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The map label for this gene is mmgC [H]

Identifier: 197119199

GI number: 197119199

Start: 3251928

End: 3253085

Strand: Reverse

Name: mmgC [H]

Synonym: Gbem_2826

Alternate gene names: 197119199

Gene position: 3253085-3251928 (Counterclockwise)

Preceding gene: 308535321

Following gene: 197119198

Centisome position: 70.49

GC content: 62.87

Gene sequence:

>1158_bases
ATGTTTCTGGAACTAAACGAAGAGCAGAAGCTGATTCAGGAGACTGCGCGCGAATTCGCCAAGGCGCAGTTGGAGCCGCT
GGCGGCGAGGCTTGACCGGGAGGATGACCGCCCCGCTTTCCTCGCCAACTTGAAGAAGCTGGCGGAATTAGGCTTCATGG
GGCTGAACGTCTCCGCCGAGTACGGAGGATCGGAAGCGGGAGTGGTCGCCTTCAGCGTCGCCATGACCGAGATCGCCCGG
GCCTGCGCCTCCACGGCGGTCACCGTGTCCGTCAACAACATGGTCTGCGAGGTGATCCAGGCGATCGGCTCGGCCGAGCA
AAAAAAGAAGTACATCCCGCGCATCTGTTCGGGAGAGTACGCCGCCGGTGCCTTCGCCCTGACCGAGACCGGTGCTGGTT
CCGATCCGGCCGGCATGACTACCTCCGCGGTAGCGGAGGGGGACCAGTGGGTGCTGAACGGCTCCAAGATCTTCATCACC
AGCGCCCCGTACGCCGGTGTCTTCGTGGTCTGGGCCGTCACCGATAAGGACGCTCCCAAAGGGAAAGGAATCAGCTGTTT
CCTGGTGGAGCAGGGCGCGCCCGGGCTGGTGATAGGGAAGCAGGAAGAGAAGACCGGCCAGCACGCCTCCGCCACCTGCG
AGGTGCTCTTTGACAACTGCAGGATTCCCAAGGACGCCCTGATGGGGAAGCTGAACGACGGTTTCCGCATAGCGGTCGGC
GAGTTGGCCGGCGGGAGGATCGGCATCGGTTCCCTTGGGCTGGGAGTGGGACTTGCGGCGATGGACTTCGCCACCAGGTA
CGCCAGCGAGAGGGTGCAGTTCGGGCAGAAGATCACCAATTTCCAGGCCATCCAGTGGATGGTAGCCGAGGCCTACACGG
AGCTTGAGGCCGCGCGCCTGTTGCTGATGCAGGCCGCCTACCGCAAGGATGCCGGCAAGTCCTTTGCCAAGGAAGCCTCC
ATGGCCAAGATGTACGCCACCGAGGCGGCGAACCGGGCCTGCTACAGCGCGGTCCAGATGCTGGGGGGGTACGGCTACAC
CCGCGACTTCCCCGTCGAACGCTATGCCCGCGACGCCCGCATCACCGCTATTTACGAGGGTACCAACGAGATTCAGCGGG
TGATCATAGCCAGGGAGATATTGCGCAACTTCAATTGA

Upstream 100 bases:

>100_bases
AAAAAAGCGCGGCAAATTGGCAACAGTGGGGGCAGGAAAACGATGTGCCGATAGTCGCTTTGGCGTGATGACCTGGGGTT
GCACCTGAAGGGAGGAATCG

Downstream 100 bases:

>100_bases
AGCGTCCGACAGGTCAGACAGGTCAGACAGGTCCGACTGATTGAGAAAACAGGAGGGTGTCTATGACTGGCAAGCGCATC
ACCTTACAGCAGGCTGCGGA

Product: short-chain acyl-CoA dehydrogenase

Products: 2-butenoyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MFLELNEEQKLIQETAREFAKAQLEPLAARLDREDDRPAFLANLKKLAELGFMGLNVSAEYGGSEAGVVAFSVAMTEIAR
ACASTAVTVSVNNMVCEVIQAIGSAEQKKKYIPRICSGEYAAGAFALTETGAGSDPAGMTTSAVAEGDQWVLNGSKIFIT
SAPYAGVFVVWAVTDKDAPKGKGISCFLVEQGAPGLVIGKQEEKTGQHASATCEVLFDNCRIPKDALMGKLNDGFRIAVG
ELAGGRIGIGSLGLGVGLAAMDFATRYASERVQFGQKITNFQAIQWMVAEAYTELEAARLLLMQAAYRKDAGKSFAKEAS
MAKMYATEAANRACYSAVQMLGGYGYTRDFPVERYARDARITAIYEGTNEIQRVIIAREILRNFN

Sequences:

>Translated_385_residues
MFLELNEEQKLIQETAREFAKAQLEPLAARLDREDDRPAFLANLKKLAELGFMGLNVSAEYGGSEAGVVAFSVAMTEIAR
ACASTAVTVSVNNMVCEVIQAIGSAEQKKKYIPRICSGEYAAGAFALTETGAGSDPAGMTTSAVAEGDQWVLNGSKIFIT
SAPYAGVFVVWAVTDKDAPKGKGISCFLVEQGAPGLVIGKQEEKTGQHASATCEVLFDNCRIPKDALMGKLNDGFRIAVG
ELAGGRIGIGSLGLGVGLAAMDFATRYASERVQFGQKITNFQAIQWMVAEAYTELEAARLLLMQAAYRKDAGKSFAKEAS
MAKMYATEAANRACYSAVQMLGGYGYTRDFPVERYARDARITAIYEGTNEIQRVIIAREILRNFN
>Mature_385_residues
MFLELNEEQKLIQETAREFAKAQLEPLAARLDREDDRPAFLANLKKLAELGFMGLNVSAEYGGSEAGVVAFSVAMTEIAR
ACASTAVTVSVNNMVCEVIQAIGSAEQKKKYIPRICSGEYAAGAFALTETGAGSDPAGMTTSAVAEGDQWVLNGSKIFIT
SAPYAGVFVVWAVTDKDAPKGKGISCFLVEQGAPGLVIGKQEEKTGQHASATCEVLFDNCRIPKDALMGKLNDGFRIAVG
ELAGGRIGIGSLGLGVGLAAMDFATRYASERVQFGQKITNFQAIQWMVAEAYTELEAARLLLMQAAYRKDAGKSFAKEAS
MAKMYATEAANRACYSAVQMLGGYGYTRDFPVERYARDARITAIYEGTNEIQRVIIAREILRNFN

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=383, Percent_Identity=46.9973890339426, Blast_Score=336, Evalue=3e-92,
Organism=Homo sapiens, GI4501859, Length=377, Percent_Identity=41.1140583554377, Blast_Score=297, Evalue=1e-80,
Organism=Homo sapiens, GI7656849, Length=383, Percent_Identity=39.686684073107, Blast_Score=271, Evalue=6e-73,
Organism=Homo sapiens, GI226958412, Length=384, Percent_Identity=35.4166666666667, Blast_Score=250, Evalue=1e-66,
Organism=Homo sapiens, GI187960098, Length=384, Percent_Identity=36.1979166666667, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI4557231, Length=384, Percent_Identity=36.1979166666667, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI226958414, Length=355, Percent_Identity=36.056338028169, Blast_Score=231, Evalue=6e-61,
Organism=Homo sapiens, GI21361497, Length=387, Percent_Identity=36.6925064599483, Blast_Score=218, Evalue=9e-57,
Organism=Homo sapiens, GI4501857, Length=381, Percent_Identity=32.2834645669291, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI76496475, Length=389, Percent_Identity=33.6760925449871, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI4557235, Length=389, Percent_Identity=33.6760925449871, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI4503943, Length=384, Percent_Identity=30.7291666666667, Blast_Score=156, Evalue=4e-38,
Organism=Homo sapiens, GI7669494, Length=370, Percent_Identity=30.2702702702703, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI211971008, Length=298, Percent_Identity=28.8590604026846, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI48976061, Length=298, Percent_Identity=28.8590604026846, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI38505218, Length=365, Percent_Identity=26.8493150684932, Blast_Score=105, Evalue=5e-23,
Organism=Escherichia coli, GI1786223, Length=385, Percent_Identity=30.9090909090909, Blast_Score=171, Evalue=5e-44,
Organism=Escherichia coli, GI87081958, Length=385, Percent_Identity=29.8701298701299, Blast_Score=161, Evalue=7e-41,
Organism=Escherichia coli, GI87081702, Length=372, Percent_Identity=27.6881720430108, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI87082384, Length=277, Percent_Identity=26.7148014440433, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17508101, Length=377, Percent_Identity=40.3183023872679, Blast_Score=281, Evalue=4e-76,
Organism=Caenorhabditis elegans, GI17506239, Length=377, Percent_Identity=39.2572944297082, Blast_Score=277, Evalue=6e-75,
Organism=Caenorhabditis elegans, GI17538396, Length=382, Percent_Identity=37.696335078534, Blast_Score=265, Evalue=4e-71,
Organism=Caenorhabditis elegans, GI17534899, Length=386, Percent_Identity=35.4922279792746, Blast_Score=246, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI17533517, Length=371, Percent_Identity=36.1185983827493, Blast_Score=244, Evalue=4e-65,
Organism=Caenorhabditis elegans, GI17570075, Length=384, Percent_Identity=34.1145833333333, Blast_Score=237, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI17569725, Length=384, Percent_Identity=34.1145833333333, Blast_Score=234, Evalue=8e-62,
Organism=Caenorhabditis elegans, GI71990804, Length=306, Percent_Identity=38.8888888888889, Blast_Score=221, Evalue=4e-58,
Organism=Caenorhabditis elegans, GI71985184, Length=361, Percent_Identity=35.4570637119114, Blast_Score=178, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI32563615, Length=233, Percent_Identity=39.9141630901288, Blast_Score=174, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI71982178, Length=280, Percent_Identity=33.9285714285714, Blast_Score=171, Evalue=6e-43,
Organism=Caenorhabditis elegans, GI17534353, Length=381, Percent_Identity=29.6587926509186, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17531909, Length=247, Percent_Identity=36.4372469635627, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI71985192, Length=305, Percent_Identity=33.4426229508197, Blast_Score=134, Evalue=8e-32,
Organism=Caenorhabditis elegans, GI17551932, Length=378, Percent_Identity=26.984126984127, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17505929, Length=378, Percent_Identity=26.7195767195767, Blast_Score=118, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI17531913, Length=184, Percent_Identity=33.695652173913, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17562446, Length=290, Percent_Identity=28.9655172413793, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI86563381, Length=376, Percent_Identity=26.8617021276596, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI86563383, Length=376, Percent_Identity=26.8617021276596, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI21356377, Length=381, Percent_Identity=42.7821522309711, Blast_Score=305, Evalue=5e-83,
Organism=Drosophila melanogaster, GI24646207, Length=380, Percent_Identity=40.5263157894737, Blast_Score=301, Evalue=4e-82,
Organism=Drosophila melanogaster, GI24666513, Length=382, Percent_Identity=40.3141361256544, Blast_Score=286, Evalue=2e-77,
Organism=Drosophila melanogaster, GI24660351, Length=378, Percent_Identity=36.2433862433862, Blast_Score=244, Evalue=1e-64,
Organism=Drosophila melanogaster, GI21355753, Length=382, Percent_Identity=33.7696335078534, Blast_Score=230, Evalue=1e-60,
Organism=Drosophila melanogaster, GI281363737, Length=350, Percent_Identity=37.4285714285714, Blast_Score=202, Evalue=2e-52,
Organism=Drosophila melanogaster, GI19920834, Length=385, Percent_Identity=31.4285714285714, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24652780, Length=310, Percent_Identity=22.258064516129, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45550141, Length=396, Percent_Identity=25.5050505050505, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI221473076, Length=396, Percent_Identity=25.5050505050505, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.2

Molecular weight: Translated: 41442; Mature: 41442

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLELNEEQKLIQETAREFAKAQLEPLAARLDREDDRPAFLANLKKLAELGFMGLNVSAE
CEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCEEECC
YGGSEAGVVAFSVAMTEIARACASTAVTVSVNNMVCEVIQAIGSAEQKKKYIPRICSGEY
CCCCCCCHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHCCHHHHHHHCCHHCCCCC
AAGAFALTETGAGSDPAGMTTSAVAEGDQWVLNGSKIFITSAPYAGVFVVWAVTDKDAPK
CCCEEEEEECCCCCCCCCCCHHHHCCCCEEEEECCEEEEEECCCCCEEEEEEEECCCCCC
GKGISCFLVEQGAPGLVIGKQEEKTGQHASATCEVLFDNCRIPKDALMGKLNDGFRIAVG
CCCEEEEEEECCCCEEEEECCHHHCCCCCHHHHEEHHCCCCCCHHHHHCCCCCCEEEEEE
ELAGGRIGIGSLGLGVGLAAMDFATRYASERVQFGQKITNFQAIQWMVAEAYTELEAARL
CCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLMQAAYRKDAGKSFAKEASMAKMYATEAANRACYSAVQMLGGYGYTRDFPVERYARDAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCE
ITAIYEGTNEIQRVIIAREILRNFN
EEEEECCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFLELNEEQKLIQETAREFAKAQLEPLAARLDREDDRPAFLANLKKLAELGFMGLNVSAE
CEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCEEECC
YGGSEAGVVAFSVAMTEIARACASTAVTVSVNNMVCEVIQAIGSAEQKKKYIPRICSGEY
CCCCCCCHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHCCHHHHHHHCCHHCCCCC
AAGAFALTETGAGSDPAGMTTSAVAEGDQWVLNGSKIFITSAPYAGVFVVWAVTDKDAPK
CCCEEEEEECCCCCCCCCCCHHHHCCCCEEEEECCEEEEEECCCCCEEEEEEEECCCCCC
GKGISCFLVEQGAPGLVIGKQEEKTGQHASATCEVLFDNCRIPKDALMGKLNDGFRIAVG
CCCEEEEEEECCCCEEEEECCHHHCCCCCHHHHEEHHCCCCCCHHHHHCCCCCCEEEEEE
ELAGGRIGIGSLGLGVGLAAMDFATRYASERVQFGQKITNFQAIQWMVAEAYTELEAARL
CCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLMQAAYRKDAGKSFAKEASMAKMYATEAANRACYSAVQMLGGYGYTRDFPVERYARDAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCE
ITAIYEGTNEIQRVIIAREILRNFN
EEEEECCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: butanoyl-CoA; acceptor

Specific reaction: butanoyl-CoA + acceptor = 2-butenoyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]