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The map label for this gene is zraS [H]

Identifier: 197120363

GI number: 197120363

Start: 4540417

End: 4542714

Strand: Direct

Name: zraS [H]

Synonym: Gbem_4002

Alternate gene names: 197120363

Gene position: 4540417-4542714 (Clockwise)

Preceding gene: 197120362

Following gene: 197120364

Centisome position: 98.38

GC content: 64.19

Gene sequence:

>2298_bases
ATGGCTGGCCGGAAGGGACAAAACCTCCTGGAGCAAGCATTAACTATTGCCCAGGCCCCAGGTCGGTCCCATCAGGTCCG
CCTCAACAGCCTGCTTCGCCTGGCGGCCCGTTGGCATTCCCTCGCCTCGGCCACCATCTATCTCCCCGATCCCAAAGGGG
TGGTGTTGCAGCGTCGCTTCAGCACGCTGGCCACCCCCTCCGGCCACAACTGCCACATCCCTTACGGCGTGGGTCTCGCC
GGGCGCACCGCCGCCACCCTTTCACCCCAATCCGCCAGTGCCGACCTGCTTCATCCCGACGAGCCCTGTTCCGGCAACGG
CTCCATCGCTGCGCTCCCCCTTTTGGACGGGGACCGGCTCTTCGCCGTGCTGGCGCTGGAGAGCGGCGCCGCGGAAGTCG
CCCGGGAAGCCGTCGACGCGGCCGGTACCCTGGCGCCCGTCTTCTCCCTGACCGTAGCCCGCATGGCCGCAGCCGAAGAG
GCTGAGGAGGCGCAGCGCAACCTGTCGCTACTTTCGGCGCTGGCCAAGCTCTTGAGCTCGCCGCAGCCGCGCGGGGTGCT
GCTGCACCGGTTGATGCAGCTTTGCACCAGTTCCGGCCTCTCCAGTTGCGCCATCGTCCGCTTGAAGCAGAGGAATTCCG
GCAAGGAGAGGGTGATCCGGAGCTGCCGCAGGGGAATGGGCGACAAGCTCCCCGACCTGCTGGAAAAAGAAGCTGCCCTG
GCGGTCCATGTCTGCGCCACCGAGACCACCTGCGCCGAGGAACTCGGAGACGACTCCAGCTACCGGTACGCCCTCTGCAC
CCCGCTGGGAAGCAACGGCGCGGCGCTGGGGACCATGACCCTCTTCGGGGGGCCCGAACTGACCGCGCCCAAGCAGATCG
AGCTTGCCGAAACGGTCGCGCGACTTTTGTCCGGCGCCATGGCCGAGGCGATCTGCAAGGAGCAGATCAAGACCTACGAC
AGCGAGAACGAGAAGAAGCTGAAAGAGCTGTCCCTTCTCTACCGGATGAGCAACACCATGCTCTCCACCATCCAGCTGAA
CAAACTGATCCACCTCACCCTGACCGCGCTCACCTCGGGTCCCACCCCCTTCTTCGACCGGGCCATGCTCTTTCTCACCA
ACGAGCGTTCCGGGATGTTGCTCGGCATGCTGGGGGTAACGACGGAGACCTCCCCTTCCCTCTCCAGCCAAAACGGAGGG
AGCGACGACCTCCTCTCCAGCCGGTGGGACATCTCCGATGAAGAGATGGCCGCCCAGCGCAACTCCGAATTCTGCCGGCA
GGTACAGGGGAGACGGCTTGAGCTGGACGGAACGCTCAACATCGCTTCCCAGGCCGTGCTGGAAAAGAGGCTGATCTACA
TCCCCGAAGAAGGCGGCATCGGCGGCCCCCTCCATTCCCGGCGCAGCGCCCTGGCCGCCTCTCCGCTCATCGCGCATGGG
CAGGCCGTAGGGGCGGTACTGGTGGACAACGCCCTCACCCACAAGCCGATCAACCAGGAGCACCTGCGTTTCCTGCAGCT
CTTCACCAACCAGGCGGGAATGGCCATCGAGAACTCGATGCTCTACAACAAGATCGAGGACGCGAACCATCAGTTGAGCG
AGGCGCAGGAGAACCTGCTCCAGAAGGAGCGGCTTGCCGCCATCGGCGAAATGGCCGCCGGCATCGCACACGAGTTGAAG
GGGCCGCTGGTCTCCATCGGCGGCTTCGCCGGCAGGCTCGCCAGGAAACTCCCCCAGGACACCAGCGAGTGGGCCCATGC
CGACCTGATCGTGCGCGAAGTGCTCCGGTTGGAGGGAATCCTCTCCGAGATCCTGCTCTTTTCGAAGAAAACCACCATCT
GTTACACCCGGTGCGACCTCTCCGAGGTCGTGAAGGAGTCGCTCGCCGTGGTCACCCCTCCACTGGAGGAGAAGCAGATC
AGCGTGAACGCCAAATTCCCGCGGCATAAGCTCTTGCTTTTGGGGGACGGACAGCAGTTGAAGCAGGTGTTCATCAACAT
CATCCTGAACGCCCTCGATGCCATGGGGACAGGGGGGGCGCTGAACATCCAGGTCTCGGCGGCCGAGATGGACGACAAGG
AAGCCGTCCAGGTGAAGATATCCGACACCGGCGGCGGCATCCCGCTGGAGTCCTTGAACAGCATCTTCACCCCCTTCTTC
ACCACCAAAGGAAGCGGCACCGGCTTGGGGCTCCCCATCGCCAACCGCATCATCACCAACCACGGCGGCAAGATCCAAGT
CACCAACAACCCCGGCCTCGGGGTCGAGTTCAGGGTCATCCTGCCCAAGCACTGGTGA

Upstream 100 bases:

>100_bases
CACCACGCTCTGCATCGACTGCAAGATGGAACAAGAAAAGAAAGAACGCTTTCGGTAACCAACCCAACCCCCTAGAGCTG
TCATTTCCTTCGGAGTTCCC

Downstream 100 bases:

>100_bases
CGCGGAATTTCACTTTTCCTCCTCATTTGCTCCTCATTTTTCTCCTAACCTGAAACTAAACGGGACGCAGGTACCGGAAT
TTTCAGGCCAAAGGAGAATG

Product: GAF domain-containing sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 765; Mature: 764

Protein sequence:

>765_residues
MAGRKGQNLLEQALTIAQAPGRSHQVRLNSLLRLAARWHSLASATIYLPDPKGVVLQRRFSTLATPSGHNCHIPYGVGLA
GRTAATLSPQSASADLLHPDEPCSGNGSIAALPLLDGDRLFAVLALESGAAEVAREAVDAAGTLAPVFSLTVARMAAAEE
AEEAQRNLSLLSALAKLLSSPQPRGVLLHRLMQLCTSSGLSSCAIVRLKQRNSGKERVIRSCRRGMGDKLPDLLEKEAAL
AVHVCATETTCAEELGDDSSYRYALCTPLGSNGAALGTMTLFGGPELTAPKQIELAETVARLLSGAMAEAICKEQIKTYD
SENEKKLKELSLLYRMSNTMLSTIQLNKLIHLTLTALTSGPTPFFDRAMLFLTNERSGMLLGMLGVTTETSPSLSSQNGG
SDDLLSSRWDISDEEMAAQRNSEFCRQVQGRRLELDGTLNIASQAVLEKRLIYIPEEGGIGGPLHSRRSALAASPLIAHG
QAVGAVLVDNALTHKPINQEHLRFLQLFTNQAGMAIENSMLYNKIEDANHQLSEAQENLLQKERLAAIGEMAAGIAHELK
GPLVSIGGFAGRLARKLPQDTSEWAHADLIVREVLRLEGILSEILLFSKKTTICYTRCDLSEVVKESLAVVTPPLEEKQI
SVNAKFPRHKLLLLGDGQQLKQVFINIILNALDAMGTGGALNIQVSAAEMDDKEAVQVKISDTGGGIPLESLNSIFTPFF
TTKGSGTGLGLPIANRIITNHGGKIQVTNNPGLGVEFRVILPKHW

Sequences:

>Translated_765_residues
MAGRKGQNLLEQALTIAQAPGRSHQVRLNSLLRLAARWHSLASATIYLPDPKGVVLQRRFSTLATPSGHNCHIPYGVGLA
GRTAATLSPQSASADLLHPDEPCSGNGSIAALPLLDGDRLFAVLALESGAAEVAREAVDAAGTLAPVFSLTVARMAAAEE
AEEAQRNLSLLSALAKLLSSPQPRGVLLHRLMQLCTSSGLSSCAIVRLKQRNSGKERVIRSCRRGMGDKLPDLLEKEAAL
AVHVCATETTCAEELGDDSSYRYALCTPLGSNGAALGTMTLFGGPELTAPKQIELAETVARLLSGAMAEAICKEQIKTYD
SENEKKLKELSLLYRMSNTMLSTIQLNKLIHLTLTALTSGPTPFFDRAMLFLTNERSGMLLGMLGVTTETSPSLSSQNGG
SDDLLSSRWDISDEEMAAQRNSEFCRQVQGRRLELDGTLNIASQAVLEKRLIYIPEEGGIGGPLHSRRSALAASPLIAHG
QAVGAVLVDNALTHKPINQEHLRFLQLFTNQAGMAIENSMLYNKIEDANHQLSEAQENLLQKERLAAIGEMAAGIAHELK
GPLVSIGGFAGRLARKLPQDTSEWAHADLIVREVLRLEGILSEILLFSKKTTICYTRCDLSEVVKESLAVVTPPLEEKQI
SVNAKFPRHKLLLLGDGQQLKQVFINIILNALDAMGTGGALNIQVSAAEMDDKEAVQVKISDTGGGIPLESLNSIFTPFF
TTKGSGTGLGLPIANRIITNHGGKIQVTNNPGLGVEFRVILPKHW
>Mature_764_residues
AGRKGQNLLEQALTIAQAPGRSHQVRLNSLLRLAARWHSLASATIYLPDPKGVVLQRRFSTLATPSGHNCHIPYGVGLAG
RTAATLSPQSASADLLHPDEPCSGNGSIAALPLLDGDRLFAVLALESGAAEVAREAVDAAGTLAPVFSLTVARMAAAEEA
EEAQRNLSLLSALAKLLSSPQPRGVLLHRLMQLCTSSGLSSCAIVRLKQRNSGKERVIRSCRRGMGDKLPDLLEKEAALA
VHVCATETTCAEELGDDSSYRYALCTPLGSNGAALGTMTLFGGPELTAPKQIELAETVARLLSGAMAEAICKEQIKTYDS
ENEKKLKELSLLYRMSNTMLSTIQLNKLIHLTLTALTSGPTPFFDRAMLFLTNERSGMLLGMLGVTTETSPSLSSQNGGS
DDLLSSRWDISDEEMAAQRNSEFCRQVQGRRLELDGTLNIASQAVLEKRLIYIPEEGGIGGPLHSRRSALAASPLIAHGQ
AVGAVLVDNALTHKPINQEHLRFLQLFTNQAGMAIENSMLYNKIEDANHQLSEAQENLLQKERLAAIGEMAAGIAHELKG
PLVSIGGFAGRLARKLPQDTSEWAHADLIVREVLRLEGILSEILLFSKKTTICYTRCDLSEVVKESLAVVTPPLEEKQIS
VNAKFPRHKLLLLGDGQQLKQVFINIILNALDAMGTGGALNIQVSAAEMDDKEAVQVKISDTGGGIPLESLNSIFTPFFT
TKGSGTGLGLPIANRIITNHGGKIQVTNNPGLGVEFRVILPKHW

Specific function: Member of the two-component regulatory system zraS/zraR. May function as a membrane-associated protein kinase that phosphorylates zraR in response to high concentrations of zinc or lead in the medium [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=229, Percent_Identity=35.3711790393013, Blast_Score=149, Evalue=9e-37,
Organism=Escherichia coli, GI1788549, Length=229, Percent_Identity=34.4978165938865, Blast_Score=140, Evalue=4e-34,
Organism=Escherichia coli, GI1790300, Length=256, Percent_Identity=30.859375, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI145693157, Length=253, Percent_Identity=29.2490118577075, Blast_Score=83, Evalue=8e-17,
Organism=Escherichia coli, GI1788713, Length=242, Percent_Identity=28.9256198347107, Blast_Score=77, Evalue=5e-15,
Organism=Escherichia coli, GI1786912, Length=301, Percent_Identity=26.9102990033223, Blast_Score=76, Evalue=9e-15,
Organism=Escherichia coli, GI1789149, Length=249, Percent_Identity=26.1044176706827, Blast_Score=74, Evalue=4e-14,
Organism=Escherichia coli, GI1790346, Length=219, Percent_Identity=26.9406392694064, Blast_Score=71, Evalue=3e-13,
Organism=Escherichia coli, GI1788393, Length=226, Percent_Identity=26.9911504424779, Blast_Score=67, Evalue=5e-12,
Organism=Escherichia coli, GI48994928, Length=112, Percent_Identity=32.1428571428571, Blast_Score=66, Evalue=1e-11,
Organism=Escherichia coli, GI87081816, Length=219, Percent_Identity=27.8538812785388, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 82137; Mature: 82005

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGRKGQNLLEQALTIAQAPGRSHQVRLNSLLRLAARWHSLASATIYLPDPKGVVLQRRF
CCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHH
STLATPSGHNCHIPYGVGLAGRTAATLSPQSASADLLHPDEPCSGNGSIAALPLLDGDRL
HHHCCCCCCCEECCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCE
FAVLALESGAAEVAREAVDAAGTLAPVFSLTVARMAAAEEAEEAQRNLSLLSALAKLLSS
EEEEEECCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PQPRGVLLHRLMQLCTSSGLSSCAIVRLKQRNSGKERVIRSCRRGMGDKLPDLLEKEAAL
CCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHE
AVHVCATETTCAEELGDDSSYRYALCTPLGSNGAALGTMTLFGGPELTAPKQIELAETVA
EEEEECCCHHHHHHHCCCCCCEEEEEECCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHH
RLLSGAMAEAICKEQIKTYDSENEKKLKELSLLYRMSNTMLSTIQLNKLIHLTLTALTSG
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCC
PTPFFDRAMLFLTNERSGMLLGMLGVTTETSPSLSSQNGGSDDLLSSRWDISDEEMAAQR
CCCHHHCEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHH
NSEFCRQVQGRRLELDGTLNIASQAVLEKRLIYIPEEGGIGGPLHSRRSALAASPLIAHG
HHHHHHHHCCCEEEECCCHHHHHHHHHHHHEEEEECCCCCCCCCHHHHHHHHCCCHHHCC
QAVGAVLVDNALTHKPINQEHLRFLQLFTNQAGMAIENSMLYNKIEDANHQLSEAQENLL
CHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHH
QKERLAAIGEMAAGIAHELKGPLVSIGGFAGRLARKLPQDTSEWAHADLIVREVLRLEGI
HHHHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
LSEILLFSKKTTICYTRCDLSEVVKESLAVVTPPLEEKQISVNAKFPRHKLLLLGDGQQL
HHHHHHHCCCCEEEEEECCHHHHHHHHHHEECCCCCCCEEEEECCCCCEEEEEEECCHHH
KQVFINIILNALDAMGTGGALNIQVSAAEMDDKEAVQVKISDTGGGIPLESLNSIFTPFF
HHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCEEEEEEECCCCCCCHHHHHHHHCCCE
TTKGSGTGLGLPIANRIITNHGGKIQVTNNPGLGVEFRVILPKHW
ECCCCCCCCCCHHHHHHHCCCCCEEEEECCCCCCEEEEEECCCCC
>Mature Secondary Structure 
AGRKGQNLLEQALTIAQAPGRSHQVRLNSLLRLAARWHSLASATIYLPDPKGVVLQRRF
CCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHH
STLATPSGHNCHIPYGVGLAGRTAATLSPQSASADLLHPDEPCSGNGSIAALPLLDGDRL
HHHCCCCCCCEECCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCE
FAVLALESGAAEVAREAVDAAGTLAPVFSLTVARMAAAEEAEEAQRNLSLLSALAKLLSS
EEEEEECCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PQPRGVLLHRLMQLCTSSGLSSCAIVRLKQRNSGKERVIRSCRRGMGDKLPDLLEKEAAL
CCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHE
AVHVCATETTCAEELGDDSSYRYALCTPLGSNGAALGTMTLFGGPELTAPKQIELAETVA
EEEEECCCHHHHHHHCCCCCCEEEEEECCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHH
RLLSGAMAEAICKEQIKTYDSENEKKLKELSLLYRMSNTMLSTIQLNKLIHLTLTALTSG
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCC
PTPFFDRAMLFLTNERSGMLLGMLGVTTETSPSLSSQNGGSDDLLSSRWDISDEEMAAQR
CCCHHHCEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHH
NSEFCRQVQGRRLELDGTLNIASQAVLEKRLIYIPEEGGIGGPLHSRRSALAASPLIAHG
HHHHHHHHCCCEEEECCCHHHHHHHHHHHHEEEEECCCCCCCCCHHHHHHHHCCCHHHCC
QAVGAVLVDNALTHKPINQEHLRFLQLFTNQAGMAIENSMLYNKIEDANHQLSEAQENLL
CHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHH
QKERLAAIGEMAAGIAHELKGPLVSIGGFAGRLARKLPQDTSEWAHADLIVREVLRLEGI
HHHHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
LSEILLFSKKTTICYTRCDLSEVVKESLAVVTPPLEEKQISVNAKFPRHKLLLLGDGQQL
HHHHHHHCCCCEEEEEECCHHHHHHHHHHEECCCCCCCEEEEECCCCCEEEEEEECCHHH
KQVFINIILNALDAMGTGGALNIQVSAAEMDDKEAVQVKISDTGGGIPLESLNSIFTPFF
HHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCEEEEEEECCCCCCCHHHHHHHHCCCE
TTKGSGTGLGLPIANRIITNHGGKIQVTNNPGLGVEFRVILPKHW
ECCCCCCCCCCHHHHHHHCCCCCEEEEECCCCCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11243806 [H]