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The map label for this gene is pth

Identifier: 197294654

GI number: 197294654

Start: 605383

End: 605952

Strand: Direct

Name: pth

Synonym: PAa_0610

Alternate gene names: 197294654

Gene position: 605383-605952 (Clockwise)

Preceding gene: 197294653

Following gene: 197294665

Centisome position: 68.8

GC content: 24.39

Gene sequence:

>570_bases
ATGAAAAAAATTATCATTGGTTTAGGAAATCCAGGAAAAGAATTTCAAAATACATATCATAATATAGGTTTTTTAGCTTT
AGAATCTTTTTTAAAAAATAATAAACATCAAATGATTCCGAATTCATATCAAGGCCATCTTTATCAAATTCAGTTAAATA
ACTGTATATCTTTTTTAGTTAAACCACAAATGTATATGAATTCATCTGGCAAAGTAGTTAAAAAAATTTTAGATGCATAT
CAGATTAAAATAGAAGATATTTTAGTTATTCTAGATGATATTTATTTACCAGAAGGAAAAATTAAATTAAGACCTCAAGG
TGGCCACGCAGGACATAATGGTTTAAGAAATATTATTGAATGTTGCAATACTAATAAATTTAAAAGATTAAAAATTGGGG
TCGGTTATGATTCAAACATCCCTTTAAATCAATACCTTTTAACCCCTTTTAATTTGCACCAAAAAAAGCAAATATTGCAA
AATATTGACAAGATACATGAAATTATGAGCAAATTTATCCAAGGAATAAGTTTTAATAATTTGATGAATCAATATAACGT
AATAAAATAA

Upstream 100 bases:

>100_bases
ATTTAAAGTTGCAACAAGTTTTATTTTTTTATTAAATTTAAAAAATTTGGATAACTATTTTTTATCTAACAAATGAGAAC
ATAAAAAAAGGGAAAAAATG

Downstream 100 bases:

>100_bases
AAAAAGCAAGTAATTTAATTACTTGCTTTTAATTCATTTGTAGCGATGGATAAGATATTTTTGCGAATTTTAATTTTAGA
AATAACTTTATCTTTGAGTT

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 189; Mature: 189

Protein sequence:

>189_residues
MKKIIIGLGNPGKEFQNTYHNIGFLALESFLKNNKHQMIPNSYQGHLYQIQLNNCISFLVKPQMYMNSSGKVVKKILDAY
QIKIEDILVILDDIYLPEGKIKLRPQGGHAGHNGLRNIIECCNTNKFKRLKIGVGYDSNIPLNQYLLTPFNLHQKKQILQ
NIDKIHEIMSKFIQGISFNNLMNQYNVIK

Sequences:

>Translated_189_residues
MKKIIIGLGNPGKEFQNTYHNIGFLALESFLKNNKHQMIPNSYQGHLYQIQLNNCISFLVKPQMYMNSSGKVVKKILDAY
QIKIEDILVILDDIYLPEGKIKLRPQGGHAGHNGLRNIIECCNTNKFKRLKIGVGYDSNIPLNQYLLTPFNLHQKKQILQ
NIDKIHEIMSKFIQGISFNNLMNQYNVIK
>Mature_189_residues
MKKIIIGLGNPGKEFQNTYHNIGFLALESFLKNNKHQMIPNSYQGHLYQIQLNNCISFLVKPQMYMNSSGKVVKKILDAY
QIKIEDILVILDDIYLPEGKIKLRPQGGHAGHNGLRNIIECCNTNKFKRLKIGVGYDSNIPLNQYLLTPFNLHQKKQILQ
NIDKIHEIMSKFIQGISFNNLMNQYNVIK

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=184, Percent_Identity=24.4565217391304, Blast_Score=76, Evalue=2e-14,
Organism=Escherichia coli, GI1787455, Length=166, Percent_Identity=33.7349397590361, Blast_Score=68, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6321983, Length=141, Percent_Identity=31.9148936170213, Blast_Score=71, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_PHYAS (B1VAH1)

Other databases:

- EMBL:   AM422018
- RefSeq:   YP_001799195.1
- ProteinModelPortal:   B1VAH1
- SMR:   B1VAH1
- GeneID:   6799244
- GenomeReviews:   AM422018_GR
- HOGENOM:   HBG610927
- OMA:   FSPKHNA
- ProtClustDB:   PRK05426
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 21787; Mature: 21787

Theoretical pI: Translated: 10.04; Mature: 10.04

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKIIIGLGNPGKEFQNTYHNIGFLALESFLKNNKHQMIPNSYQGHLYQIQLNNCISFLV
CCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEHHHHHHHHH
KPQMYMNSSGKVVKKILDAYQIKIEDILVILDDIYLPEGKIKLRPQGGHAGHNGLRNIIE
CCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHH
CCNTNKFKRLKIGVGYDSNIPLNQYLLTPFNLHQKKQILQNIDKIHEIMSKFIQGISFNN
HHCCCCEEEEEEECCCCCCCCCHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
LMNQYNVIK
HHHHHCCCC
>Mature Secondary Structure
MKKIIIGLGNPGKEFQNTYHNIGFLALESFLKNNKHQMIPNSYQGHLYQIQLNNCISFLV
CCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEHHHHHHHHH
KPQMYMNSSGKVVKKILDAYQIKIEDILVILDDIYLPEGKIKLRPQGGHAGHNGLRNIIE
CCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHH
CCNTNKFKRLKIGVGYDSNIPLNQYLLTPFNLHQKKQILQNIDKIHEIMSKFIQGISFNN
HHCCCCEEEEEEECCCCCCCCCHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
LMNQYNVIK
HHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA