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The map label for this gene is galK [H]

Identifier: 197120378

GI number: 197120378

Start: 4562686

End: 4563759

Strand: Direct

Name: galK [H]

Synonym: Gbem_4019

Alternate gene names: 197120378

Gene position: 4562686-4563759 (Clockwise)

Preceding gene: 197120377

Following gene: 197120379

Centisome position: 98.86

GC content: 66.85

Gene sequence:

>1074_bases
ATGTCCGCTGCTACCGACTTTGAAAAGACCTTCGAGTCCCCCTGCGAAGTGACCGCCCGCGCCCCCGGACGGGTGAACCT
CCTAGGGGAGCATACCGACTACAACGACGGCTTCGTCCTCCCCATCGCGGTGCCGCTGGAGACCACGGTGGAGTTGGCCA
GAAGCCGCGACGGCCGGAACCACTACTATGCCGAGGAGCTGCAGGAAAGGGCGTGGTCGGAGACCGGAGGTGCGGTCCCG
AGCGGCTTCGCCGCCTATCTGCACGGCTGCCTCGCCCTTTTGCGCCTCTCCGGGCACCACGTGGACCCGGTGTCGGTGCG
GGTCACCTCCCAGGTACCGATGGGGAGCGGACTCTCCTCCAGCGCCGCGCTCGAAGTCGCCTTCCTGCGCGGGATGCGGG
AGCTGTTCCGCCTCGACCTTGACGACGTCGAGATTGCGCTCATGGCCCAGCAGGCCGAGATCCGCTACGCCGGGGTCAAC
TGCGGCATCATGGACCAGATGGCGGCAAGCCTCGCCGACTCCACCCACATGCTCTTCATCGACACCCGGTCGCTGGAACG
CAAGCTCCTCCCGCTTCCCCCGCGCTCCGAGCTCCTGGTCATCGACTGCGGGATCCCGCGAAAGCTCGGCGAGAGCATGT
ACAACCTGCGCCGGCAGGAGTGCGAGGAGGCTGTGGAGCTTCTGGGTATTGCTTCGCTGCGGGAGCTGTCGGACCTGGGC
CAGCTCATCAAGCTGCCGCGCAACCTGGCTCAGCGCGCCCGGCACGTGCTGACCGAGAACGAGCGGGTGCTGGAAGCGGT
CAAAGGCGTGCACGGCTGCCGCTTCGGGGAATTGATGAACGCCTCGCACATGAGCCTCAGGGACGACTTCCAGGTCTCCA
TACCCGAACTGGACCTTCTGGCCAGGCTGCTGCAGGAGCAGGTCGACGTGTACGGAGCGCGGCTCACCGGGGCCGGCTTC
GGAGGTGCCTGCGTGGCGCTGGTGCGCGAGGGGAAAGCGGCGGAGGTAGCGTCGAACGTGTTGGCGCTCTACCGCGAGCA
GGGGCAACAGGGGAAGCTATTGGTGCCGCAGTAG

Upstream 100 bases:

>100_bases
CAGAGACCGGAGTCGAGAACCTGACGCTCGACCCGGCCTGGCCGACGGTGCTAGCGGCCGGCCTGGAGCGGCCGCTCGTC
CTTCGGCGATAGGAGCCATC

Downstream 100 bases:

>100_bases
CCGCGGCCGGCGGGAAAAGGCCATGAGCAATGACAGGCATAAAGAGAGAGTCCCCGAGCTGTGGGGGGGGATGGAATGCA
CCCTGAACCGCGTGGGGAAG

Product: galactose 1-kinase

Products: NA

Alternate protein names: Galactose kinase [H]

Number of amino acids: Translated: 357; Mature: 356

Protein sequence:

>357_residues
MSAATDFEKTFESPCEVTARAPGRVNLLGEHTDYNDGFVLPIAVPLETTVELARSRDGRNHYYAEELQERAWSETGGAVP
SGFAAYLHGCLALLRLSGHHVDPVSVRVTSQVPMGSGLSSSAALEVAFLRGMRELFRLDLDDVEIALMAQQAEIRYAGVN
CGIMDQMAASLADSTHMLFIDTRSLERKLLPLPPRSELLVIDCGIPRKLGESMYNLRRQECEEAVELLGIASLRELSDLG
QLIKLPRNLAQRARHVLTENERVLEAVKGVHGCRFGELMNASHMSLRDDFQVSIPELDLLARLLQEQVDVYGARLTGAGF
GGACVALVREGKAAEVASNVLALYREQGQQGKLLVPQ

Sequences:

