCCCEEEEEECCHHHHCCCCCCCEEECCCEEEEEECCCCCEEEEEEE
TASGSQVFLFLDERDPQKALWDGDLLSFSEASKISCLKEEKIQKNTLFNSFLLETINPLR
CCCCCEEEEEEECCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SFSTASIDAFYFDLSSSSRNLTQENNQALMFCQKLLSLYPFLKIKNSSPFLLALRQSKNL
CCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCEEEECCCCCEEEEEECCCCH
YEQTQIKKALEINAQSLTQLMTQIKPLNNENDVASFFRYFLEKNQTKEAFDTIAASGKNA
HHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCE
LVLHYIRNSAQLNHNEVLLFDAGVNYNHYSSDITRCYPIGGVFTPFQKQIYNLVLKANKA
EEEEEECCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCHH
IISFVRPHHTLAQLNHYGKNILAEGLKELSLWQENDRIDNYCYHGLCHHLGLDVHDVCNY
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHCCH
SDIIGENSVITVEPGLYFQKFNLGIRIEDDILVTKNGAINLSQKIPKEITEIEALMKSFC
HHHCCCCCEEEECCCCEEEEECCCEEEECCEEEECCCCEECHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFLQNRDNLIQKMEQNTAAVFFSGKKIVKSGDQFFPFEVDHNFYYLTGINQPNSILFIKK
CCCCCHHHHHHHHHCCCEEEEEECCHHHHCCCCCCCEEECCCEEEEEECCCCCEEEEEEE
TASGSQVFLFLDERDPQKALWDGDLLSFSEASKISCLKEEKIQKNTLFNSFLLETINPLR
CCCCCEEEEEEECCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SFSTASIDAFYFDLSSSSRNLTQENNQALMFCQKLLSLYPFLKIKNSSPFLLALRQSKNL
CCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCEEEECCCCCEEEEEECCCCH
YEQTQIKKALEINAQSLTQLMTQIKPLNNENDVASFFRYFLEKNQTKEAFDTIAASGKNA
HHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCE
LVLHYIRNSAQLNHNEVLLFDAGVNYNHYSSDITRCYPIGGVFTPFQKQIYNLVLKANKA
EEEEEECCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCHH
IISFVRPHHTLAQLNHYGKNILAEGLKELSLWQENDRIDNYCYHGLCHHLGLDVHDVCNY
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHCCH
SDIIGENSVITVEPGLYFQKFNLGIRIEDDILVTKNGAINLSQKIPKEITEIEALMKSFC
HHHCCCCCEEEECCCCEEEEECCCEEEECCEEEECCCCEECHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2659585; 1339425; 9278503; 9520390 [H]