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The map label for this gene is p49 [H]

Identifier: 197119330

GI number: 197119330

Start: 3425000

End: 3426424

Strand: Direct

Name: p49 [H]

Synonym: Gbem_2958

Alternate gene names: 197119330

Gene position: 3425000-3426424 (Clockwise)

Preceding gene: 308535328

Following gene: 197119333

Centisome position: 74.21

GC content: 65.47

Gene sequence:

>1425_bases
ATGCCGCCGAACAGCACGCCCGATGCCGTCGTGGTGGGTTCCGGACCCAACGGCCTCGCCGCCGCCATCACCCTGGCGCG
AGCGGGGCTTTCCGTGACCGTCTTCGAGGAATACCGCACCATCGGCGGCGGAACCAGGACGGAGGAACTCACCCTCCCCG
GGTTCTGGCATGACGTCTGCTCCGCCGTCCATCCCCTGGGCGTAGCCTCGCCGTTCTTTCTTTCGCTCCCCCTTCATGAA
CACGGGCTGGAATGGATCTACCCTGAGATCCAGCTCGCACATCCCTTGCCCGACGGCACCTCCGCCCTTTTATACCGCTC
CATAGACAAGACCGCTGAACTCCTGGGGAGCGACGGAAAAGCTTACCTGCGGCTCATGTCTCCTCTGGTGCGGCAGTGGG
ACGATTTGGCCCCCGATCTGCTCGCGCCGCTGCATTACCCGCAGCACCCGCTGGCGATGCTGCTCTTCGGCCTGCGAGGG
ATCACCTCCGCGCAGCGGATGGGCAACTCCTGCTTCAAAGAGCCAGCCGCGCGCGCCCTTTTCGCCGGGCTGGCCGCGCA
TTCCTTCCTGCCGCTCACCGAGCCTCTATCCTCTGCGTTCGGCCTCGTTCTCGGCGCCCTCGGACACGTGGCCGGTTGGC
CGGTGGCAAAGGGAGGCTCCCGCATGATAGCCGCAGCACTTGCCTCCTATCTCCGCTCCTTGGGAGGGGAGATCGTCACC
GATACCGGAATCAACTCGCTGACGGAACTCCCCAAAGCCCGCCTCACCATGCTCGACCTGACGCCGCGCCAGTTGTTGAA
GATCGACGCCCCCCTGCCGGAACGGTACCGGCAGAAGATCGAGGCGTATCGCTACGGCCCCGGCGTCTTCAAGATCGACT
GGGCGCTGGACGCTCCGATACCGTGGGCGTCGGAAGGGTGCCGCCGCGCGACGACGGTGCATCTCGCCGGGACCGCGGAC
GAGCTTGCCCGCTCCGAGCGTGAGGTGTCGCAAGGAAAACATCCGCACCACCCCTTCGTTTTGCTCGCGCAGCCGACGCT
GGTGGACCAAAGCCGGGCGCCGCTCGGAAAGCATGTGGGATGGGCGTACTGCCATGTCCCCCACGGCTCCACCGTCGACA
TGACAGAACGGATCGAGGCGCAGGTGGAGCGCTTCGCACCCGGTTTTCGCAGCCTGGTGCTGGCCCGCCATACCCGCAAC
TGCGCGGAGCTTGAGCGCTACAACCGAAACCTGATCGGTGGAGACATAAACGGAGGGATACAGGACCTGCGCCAGTTCAT
GGCGCGGCCGACGCTTTTTTCACCGTACCGGACGCCGCTAAAAGGACTCTACCTCTGCTCTTCGGGCACCCCGCCGGGCG
GAGGCGTCCACGGCATGTGCGGCTACCACGCCGCGAGCCTGGCTCTGGAGGATATCAAGAGATGA

Upstream 100 bases:

>100_bases
TGAAAGGTTTTTTTGAGCTTTGTGATTTTCCTGCTTCTGTTTTTCCTCTGTGCCCTCTGTGTCCTCTGTGGTGAAAGCTT
TTTGGTTTTAGGAGGAGATT

Downstream 100 bases:

>100_bases
ACTTCAAAGGCGCTTAACAGGGATAAAAACAGATGAAAGGGATAAAACCAGACAAATAGCTTCTGGTTTTAACCAAAGTT
TTTGCCTTTGCAGTTATCCC

Product: phytoene dehydrogenase family FAD-dependent oxidoreductase

Products: H+; Nicotinamide adenine dinucleotide; Nicotinamide adenine dinucleotide phosphate - reduced [C]

Alternate protein names: NA

Number of amino acids: Translated: 474; Mature: 473

Protein sequence:

>474_residues
MPPNSTPDAVVVGSGPNGLAAAITLARAGLSVTVFEEYRTIGGGTRTEELTLPGFWHDVCSAVHPLGVASPFFLSLPLHE
HGLEWIYPEIQLAHPLPDGTSALLYRSIDKTAELLGSDGKAYLRLMSPLVRQWDDLAPDLLAPLHYPQHPLAMLLFGLRG
ITSAQRMGNSCFKEPAARALFAGLAAHSFLPLTEPLSSAFGLVLGALGHVAGWPVAKGGSRMIAAALASYLRSLGGEIVT
DTGINSLTELPKARLTMLDLTPRQLLKIDAPLPERYRQKIEAYRYGPGVFKIDWALDAPIPWASEGCRRATTVHLAGTAD
ELARSEREVSQGKHPHHPFVLLAQPTLVDQSRAPLGKHVGWAYCHVPHGSTVDMTERIEAQVERFAPGFRSLVLARHTRN
CAELERYNRNLIGGDINGGIQDLRQFMARPTLFSPYRTPLKGLYLCSSGTPPGGGVHGMCGYHAASLALEDIKR

Sequences:

>Translated_474_residues
MPPNSTPDAVVVGSGPNGLAAAITLARAGLSVTVFEEYRTIGGGTRTEELTLPGFWHDVCSAVHPLGVASPFFLSLPLHE
HGLEWIYPEIQLAHPLPDGTSALLYRSIDKTAELLGSDGKAYLRLMSPLVRQWDDLAPDLLAPLHYPQHPLAMLLFGLRG
ITSAQRMGNSCFKEPAARALFAGLAAHSFLPLTEPLSSAFGLVLGALGHVAGWPVAKGGSRMIAAALASYLRSLGGEIVT
DTGINSLTELPKARLTMLDLTPRQLLKIDAPLPERYRQKIEAYRYGPGVFKIDWALDAPIPWASEGCRRATTVHLAGTAD
ELARSEREVSQGKHPHHPFVLLAQPTLVDQSRAPLGKHVGWAYCHVPHGSTVDMTERIEAQVERFAPGFRSLVLARHTRN
CAELERYNRNLIGGDINGGIQDLRQFMARPTLFSPYRTPLKGLYLCSSGTPPGGGVHGMCGYHAASLALEDIKR
>Mature_473_residues
PPNSTPDAVVVGSGPNGLAAAITLARAGLSVTVFEEYRTIGGGTRTEELTLPGFWHDVCSAVHPLGVASPFFLSLPLHEH
GLEWIYPEIQLAHPLPDGTSALLYRSIDKTAELLGSDGKAYLRLMSPLVRQWDDLAPDLLAPLHYPQHPLAMLLFGLRGI
TSAQRMGNSCFKEPAARALFAGLAAHSFLPLTEPLSSAFGLVLGALGHVAGWPVAKGGSRMIAAALASYLRSLGGEIVTD
TGINSLTELPKARLTMLDLTPRQLLKIDAPLPERYRQKIEAYRYGPGVFKIDWALDAPIPWASEGCRRATTVHLAGTADE
LARSEREVSQGKHPHHPFVLLAQPTLVDQSRAPLGKHVGWAYCHVPHGSTVDMTERIEAQVERFAPGFRSLVLARHTRNC
AELERYNRNLIGGDINGGIQDLRQFMARPTLFSPYRTPLKGLYLCSSGTPPGGGVHGMCGYHAASLALEDIKR

Specific function: Conversion Of NADPH, Generated By Peripheral Catabolic Pathways, To NADH, Which Can Enter The Respiratory Chain For Energy Generation. [C]

COG id: COG1233

COG function: function code Q; Phytoene dehydrogenase and related proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI229577391, Length=566, Percent_Identity=28.4452296819788, Blast_Score=115, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17540238, Length=541, Percent_Identity=25.1386321626617, Blast_Score=105, Evalue=6e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 1.6.1.1 [C]

Molecular weight: Translated: 51347; Mature: 51215

Theoretical pI: Translated: 7.91; Mature: 7.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPNSTPDAVVVGSGPNGLAAAITLARAGLSVTVFEEYRTIGGGTRTEELTLPGFWHDVC
CCCCCCCCEEEECCCCCCHHHHHHHHHCCCEEEEHHHHHHHCCCCCCCEEECCCHHHHHH
SAVHPLGVASPFFLSLPLHEHGLEWIYPEIQLAHPLPDGTSALLYRSIDKTAELLGSDGK
HHHCCCCCCCCCEEECCHHHCCCCEECCCEEEECCCCCCCHHHHHHHHHHHHHHHCCCCH
AYLRLMSPLVRQWDDLAPDLLAPLHYPQHPLAMLLFGLRGITSAQRMGNSCFKEPAARAL
HHHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
FAGLAAHSFLPLTEPLSSAFGLVLGALGHVAGWPVAKGGSRMIAAALASYLRSLGGEIVT
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCEEE
DTGINSLTELPKARLTMLDLTPRQLLKIDAPLPERYRQKIEAYRYGPGVFKIDWALDAPI
CCCCHHHHHCCHHHEEEEECCHHHHHEECCCCCHHHHHHHHHHCCCCCEEEEEEEECCCC
PWASEGCRRATTVHLAGTADELARSEREVSQGKHPHHPFVLLAQPTLVDQSRAPLGKHVG
CCCCCCCCCEEEEEEECCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCC
WAYCHVPHGSTVDMTERIEAQVERFAPGFRSLVLARHTRNCAELERYNRNLIGGDINGGI
EEEEECCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCH
QDLRQFMARPTLFSPYRTPLKGLYLCSSGTPPGGGVHGMCGYHAASLALEDIKR
HHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PPNSTPDAVVVGSGPNGLAAAITLARAGLSVTVFEEYRTIGGGTRTEELTLPGFWHDVC
CCCCCCCEEEECCCCCCHHHHHHHHHCCCEEEEHHHHHHHCCCCCCCEEECCCHHHHHH
SAVHPLGVASPFFLSLPLHEHGLEWIYPEIQLAHPLPDGTSALLYRSIDKTAELLGSDGK
HHHCCCCCCCCCEEECCHHHCCCCEECCCEEEECCCCCCCHHHHHHHHHHHHHHHCCCCH
AYLRLMSPLVRQWDDLAPDLLAPLHYPQHPLAMLLFGLRGITSAQRMGNSCFKEPAARAL
HHHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
FAGLAAHSFLPLTEPLSSAFGLVLGALGHVAGWPVAKGGSRMIAAALASYLRSLGGEIVT
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCEEE
DTGINSLTELPKARLTMLDLTPRQLLKIDAPLPERYRQKIEAYRYGPGVFKIDWALDAPI
CCCCHHHHHCCHHHEEEEECCHHHHHEECCCCCHHHHHHHHHHCCCCCEEEEEEEECCCC
PWASEGCRRATTVHLAGTADELARSEREVSQGKHPHHPFVLLAQPTLVDQSRAPLGKHVG
CCCCCCCCCEEEEEEECCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCC
WAYCHVPHGSTVDMTERIEAQVERFAPGFRSLVLARHTRNCAELERYNRNLIGGDINGGI
EEEEECCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCH
QDLRQFMARPTLFSPYRTPLKGLYLCSSGTPPGGGVHGMCGYHAASLALEDIKR
HHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 2'-AMP; FAD; p-Hydroxymercuribenzoate [C]

Metal ions: Ca2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H+; Nicotinamide adenine dinucleotide - reduced; Nicotinamide adenine dinucleotide phosphate [C]

Specific reaction: (2) H+ (Extracellular) + Nicotinamide adenine dinucleotide - reduced + Nicotinamide adenine dinucleotide phosphate --> (2) H+ + Nicotinamide adenine dinucleotide + Nicotinamide adenine dinucleotide phosphate - reduced [C]

General reaction: Redox reaction [C]

Inhibitor: p-Hydroxy mercuribenzoate reducedsubstrate, [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3453116 [H]