>Translated_357_residues
MSAATDFEKTFESPCEVTARAPGRVNLLGEHTDYNDGFVLPIAVPLETTVELARSRDGRNHYYAEELQERAWSETGGAVP
SGFAAYLHGCLALLRLSGHHVDPVSVRVTSQVPMGSGLSSSAALEVAFLRGMRELFRLDLDDVEIALMAQQAEIRYAGVN
CGIMDQMAASLADSTHMLFIDTRSLERKLLPLPPRSELLVIDCGIPRKLGESMYNLRRQECEEAVELLGIASLRELSDLG
QLIKLPRNLAQRARHVLTENERVLEAVKGVHGCRFGELMNASHMSLRDDFQVSIPELDLLARLLQEQVDVYGARLTGAGF
GGACVALVREGKAAEVASNVLALYREQGQQGKLLVPQ
>Mature_356_residues
SAATDFEKTFESPCEVTARAPGRVNLLGEHTDYNDGFVLPIAVPLETTVELARSRDGRNHYYAEELQERAWSETGGAVPS
GFAAYLHGCLALLRLSGHHVDPVSVRVTSQVPMGSGLSSSAALEVAFLRGMRELFRLDLDDVEIALMAQQAEIRYAGVNC
GIMDQMAASLADSTHMLFIDTRSLERKLLPLPPRSELLVIDCGIPRKLGESMYNLRRQECEEAVELLGIASLRELSDLGQ
LIKLPRNLAQRARHVLTENERVLEAVKGVHGCRFGELMNASHMSLRDDFQVSIPELDLLARLLQEQVDVYGARLTGAGFG
GACVALVREGKAAEVASNVLALYREQGQQGKLLVPQ

Specific function: Galactose metabolism; first step. [C]

COG id: COG0153

COG function: function code G; Galactokinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. GalK subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503895, Length=360, Percent_Identity=37.7777777777778, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI4503897, Length=414, Percent_Identity=29.951690821256, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI48527957, Length=414, Percent_Identity=29.951690821256, Blast_Score=97, Evalue=3e-20,
Organism=Escherichia coli, GI1786972, Length=338, Percent_Identity=39.0532544378698, Blast_Score=230, Evalue=8e-62,
Organism=Caenorhabditis elegans, GI71989053, Length=415, Percent_Identity=25.7831325301205, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24661292, Length=416, Percent_Identity=25.7211538461538, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21355577, Length=416, Percent_Identity=25.7211538461538, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24661285, Length=416, Percent_Identity=25.7211538461538, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000705
- InterPro:   IPR022963
- InterPro:   IPR019741
- InterPro:   IPR019539
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006206
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF10509 GalKase_gal_bdg; PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.6 [H]

Molecular weight: Translated: 39123; Mature: 38992

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAATDFEKTFESPCEVTARAPGRVNLLGEHTDYNDGFVLPIAVPLETTVELARSRDGRN
CCCCCCHHHHHCCCCCEEECCCCCEEEEECCCCCCCCEEEEEECCHHHHHHHHHCCCCCC
HYYAEELQERAWSETGGAVPSGFAAYLHGCLALLRLSGHHVDPVSVRVTSQVPMGSGLSS
CHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCC
SAALEVAFLRGMRELFRLDLDDVEIALMAQQAEIRYAGVNCGIMDQMAASLADSTHMLFI
HHHHHHHHHHHHHHHHHCCCCCHHEEEEEHHHHEEEECCCCCHHHHHHHHHCCCCEEEEE
DTRSLERKLLPLPPRSELLVIDCGIPRKLGESMYNLRRQECEEAVELLGIASLRELSDLG
ECCHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QLIKLPRNLAQRARHVLTENERVLEAVKGVHGCRFGELMNASHMSLRDDFQVSIPELDLL
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCEECCCCHHHH
ARLLQEQVDVYGARLTGAGFGGACVALVREGKAAEVASNVLALYREQGQQGKLLVPQ
HHHHHHHHHHHCCEEECCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCEECCC
>Mature Secondary Structure 
SAATDFEKTFESPCEVTARAPGRVNLLGEHTDYNDGFVLPIAVPLETTVELARSRDGRN
CCCCCHHHHHCCCCCEEECCCCCEEEEECCCCCCCCEEEEEECCHHHHHHHHHCCCCCC
HYYAEELQERAWSETGGAVPSGFAAYLHGCLALLRLSGHHVDPVSVRVTSQVPMGSGLSS
CHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCC
SAALEVAFLRGMRELFRLDLDDVEIALMAQQAEIRYAGVNCGIMDQMAASLADSTHMLFI
HHHHHHHHHHHHHHHHHCCCCCHHEEEEEHHHHEEEECCCCCHHHHHHHHHCCCCEEEEE
DTRSLERKLLPLPPRSELLVIDCGIPRKLGESMYNLRRQECEEAVELLGIASLRELSDLG
ECCHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QLIKLPRNLAQRARHVLTENERVLEAVKGVHGCRFGELMNASHMSLRDDFQVSIPELDLL
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCEECCCCHHHH
ARLLQEQVDVYGARLTGAGFGGACVALVREGKAAEVASNVLALYREQGQQGKLLVPQ
HHHHHHHHHHHCCEEECCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA