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The map label for this gene is uvrB [H]

Identifier: 197294511

GI number: 197294511

Start: 452651

End: 454642

Strand: Direct

Name: uvrB [H]

Synonym: PAa_0453

Alternate gene names: 197294511

Gene position: 452651-454642 (Clockwise)

Preceding gene: 197294510

Following gene: 197294512

Centisome position: 51.44

GC content: 30.32

Gene sequence:

>1992_bases
ATGAACATGTTTAAGTTAAAAACTGATTTAAAGCCGAACGGCGATCAACCGCAGGCGATTAAAAAATTAGTTCAAGGCTT
TGAAAAGGGTTTTAAAGAACAAATTCTTTTAGGAGCAACAGGAACTGGAAAAACTTTTACTATTGCAAACATTATCCAAC
ATTTACAACAACAAACTTTAGTGATTGCGCACAACAAAACTTTAGCAGGGCAACTTTATAATGAATTAAAAATGATGTTC
CCTGAAAATAAAGTTGAATATTTTATCTCTTATTATGATTATTATCAACCAGAAGCATATGTAACTTCCAGTGATACTTA
CATTGAAAAAGACTCTAAGATTAATGATGAAATTGATCAATTGCGTCACAATGCTATTGTTTCTTTATTAAACAGAAAAG
ATGTAATTGTTGTTGCTTCGGTTTCATGTATTTATGGGGTGGGAGATTTAGAAGATTACCAATCATCAACTTTATTTTTA
CAAATAGGTGATCGCTTTGAAAGAAATCTTTTTTTAAAAAAATTAGTAGAGTTGAAGTTTCAAAGAAATGAAGTTAATTT
TGGCAGAGGAACTTTTAGAGTTAGAGGAGATATTGTAGAAATTATCCCTTCATCTCACAAAGAAATAGGTATTCGGATTA
TTTTTTTTGGTGATGAAATAGAAAGAATACAACTTTTTGAATTATTAAACGCAAAAGTAATTGAAAATCTTAAAGTAACC
AAAATTTTTCCTGCGAGCCTTTATGCTGTTAATGCTGAAAAAATTAAAGAAAGTATCAAAAGGATTCGACAAGAATTAAA
AGAACAAATAAAACATTTTGAAAAAGAAAAGAATCTTGTAGCCGCCCAAAAAATTAAAATGCGTACTTCGCATGATTTGG
AAATGTTGGCAGAAATGGGTCATTGTAGCGGAATCGAAAATTATTCCAGACATTTATCTTTAAAAGAACAAGGGCAACCG
CCATCAACTTTAATTGATTTTTTTGACAAGGAATTTTTAACGATTATTGATGAATCGCATGTCACAGTCCCTCAAATTAA
AGGGATGTATTTTGGTGATTTTTCGCGAAAGTCAAATCTAGTTAATTATGGTTTTCGTCTTCCTAGTGCTTTGGACAACA
GACCTTTAAAATTTCATGAGTTTGAAGAAAAAATAGACAAAATCATTTATTTATCGGCAACTCCAGGAGATCACGAGATT
GAACGTAAATTGCCTATTATCGAGCAAATAATTCGTCCTACTTTTGTGCTTGATCCCGAAATCGAAGTAAAAAGAACCCA
AAATCAAATGGATGATCTGTACTTTGAAATCAAAAAAAGAATCCAAAAAAACCAAAGAGTTTTAATTACCACTTTAACTA
TTAATATGAGCGAAGATTTAACTGCTTATCTGAAAAATTTAGGTATTAAAGTAACTTATTTGCATAGCGAAATCAAATCT
TTACAAAGACTAGAAATTTTGAGAGATTTAAGATTAGGCAAATATGATTGTTTAGTGGGAGTTAACCTTTTGAGAGAGGG
CCTGGATTTACCTGAAGTTTCTTTAGTGGCTATTTTAGACGCTGATAAACAAGGTTTTTTAAGAAACCAAAGAAGCTTAA
TTCAAACTATCGGAAGAGCAGCACGTAATGTTGATGGCAAGGTTATTATGTATGCTGATAATACAAGTGATGCCATGAAA
TTAGCAATTACAGAAACTAATCGAAGAAGACAAATTCAAAAAGATTATAACCAAAAAAATCAGTTAACGCCATTATCTCT
TAAGAAAAATATTTCAGAAAGTGTTTCGATTCAAACCAAAGACAAAGCAACTTCCAAAAAAGAACCAATGTTTGATTTGA
AAAATATTAACCAACAAATTAAAAAACTAACTAATGATATGAAAAAAGCAGCGGAAAAATTGGATTTCGAAAAAGCAGCA
TCATTAAGAGATTTAATTTTGGAGTTAGAAAAGAAAGATAAAAAAGCAATGAAAAAATTTTCTAAGCGTTAG

Upstream 100 bases:

>100_bases
ATTATTTTTTTGAAACAATTAAAAATAAGCTTTCAAAATTGAAAAATTCAACTTTATAACTTTCAGCTAAATAAAAATAA
TAAAAAAAGAGGATAAAAAA

Downstream 100 bases:

>100_bases
TTGACACCAACTTCAAAACAAATTAGTAAATTAAAAAGTCATCTTCATTAAGTTTAAAAAAAGAAATTAGTAATTGTTTT
TCATTTAAAATTTTTTTAAA

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 663; Mature: 663

Protein sequence:

>663_residues
MNMFKLKTDLKPNGDQPQAIKKLVQGFEKGFKEQILLGATGTGKTFTIANIIQHLQQQTLVIAHNKTLAGQLYNELKMMF
PENKVEYFISYYDYYQPEAYVTSSDTYIEKDSKINDEIDQLRHNAIVSLLNRKDVIVVASVSCIYGVGDLEDYQSSTLFL
QIGDRFERNLFLKKLVELKFQRNEVNFGRGTFRVRGDIVEIIPSSHKEIGIRIIFFGDEIERIQLFELLNAKVIENLKVT
KIFPASLYAVNAEKIKESIKRIRQELKEQIKHFEKEKNLVAAQKIKMRTSHDLEMLAEMGHCSGIENYSRHLSLKEQGQP
PSTLIDFFDKEFLTIIDESHVTVPQIKGMYFGDFSRKSNLVNYGFRLPSALDNRPLKFHEFEEKIDKIIYLSATPGDHEI
ERKLPIIEQIIRPTFVLDPEIEVKRTQNQMDDLYFEIKKRIQKNQRVLITTLTINMSEDLTAYLKNLGIKVTYLHSEIKS
LQRLEILRDLRLGKYDCLVGVNLLREGLDLPEVSLVAILDADKQGFLRNQRSLIQTIGRAARNVDGKVIMYADNTSDAMK
LAITETNRRRQIQKDYNQKNQLTPLSLKKNISESVSIQTKDKATSKKEPMFDLKNINQQIKKLTNDMKKAAEKLDFEKAA
SLRDLILELEKKDKKAMKKFSKR

Sequences:

>Translated_663_residues
MNMFKLKTDLKPNGDQPQAIKKLVQGFEKGFKEQILLGATGTGKTFTIANIIQHLQQQTLVIAHNKTLAGQLYNELKMMF
PENKVEYFISYYDYYQPEAYVTSSDTYIEKDSKINDEIDQLRHNAIVSLLNRKDVIVVASVSCIYGVGDLEDYQSSTLFL
QIGDRFERNLFLKKLVELKFQRNEVNFGRGTFRVRGDIVEIIPSSHKEIGIRIIFFGDEIERIQLFELLNAKVIENLKVT
KIFPASLYAVNAEKIKESIKRIRQELKEQIKHFEKEKNLVAAQKIKMRTSHDLEMLAEMGHCSGIENYSRHLSLKEQGQP
PSTLIDFFDKEFLTIIDESHVTVPQIKGMYFGDFSRKSNLVNYGFRLPSALDNRPLKFHEFEEKIDKIIYLSATPGDHEI
ERKLPIIEQIIRPTFVLDPEIEVKRTQNQMDDLYFEIKKRIQKNQRVLITTLTINMSEDLTAYLKNLGIKVTYLHSEIKS
LQRLEILRDLRLGKYDCLVGVNLLREGLDLPEVSLVAILDADKQGFLRNQRSLIQTIGRAARNVDGKVIMYADNTSDAMK
LAITETNRRRQIQKDYNQKNQLTPLSLKKNISESVSIQTKDKATSKKEPMFDLKNINQQIKKLTNDMKKAAEKLDFEKAA
SLRDLILELEKKDKKAMKKFSKR
>Mature_663_residues
MNMFKLKTDLKPNGDQPQAIKKLVQGFEKGFKEQILLGATGTGKTFTIANIIQHLQQQTLVIAHNKTLAGQLYNELKMMF
PENKVEYFISYYDYYQPEAYVTSSDTYIEKDSKINDEIDQLRHNAIVSLLNRKDVIVVASVSCIYGVGDLEDYQSSTLFL
QIGDRFERNLFLKKLVELKFQRNEVNFGRGTFRVRGDIVEIIPSSHKEIGIRIIFFGDEIERIQLFELLNAKVIENLKVT
KIFPASLYAVNAEKIKESIKRIRQELKEQIKHFEKEKNLVAAQKIKMRTSHDLEMLAEMGHCSGIENYSRHLSLKEQGQP
PSTLIDFFDKEFLTIIDESHVTVPQIKGMYFGDFSRKSNLVNYGFRLPSALDNRPLKFHEFEEKIDKIIYLSATPGDHEI
ERKLPIIEQIIRPTFVLDPEIEVKRTQNQMDDLYFEIKKRIQKNQRVLITTLTINMSEDLTAYLKNLGIKVTYLHSEIKS
LQRLEILRDLRLGKYDCLVGVNLLREGLDLPEVSLVAILDADKQGFLRNQRSLIQTIGRAARNVDGKVIMYADNTSDAMK
LAITETNRRRQIQKDYNQKNQLTPLSLKKNISESVSIQTKDKATSKKEPMFDLKNINQQIKKLTNDMKKAAEKLDFEKAA
SLRDLILELEKKDKKAMKKFSKR

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=661, Percent_Identity=50.8320726172466, Blast_Score=679, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 76733; Mature: 76733

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMFKLKTDLKPNGDQPQAIKKLVQGFEKGFKEQILLGATGTGKTFTIANIIQHLQQQTL
CCCEEEECCCCCCCCCHHHHHHHHHHHHHCCHHEEEEECCCCCCEEEHHHHHHHHHHCEE
VIAHNKTLAGQLYNELKMMFPENKVEYFISYYDYYQPEAYVTSSDTYIEKDSKINDEIDQ
EEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEECCCCEECCCCCCHHHHHH
LRHNAIVSLLNRKDVIVVASVSCIYGVGDLEDYQSSTLFLQIGDRFERNLFLKKLVELKF
HHHHHHHHHHCCCCEEEEEEHHHHCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHH
QRNEVNFGRGTFRVRGDIVEIIPSSHKEIGIRIIFFGDEIERIQLFELLNAKVIENLKVT
HCCCCCCCCCEEEECCCEEEECCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHCCCEEE
KIFPASLYAVNAEKIKESIKRIRQELKEQIKHFEKEKNLVAAQKIKMRTSHDLEMLAEMG
EEECCHHEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHH
HCSGIENYSRHLSLKEQGQPPSTLIDFFDKEFLTIIDESHVTVPQIKGMYFGDFSRKSNL
CCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCCCCCCCC
VNYGFRLPSALDNRPLKFHEFEEKIDKIIYLSATPGDHEIERKLPIIEQIIRPTFVLDPE
CCCCCCCCHHHCCCCCCHHHHHHHHCEEEEEECCCCCHHHHHCCHHHHHHHCCCEEECCC
IEVKRTQNQMDDLYFEIKKRIQKNQRVLITTLTINMSEDLTAYLKNLGIKVTYLHSEIKS
CHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCHHHHHHHHHCCCEEEEEHHHHHH
LQRLEILRDLRLGKYDCLVGVNLLREGLDLPEVSLVAILDADKQGFLRNQRSLIQTIGRA
HHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHH
ARNVDGKVIMYADNTSDAMKLAITETNRRRQIQKDYNQKNQLTPLSLKKNISESVSIQTK
HHCCCCEEEEEECCCCCEEEEEEECCHHHHHHHHHHCCCCCCCCHHHHHCCCHHCEEEEC
DKATSKKEPMFDLKNINQQIKKLTNDMKKAAEKLDFEKAASLRDLILELEKKDKKAMKKF
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
SKR
HCC
>Mature Secondary Structure
MNMFKLKTDLKPNGDQPQAIKKLVQGFEKGFKEQILLGATGTGKTFTIANIIQHLQQQTL
CCCEEEECCCCCCCCCHHHHHHHHHHHHHCCHHEEEEECCCCCCEEEHHHHHHHHHHCEE
VIAHNKTLAGQLYNELKMMFPENKVEYFISYYDYYQPEAYVTSSDTYIEKDSKINDEIDQ
EEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEECCCCEECCCCCCHHHHHH
LRHNAIVSLLNRKDVIVVASVSCIYGVGDLEDYQSSTLFLQIGDRFERNLFLKKLVELKF
HHHHHHHHHHCCCCEEEEEEHHHHCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHH
QRNEVNFGRGTFRVRGDIVEIIPSSHKEIGIRIIFFGDEIERIQLFELLNAKVIENLKVT
HCCCCCCCCCEEEECCCEEEECCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHCCCEEE
KIFPASLYAVNAEKIKESIKRIRQELKEQIKHFEKEKNLVAAQKIKMRTSHDLEMLAEMG
EEECCHHEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHH
HCSGIENYSRHLSLKEQGQPPSTLIDFFDKEFLTIIDESHVTVPQIKGMYFGDFSRKSNL
CCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCCCCCCCC
VNYGFRLPSALDNRPLKFHEFEEKIDKIIYLSATPGDHEIERKLPIIEQIIRPTFVLDPE
CCCCCCCCHHHCCCCCCHHHHHHHHCEEEEEECCCCCHHHHHCCHHHHHHHCCCEEECCC
IEVKRTQNQMDDLYFEIKKRIQKNQRVLITTLTINMSEDLTAYLKNLGIKVTYLHSEIKS
CHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCHHHHHHHHHCCCEEEEEHHHHHH
LQRLEILRDLRLGKYDCLVGVNLLREGLDLPEVSLVAILDADKQGFLRNQRSLIQTIGRA
HHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHH
ARNVDGKVIMYADNTSDAMKLAITETNRRRQIQKDYNQKNQLTPLSLKKNISESVSIQTK
HHCCCCEEEEEECCCCCEEEEEEECCHHHHHHHHHHCCCCCCCCHHHHHCCCHHCEEEEC
DKATSKKEPMFDLKNINQQIKKLTNDMKKAAEKLDFEKAASLRDLILELEKKDKKAMKKF
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
SKR
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA