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The map label for this gene is fba [H]

Identifier: 197294557

GI number: 197294557

Start: 505806

End: 506672

Strand: Reverse

Name: fba [H]

Synonym: PAa_0512

Alternate gene names: 197294557

Gene position: 506672-505806 (Counterclockwise)

Preceding gene: 197294558

Following gene: 197294556

Centisome position: 57.58

GC content: 34.26

Gene sequence:

>867_bases
ATGTTAACTTCAGATAAAAAAATTATTTTAAAAGCTCATCAACAAAAATATGCAATCGCTCAAGTAAACATCAACAATTT
AGAATGGACTAAGGCTGCTTTGCAAACAGCTCAAGAATTACAATCACCAATTATTTTAGGGGTTTCTGAGGGTGCTGCCA
AATATTTCGGAGGTTTTAAAACAGCTTTTGCTTTAGTAAAATCCCTTGATGATTATTATAAAATTTCTGTTCCTGTTATT
CTTCATGCAGACCATAGTTCTTATGAAGCAGCTTTAGAGGCAATTGAGGCGGGTTTTACTTCTATTATGTTTGATGGAAG
TCATTTTGATTTCGAAACAAACTTAAGTAAAACAAAAGCGATGACAAAGATATGTCATGACAAAGGTCTTTTAATTGAAG
CAGAAGTTGGAAGTATCGGCGGAGAAGAGGATGGTATCGTTGGCAAAGGAGAAATCGCTGATCCAGAAGAATGTAAAAAA
ATTGCTGATTTAGGGGTTGATTTACTTGCTGCAGGAATCGGAAACATTCACGGAAAATACCCTCCCAATTGGCCTGGTCT
TGATTTCGAAGTTTTAAAGAAAATTAGGGAATTAACGAACAATAAAACTCCTTTAGTTTTACACGGAGGAAGCGGAATTT
CTGAAGAAGTTGTTAAACAAACTATCGCTTTAGGAGTGGCCAAAGTTAACGTTAACACAGAGTTCCAATTAGTTTTCGCT
AAAGCAACTAGAAAATATATTGAAGAAGGAAAAGATTTAACGAGTAAAGGTTTTGATCCTCGTAAATTATTAAATCCAGG
TTTTTTAGCGATTAAAGAAGAAATTAAACGCAAATTAACTCTTTTTGGTTCCGTCAACAAAGCTTAA

Upstream 100 bases:

>100_bases
AAATAATTTAATTTAAAAAATGTGGTTTTATTTTTATCTTTTTCTAATTAGGAAATAATTTATTAATAATGATTTGAAAT
CAAAGAAAGCGTAAAATGAA

Downstream 100 bases:

>100_bases
AATAAAAAAAATTAAAATAAAAGGTATAATTGTTATGAAGAATCAATTAACTAATTTAAAGATCGAAAATAAAAAAGTTT
TATTGCGGGCTGATTTGAAT

Product: Fructose-bisphosphate aldolase class II

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MLTSDKKIILKAHQQKYAIAQVNINNLEWTKAALQTAQELQSPIILGVSEGAAKYFGGFKTAFALVKSLDDYYKISVPVI
LHADHSSYEAALEAIEAGFTSIMFDGSHFDFETNLSKTKAMTKICHDKGLLIEAEVGSIGGEEDGIVGKGEIADPEECKK
IADLGVDLLAAGIGNIHGKYPPNWPGLDFEVLKKIRELTNNKTPLVLHGGSGISEEVVKQTIALGVAKVNVNTEFQLVFA
KATRKYIEEGKDLTSKGFDPRKLLNPGFLAIKEEIKRKLTLFGSVNKA

Sequences:

>Translated_288_residues
MLTSDKKIILKAHQQKYAIAQVNINNLEWTKAALQTAQELQSPIILGVSEGAAKYFGGFKTAFALVKSLDDYYKISVPVI
LHADHSSYEAALEAIEAGFTSIMFDGSHFDFETNLSKTKAMTKICHDKGLLIEAEVGSIGGEEDGIVGKGEIADPEECKK
IADLGVDLLAAGIGNIHGKYPPNWPGLDFEVLKKIRELTNNKTPLVLHGGSGISEEVVKQTIALGVAKVNVNTEFQLVFA
KATRKYIEEGKDLTSKGFDPRKLLNPGFLAIKEEIKRKLTLFGSVNKA
>Mature_288_residues
MLTSDKKIILKAHQQKYAIAQVNINNLEWTKAALQTAQELQSPIILGVSEGAAKYFGGFKTAFALVKSLDDYYKISVPVI
LHADHSSYEAALEAIEAGFTSIMFDGSHFDFETNLSKTKAMTKICHDKGLLIEAEVGSIGGEEDGIVGKGEIADPEECKK
IADLGVDLLAAGIGNIHGKYPPNWPGLDFEVLKKIRELTNNKTPLVLHGGSGISEEVVKQTIALGVAKVNVNTEFQLVFA
KATRKYIEEGKDLTSKGFDPRKLLNPGFLAIKEEIKRKLTLFGSVNKA

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789526, Length=291, Percent_Identity=37.1134020618557, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI87082041, Length=292, Percent_Identity=32.8767123287671, Blast_Score=165, Evalue=3e-42,
Organism=Escherichia coli, GI1788072, Length=290, Percent_Identity=35.5172413793103, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1789293, Length=348, Percent_Identity=25.5747126436782, Blast_Score=92, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6322790, Length=336, Percent_Identity=30.3571428571429, Blast_Score=103, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011289
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 31361; Mature: 31361

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTSDKKIILKAHQQKYAIAQVNINNLEWTKAALQTAQELQSPIILGVSEGAAKYFGGFK
CCCCCCCCEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHCHHH
TAFALVKSLDDYYKISVPVILHADHSSYEAALEAIEAGFTSIMFDGSHFDFETNLSKTKA
HHHHHHHHHHHHEEEEEEEEEECCCCHHHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHH
MTKICHDKGLLIEAEVGSIGGEEDGIVGKGEIADPEECKKIADLGVDLLAAGIGNIHGKY
HHHHHHCCCCEEEEECCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
PPNWPGLDFEVLKKIRELTNNKTPLVLHGGSGISEEVVKQTIALGVAKVNVNTEFQLVFA
CCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHEEEEECCCEEEEEEH
KATRKYIEEGKDLTSKGFDPRKLLNPGFLAIKEEIKRKLTLFGSVNKA
HHHHHHHHCCCCHHHCCCCHHHHCCCCHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MLTSDKKIILKAHQQKYAIAQVNINNLEWTKAALQTAQELQSPIILGVSEGAAKYFGGFK
CCCCCCCCEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHCHHH
TAFALVKSLDDYYKISVPVILHADHSSYEAALEAIEAGFTSIMFDGSHFDFETNLSKTKA
HHHHHHHHHHHHEEEEEEEEEECCCCHHHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHH
MTKICHDKGLLIEAEVGSIGGEEDGIVGKGEIADPEECKKIADLGVDLLAAGIGNIHGKY
HHHHHHCCCCEEEEECCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
PPNWPGLDFEVLKKIRELTNNKTPLVLHGGSGISEEVVKQTIALGVAKVNVNTEFQLVFA
CCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHEEEEECCCEEEEEEH
KATRKYIEEGKDLTSKGFDPRKLLNPGFLAIKEEIKRKLTLFGSVNKA
HHHHHHHHCCCCHHHCCCCHHHHCCCCHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8948633 [H]